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	<id>https://camih.med.uni-jena.de/camih/api.php?action=feedcontributions&amp;feedformat=atom&amp;user=Cotto</id>
	<title>CAMIH - User contributions [en]</title>
	<link rel="self" type="application/atom+xml" href="https://camih.med.uni-jena.de/camih/api.php?action=feedcontributions&amp;feedformat=atom&amp;user=Cotto"/>
	<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/wiki/Special:Contributions/Cotto"/>
	<updated>2026-06-21T10:57:02Z</updated>
	<subtitle>User contributions</subtitle>
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	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Main_Page&amp;diff=8246</id>
		<title>Main Page</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Main_Page&amp;diff=8246"/>
		<updated>2026-01-16T13:52:29Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;html&amp;gt;&lt;br /&gt;
== What is CAMIH? ==&lt;br /&gt;
CAMIH is a database offering up-to-date evidence from randomized controlled trials on complementary approaches and methods for treating oncology patients. Each study has been meticulously reviewed and critically evaluated for methodological rigor using the Cochrane Risk of Bias Tool 2.0. This approach ensures that the database not only provides a comprehensive collection of evidence but also contextualizes these findings within a framework of methodological quality.&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
Study searches can be conducted directly via the search bar, but we also offer a thematically organized overview of all studies. Additionally, CAMIH provides an option for specific, customized search queries (via the Query Helper) to generate a targeted summary on the topic of interest. &lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
Via FAQ you can get information on the Level of Evidence, the RoB Tool 2.0. and types of analyses. &lt;br /&gt;
&lt;br /&gt;
== Important Links ==&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
File:studies_by_type.png |&#039;&#039;&#039;Studies by study type&#039;&#039;&#039;|link=Category:Study&lt;br /&gt;
File:studies_by_topic.png |&#039;&#039;&#039;Studies by topic&#039;&#039;&#039;|link=Study_Overview&lt;br /&gt;
File:all_publications.png |&#039;&#039;&#039;Available publications&#039;&#039;&#039;|link=Category:Publication&lt;br /&gt;
File:faq.png |&#039;&#039;&#039;FAQ&#039;&#039;&#039;|link=FAQ&lt;br /&gt;
File:helper.png |&#039;&#039;&#039;Query helper&#039;&#039;&#039;|link=https://camih.med.uni-jena.de/helper&lt;br /&gt;
&amp;lt;/gallery&amp;gt;&lt;br /&gt;
&lt;br /&gt;
== Creator Tools ==&lt;br /&gt;
* [[Form:Author|New Author]]&lt;br /&gt;
* [[Form:Publication|New Publication]]&lt;br /&gt;
* [[Form:RCT_Study|New RCT Study]]&lt;br /&gt;
* [[Form:SR_Study|New SR Study]]&lt;br /&gt;
&lt;br /&gt;
== Need an account? ==&lt;br /&gt;
Write an E-Mail to [mailto:christian.otto@med.uni-jena.de this address] with the following information:&lt;br /&gt;
* first name&lt;br /&gt;
* last name&lt;br /&gt;
* any kind of proof that you are affiliated with a medical institute or hospital (E-Mail address is sufficient)&lt;br /&gt;
We will send you your login information as soon as possible!&lt;br /&gt;
&lt;br /&gt;
{{DISPLAYTITLE:CAMIH — the Complementary and Alternative Medicine Insights Hub}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Main_Page&amp;diff=8245</id>
		<title>Main Page</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Main_Page&amp;diff=8245"/>
		<updated>2025-06-25T12:40:44Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;html&amp;gt;&lt;br /&gt;
== What is CAMIH? ==&lt;br /&gt;
CAMIH is a database offering up-to-date evidence from randomized controlled trials on complementary approaches and methods for treating oncology patients. Each study has been meticulously reviewed and critically evaluated for methodological rigor using the Cochrane Risk of Bias Tool 2.0. This approach ensures that the database not only provides a comprehensive collection of evidence but also contextualizes these findings within a framework of methodological quality.&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
Study searches can be conducted directly via the search bar, but we also offer a thematically organized overview of all studies. Additionally, CAMIH provides an option for specific, customized search queries (via the Query Helper) to generate a targeted summary on the topic of interest. &lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
Via FAQ you can get information on the Level of Evidence, the RoB Tool 2.0. and types of analyses. &lt;br /&gt;
&lt;br /&gt;
== Important Links ==&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
File:studies_by_type.png |&#039;&#039;&#039;Studies by study type&#039;&#039;&#039;|link=Category:Study&lt;br /&gt;
File:studies_by_topic.png |&#039;&#039;&#039;Studies by topic&#039;&#039;&#039;|link=Study_Overview&lt;br /&gt;
File:all_publications.png |&#039;&#039;&#039;Available publications&#039;&#039;&#039;|link=Category:Publication&lt;br /&gt;
File:faq.png |&#039;&#039;&#039;FAQ&#039;&#039;&#039;|link=FAQ&lt;br /&gt;
File:helper.png |&#039;&#039;&#039;Query helper&#039;&#039;&#039;|link=https://camih.med.uni-jena.de/helper&lt;br /&gt;
&amp;lt;/gallery&amp;gt;&lt;br /&gt;
&lt;br /&gt;
== Creator Tools ==&lt;br /&gt;
* [[Form:Author|New Author]]&lt;br /&gt;
* [[Form:Publication|New Publication]]&lt;br /&gt;
* [[Form:RCT_Study|New RCT Study]]&lt;br /&gt;
* [[Form:SR_Study|New SR Study]]&lt;br /&gt;
&lt;br /&gt;
== Need an account? ==&lt;br /&gt;
Write an E-Mail to [mailto:christian.otto@med.uni-jena.de this adress] with the following information:&lt;br /&gt;
* first name&lt;br /&gt;
* last name&lt;br /&gt;
* any kind of proof that you are affiliated with a medical institute or hospital (E-Mail adress is sufficient)&lt;br /&gt;
We will send you your login information as soon as possible!&lt;br /&gt;
&lt;br /&gt;
{{DISPLAYTITLE:CAMIH — the Complementary and Alternative Medicine Insights Hub}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Main_Page&amp;diff=8244</id>
		<title>Main Page</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Main_Page&amp;diff=8244"/>
		<updated>2025-03-26T08:46:14Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;html&amp;gt;&lt;br /&gt;
== What is CAMIH? ==&lt;br /&gt;
CAMIH is a database offering up-to-date evidence from randomized controlled trials on complementary approaches and methods for treating oncology patients. Each study has been meticulously reviewed and critically evaluated for methodological rigor using the Cochrane Risk of Bias Tool 2.0. This approach ensures that the database not only provides a comprehensive collection of evidence but also contextualizes these findings within a framework of methodological quality.&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
Study searches can be conducted directly via the search bar, but we also offer a thematically organized overview of all studies. Additionally, CAMIH provides an option for specific, customized search queries (via the Query Helper) to generate a targeted summary on the topic of interest. &lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
Via FAQ you can get information on the Level of Evidence, the RoB Tool 2.0. and types of analyses. &lt;br /&gt;
&lt;br /&gt;
== Important Links ==&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
File:studies_by_type.png |&#039;&#039;&#039;Studies by study type&#039;&#039;&#039;|link=Category:Study&lt;br /&gt;
File:studies_by_topic.png |&#039;&#039;&#039;Studies by topic&#039;&#039;&#039;|link=Study_Overview&lt;br /&gt;
File:all_publications.png |&#039;&#039;&#039;Available publications&#039;&#039;&#039;|link=Category:Publication&lt;br /&gt;
File:faq.png |&#039;&#039;&#039;FAQ&#039;&#039;&#039;|link=FAQ&lt;br /&gt;
File:helper.png |&#039;&#039;&#039;Query helper&#039;&#039;&#039;|link=https://camih.med.uni-jena.de/helper&lt;br /&gt;
&amp;lt;/gallery&amp;gt;&lt;br /&gt;
&lt;br /&gt;
== Creator Tools ==&lt;br /&gt;
* [[Form:Author|New Author]]&lt;br /&gt;
* [[Form:Publication|New Publication]]&lt;br /&gt;
* [[Form:RCT_Study|New RCT Study]]&lt;br /&gt;
* [[Form:SR_Study|New SR Study]]&lt;br /&gt;
&lt;br /&gt;
{{DISPLAYTITLE:Welcome to CAMIH, the Complementary and Alternative Medicine Insights Hub!}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Chung_et_al._(2026):_Randomized_Trial_of_Vitamin_C/E_Complex_for_Prevention_of_Radiation-_Induced_Xerostomia_in_Patients_with_Head_and_Neck_Cancer&amp;diff=8243</id>
		<title>Chung et al. (2026): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Chung_et_al._(2026):_Randomized_Trial_of_Vitamin_C/E_Complex_for_Prevention_of_Radiation-_Induced_Xerostomia_in_Patients_with_Head_and_Neck_Cancer&amp;diff=8243"/>
		<updated>2024-12-12T10:31:10Z</updated>

		<summary type="html">&lt;p&gt;Cotto: Cotto moved page Chung et al. (2026): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer to Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer: wrong publication year&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;#REDIRECT [[Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer]]&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Chung_et_al._(2016):_Randomized_Trial_of_Vitamin_C/E_Complex_for_Prevention_of_Radiation-_Induced_Xerostomia_in_Patients_with_Head_and_Neck_Cancer&amp;diff=8242</id>
		<title>Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Chung_et_al._(2016):_Randomized_Trial_of_Vitamin_C/E_Complex_for_Prevention_of_Radiation-_Induced_Xerostomia_in_Patients_with_Head_and_Neck_Cancer&amp;diff=8242"/>
		<updated>2024-12-12T10:31:10Z</updated>

		<summary type="html">&lt;p&gt;Cotto: Cotto moved page Chung et al. (2026): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer to Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer: wrong publication year&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{Reference&lt;br /&gt;
|Reference=Publication: Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer&lt;br /&gt;
}}&lt;br /&gt;
{{Study Note}}&lt;br /&gt;
=Brief summary=&lt;br /&gt;
Data from 45 patients were analyzed in this study. The patients were randomly divided into groups and received either a vitamin combination of vitamin C and E or a placebo. The intake took place from one week before the concurrent radiotherapy over an average duration of three months. The effects on the patients&#039; dry mouth (xerostomia), the general survival time and the length of the disease-free interval were observed. It was found that the group that had taken the vitamin combination showed a deterioration in their dry mouth score one month after radiotherapy treatment, but then showed a clear improvement after six months. The placebo group also showed a deterioration one month after the therapy, but remained relatively constant overall - even six months later - in their assessment of the severity of dry mouth. The same results were also confirmed by the observers. Measured by salivary scintigraphy, there were advantages for the intervention group, which indicates a positive influence of the vitamin combination on the maintenance of salivary activity. No differences were found between the groups with regard to general survival time and the length of the disease-free interval. However, most of the results describe the progression of the individual groups rather than a direct group comparison. Furthermore, significantly more patients in the vitamin group dropped out during the course of the study than in the placebo group, although the reasons for this are not explained. Due to these factors and the relatively small sample size, the results can only be trusted to a limited extent.&lt;br /&gt;
&lt;br /&gt;
In dieser Studie wurden Daten von 45 Patienten ausgewertet. Die Patienten erhielten in zufällig aufgeteilten Gruppen entweder eine Vitaminkombination aus Vitamin C und E oder ein Placebo. Die Einnahme erfolgte ab einer Woche vor der gleichzeitig stattfindenden Radiotherapie über eine durchschnittliche Dauer von drei Monaten. Beobachtet wurden die Auswirkungen auf die Mundtrockenheit (Xerostomie) der Patienten, die allgemeine Überlebensdauer sowie die Länge des krankheitsfreien Intervalls. Man fand heraus, dass sich die Gruppe, die die Vitaminkombination genommen hatte laut den eigenen Angaben im Wert bzgl. ihrer Mundtrockenheit einen Monat nach der Radiotherapiebehandlung verschlechterte, nach sechs Monaten dann aber eine deutliche Verbesserung zeigte. Die Placebo-Gruppe zeigte einen Monat nach der Therapie zwar auch eine Verschlechterung, blieb insgesamt – auch sechs Monate danach – aber relativ konstant in ihrer Einschätzung der Stärke der Mundtrockenheit. Die gleichen Ergebnisse konnte man auch durch die Angaben der Beobachter bestätigen. Gemessen durch eine Speichel Szintigrafie, zeigten sich Vorteile für die Interventionsgruppe, was für einen positiven Einfluss der Vitaminkombination auf den Erhalt der Speicheltätigkeit spricht. Bezüglich der allgemeinen Überlebensdauer und der Länge des krankheitsfreien Intervalls ließen sich keine Unterschiede zwischen den Gruppen feststellen. In den meisten Ergebnissen werden jedoch eher die Verläufe der einzelnen Gruppen beschrieben und kein direkter Gruppenvergleich durchgeführt. Des Weiteren sind in der Vitamin-Gruppe deutlich mehr Patienten im Verlauf der Studie ausgestiegen, als in der Placebo-Gruppe, wobei die Gründe dafür nicht erläutert werden. Aufgrund dieser Faktoren sowie der relativ kleinen Stichprobengröße kann man den Ergebnissen nur bedingt vertrauen.&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
&lt;br /&gt;
{{Study Design (RCT)&lt;br /&gt;
|Perspective=Prospective&lt;br /&gt;
|Centralized=Monocentric&lt;br /&gt;
|Blinding=Double&lt;br /&gt;
|Is randomized=Yes&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|Number of arms=2&lt;br /&gt;
}}&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
&lt;br /&gt;
{{RCT study general properties&lt;br /&gt;
|Inclusion criteria=Diagnosed with biopsy-proven Head-Neck-Cancer, treated with &amp;gt;4000-cGy intensity-modulated radiotherapy&lt;br /&gt;
|Exclusion criteria=- Simultaneous malignancies&lt;br /&gt;
- Karnofsky performance score &amp;lt;60%&lt;br /&gt;
- Previous adverse reactions to the investigational product or salivary scintigraphy&lt;br /&gt;
- History of vitamin medication within the past 3 months OR&lt;br /&gt;
- Salivary gland excision during surgery&lt;br /&gt;
|N randomized=52&lt;br /&gt;
|Analysis=mITT Analysis&lt;br /&gt;
|Specifications on analyses=According to authors ITT analysis but loss to follow-up (n=7) not included in analyses&lt;br /&gt;
|Countries of data collection=NI&lt;br /&gt;
|LoE=2b Oxford 2009&lt;br /&gt;
|Outcome timeline=T0: before radiotherapy, &lt;br /&gt;
T1: 1 month post-radiotherapy,&lt;br /&gt;
T2: 6 months post-radiotherapy&lt;br /&gt;
}}&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
&lt;br /&gt;
{{Characteristics of participants&lt;br /&gt;
|Setting=Curative, Adjuvant&lt;br /&gt;
|Types of cancer=Head and Neck Cancers, Head and Neck Cancers - Oral Cancer, Head and Neck Cancers - Oropharyngeal Cancer, Head and Neck Cancers - Laryngeal Cancer, Head and Neck Cancers - Nasopharyngeal Cancer&lt;br /&gt;
|Stage cancer=Early Stage, Advanced Stage&lt;br /&gt;
|Cancer stage specification=N per arm:&lt;br /&gt;
- intervention: 9x stage I-II, 16x stage III-IV&lt;br /&gt;
- placebo: 6x stage I-II, 14x stage III-IV&lt;br /&gt;
|Comorbidity=NI&lt;br /&gt;
|Current cancer therapy=Chemotherapy, Radiation therapy&lt;br /&gt;
|Specifications on cancer therapies=Types of radiotherapy per arm:&lt;br /&gt;
- intervention: 9x radiotherapy, 16x concurrent chemoradiotherapy&lt;br /&gt;
- placebo: 6x radiotherapy, 14x concurrent chemoradiotherapy&lt;br /&gt;
&lt;br /&gt;
N for adjuvant/definitive setting per arm: &lt;br /&gt;
- intervention: 15/10&lt;br /&gt;
- placebo:9/11&lt;br /&gt;
|Previous cancer therapies=Surgery&lt;br /&gt;
|Gender=Mixed&lt;br /&gt;
|Gender specifications=Overall 11.1% female, male/female per arm:&lt;br /&gt;
- intervention: 22/3&lt;br /&gt;
- placebo: 18/2&lt;br /&gt;
|Age groups=Adults (18+)&lt;br /&gt;
|Age groups specification=Overall age in years, mean (SD) = 58.8 (10.5); per arm:&lt;br /&gt;
- intervention: 56.6 (11.3)&lt;br /&gt;
- placebo: 61.6 (9.6)&lt;br /&gt;
}}&lt;br /&gt;
=Arms=&lt;br /&gt;
&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Intervention&lt;br /&gt;
|Number of participants (arm)=26&lt;br /&gt;
|Drop-out=1&lt;br /&gt;
|Drop-out reasons=Lost to follow-up 6 month post-radiotherapy (n=1, refusal)&lt;br /&gt;
|Intervention=Radiotherapy + vitamin E + vitamin C&lt;br /&gt;
|Dosage and regime=100 IU vitamin E + 500mg vitamin C, orally, 2x daily, duration: 1 week prior to radiotherapy until 1 month after radiotherapy (average intervention period: 3 months)&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=-999&lt;br /&gt;
|Side Effects / Interactions=No significant adverse events or side effects related to study medication noticed/reported throughout the trial&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Arm topic=Vitamin C, Vitamin E&lt;br /&gt;
}}&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Placebo&lt;br /&gt;
|Number of participants (arm)=26&lt;br /&gt;
|Drop-out=6&lt;br /&gt;
|Drop-out reasons=Lost to follow-up 1 month post-radiotherapy (n=2, refusal/poor compliance)&lt;br /&gt;
Lost to follow-up 6 month post-radiotherapy (n=4, 2x refusal/poor compliance), 2x disease recurrence)&lt;br /&gt;
|Intervention=Radiotherapy + placebo&lt;br /&gt;
|Dosage and regime=Placebo pill, orally, 2x daily, duration: 1 week prior to radiotherapy until 1 month after radiotherapy (average intervention period: 3 months)&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=-999&lt;br /&gt;
|Side Effects / Interactions=No significant adverse events or side effects related to study medication noticed/reported throughout the trial&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Arm topic=Vitamin C, Vitamin E&lt;br /&gt;
}}&lt;br /&gt;
{{Arm Overview}}&lt;br /&gt;
=Outcomes=&lt;br /&gt;
&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=NI&lt;br /&gt;
|Outcome name=Xerostomia&lt;br /&gt;
|Outcome specification=- Patient self-assessment by xerostomia questionnaire (XQ)&lt;br /&gt;
- Xerostomia score assessed by observer (XS)&lt;br /&gt;
- Salivary scintigraphy (maximum accumulation, ejection fraction and prestimulatory and poststimulatory oral index)&lt;br /&gt;
|Type of measurement=Observation, Scintigraphy, Self-developed measurement instrument&lt;br /&gt;
|Results during intervention=NA&lt;br /&gt;
|Results after intervention=T0: before radiotherapy, &lt;br /&gt;
T1: 1 month post-radiotherapy,&lt;br /&gt;
T2: 6 months post-radiotherapy&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Xerostomia questionnaire&#039;&#039;&#039; (mean (SD), no group comparison reported)&lt;br /&gt;
Intervention arm&lt;br /&gt;
T0: 5.4 (4.3), T1: 8.1 (4.2), T2: 5.4 (4.0)&lt;br /&gt;
T0-T1: p = 0.02, T1-T2: p = 0.007&lt;br /&gt;
Placebo arm&lt;br /&gt;
T0: 4.6 (3.8), T1: 7.0 (4.5), T2: 7.0 (4.6) &lt;br /&gt;
T0-T1: p = 0.06 T1-T2: p = 0.97&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Xerostomia score&#039;&#039;&#039; (no group comparison reported)&lt;br /&gt;
Intervention arm&lt;br /&gt;
T0: 2.8 (2.3), T1: 5.0 (2.8), T2: 3.7 (3.9) &lt;br /&gt;
T0-T1: p = 0.004, T1-T2: p = 0.008&lt;br /&gt;
Placebo arm&lt;br /&gt;
T0: 1.7 (1.4), T1: 3.9 (2.4), T2: 3.3 (2.3) &lt;br /&gt;
T0-T1: p = 0.004, T1-T2: p = 0.47&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Salivary scintigraphy&#039;&#039;&#039;&lt;br /&gt;
No group difference for maximum accumulation, or ejection fraction at T1 or T2 (p=0.86, p=0.15; p=0.57, p=0.68), &lt;br /&gt;
Intervention arm showed better values before (p=0.01) and after stimulation (p=0.009) compared to placebo arm at T1&lt;br /&gt;
|Bias arising from the randomization process=?&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=?&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=?&lt;br /&gt;
|Bias in measurement of the outcome=?&lt;br /&gt;
|Bias in selection of the reported result=?&lt;br /&gt;
|Other sources of bias=?&lt;br /&gt;
|Overall RoB judgment=?&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Outcome topic=Vitamin C, Vitamin E&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=NI&lt;br /&gt;
|Outcome name=OS (Overall Survival)&lt;br /&gt;
|Outcome specification=NA&lt;br /&gt;
|Type of measurement=Observation&lt;br /&gt;
|Results during intervention=NA&lt;br /&gt;
|Results after intervention=&#039;&#039;&#039;Overall&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
No significant differences between arms (p = 0.75)&lt;br /&gt;
|Bias arising from the randomization process=?&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=?&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=?&lt;br /&gt;
|Bias in measurement of the outcome=?&lt;br /&gt;
|Bias in selection of the reported result=?&lt;br /&gt;
|Other sources of bias=?&lt;br /&gt;
|Overall RoB judgment=?&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Outcome topic=Vitamin C, Vitamin E&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=NI&lt;br /&gt;
|Outcome name=DFS (Disease-Free Survival)&lt;br /&gt;
|Outcome specification=NA&lt;br /&gt;
|Type of measurement=Observation&lt;br /&gt;
|Results during intervention=NA&lt;br /&gt;
|Results after intervention=&#039;&#039;&#039;Overall&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
No significant differences between arms (p = 0.87)&lt;br /&gt;
|Bias arising from the randomization process=?&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=?&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=?&lt;br /&gt;
|Bias in measurement of the outcome=?&lt;br /&gt;
|Bias in selection of the reported result=?&lt;br /&gt;
|Other sources of bias=?&lt;br /&gt;
|Overall RoB judgment=?&lt;br /&gt;
|Order number=3&lt;br /&gt;
|Outcome topic=Vitamin C, Vitamin E&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome Overview}}&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
&lt;br /&gt;
{{Funding and Conflicts of Interest&lt;br /&gt;
|Funding=National R&amp;amp;D Program for Cancer Control (No. 0820300), Ministry of Health and Welfare, Seoul, Republic of Korea.&lt;br /&gt;
|Conflicts of Interest=According to authors no conflict of interest&lt;br /&gt;
}}&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
&lt;br /&gt;
{{Further points for assessing the study&lt;br /&gt;
|power analysis performed=?&lt;br /&gt;
|Sample size corresponds to power analysis=?&lt;br /&gt;
|Reasons given for samples being too small according to power analysis=?&lt;br /&gt;
|Samples sufficiently large=?&lt;br /&gt;
|Ethnicity mentioned=?&lt;br /&gt;
|Other explanations for an effect besides the investigated intervention=?&lt;br /&gt;
|Possibility of attention effects=?&lt;br /&gt;
|Possibility of placebo effects=?&lt;br /&gt;
|Other reasons=?&lt;br /&gt;
|Correct use of parametric and non-parametric tests=?&lt;br /&gt;
|Correction for multiple testing=?&lt;br /&gt;
|Measurement of compliance=?&lt;br /&gt;
|Consistent reporting in numbers=?&lt;br /&gt;
|Comprehensive and coherent reporting=?&lt;br /&gt;
|Cross-over=?&lt;br /&gt;
|sufficient washout period=?&lt;br /&gt;
|Tested for carry-over effects=?&lt;br /&gt;
|Were sequence effects tested=?&lt;br /&gt;
|Effect sizes reported=?&lt;br /&gt;
|Were side effects systematically recorded=?&lt;br /&gt;
|Side effects taken into account in the interpretation of the results=?&lt;br /&gt;
|Ethics / CoI / Funding=?&lt;br /&gt;
|reasons given for samples being too small according to power analysis=?&lt;br /&gt;
|Testing for normal distribution=?&lt;br /&gt;
|Correct application of statistical tests=?&lt;br /&gt;
|Blinding reliable=?&lt;br /&gt;
|Check whether blinding was successful=?&lt;br /&gt;
|mono- or multicentric=?&lt;br /&gt;
}}&lt;br /&gt;
{{Additional Notes&lt;br /&gt;
|Additional Notes=PRO: &lt;br /&gt;
* Ethics vote&lt;br /&gt;
* Double blinding &lt;br /&gt;
* Intention-to-treat&lt;br /&gt;
CONTRA: &lt;br /&gt;
* No proper group comparisons between intervention and placebo arm on xerostomia questionnaire and xerostomia score&lt;br /&gt;
* Small sample without power analysis &lt;br /&gt;
* Unequal dropout (intervention arm: 4%, placebo arm: 23%) &lt;br /&gt;
* No validation information on the measurement instruments used &lt;br /&gt;
* Poor reporting quality (e.g. results reported confusingly)&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=8046</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=8046"/>
		<updated>2024-12-11T13:22:56Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== What are the indications for taking selenium? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
[[Outcome topic::Selenium]]&lt;br /&gt;
|?Outcome name&lt;br /&gt;
|?Results during intervention&lt;br /&gt;
|?Overall RoB judgment&lt;br /&gt;
|limit=5&lt;br /&gt;
|headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== What are the side effects of cannabis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabinoids]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Does curcumin help against nausea? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Curcumin]]&lt;br /&gt;
 [[Outcome name::Nausea||Nausea and Vomiting||CINV (Chemotherapy-Induced Nausea and Vomiting)]]&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |?Outcome specification&lt;br /&gt;
 |?Results during intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== What is cannabis recommended for/against? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabiniods]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Does selenium help with mucositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Selenium]]&lt;br /&gt;
 [[Outcome name::Mucositis]]&lt;br /&gt;
 |?Outcome specification&lt;br /&gt;
 |?Results during intervention&lt;br /&gt;
 |?Results after intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== What is the optimal dosage of cannabis for the treatment of nausea? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Cannabinoids]]&lt;br /&gt;
 [[Outcome name::CINV (Chemotherapy-Induced Nausea and Vomiting)||Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |?Outcome specification&lt;br /&gt;
 |?Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:Outcome&amp;diff=7897</id>
		<title>Template:Outcome</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:Outcome&amp;diff=7897"/>
		<updated>2024-12-10T07:31:40Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
{{#template_params:Outcome type (list;property=Outcome type)|Outcome name (list;property=Outcome name)|Outcome specification (property=Outcome specification)|Type of measurement (list;property=Type of measurement)|Timestamp measurement (property=Timestamp measurement)|Result (property=Result)|Bias arising from the randomization process (label=arising from the randomization process;property=Bias arising from the randomization process)|Bias due to deviation from intended intervention (assignment to intervention) (property=Bias due to deviation from intended intervention (assignment to intervention))|Bias due to deviation from intended intervention (adhering to intervention) (property=Bias due to deviation from intended intervention (adhering to intervention)) |Bias due to missing outcome data (property=Bias due to missing outcome data)|Bias in measurement of the outcome (property=Bias in measurement of the outcome)|Bias in selection of the reported result (property=Bias in selection of the reported result)|Other sources of bias (property=Other sources of bias)|Overall RoB judgment (property=Overall RoB judgment)}}&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
{{#subobject:|&lt;br /&gt;
|Outcome name={{{Outcome name|}}}|+sep=,&lt;br /&gt;
|Outcome type={{{Outcome type|}}} &lt;br /&gt;
|Outcome specification={{{Outcome specification|}}}&lt;br /&gt;
|Type of measurement={{{Type of measurement|}}}|+sep=,&lt;br /&gt;
|Results during intervention={{{Results during intervention|}}}&lt;br /&gt;
|Results after intervention={{{Results after intervention|}}}&lt;br /&gt;
|Bias arising from the randomization process={{{Bias arising from the randomization process|}}}&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)={{{Bias due to deviation from intended intervention (assignment to intervention)|}}}&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)={{{Bias due to deviation from intended intervention (adhering to intervention) }}}&lt;br /&gt;
|Bias due to missing outcome data={{{Bias due to missing outcome data|}}}&lt;br /&gt;
|Bias in measurement of the outcome={{{Bias in measurement of the outcome|}}}&lt;br /&gt;
|Bias in selection of the reported result={{{Bias in selection of the reported result|}}}&lt;br /&gt;
|Other sources of bias={{{Other sources of bias|}}}&lt;br /&gt;
|Overall RoB judgment={{{Overall RoB judgment|}}}&lt;br /&gt;
|Outcome topic={{{Outcome topic|}}}|+sep=,&lt;br /&gt;
|Order number={{{Order number|}}}&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:Arm&amp;diff=7588</id>
		<title>Template:Arm</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:Arm&amp;diff=7588"/>
		<updated>2024-12-09T08:34:45Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
{{#template_params:Arm type (list;property=Arm type)|Number of participants (property=Number of participants (arm))|Drop-out (property=Drop-out)|Drop-out reasons (property=Drop-out reasons)|Intervention (property=Intervention)|Dosage and regime (property=Dosage and regime)|One-time application (property=One-time application)|Duration in days (property=Duration in days)|Side Effects / Interactions (property=Side Effects / Interactions)|Order number (property=Order number)}}&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&amp;lt;includeonly&amp;gt;&lt;br /&gt;
{{#subobject:|&lt;br /&gt;
|Arm type={{{Arm type|}}}|+sep=,&lt;br /&gt;
|Number of participants (arm)={{{Number of participants (arm)|}}}&lt;br /&gt;
|Drop-out={{{Drop-out|}}}&lt;br /&gt;
|Drop-out reasons={{{Drop-out reasons|}}}&lt;br /&gt;
|Intervention={{{Intervention|}}}&lt;br /&gt;
|Dosage and regime={{{Dosage and regime|}}}&lt;br /&gt;
|One-time application={{{One-time application|}}}&lt;br /&gt;
|Duration in days={{{Duration in days|}}}&lt;br /&gt;
|Side Effects / Interactions={{{Side Effects / Interactions|}}}&lt;br /&gt;
|Order number={{{Order number|}}}&lt;br /&gt;
|Arm topic={{{Arm topic|}}}|+sep=,&lt;br /&gt;
}}&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=7512</id>
		<title>Form:RCT Study</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=7512"/>
		<updated>2024-12-03T09:17:22Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
This is the &amp;quot;RCT Study&amp;quot; form.&lt;br /&gt;
To create a page with this form, enter the page name below;&lt;br /&gt;
if a page with that name already exists, you will be sent to a form to edit that page.&lt;br /&gt;
&lt;br /&gt;
{{#forminput:form=RCT Study}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&amp;lt;includeonly&amp;gt;&lt;br /&gt;
&lt;br /&gt;
=Publication=&lt;br /&gt;
&lt;br /&gt;
{{{for template|Reference}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Publication: &lt;br /&gt;
| {{{field|Reference|input type=text|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Note}}}&lt;br /&gt;
==Study Note==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Study Note|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Brief summary=&lt;br /&gt;
{{{section|Brief summary|level=1}}}&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
{{{section|Study Design|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Design (RCT)}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Prospective / Retrospective: {{#info: Prospective: forward-looking, examples include clinical trials, cohort studies, and long-term observational studies; &lt;br /&gt;
Retrospective: backward-looking, relying on existing data, examples include case-control studies and retrospective cohort studies|note}}&lt;br /&gt;
| {{{field|Perspective|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Monocentric / Multicentric:  {{#info: Monocentric: conducted in one center/ hospital; &lt;br /&gt;
Multicentric: conducted in multiple centers/ hospitals|note}}&lt;br /&gt;
| {{{field|Centralized|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Blinding: {{#info: No: Open, all parties are aware of group assignments; &lt;br /&gt;
Single: one party is unaware of group assignments (generally participants); &lt;br /&gt;
Double: two parties are unaware of group assignments (generally the participants and the researchers); &lt;br /&gt;
Triple: concealing group assignment from additional parties|note}}&lt;br /&gt;
| {{{field|Blinding|input type=radiobutton|mandatory|default=?|values=?,No,Single,Double,Triple,NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Is randomized: &lt;br /&gt;
| {{{field|Is randomized|input type=checkbox|default=Yes}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-over: {{#info: Participants alternate between different treatment groups or conditions over a specified period, allowing each participant to serve as their own control|note}}&lt;br /&gt;
| {{{field|Cross-over|input type=checkbox|default=No}}}&lt;br /&gt;
|-&lt;br /&gt;
! Number of arms: &lt;br /&gt;
| {{{field|Number of arms|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
{{{section|Study characteristics|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|RCT study general properties}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Inclusion criteria: &lt;br /&gt;
| {{{field|Inclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Exclusion criteria: &lt;br /&gt;
| {{{field|Exclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! N randomized: &lt;br /&gt;
| {{{field|N randomized|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|-&lt;br /&gt;
! Analysis: {{#info: PP: Per Protocol analysis, i.e. only participants included who adhered to the study protocol.&lt;br /&gt;
ITT: Intention-to-treat analysis, i.e. all randomized participants included regardless of any drop-outs or changes in assignment.&lt;br /&gt;
mITT: modified Intention-to-treat analysis can refer to analyses in which participants with missing outcome data are excluded or it can refer to analyses in which only participants who received at least one treatment dose are included. In this case, participants dropped out of the study prematurely for reasons unrelated to the treatment.|note}}&lt;br /&gt;
| {{{field|Analysis|input type=checkboxes|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on analyses:&lt;br /&gt;
| {{{field|Specifications on analyses|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Countries of data collection: &lt;br /&gt;
| {{{field|Countries of data collection|input type=text with autocomplete|delimiter=,|values=Afghanistan,Albania,Algeria,Andorra,Angola,Antigua &amp;amp; Deps,Argentina,Armenia,Australia,Austria,Azerbaijan,Bahamas,Bahrain,Bangladesh,Barbados,Belarus,Belgium,Belize,Benin,Bhutan,Bolivia,Bosnia Herzegovina,Botswana,Brazil,Brunei,Bulgaria,Burkina,Burundi,Cambodia,Cameroon,Canada,Cape Verde,Central African Rep,Chad,Chile,China,Colombia,Comoros,Congo,Congo {Democratic Rep},Costa Rica,Croatia,Cuba,Cyprus,Czech Republic,Denmark,Djibouti,Dominica,Dominican Republic,East Timor,Ecuador,Egypt,El Salvador,Equatorial Guinea,Eritrea,Estonia,Ethiopia,Europe,Fiji,Finland,France,Gabon,Gambia,Georgia,Germany,Ghana,Greece,Grenada,Guatemala,Guinea,Guinea-Bissau,Guyana,Haiti,Honduras,Hungary,Iceland,India,Indonesia,Iran,Iraq,Ireland {Republic},Israel,Italy,Ivory Coast,Jamaica,Japan,Jordan,Kazakhstan,Kenya,Kiribati,Korea North,Korea South,Kosovo,Kuwait,Kyrgyzstan,Laos,Latin America,Latvia,Lebanon,Lesotho,Liberia,Libya,Liechtenstein,Lithuania,Luxembourg,Macedonia,Madagascar,Malawi,Malaysia,Maldives,Mali,Malta,Marshall Islands,Mauritania,Mauritius,Mexico,Micronesia,Moldova,Monaco,Mongolia,Montenegro,Morocco,Mozambique,Myanmar,{Burma},Namibia,Nauru,Nepal,Netherlands,New Zealand,Nicaragua,Niger,Nigeria,North America,Norway,Oman,Pakistan,Palau,Panama,Papua New Guinea,Paraguay,Peru,Philippines,Poland,Portugal,Qatar,Romania,Russian Federation,Rwanda,St Kitts &amp;amp; Nevis,St Lucia,Saint Vincent &amp;amp; the Grenadines,Samoa,San Marino,Sao Tome &amp;amp; Principe,Saudi Arabia,Senegal,Serbia,Seychelles,Sierra Leone,Singapore,Slovakia,Slovenia,Solomon Islands,Somalia,South Africa,South Sudan,Spain,Sri Lanka,Sudan,Suriname,Swaziland,Sweden,Switzerland,Syria,Taiwan,Tajikistan,Tanzania,Thailand,Togo,Tonga,Trinidad &amp;amp; Tobago,Tunisia,Turkey,Turkmenistan,Tuvalu,Uganda,Ukraine,United Arab Emirates,United Kingdom,United Kingdom - Great Britain,United States,United States - New York,United States - Texas,Uruguay,Uzbekistan,Vanuatu,Vatican City,Venezuela,Vietnam,Yemen,Zambia,Zimbabwe,NI,?|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! LoE: {{#info: Level of evidence|note}}&lt;br /&gt;
| {{{field|LoE|input type=dropdown|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Outcome timeline: {{#info: Data collection times|note}}&lt;br /&gt;
| {{{field|Outcome timeline|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
{{{section|Characteristics of participants|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Characteristics of participants}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Setting: {{#info: Refers to cancer therapy setting.&lt;br /&gt;
- Curative therapy: aims to completely eradicate a disease and achieve a full recovery; &lt;br /&gt;
- Neo-adjuvant therapy: form of curative therapy, given before the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Adjuvant therapy: form of curative therapy, given after the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Palliative therapy: focuses on providing relief from symptoms and improving the quality of life for patients, without necessarily targeting the underlying disease; &lt;br /&gt;
- Active surveillance: involves close monitoring of disease progression without any intervention (typically used for prostate cancer);&lt;br /&gt;
- No therapy setting: Patients who completed therapy/are currently not in cancer treatment, cancer survivors.|note}}&lt;br /&gt;
| {{{field|Setting|input type=checkboxes|delimiter=,|default=?|mandatory|values=?, Curative, Neo-adjuvant, Adjuvant, Palliative, Active surveillance, No therapy setting, NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Types of cancer: {{#info: &amp;quot;Other Cancers&amp;quot; means that only a subpopulation was specified, but further unspecified cancer types were included|note}}&lt;br /&gt;
| {{{field|Types of cancer|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Adrenal Cancer,Anal Cancer,Bile Duct Cancer,Bone and Soft Tissue Cancers, Bone and Soft Tissue Cancers - Osteosarcoma,Bone and Soft Tissue Cancers - Ewing Sarcoma,Bone and Soft Tissue Cancers - Chondrosarcoma,Bone and Soft Tissue Cancers - Rhabdomyosarcoma,Bone and Soft Tissue Cancers – Liposarcoma,Brain and Central Nervous System (CNS) Cancers,Brain and Central Nervous System (CNS) Cancers - Astrocytoma,Brain and Central Nervous System (CNS) Cancers - Glioblastoma,Brain and Central Nervous System (CNS) Cancers - High-Grade Glioma,Brain and Central Nervous System (CNS) Cancers - Meningioma,Breast Cancer,Breast Cancer - Ductal Carcinoma,Breast Cancer - Lobular Carcinoma,Breast Cancer - Inflammatory Breast Cancer,Breast Cancer - Triple-Negative Breast Cancer,Carcinosarcoma,Chest Cancer,Colorectal Cancer,Colorectal Cancer - Colon Cancer,Colorectal Cancer - Rectal Cancer,Eye Cancer,Eye Cancer - Retinoblastoma,Gastrointestinal Cancers,Gastrointestinal Cancers - Gallbladder Cancer,Gastrointestinal Cancers - Gastric (Stomach) Cancer,Gastrointestinal Cancers - Esophageal Cancer,Gastrointestinal Cancers - Pancreatic Cancer,Gastrointestinal Cancers - Liver Cancer,Genitourinary Cancers,Genitourinary Cancers - Bladder Cancer,Genitourinary Cancers - Kidney (Renal) Cancer,Genitourinary Cancers - Testicular Cancer,Genitourinary Cancers - Urethral Cancer,Gynecologic Cancers,Gynecologic Cancers - Ovarian Cancer,Gynecologic Cancers - Cervical Cancer,Gynecologic Cancers - Uterine Cancer,Gynecologic Cancers - Endometrial Cancer,Gynecologic Cancers - Vulvar Cancer,Head and Neck Cancers, Head and Neck Cancers - Oral Cancer,Head and Neck Cancers - Oropharyngeal Cancer,Head and Neck Cancers - Laryngeal Cancer,Head and Neck Cancers - Nasopharyngeal Cancer,Head and Neck Cancers - Tongue Cancer,Head and Neck Cancers - Thyroid Cancer,Head and Neck Cancers - Ethmoid Sinus Cancer,Hematologic Cancers, Hematologic Cancers - Leukemia (Acute Lymphocytic/Acute Myeloid/Chronic Lymphocytic/Chronic Myeloid), Hematologic Cancers - Lymphoma (Hodgkin and Non-Hodgkin),Hematologic Cancers - Multiple Myeloma,Lung Cancer,Lung Cancer - Small Cell Lung Cancer,Lung Cancer - Non-Small Cell Lung Cancer,Mesothelioma,Neuroblastoma,Prostate Cancer,Skin Cancer,Skin Cancer - Basal Cell Carcinoma,Skin Cancer - Squamous Cell Carcinoma,Skin Cancer – Melanoma,Stomach Cancer,Solid Malignancies,Thymoma and Thymic Carcinoma,Unspecified Sarcoma,Other Cancers,NI,?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage: {{#info: Early Stage: generally refers to cancer that is localized to the area where it started, mostly stages I and II;&lt;br /&gt;
Advanced Stage: cancer that has spread beyond its original site, mostly stages III and IV, with stage IV indicating distant metastasis|note}}&lt;br /&gt;
| {{{field|Stage cancer|input type=checkboxes|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage specification: &lt;br /&gt;
| {{{field|Cancer stage specification|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comorbidity: &lt;br /&gt;
| {{{field|Comorbidity|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Current cancer therapy: &lt;br /&gt;
| {{{field|Current cancer therapy|input type=text with autocomplete|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on cancer therapies: &lt;br /&gt;
| {{{field|Specifications on cancer therapies|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Previous cancer therapies: &lt;br /&gt;
| {{{field|Previous cancer therapies|input type=text with autocomplete|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender: &lt;br /&gt;
| {{{field|Gender|input type=radiobutton|mandatory|values=?, Male, Female, Mixed, NI|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender specifications: &lt;br /&gt;
| {{{field|Gender specifications|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups: &lt;br /&gt;
| {{{field|Age groups|input type=checkboxes|values=?, Children (0-15), Adolescents and young adults (15-39), Adults (18+), Elderly (65+), NI|default=adults (18+)}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups specification: &lt;br /&gt;
| {{{field|Age groups specification|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
=Arms=&lt;br /&gt;
{{{section|Arms|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Arm type:&#039;&#039;&#039; {{#info: Active control: group receives active treatment; &lt;br /&gt;
Passive control: for example: treatment as usual, waiting control, no treatment|note}}&lt;br /&gt;
{{{field|Arm type|input type=checkboxes|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Number of participants (arm):&#039;&#039;&#039; {{{field|Number of participants (arm)|input type=text|mandatory|default=-999}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out:&#039;&#039;&#039; {{#info: Number of participants who left the study for any reason or did not provide information on every data collection date|note}} {{{field|Drop-out|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out reasons:&#039;&#039;&#039; {{{field|Drop-out reasons|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Intervention:&#039;&#039;&#039; {{{field|Intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Dosage and regime:&#039;&#039;&#039; {{{field|Dosage and regime|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;One-time application:&#039;&#039;&#039; {{{field|One-time application|input type=checkbox|mandatory|default=No}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Duration in days:&#039;&#039;&#039; {{#info: For long-term interventions, the number of days is an estimate.&lt;br /&gt;
A value of -999 indicates that the exact duration cannot be extracted from the study due to ambiguous or incomplete information. See &#039;&#039;Outcome timeline&#039;&#039; or &#039;&#039;Dosage and regime&#039;&#039; for further information. |note}}&lt;br /&gt;
{{{field|Duration in days|input type=regexp|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Side Effects / Interactions:&#039;&#039;&#039; {{{field|Side Effects / Interactions|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Arm topic:&#039;&#039;&#039; {{{field|Arm topic|input type=tokens|mandatory|delimiter=,|values=Aloe vera,Boswellia serrata,Cannabinoids,Carnitine,Curcumin,Electroacupuncture,Enzymes (bromelain papain),Folic acid,Ginger,Ginkgo,Green tea (EGCG),Guarana,Low-carbohydrate or ketogenic diet,Lycopene,Reflexology,Resveratrol,Selenium,Vitamin A (beta-carotene),Vitamin B1,Vitamin B12,Vitamin B6,Vitamin C,Vitamin D,Vitamin E,Zeolites,Zinc,NI,?}}}&lt;br /&gt;
&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Outcomes=&lt;br /&gt;
{{{section|Outcomes|level=1}}}&lt;br /&gt;
{{{for template|Outcome|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Outcome type:&#039;&#039;&#039; {{#info: As specificed by the authors| note}} {{{field|Outcome type|input type=radiobutton|mandatory|default=?|values=?,Primary,Secondary,Others,NI}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome name:&#039;&#039;&#039; {{{field|Outcome name|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Additional medication,Anorexia/Cachexia,Antibodies,Anxiety,Appetite,Arterial inflow,BMD (Bone Mineral Density),Body composition,Carnitine level,Carotenoid concentration,Cerebral oedema,CINV (Chemotherapy-Induced Nausea and Vomiting),Cognitive functioning,Cognitive impairment,Depression,Dermatitis,DFS (Disease-Free Survival),Diarrhoe,Distress,Dysgeusia,Ejection fraction,Erectile dysfunction,Erythema,Esophagitis,Fatigue,Fever,Fibrosis,Folic acid level,Functionality,Haematological indices,Haematological toxicity,Hand-foot syndrome,Hand grip strength,Hormone level,Ileus (intestinal obstruction),Incidence of acute GVHD (Graft-Versus-Host Disease),Infection,Interaction with cancer treatment,Laboratory parameters,Length of hospital stay,Lymphedema,Menopausal symptoms,Mental status/ function,Mood/Affect,Mortality rate,Mucositis,Musculoskeletal symptoms,Nausea,Nausea and Vomiting,Nerve conduction velocity,Neurotoxicity,Neutropenia,Non-haematological indices,Nutrition status,Objective signs and subjective symptoms,Oral ulcus,OS (Overall Survival),Ototoxicity,Pain,PD (Pharmacodynamics),Performance Status,Peripheral neuropathy,PFS (Progression-Free Survival),Pharyngitis,Physical functioning,PK (Pharmacokinetics),Postoperative morbidity/ complications,PSA level (Prostate-Specific Antigen),Quality of life,Recurrence rate,REE (Resting Energy Expenditure),Relaxation,RFS (Recurrence-Free Survival),Salivary gland function,Selenium level,Seroconversion,Sleep,Stomatitis,Stress,Symptom load,Taste alteration,Tea polyphenol uptake,Thromboembolic event rates,Toxicity,Treatment interruption,Tumor progression,Tumor response,Vaginal atrophy,Vitamin A level,Vitamin B6 level,Vitamin B12 level,Vitamin B17 level,Vitamin C level,Vitamin D level,Vitamin E level,Vomiting,Weight,Well-being,Wound healing,Wound odour,Xerostomia,Zinc level,Unspecified effects,NI,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome specification:&#039;&#039;&#039; {{{field|Outcome specification|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Type of measurement:&#039;&#039;&#039; {{{field|Type of measurement|input type=tokens|mandatory|default=?|delimiter=,|values=AQoL-8D (Assessment of Quality of Life),ASAT (Auditory Sustained Attention Test),Atomic absorption,Audiogram,AUSCAN (Australian/Canadian Osteoarthritis Hand Index),BCPT (Breast Cancer Prevention Symptom Scales),BDI (Beck Depression Inventory),BFI (Brief Fatigue Inventory),BIA (Bioelectrical impedance analysis),Blood Test,BPI-SF (Brief Pain Inventory - Short Form),CES-D (Center for Epidemiologic Studies - Depression Scale),Chemiluminescent immunoassay,CNPI (Checklist of Non-Verbal Pain Indicators),CSSP (Catterall Skin Scoring Profile),CT (Computed Tomography),CTCAE (Common Terminology Criteria of Adverse Events),Cystoscopy,Diary questionnaire,DXA (Dual energy X-ray Absorptiometry),Dynamometer,Echo-color Doppler,ECOG Performance Status Scale (Eastern Cooperative Oncology Group),Electronic monitoring device,Electrophysiological evaluation,ELISA protocol (Enzyme-Linked Immunoabsorbent Assay),EORTC QLQ (European Organisation for Research and Treatment of Cancer Core/ Quality of Life questionnaire),ESAS (Edmonton Symptom Assessment Scale),FAACT (Functional Assessment of Anorexia-Cachexia Therapy),FACIT (Functional Assessment of Chronic Illness Therapy),FACT (Functional Assessment of Cancer Therapy),FGS (Hughes&#039; Functional Grading Scale),FIQ (Fibromyalgia Impact Questionnaire),FLIE (Functional Living Index for Emesis),Genitourinary atrophy self-assessment tool,GFAAS (Graphite Furnace Atomic Absorption Spectrometry),Global Charter Fatigue Scale,HADS (Hospital Anxiety and Depression Scale),HAQ-DI (Health Assessment Questionnaire-Disability Index),HFRDIS (Hot Flash Related Daily Interference Scale),HFS (Hot Flush Score),HGST Maximum (Handgrip Strength Test),Histological examination,HNQR (Head and Neck Radiotherapy Questionnaire),HSCS (High Sensitivity Cognitive Screen),ICI Test (Intracavernosal Injection Test),IIEF (International Index of Erectile Function),Interview,KPS (Karnofsky Performance Status),LASA (Linear Analogue Self-Assessment),LENT SOMA Scale (Late Effects on Normal Tissues/ Subjective Objective Management Analysis),MADRS (Montgomery-Asberg Depression Rating Scale),MAT (Multinational Association of Supportive Care in Cancer-Antiemesis Tool),McDonald criteria,MDASI (M. D. Anderson Symptom Inventory),Measuring tape,MENQOL (Menopause-Specific Quality of Life),MFI-20 (Multidimensional Fatigue Inventory-20),MMSE (Mini-Mental State Exam),Morbidity rating scale (by Dische),MOS SF-12 (Medical Outcomes Study/ 12-Item Short Form Health Survey),MPQ-SF (McGill Pain Questionnaire - Short Form),MRI (Magnetic Resonance Imaging),MRS (Mood Rating Scale),MYCaW (Measure Yourself Concerns and Wellbeing),NCI-CTC v.2 (National Cancer Institute-Common Toxic Criteria),NCI Grading Scale (National Cancer Institute),NDS (Neurological Disability Score),Neurologic examination,Neuropathy specific question,NRS (Numeric Rating Scale),NRS (Nutritional Risk Screening),NSS (Neurological Symptom Score),Observation,OMAS (Oral Mucositis Assessment Scale),Otoacoustic Emissions Testing,PAC-QoL (Patient Assessment of Constipation - Quality of Life),PGIC (Physician Global Impression of Change),PG-SGA (Patient-Generated Subjective Global Assessment),PHLF (Post Hepatectomy Liver Failure),PHS (Cognitive subscale of the Perceived Health Scale),pH-value,Physical examination,Physical functioning (grip strength;6 minute walk;leg extension),POMS (Profile of Mood States),PoSSe (Postoperative Symptom Severity Scale),Postoperative morbidity/complications (classification according to Clavien-Dindo),PROMIS (Patient-Reported Outcomes Measurement Information System),PSQ (Patient Satisfaction Questionnaire),PSQI (Pittsburgh Sleep Quality Index),QoR-40 (Quality of Recovery-40 Questionnaire),RDS (Radiation Dermatitis Severity),RECIST 1.0 Criteria (Response Evaluation Criteria in Solid Tumors),Reidel-Seiffer tuning fork,Rhodes Inventory of Nausea,RPSAS (Radiation Proctopathy System Assessment Scale),RTOG Acute Radiation Morbidity Scoring Criteria (Radiation Therapy Oncology Group),Scale,SCID (Structured Clinical Interview for DSM IV),Scintigraphy,Self-developed measurement instrument,SF-36 (Short Form-36 Health Survey),SF-MPQ (Short-Form McGill Pain Questionnaire),SGIC (Subject Global Impression of Change),SI (Symptom Inventory questionnaire),SOMA (Subjective Objective Medical management and Analytic evaluation of injury),SPECT (Single Photon Emission Computed Tomography),Spectrophotometry,SPPB (Short Physical Performance Battery),STAI (State-Trait-Anxiety-Inventory),Symptom experience diary (NCCTG),Thermometer,Three-stimulus drop technique (by Henkin),Tissue testing,TMT (Trail Making Test),TNS (Total Neuropathy Score),Ultrasonography,Unspecified questionnaire,Urinalysis,VAS (Visual Analogue Scale),VMI (Vaginal Maturation Index),VNS (Verbal Numerical Scale),Volometer,Western Ontario and McMaster Osteoarthritis Index,WHO-Scale (World Health Organisation),Wound volume,NI,NA,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Results during intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results during intervention&#039;&#039; means that the time of data collection is during or shortly after the period of the intervention (e.g. on the last day or a few days after). The results therefore still relate to the direct effects of the intervention.|note}}&lt;br /&gt;
{{{field|Results during intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&#039;&#039;&#039;Results after intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results after intervention&#039;&#039; means there is a longer break between the time of data collection and the end of the intervention, e.g. more than a week. The results relate more to long-term effects. &lt;br /&gt;
If a categorization in &#039;&#039;Results during vs. after intervention&#039;&#039; is not possible (e.g. survival data), the results are summarized under &#039;&#039;Results after intervention&#039;&#039; under the headline &amp;quot;Overall&amp;quot;.|note}}&lt;br /&gt;
{{{field|Results after intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
==Risk of Bias Assessment: Cochrane RoB tool 2.0==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Bias arising from the randomization process&lt;br /&gt;
| {{{field|Bias arising from the randomization process|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (assignment to intervention) &lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (assignment to intervention)|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (adhering to intervention)&lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (adhering to intervention)|input type=radiobutton|mandatory|default=NA|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to missing outcome data&lt;br /&gt;
| {{{field|Bias due to missing outcome data|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in measurement of the outcome&lt;br /&gt;
| {{{field|Bias in measurement of the outcome|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in selection of the reported result&lt;br /&gt;
| {{{field|Bias in selection of the reported result|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Other sources of bias&lt;br /&gt;
| {{{field|Other sources of bias|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Overall RoB judgment&lt;br /&gt;
| {{{field|Overall RoB judgment|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome topic:&#039;&#039;&#039; {{{field|Outcome topic|input type=tokens|mandatory|delimiter=,|values=Aloe vera,Boswellia serrata,Cannabinoids,Carnitine,Curcumin,Electroacupuncture,Enzymes (bromelain papain),Folic acid,Ginger,Ginkgo,Green tea (EGCG),Guarana,Low-carbohydrate or ketogenic diet,Lycopene,Reflexology,Resveratrol,Selenium,Vitamin A (beta-carotene),Vitamin B1,Vitamin B12,Vitamin B6,Vitamin C,Vitamin D,Vitamin E,Zeolites,Zinc,NI,?}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
{{{for template|Outcome Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
{{{section|Funding and Conflicts of Interest|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Funding and Conflicts of Interest}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Funding: &lt;br /&gt;
| {{{field|Funding|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Conflicts of Interest: &lt;br /&gt;
| {{{field|Conflicts of Interest|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
{{{section|Further points for assessing the study|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Further points for assessing the study}}}&lt;br /&gt;
==Sample==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Power analysis performed&lt;br /&gt;
| {{{field|power analysis performed|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sample size corresponds to power analysis&lt;br /&gt;
| {{{field|Sample size corresponds to power analysis|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Reasons for insufficient sample size based on power analysis&lt;br /&gt;
| {{{field|Reasons given for samples being too small according to power analysis|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! If no power analysis performed: at least moderate sample size (n &amp;gt;= 30 per arm)&lt;br /&gt;
| {{{field|Samples sufficiently large|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethnicity mentioned&lt;br /&gt;
| {{{field|Ethnicity mentioned|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Alternative Explanation==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Other explanations for an effect besides the investigated intervention&lt;br /&gt;
| {{{field|Other explanations for an effect besides the investigated intervention|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of attention effects {{#info: e.g. due to lack of a placebo arm|note}}&lt;br /&gt;
| {{{field|Possibility of attention effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of placebo effects&lt;br /&gt;
| {{{field|Possibility of placebo effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Other reasons&lt;br /&gt;
| {{{field|Other reasons|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Statistics==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Correct use of parametric and non-parametric tests {{#info: Testing for normal distribution only necessary if parametric tests are used, NI: use of parametric tests without report of normal distribution testing|note}} &lt;br /&gt;
| {{{field|Correct use of parametric and non-parametric tests|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Correction for multiple testing&lt;br /&gt;
| {{{field|Correction for multiple testing|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Measurement of compliance&lt;br /&gt;
| {{{field|Measurement of compliance|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Consistent reporting in numbers (figures, flowchart, abstract, results)&lt;br /&gt;
| {{{field|Consistent reporting in numbers|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comprehensive and coherent reporting&lt;br /&gt;
| {{{field|Comprehensive and coherent reporting|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-Over study&lt;br /&gt;
| {{{field|Cross-over|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sufficient washout period&lt;br /&gt;
| {{{field|sufficient washout period|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for carry-over effects&lt;br /&gt;
| {{{field|Tested for carry-over effects|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for sequence effects&lt;br /&gt;
| {{{field|Were sequence effects tested|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Interpretation of results==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Effect sizes reported (clinical vs. statistical significance)&lt;br /&gt;
| {{{field|Effect sizes reported|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects systematically recorded&lt;br /&gt;
| {{{field|Were side effects systematically recorded|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects considered in result interpretation&lt;br /&gt;
| {{{field|Side effects taken into account in the interpretation of the results|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethics votum&lt;br /&gt;
| {{{field|Ethics / CoI / Funding|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Additional Notes}}}&lt;br /&gt;
==Additional Notes==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Additional Notes|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=7297</id>
		<title>MediaWiki:Common.css</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=7297"/>
		<updated>2024-11-27T09:33:01Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;/* CSS placed here will be applied to all skins */&lt;br /&gt;
&lt;br /&gt;
// linksbuendiger text in Queries&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(n) {&lt;br /&gt;
    text-align: justify;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
// weiße Reference Überschrift&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:visited {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:link{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:hover{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:active {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
// Tabellen Todos Ende&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;low risk&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;some concerns&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
input[value=&amp;quot;high risk&amp;quot;]  {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(2) {&lt;br /&gt;
    color: green;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(3) {&lt;br /&gt;
    color: orange;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(4) {&lt;br /&gt;
    color: red;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.low-risk {&lt;br /&gt;
    color: green;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.some-concerns {&lt;br /&gt;
    color: orange;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.high-risk {&lt;br /&gt;
    color: red;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(2) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(4) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#bodyContent &amp;gt; div.mw-body-subheader {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(1) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.uniform-width-table {&lt;br /&gt;
  width:100%;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(1), .wikitable.uniform-width-table td:nth-child(1){&lt;br /&gt;
  width: 60%; /* Width for the first column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(2), .wikitable.uniform-width-table td:nth-child(2){&lt;br /&gt;
  width: 5%; /* Width for the second column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(3), .wikitable.uniform-width-table td:nth-child(3){&lt;br /&gt;
  width: 5%; /* Width for the third column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(4), .wikitable.uniform-width-table td:nth-child(4){&lt;br /&gt;
  width: 30%; /* Width for the fourth column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.vector-body p {&lt;br /&gt;
  margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable {&lt;br /&gt;
        background-color: #ffffff;&lt;br /&gt;
        color: #202122;&lt;br /&gt;
        margin: 1em 0;&lt;br /&gt;
        border: 1px solid #a2a9b1;&lt;br /&gt;
        border-collapse: collapse&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; tbody &amp;gt; tr:nth-child(n) &amp;gt; th {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
} &lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; thead &amp;gt; tr &amp;gt; th:nth-child(n) {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable &amp;gt; * &amp;gt; tr &amp;gt; td {&lt;br /&gt;
    vertical-align: top;&lt;br /&gt;
}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=7296</id>
		<title>MediaWiki:Common.css</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=7296"/>
		<updated>2024-11-27T09:31:53Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;/* CSS placed here will be applied to all skins */&lt;br /&gt;
&lt;br /&gt;
// linksbuendiger text in Queries&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(n) {&lt;br /&gt;
    text-align: justify;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
// weiße Reference Überschrift&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:visited {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:link{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:hover{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:active {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
// Tabellen Todos Ende&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;low risk&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;some concerns&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
input[value=&amp;quot;high risk&amp;quot;]  {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(2) {&lt;br /&gt;
    color: green;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(3) {&lt;br /&gt;
    color: orange;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(4) {&lt;br /&gt;
    color: red;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.low-risk {&lt;br /&gt;
    color: green;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.some-concerns {&lt;br /&gt;
    color: orange;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.high-risk {&lt;br /&gt;
    color: red;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(2) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(4) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#bodyContent &amp;gt; div.mw-body-subheader {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(1) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.uniform-width-table {&lt;br /&gt;
  width:100%;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(1), .wikitable.uniform-width-table td:nth-child(1){&lt;br /&gt;
  width: 60%; /* Width for the first column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(2), .wikitable.uniform-width-table td:nth-child(2){&lt;br /&gt;
  width: 5%; /* Width for the second column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(3), .wikitable.uniform-width-table td:nth-child(3){&lt;br /&gt;
  width: 5%; /* Width for the third column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(4), .wikitable.uniform-width-table td:nth-child(4){&lt;br /&gt;
  width: 30%; /* Width for the fourth column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.vector-body p {&lt;br /&gt;
  margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable {&lt;br /&gt;
        background-color: #ffffff;&lt;br /&gt;
        color: #202122;&lt;br /&gt;
        margin: 1em 0;&lt;br /&gt;
        border: 1px solid #a2a9b1;&lt;br /&gt;
        border-collapse: collapse&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; tbody &amp;gt; tr:nth-child(n) &amp;gt; th {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
    vertical-align: top;&lt;br /&gt;
} &lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; thead &amp;gt; tr &amp;gt; th:nth-child(n) {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
    vertical-align: top;&lt;br /&gt;
}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6988</id>
		<title>Example Queries II</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6988"/>
		<updated>2024-11-22T08:28:55Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== What effects of selenium have been investigated? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |default=No results found.&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? - outcome-based ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Selenium]]&lt;br /&gt;
 [[Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |?Results after intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Which intervention for depression in cancer was investigated in studies with a placebo arm? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Outcome name::Depression]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Reference.Topic&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies -- study-based ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabinoids]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |?Were side effects systematically recorded&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies -- arm-based ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Arm topic::Cannabinoids]]&lt;br /&gt;
 [[Arm type::Placebo]]&lt;br /&gt;
 |?Intervention&lt;br /&gt;
 |?Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6987</id>
		<title>Example Queries II</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6987"/>
		<updated>2024-11-22T08:22:32Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Side effects of Cannabis in placebo-controlled studies -- arm-based */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== What effects of selenium have been investigated? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? - outcome-based ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Selenium]]&lt;br /&gt;
 [[Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |?Results after intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Which intervention for depression in cancer was investigated in studies with a placebo arm? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Outcome name::Depression]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Reference.Topic&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies -- study-based ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabinoids]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |?Were side effects systematically recorded&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies -- arm-based ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Arm topic::Cannabinoids]]&lt;br /&gt;
 [[Arm type::Placebo]]&lt;br /&gt;
 |?Intervention&lt;br /&gt;
 |?Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=C%C3%B4t%C3%A9_et_al._(2016):_Improving_Quality_of_Life_With_Nabilone_During_Radiotherapy_Treatments_for_Head_and_Neck_Cancers:_A_Randomized_Double-Blind_Placebo-Controlled_Trial&amp;diff=6986</id>
		<title>Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=C%C3%B4t%C3%A9_et_al._(2016):_Improving_Quality_of_Life_With_Nabilone_During_Radiotherapy_Treatments_for_Head_and_Neck_Cancers:_A_Randomized_Double-Blind_Placebo-Controlled_Trial&amp;diff=6986"/>
		<updated>2024-11-22T08:22:04Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{Reference&lt;br /&gt;
|Reference=Publication: Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial&lt;br /&gt;
}}&lt;br /&gt;
{{Study Note}}&lt;br /&gt;
=Brief summary=&lt;br /&gt;
In the study, 56 patients with head and neck tumors were randomly divided into two arms, one received nabilone (synthetic THC) every day and the other a placebo. All patients received radiotherapy or a combination of radiotherapy and chemotherapy for seven weeks. At the end of the study, the authors found no differences between the arms for quality of life in general, as well as the symptoms of pain, weight fluctuations, appetite, nausea, mood and sleep. The study sample was small and 24 patients dropped out over the course of the study. The presentation of the results is superficial and inadequate. Without statistical values (mean values), the analysis is not transparent. Further methodological deficiencies in the analysis do not allow any conclusions to be drawn about the results. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
In der Studie wurden 56 Patienten mit Kopf-Hals Tumoren zufällig in zwei Gruppen eingeteilt, wovon eine Gruppe jeden Tag Nabilon (synthetisches THC) bekam und die andere ein Placebo. Alle Patienten bekamen für sieben Wochen Radiotherapie oder eine Kombination aus Radio- und Chemotherapie. Am Ende der Studie fanden die Autoren keine Unterschiede zwischen den Gruppen für Lebensqualität allgemein, als auch für die Symptome Schmerz, Gewichtsschwankungen, Appetit, Übelkeit, Stimmung und Schlaf. Die Stichprobe der Studie war klein und es sind über den Verlauf der Studie noch 24 Patienten ausgestiegen. Die Darstellung der Ergebnisse ist oberflächlich und unzureichend. Ohne Angabe von statistischen Werten (Mittelwerte) ist eine Transparenz der Analyse nicht gegeben. Weitere methodische Mängel in der Analyse lassen keine Aussagen zu den Ergebnissen zu.&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
&lt;br /&gt;
{{Study Design (RCT)&lt;br /&gt;
|Perspective=Prospective&lt;br /&gt;
|Centralized=Monocentric&lt;br /&gt;
|Blinding=Double&lt;br /&gt;
|Is randomized=Yes&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|Number of arms=2&lt;br /&gt;
}}&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
&lt;br /&gt;
{{RCT study general properties&lt;br /&gt;
|Inclusion criteria=Histological diagnosis of squamous cell carcinoma of the oral cavity, the oropharynx, the hypopharynx, and/or the larynx; treated by radiotherapy alone, postoperative radiotherapy, radiochemotherapy alone, or postoperative radiochemotherapy; aged 18 to 80 years; no other cancer diagnosis in the past 5 years, except for basal cell and squamous cell carcinoma of the skin&lt;br /&gt;
|Exclusion criteria=Metastatic disease; history of radiotherapy in the head and neck region; Karnofsky score &amp;lt;60; cognitive impairment; hepatic insufficiency; pregnant or breastfeeding woman; history of hypersensitivity or adverse reactions to marijuana or other cannabinoids; history of schizophrenia or any other form of psychosis&lt;br /&gt;
|N randomized=56&lt;br /&gt;
|Analysis=PP Analysis&lt;br /&gt;
|Specifications on analyses=Repeated measures analyses of variance (ANOVA), estimated with a linear mixed model, enable us to test the effect of time and treatment on continuous outcomes, while a generalized linear mixed model is used as a logistic regression for dichotomous outcomes. The P-values that are presented are for the interaction term of these models. All the analyses were also carried out while adjusting for site, treatment, and tumor size.&lt;br /&gt;
|Countries of data collection=Canada&lt;br /&gt;
|LoE=Level 2 Oxford 2011&lt;br /&gt;
|Outcome timeline=T0: baseline before radiotherapy&lt;br /&gt;
&lt;br /&gt;
T1: first week&lt;br /&gt;
&lt;br /&gt;
T2: second week until&lt;br /&gt;
&lt;br /&gt;
T3: 7&amp;lt;sup&amp;gt;th&amp;lt;/sup&amp;gt; week &lt;br /&gt;
&lt;br /&gt;
Follow-up: between 9&amp;lt;sup&amp;gt;th&amp;lt;/sup&amp;gt; - 11&amp;lt;sup&amp;gt;th&amp;lt;/sup&amp;gt; week&lt;br /&gt;
}}&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
&lt;br /&gt;
{{Characteristics of participants&lt;br /&gt;
|Setting=Curative, Neo-adjuvant, Adjuvant&lt;br /&gt;
|Types of cancer=Head and Neck Cancers&lt;br /&gt;
|Stage cancer=NI&lt;br /&gt;
|Cancer stage specification=NI&lt;br /&gt;
|Comorbidity=NI&lt;br /&gt;
|Current cancer therapy=Chemotherapy, Radiation therapy&lt;br /&gt;
|Specifications on cancer therapies=Radiotherapy only: &lt;br /&gt;
&lt;br /&gt;
intervention arm = 13; placebo arm = 10&lt;br /&gt;
&lt;br /&gt;
Radiotherapy postoperative: &lt;br /&gt;
&lt;br /&gt;
intervention arm = 7; placebo arm = 2&lt;br /&gt;
&lt;br /&gt;
Radiochemotherapy: &lt;br /&gt;
&lt;br /&gt;
intervention arm = 7; placebo arm = 15&lt;br /&gt;
&lt;br /&gt;
Radiochemotherapy postoperative: &lt;br /&gt;
&lt;br /&gt;
intervention arm = 1, placebo arm = 1&lt;br /&gt;
|Previous cancer therapies=Surgery, No therapy&lt;br /&gt;
|Gender=Mixed&lt;br /&gt;
|Gender specifications=Female n = 10 (17.86%); male n = 46 (82.14%)&lt;br /&gt;
|Age groups=Adults (18+)&lt;br /&gt;
|Age groups specification=Mean age per arm:&lt;br /&gt;
&lt;br /&gt;
intervention arm = 63.5 years&lt;br /&gt;
&lt;br /&gt;
placebo arm = 63.8 years&lt;br /&gt;
}}&lt;br /&gt;
=Arms=&lt;br /&gt;
&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Intervention&lt;br /&gt;
|Number of participants (arm)=28&lt;br /&gt;
|Drop-out=9&lt;br /&gt;
|Drop-out reasons=Not arm specified: severe nausea (n = 5); difficulty swallowing (n = 4); hospitalization (n = 4), pneumonia (n = 1); discontinued RT (n = 1); without reason (n = 9)&lt;br /&gt;
|Intervention=Nabilon&lt;br /&gt;
&lt;br /&gt;
+ all patients: additional administration of antiemetics (metoclopramide) and painkillers (acetaminophen (paracetamol), codeine, hydromorphone or transdermal fentanyl) possible&lt;br /&gt;
|Dosage and regime=0.5 mg nabilone tablets (from Valeant Canada)&lt;br /&gt;
&lt;br /&gt;
Once a day before radiotherapy in the first week, twice a day in the second week, third week until end of radiotherpy adjusted by radiation oncologist up to maximal 4 tablets&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=49&lt;br /&gt;
|Side Effects / Interactions=No differences for sleepiness (p=0.3166), anxiety (p=0.9163) and xerostomia (p=0.8341)&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Placebo&lt;br /&gt;
|Number of participants (arm)=28&lt;br /&gt;
|Drop-out=15&lt;br /&gt;
|Drop-out reasons=Not arm specified: severe nausea (n = 5); difficulty swallowing (n = 4); hospitalization (n = 4), pneumonia (n = 1); discontinued RT (n = 1); without reason (n = 9)&lt;br /&gt;
|Intervention=Placebo&lt;br /&gt;
&lt;br /&gt;
+ all patients: additional administration of antiemetics (metoclopramide) and painkillers (acetaminophen (paracetamol), codeine, hydromorphone or transdermal fentanyl) possible&lt;br /&gt;
|Dosage and regime=Once a day before radiotherapy in the first week, twice a day in the second week, third week until end of radiotherpy adjusted by radiation oncologist up to maximal 4 tablets&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=49&lt;br /&gt;
|Side Effects / Interactions=No differences for sleepiness (p=0.3166), anxiety (p=0.9163) and xerostomia (p=0.8341)&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm Overview}}&lt;br /&gt;
=Outcomes=&lt;br /&gt;
&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Primary&lt;br /&gt;
|Outcome name=Quality of life&lt;br /&gt;
|Outcome specification=Quality of life (target improvement of 15 points at week 7)&lt;br /&gt;
|Type of measurement=EORTC QLQ (European Organisation for Research and Treatment of Cancer Core/ Quality of Life questionnaire)&lt;br /&gt;
|Results during intervention=No difference between arms (p=0.4270), even after controlling for tumor site, treatment method and cancer stage at week 7 or the entire study period&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Pain with VAS + number of other analgesics used&lt;br /&gt;
|Type of measurement=VAS (Visual Analogue Scale), Observation&lt;br /&gt;
|Results during intervention=Over the course of the intervention and after: no differences for pain (p=0.6048), analgesic use (p=0.6671), no delay in time to 20% pain increase (p=0.4614) between arms&lt;br /&gt;
|Results after intervention=Over the course of the intervention and after: no differences for pain (p=0.6048), analgesic use (p=0.6671), no delay in time to 20% pain increase (p=0.4614) between arms&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Weight&lt;br /&gt;
|Outcome specification=Weight fluctuations, total days without feeding tube or gastrostomy&lt;br /&gt;
|Type of measurement=Scale&lt;br /&gt;
|Results during intervention=Over the course of the intervention and after: no difference for weight fluctuations (p=0.1454) or need for a feeding tube (no p-value) between arms.&lt;br /&gt;
|Results after intervention=Over the course of the intervention and after: no difference for weight fluctuations (p=0.1454) or need for a feeding tube (no p-value) between arms.&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=3&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Appetite&lt;br /&gt;
|Outcome specification=Appetite with questionnaire (no further information)&lt;br /&gt;
|Type of measurement=Unspecified questionnaire&lt;br /&gt;
|Results during intervention=Over the course of the intervention and after: no difference (p=0.3295) between arms&lt;br /&gt;
|Results after intervention=Over the course of the intervention and after: no difference (p=0.3295) between arms&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=4&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Nausea&lt;br /&gt;
|Outcome specification=Nausea with questionnaire (no further information) + number of antiemetic drugs used&lt;br /&gt;
|Type of measurement=Unspecified questionnaire&lt;br /&gt;
|Results during intervention=Over the course of the intervention and after: no difference for nausea (p=0.7105) or antiemetic consumption (p=0.6124) between arms&lt;br /&gt;
|Results after intervention=Over the course of the intervention and after: no difference for nausea (p=0.7105) or antiemetic consumption (p=0.6124) between arms&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=5&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Unspecified effects&lt;br /&gt;
|Outcome specification=Sleep quality and mood (no information on survey)&lt;br /&gt;
|Type of measurement=NI&lt;br /&gt;
|Results during intervention=Over the course of the intervention and after: no differences for mood (p=0.3214) and sleep quality (p=0.4438) between arms&lt;br /&gt;
|Results after intervention=Over the course of the intervention and after: no differences for mood (p=0.3214) and sleep quality (p=0.4438) between arms&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=6&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Toxicity&lt;br /&gt;
|Outcome specification=Toxicity of nabilone&lt;br /&gt;
|Type of measurement=NI&lt;br /&gt;
|Results during intervention=No differences for sleepiness (p=0.3166), anxiety (p=0.9163) and xerostomia (p=0.8341)&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=7&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome Overview}}&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
&lt;br /&gt;
{{Funding and Conflicts of Interest&lt;br /&gt;
|Funding=The authors received research grants from the Canadian Institutes of Health Research and the Fonds de recherche en santé du Québec. ICN Valeant Pharmaceuticals provided the nabilone and the placebo pills during the trial.&lt;br /&gt;
|Conflicts of Interest=According to authors no conflict of interest.&lt;br /&gt;
}}&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
&lt;br /&gt;
{{Further points for assessing the study&lt;br /&gt;
|power analysis performed=Yes&lt;br /&gt;
|Sample size corresponds to power analysis=Yes&lt;br /&gt;
|Reasons given for samples being too small according to power analysis=NA&lt;br /&gt;
|Samples sufficiently large=NA&lt;br /&gt;
|Ethnicity mentioned=No&lt;br /&gt;
|Other explanations for an effect besides the investigated intervention=No&lt;br /&gt;
|Possibility of attention effects=NA&lt;br /&gt;
|Possibility of placebo effects=NA&lt;br /&gt;
|Other reasons=NA&lt;br /&gt;
|Correct use of parametric and non-parametric tests=NI&lt;br /&gt;
|Correction for multiple testing=No&lt;br /&gt;
|Measurement of compliance=NI&lt;br /&gt;
|Consistent reporting in numbers=Yes&lt;br /&gt;
|Comprehensive and coherent reporting=No&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|sufficient washout period=NA&lt;br /&gt;
|Tested for carry-over effects=NA&lt;br /&gt;
|Were sequence effects tested=NA&lt;br /&gt;
|Effect sizes reported=No&lt;br /&gt;
|Were side effects systematically recorded=Yes&lt;br /&gt;
|Side effects taken into account in the interpretation of the results=Yes&lt;br /&gt;
|Ethics / CoI / Funding=Yes&lt;br /&gt;
|Blinding reliable=Yes&lt;br /&gt;
|Check whether blinding was successful=No&lt;br /&gt;
|reasons given for samples being too small according to power analysis=?&lt;br /&gt;
|Testing for normal distribution=?&lt;br /&gt;
|Correct application of statistical tests=?&lt;br /&gt;
|mono- or multicentric=?&lt;br /&gt;
}}&lt;br /&gt;
{{Additional Notes&lt;br /&gt;
|Additional Notes=PRO:&lt;br /&gt;
&lt;br /&gt;
* Ethical approval&lt;br /&gt;
* Power analysis&lt;br /&gt;
* Intent-to-treat analysis&lt;br /&gt;
* Baseline comparability&lt;br /&gt;
* Mention of drop-out comparison in the discussion, though no statistical values are provided&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
CONTRA:&lt;br /&gt;
&lt;br /&gt;
* Lack of blinding control&lt;br /&gt;
* No correction for multiple testing&lt;br /&gt;
* Superficial and inadequate presentation of results: results are only shown graphically, with no mean/SD values available, lacking transparency&lt;br /&gt;
* Very high drop-out rate, with 12 out of 15 participants in placebo arm who dropped out receiving Radiochemotherapy&lt;br /&gt;
* Exact dosing from week 3 onward may vary for each participant&lt;br /&gt;
* Apart from the primary endpoint, no specific timing provided for final comparisons&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Fallon_et_al._(2017)_I:_Sativex_oromucosal_spray_as_adjunctive_therapy_in_advanced_cancer_patients_with_chronic_pain_unalleviated_by_optimized_opioid_therapy:_two_double-blind,_randomized,_placebo-controlled_phase_3_studies&amp;diff=6985</id>
		<title>Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Fallon_et_al._(2017)_I:_Sativex_oromucosal_spray_as_adjunctive_therapy_in_advanced_cancer_patients_with_chronic_pain_unalleviated_by_optimized_opioid_therapy:_two_double-blind,_randomized,_placebo-controlled_phase_3_studies&amp;diff=6985"/>
		<updated>2024-11-22T08:21:39Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{Reference&lt;br /&gt;
|Reference=Publication: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies&lt;br /&gt;
}}&lt;br /&gt;
{{Study Note&lt;br /&gt;
|Study Note=This is the first study [[Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies]].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Second study: [[Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies]].&lt;br /&gt;
}}&lt;br /&gt;
=Brief summary=&lt;br /&gt;
Two studies were reported in this article. Both studies included patients with various advanced cancers who suffered from pain despite optimized opioid therapy. In both studies, one arm (randomized) received Sativex® (containing THC and CBD) daily for 35 days and the other arm a placebo. The first 14 days were used to adjust the dose, which varied from patient to patient throughout the study. In both studies, the percentage improvement in pain perception was measured, as well as the change in average pain, the value of the worst pain, the extent of sleep disturbance, the amount of opioids taken and several questionnaires on the patient&#039;s own satisfaction, their own assessment of the change and constipation. A special feature of the second study was that all patients included were initially given Sativex® for 14 days. All patients, who then showed an improvement in pain perception of at least 15%, were then randomly divided into two arms to receive either Sativex® or a placebo.&lt;br /&gt;
&lt;br /&gt;
In the first study 399 and in the second study (after division into arms) 206 patients were included. After five weeks, there was no significant difference in the percentage improvement in pain perception, change in mean pain, score of worst pain, extent of sleep disturbance or amount of opioid intake. Only in the first study did the Sativex® arm show improvement in some of the questionnaires (personal and physician-assessed improvement). In the second study, there were no differences between the arms in the questionnaires.&lt;br /&gt;
&lt;br /&gt;
Both studies are characterised by a large sample size and a well thought-out statistical analysis. However, as the studies were conducted in centres all over the world, it should be noted that it cannot be assumed that all patients received the same basic care (especially in opioid care). In addition, both studies were funded by a pharmaceutical industry.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
In diesem Artikel wurden zwei Studien berichtet. Beide Studien schlossen Patienten mit verschiedenen fortgeschrittene Krebsarten ein, welche trotz optimierter Opioid Therapie unter Schmerz leiden. In beiden Studien bekam (zufällig eingeteilt) eine Gruppe täglich Sativex® (enthält THC und CBD) für 35 Tage und die andere ein Placebo. Die ersten 14 Tage dienten der Einstellung der Dosis und diese war über die Studie unterschiedlich von Patient zu Patient. Gemessen wurde in beiden Studien die prozentuale Verbesserung des Schmerzempfindens, sowie die Veränderung des mittleren Schmerzes, Wert des schlimmsten Schmerzes, Ausmaß von Schlafstörung, Menge der Einnahme von Opioiden sowie einige Fragebögen zur eigenen Zufriedenheit, der eigenen Einschätzung der Veränderung und Verstopfung. Besonderheit der zweiten Studie war, dass zunächst alle eingeschlossenen Patienten für 14 Tage Sativex® bekamen. Alle Patienten, die danach eine Verbesserung des Schmerzempfindens von mindestens 15% zeigten, wurden anschließend zufällig in zwei Gruppen eingeteilt, um entweder weiterhin Sativex® oder ein Placebo zu bekommen.&lt;br /&gt;
&lt;br /&gt;
In der ersten Studie wurden 399 und in der zweiten Studie (nach Aufteilung in Gruppen) 206 Patienten eingeschlossen. Nach fünf Wochen zeigte sich kein bedeutsamer Unterschied in der prozentualen Besserung des Schmerzempfindens, sowie Veränderung des mittleren Schmerzes, Wert des schlimmsten Schmerzes, Ausmaß von Schlafstörung oder Menge der Einnahme von Opioiden. Einzig in der ersten Studie zeigten sich für die Sativex® Gruppe Verbesserung in einigen der Fragebögen (persönliche und vom Arzt eingeschätzte Besserung). In der zweiten Studie zeigten sich in den Fragebögen keine Unterschiede zwischen den Gruppen.&lt;br /&gt;
&lt;br /&gt;
Beide Studien zeichnen sich durch eine große Stichprobe und eine durchdachte statistische Analyse aus. Da die Studien in Zentren über die ganze Welt durchgeführt wurden, ist jedoch zu beachten, dass nicht davon ausgegangen werden kann, dass alle Patienten die gleiche Grundversorgung (insbesondere in der Opioidversorgung) bekamen. Zudem wurden beide Studien von einer Pharmaindustrie finanziert.&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
&lt;br /&gt;
{{Study Design (RCT)&lt;br /&gt;
|Perspective=Prospective&lt;br /&gt;
|Centralized=Multicentric&lt;br /&gt;
|Blinding=Double&lt;br /&gt;
|Is randomized=Yes&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|Number of arms=2&lt;br /&gt;
}}&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
&lt;br /&gt;
{{RCT study general properties&lt;br /&gt;
|Inclusion criteria=Advanced incurable stage of cancer; ≥ 18 years of age; clinical diagnosis of cancer-related pain unalleviated by an optimized maintenance dose of Step 3 opioid therapy; ≤ 4 opioid breakthrough analgesic episodes per day (averaged over the 3 days); stable maintenance opioid therapy dose; average pain ≥ 4 and ≤ 8 on a 0–10 NRS; average pain scores on the NRS that did not change by more than 2 points from the beginning to end of screening (i.e. no more than a 2-point difference between the highest and lowest scores, with all scores remaining between 4 and 8&lt;br /&gt;
|Exclusion criteria=Baseline use of morphine at &amp;gt; 500 mg morphine equivalents/day (inclusive of maintenance and breakthrough opioids); current use of more than one type of breakthrough opioid analgesic; planned clinical interventions that would affect pain; any history of schizophrenia or substance abuse including recreational use of cannabis product&lt;br /&gt;
|N randomized=399&lt;br /&gt;
|Analysis=ITT Analysis&lt;br /&gt;
|Specifications on analyses=n = 2 no intervention received&lt;br /&gt;
&lt;br /&gt;
Wilcoxon rank-sum test was conducted for percent improvement in average pain NRS score (from baseline to end of treatment in study 1, and from eligibility &lt;br /&gt;
pre-treatment baseline to end of treatment in study 2). &lt;br /&gt;
Analysis of covariance (ANCOVA) was applied on the primary and the key secondary efficacy endpoints, including percent improvement, average pain/worst pain/sleep disruption scores, with corresponding baseline value as a covariate and treatment group as a factor. The time-course of these four efficacy endpoints from week 1 through week 5 was also analysed using Mixed-Effect Model Repeat Measurement (MMRM) on the ITT analysis set in both studies.&lt;br /&gt;
&lt;br /&gt;
For both study 1 and study 2, the primary endpoint and the key secondary endpoints were tested with their Type I error controlled by use of a hierarchical gate-keeping procedure.&lt;br /&gt;
&lt;br /&gt;
In each study, p-values from Wilcoxon rank-sum tests on percent improvement and ANCOVA on average pain/worst pain/sleep disruption scores were used for the hierarchical gate-keeping procedure in the sequence of the primary endpoint and the key secondary endpoints. No adjustments for covariates were made for the analyses of the other secondary endpoints in both studies with analysis of variance (ANOVA), including PGIC, SGIC or PSQ, and daily total, maintenance, and breakthrough opioid dose. Subgroup analyses for region (United States and rest of world (ROW)) were performed for the primary and the key secondary endpoints.&lt;br /&gt;
|Countries of data collection=Belgium, Bulgaria, Czech Republic, Estonia, Germany, Hungary, Latvia, Lithuania, Poland, Romania, United Kingdom, United States&lt;br /&gt;
|LoE=Level 2 Oxford 2011&lt;br /&gt;
|Outcome timeline=T0: baseline&lt;br /&gt;
&lt;br /&gt;
T1: after 3 weeks (day 22)&lt;br /&gt;
&lt;br /&gt;
T2: after 5 weeks (day 36)&lt;br /&gt;
&lt;br /&gt;
Follow-up: after 7 weeks (up to day 43)&lt;br /&gt;
}}&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
&lt;br /&gt;
{{Characteristics of participants&lt;br /&gt;
|Setting=NI&lt;br /&gt;
|Types of cancer=Breast Cancer, Colorectal Cancer - Colon Cancer, Gastrointestinal Cancers - Gallbladder Cancer, Gastrointestinal Cancers - Liver Cancer, Gastrointestinal Cancers - Pancreatic Cancer, Stomach Cancer, Gastrointestinal Cancers, Prostate Cancer, Lung Cancer, Genitourinary Cancers - Bladder Cancer, Brain and Central Nervous System (CNS) Cancers, Chest Cancer, Eye Cancer, Gynecologic Cancers - Cervical Cancer, Gynecologic Cancers - Ovarian Cancer, Gynecologic Cancers - Uterine Cancer, Genitourinary Cancers, Head and Neck Cancers, Hematologic Cancers, Genitourinary Cancers - Kidney (Renal) Cancer, Hematologic Cancers - Lymphoma (Hodgkin and Non-Hodgkin), Skin Cancer, Bone and Soft Tissue Cancers, Gastrointestinal Cancers - Esophageal Cancer, Other Cancers&lt;br /&gt;
|Stage cancer=Advanced Stage&lt;br /&gt;
|Cancer stage specification=Mean (SD) time since cancer diagnosis per arm:&lt;br /&gt;
&lt;br /&gt;
Sativex = 4.1 (4.2) years&lt;br /&gt;
&lt;br /&gt;
Placebo = 3.5 (5.0) years&lt;br /&gt;
|Comorbidity=Pain that could not be improved even with optimized opioid therapy (NRS ≥ 4 and ≤ 8)&lt;br /&gt;
|Current cancer therapy=NI&lt;br /&gt;
|Specifications on cancer therapies=NI&lt;br /&gt;
|Previous cancer therapies=NI&lt;br /&gt;
|Gender=Mixed&lt;br /&gt;
|Gender specifications=Male, n(%) per arm:&lt;br /&gt;
&lt;br /&gt;
Sativex = 106 (53.0)&lt;br /&gt;
&lt;br /&gt;
Placebo = 97 (48.7)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Female, n(%) per arm:&lt;br /&gt;
&lt;br /&gt;
Sativex = 194 (47.0)&lt;br /&gt;
&lt;br /&gt;
Placebo = 102 (51.3)&lt;br /&gt;
|Age groups=Adults (18+)&lt;br /&gt;
|Age groups specification=Mean (SD) age per arm: &lt;br /&gt;
&lt;br /&gt;
Sativex = 60 (11) years &lt;br /&gt;
&lt;br /&gt;
Placebo = 59.6 (11) years&lt;br /&gt;
}}&lt;br /&gt;
=Arms=&lt;br /&gt;
&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Intervention&lt;br /&gt;
|Number of participants (arm)=200&lt;br /&gt;
|Drop-out=64&lt;br /&gt;
|Drop-out reasons=Side effects (n = 38, 19%); consent withdrawn (n = 19, 9.5%); death (n = 20, 10%)&lt;br /&gt;
|Intervention=Sativex&lt;br /&gt;
|Dosage and regime=Sativex® (nabiximol, THC 27 mg/mL, CBD, 25 mg/mL) via oral spray (self-applied by patient) &lt;br /&gt;
&lt;br /&gt;
Week 1: dose finding; week 2-5: stable dose, max. 10 sprays&lt;br /&gt;
&lt;br /&gt;
First week mean number of sprays = 3.7, stabilized over 4 weeks (6.3 sprays per day)&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=36&lt;br /&gt;
|Side Effects / Interactions=Overall 68% at least one event; assessed as probably intervention-associated with frequency ≥ 5%: Total n = 64 (32.2%), of which somnolence n = 18 (9%), dizziness n = 15 (7.5%), nausea n = 10 (5%)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
2 severe side effects associated with intervention: 1x constipation (with 360mg/day morphine equivalents), 1x moderate disorientation and somnolence on day 4 (with 2.5 daily sprays of Sativex)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
None of the deaths related to intervention&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Placebo&lt;br /&gt;
|Number of participants (arm)=199&lt;br /&gt;
|Drop-out=41&lt;br /&gt;
|Drop-out reasons=Side effects (n = 29, 14.6%), consent withdrawn (n = 8, 4%), death (n = 25, 68%)&lt;br /&gt;
|Intervention=Placebo&lt;br /&gt;
|Dosage and regime=First week mean number of sprays 3.7, stabilized over 4 weeks (7.4 sprays per day)&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=36&lt;br /&gt;
|Side Effects / Interactions=Overall 64% at least one event; assessed as probably intervention-associated with frequency ≥ 5%: Total n = 41 (20.7%), of which somnolence n = 6 (3%), dizziness n = 6 (3%), nausea n = 8 (4%)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
2 severe side effects associated with intervention: 1x constipation (with 360mg/day morphine equivalents), 1x moderate disorientation and somnolence on day 4 (with 2.5 daily sprays of Sativex)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
None of the deaths related to intervention&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm Overview}}&lt;br /&gt;
=Outcomes=&lt;br /&gt;
&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Primary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Median improvement in pain with NRS in %&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No significant difference after 5 weeks&lt;br /&gt;
* Sativex arm = 7.2% vs. placebo arm = 9.5% (median difference = −1.84%; CI: −6.19%, 1.50%; p=0.274, not significant)&lt;br /&gt;
&lt;br /&gt;
Subgroup analysis with US population &lt;br /&gt;
* shows effects for Sativex arm (p=0.03), especially for patients under 65 years of age&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Change in NRS value for average pain&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No differences between arms after 5 weeks (no p-value)&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Change in NRS value for the worst pain&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No differences between arms after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=3&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Extent of sleep disturbance (assessed with NRS)&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No differences between arms after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=4&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=General intake, appropriate opioid intake for breakthrough pain and total opioid intake per day in morphine equivalents&lt;br /&gt;
|Type of measurement=Observation&lt;br /&gt;
|Results during intervention=No differences between arms after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=5&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Others&lt;br /&gt;
|Outcome name=Quality of life&lt;br /&gt;
|Outcome specification=Specification NRS: constipation NRS&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale), SGIC (Subject Global Impression of Change), PSQ (Patient Satisfaction Questionnaire), PGIC (Physician Global Impression of Change)&lt;br /&gt;
|Results during intervention=Results: &lt;br /&gt;
* Higher change in SGIC for global impression and better change assessed by physician in &#039;general functional ability&#039; of Sativex arm compared to placebo arm&lt;br /&gt;
* Scores in SGIC better in Sativex arm at week 3 (p = 0.041), 5 (p = 0.022) and last visit (p = 0.022)&lt;br /&gt;
* PGIC better at week 5 (p=0.037) compared to placebo arm&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=6&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome Overview}}&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
&lt;br /&gt;
{{Funding and Conflicts of Interest&lt;br /&gt;
|Funding=Funding for the study was obtained from Otsuka Pharmaceutical Development &amp;amp; Commercialization, Inc., Rockville, MD, USA.&lt;br /&gt;
|Conflicts of Interest=According to authors no conflict of interest.&lt;br /&gt;
}}&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
&lt;br /&gt;
{{Further points for assessing the study&lt;br /&gt;
|power analysis performed=Yes&lt;br /&gt;
|Sample size corresponds to power analysis=Yes&lt;br /&gt;
|Reasons given for samples being too small according to power analysis=NA&lt;br /&gt;
|Samples sufficiently large=NA&lt;br /&gt;
|Ethnicity mentioned=Yes&lt;br /&gt;
|Other explanations for an effect besides the investigated intervention=Yes&lt;br /&gt;
|Possibility of attention effects=NA&lt;br /&gt;
|Possibility of placebo effects=NA&lt;br /&gt;
|Other reasons=* More and cannabinoid typical side effects in intervention arms, knowledge of assignment could have influenced the result. &lt;br /&gt;
* No information whether centers were comparable in treatment of patients; especially “optimized” opioid treatment may vary from country to country&lt;br /&gt;
|Correct use of parametric and non-parametric tests=Yes&lt;br /&gt;
|Correction for multiple testing=Yes&lt;br /&gt;
|Measurement of compliance=NI&lt;br /&gt;
|Consistent reporting in numbers=Yes&lt;br /&gt;
|Comprehensive and coherent reporting=Yes&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|sufficient washout period=NA&lt;br /&gt;
|Tested for carry-over effects=NA&lt;br /&gt;
|Were sequence effects tested=NA&lt;br /&gt;
|Effect sizes reported=No&lt;br /&gt;
|Were side effects systematically recorded=Yes&lt;br /&gt;
|Side effects taken into account in the interpretation of the results=Yes&lt;br /&gt;
|Ethics / CoI / Funding=Yes&lt;br /&gt;
}}&lt;br /&gt;
{{Additional Notes&lt;br /&gt;
|Additional Notes=PRO:&lt;br /&gt;
* Ethical approval obtained&lt;br /&gt;
* Arms comparable at baseline&lt;br /&gt;
* Power analysis conducted&lt;br /&gt;
* Multiple testing controlled for endpoints pain and sleep disruption&lt;br /&gt;
* Intent-to-Treat analysis performed&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
CONTRA:&lt;br /&gt;
* High dropout rate (due to study discontinuation or death)&lt;br /&gt;
* No information on whether centers were comparable in patient treatment; particularly, &amp;quot;optimal&amp;quot; opioid treatment may vary between countries&lt;br /&gt;
* Multiple testing only controlled for pain and sleep disruption&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Fallon_et_al._(2017)_II:_Sativex_oromucosal_spray_as_adjunctive_therapy_in_advanced_cancer_patients_with_chronic_pain_unalleviated_by_optimized_opioid_therapy:_two_double-blind,_randomized,_placebo-controlled_phase_3_studies&amp;diff=6984</id>
		<title>Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Fallon_et_al._(2017)_II:_Sativex_oromucosal_spray_as_adjunctive_therapy_in_advanced_cancer_patients_with_chronic_pain_unalleviated_by_optimized_opioid_therapy:_two_double-blind,_randomized,_placebo-controlled_phase_3_studies&amp;diff=6984"/>
		<updated>2024-11-22T08:21:06Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{Reference&lt;br /&gt;
|Reference=Publication: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies&lt;br /&gt;
}}&lt;br /&gt;
{{Study Note&lt;br /&gt;
|Study Note=This is the second study [[Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
First study: [[Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies]].&lt;br /&gt;
}}&lt;br /&gt;
=Brief summary=&lt;br /&gt;
Two studies were reported in this article. Both studies included patients with various advanced cancers who suffered from pain despite optimized opioid therapy. In both studies, one arm (randomized) received Sativex® (containing THC and CBD) daily for 35 days and the other arm a placebo. The first 14 days were used to adjust the dose, which varied from patient to patient throughout the study. In both studies, the percentage improvement in pain perception was measured, as well as the change in average pain, the value of the worst pain, the extent of sleep disturbance, the amount of opioids taken and several questionnaires on the patient&#039;s own satisfaction, their own assessment of the change and constipation. A special feature of the second study was that all patients included were initially given Sativex® for 14 days. All patients, who then showed an improvement in pain perception of at least 15%, were then randomly divided into two arms to receive either Sativex® or a placebo.&lt;br /&gt;
In the first study 399 and in the second study (after division into arms) 206 patients were included. After five weeks, there was no significant difference in the percentage improvement in pain perception, change in mean pain, score of worst pain, extent of sleep disturbance or amount of opioid intake. Only in the first study did the Sativex® arm show improvement in some of the questionnaires (personal and physician-assessed improvement). In the second study, there were no differences between the arms in the questionnaires.&lt;br /&gt;
&lt;br /&gt;
Both studies are characterised by a large sample size and a well thought-out statistical analysis. However, as the studies were conducted in centres all over the world, it should be noted that it cannot be assumed that all patients received the same basic care (especially in opioid care). In addition, both studies were funded by a pharmaceutical industry.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
In diesem Artikel wurden zwei Studien berichtet. Beide Studien schlossen Patienten mit verschiedenen fortgeschrittene Krebsarten ein, welche trotz optimierter Opioid Therapie unter Schmerz leiden. In beiden Studien bekam (zufällig eingeteilt) eine Gruppe täglich Sativex® (enthält THC und CBD) für 35 Tage und die andere ein Placebo. Die ersten 14 Tage dienten der Einstellung der Dosis und diese war über die Studie unterschiedlich von Patient zu Patient. Gemessen wurde in beiden Studien die prozentuale Verbesserung des Schmerzempfindens, sowie die Veränderung des mittleren Schmerzes, Wert des schlimmsten Schmerzes, Ausmaß von Schlafstörung, Menge der Einnahme von Opioiden sowie einige Fragebögen zur eigenen Zufriedenheit, der eigenen Einschätzung der Veränderung und Verstopfung. Besonderheit der zweiten Studie war, dass zunächst alle eingeschlossenen Patienten für 14 Tage Sativex® bekamen. Alle Patienten, die danach eine Verbesserung des Schmerzempfindens von mindestens 15% zeigten, wurden anschließend zufällig in zwei Gruppen eingeteilt, um entweder weiterhin Sativex® oder ein Placebo zu bekommen.&lt;br /&gt;
In der ersten Studie wurden 399 und in der zweiten Studie (nach Aufteilung in Gruppen) 206 Patienten eingeschlossen. Nach fünf Wochen zeigte sich kein bedeutsamer Unterschied in der prozentualen Besserung des Schmerzempfindens, sowie Veränderung des mittleren Schmerzes, Wert des schlimmsten Schmerzes, Ausmaß von Schlafstörung oder Menge der Einnahme von Opioiden. Einzig in der ersten Studie zeigten sich für die Sativex® Gruppe Verbesserung in einigen der Fragebögen (persönliche und vom Arzt eingeschätzte Besserung). In der zweiten Studie zeigten sich in den Fragebögen keine Unterschiede zwischen den Gruppen.&lt;br /&gt;
Beide Studien zeichnen sich durch eine große Stichprobe und eine durchdachte statistische Analyse aus. Da die Studien in Zentren über die ganze Welt durchgeführt wurden, ist jedoch zu beachten, dass nicht davon ausgegangen werden kann, dass alle Patienten die gleiche Grundversorgung (insbesondere in der Opioidversorgung) bekamen. Zudem wurden beide Studien von einer Pharmaindustrie finanziert.&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
&lt;br /&gt;
{{Study Design (RCT)&lt;br /&gt;
|Perspective=Prospective&lt;br /&gt;
|Centralized=Multicentric&lt;br /&gt;
|Blinding=Double&lt;br /&gt;
|Is randomized=Yes&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|Number of arms=2&lt;br /&gt;
}}&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
&lt;br /&gt;
{{RCT study general properties&lt;br /&gt;
|Inclusion criteria=Advanced incurable stage of cancer; ≥18years of age; clinical diagnosis of cancer-related pain unalleviated by an optimized maintenance dose of Step 3 opioid therapy; ≤4 opioid breakthrough analgesic episodes per day (averaged over the 3 days); stable maintenance opioid therapy dose; average pain ≥ 4 and ≤8 on a 0–10 NRS; average pain scores on the NRS that did not change by more than 2 points from the beginning to end of screening (i.e. no more than a 2-point difference between the highest and lowest scores, with all scores remaining between 4 and 8&lt;br /&gt;
|Exclusion criteria=Baseline use of morphine at &amp;gt;500mg morphine equivalents/day (inclusive of maintenance and breakthrough opioids); current use of more than one type of breakthrough opioid analgesic; planned clinical interventions that would affect pain; any &lt;br /&gt;
history of schizophrenia or substance abuse including recreational use of cannabis product&lt;br /&gt;
|N randomized=399&lt;br /&gt;
|Analysis=ITT Analysis&lt;br /&gt;
|Specifications on analyses=Procedure&lt;br /&gt;
Part A: all received Sativex® for 10 days, then 4 days therapy at adjusted dose; patients who showed an improvement of at least 15% for pain (NRS) entered Part B: randomized in A or B with intervention for 5 weeks, follow-up 2 weeks later&lt;br /&gt;
&lt;br /&gt;
Discussed is part B of the study.&lt;br /&gt;
|Countries of data collection=Australia, Bulgaria, Germany, Hungary, India, Israel, Italy, Lithuania, Poland, Romania, Spain, Taiwan, United Kingdom&lt;br /&gt;
|LoE=Level 2 Oxford 2011&lt;br /&gt;
|Outcome timeline=T0: baseline&lt;br /&gt;
&lt;br /&gt;
T1: after 3 weeks (day 22)&lt;br /&gt;
&lt;br /&gt;
T2: after 5 weeks (day 36)&lt;br /&gt;
&lt;br /&gt;
Follow-up: after 7 weeks (up to day 43)&lt;br /&gt;
}}&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
&lt;br /&gt;
{{Characteristics of participants&lt;br /&gt;
|Setting=NI&lt;br /&gt;
|Types of cancer=Genitourinary Cancers - Bladder Cancer, Brain and Central Nervous System (CNS) Cancers, Breast Cancer, Chest Cancer, Eye Cancer, Colorectal Cancer - Colon Cancer, Gastrointestinal Cancers - Gallbladder Cancer, Gastrointestinal Cancers - Liver Cancer, Gastrointestinal Cancers - Pancreatic Cancer, Stomach Cancer, Gastrointestinal Cancers, Gynecologic Cancers - Cervical Cancer, Gynecologic Cancers - Ovarian Cancer, Prostate Cancer, Gynecologic Cancers - Uterine Cancer, Genitourinary Cancers, Head and Neck Cancers, Hematologic Cancers, Skin Cancer, Bone and Soft Tissue Cancers, Gastrointestinal Cancers - Esophageal Cancer, Other Cancers&lt;br /&gt;
|Stage cancer=Advanced Stage&lt;br /&gt;
|Cancer stage specification=NI&lt;br /&gt;
|Comorbidity=Pain that could not be improved even with optimized opioid therapy (NRS ≥ 4 and ≤ 8)&lt;br /&gt;
|Current cancer therapy=NI&lt;br /&gt;
|Specifications on cancer therapies=NI&lt;br /&gt;
|Previous cancer therapies=NI&lt;br /&gt;
|Gender=Mixed&lt;br /&gt;
|Gender specifications=Part A&lt;br /&gt;
&lt;br /&gt;
Female = 176 (43.6%)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Part B&lt;br /&gt;
&lt;br /&gt;
Sativex = 40 (38.8%) female&lt;br /&gt;
&lt;br /&gt;
Placebo = 48 (46.6%) female&lt;br /&gt;
|Age groups=Adults (18+)&lt;br /&gt;
|Age groups specification=Part A&lt;br /&gt;
Mean (SD) age: 61.2 (11.2) years&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Part B&lt;br /&gt;
&lt;br /&gt;
Mean (SD) age per arm: &lt;br /&gt;
&lt;br /&gt;
Sativex = 61.4 (10.9) years&lt;br /&gt;
&lt;br /&gt;
Placebo = 61.6 (11.8) years&lt;br /&gt;
}}&lt;br /&gt;
=Arms=&lt;br /&gt;
&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Intervention&lt;br /&gt;
|Number of participants (arm)=103&lt;br /&gt;
|Drop-out=Discontinued n=25&lt;br /&gt;
&lt;br /&gt;
Died during study n=23&lt;br /&gt;
&lt;br /&gt;
Study completed n=78&lt;br /&gt;
|Drop-out reasons=Adverse Events n=21&lt;br /&gt;
&lt;br /&gt;
Withdrew consent n=2&lt;br /&gt;
&lt;br /&gt;
Withdrawn by investigator n=1&lt;br /&gt;
&lt;br /&gt;
Lack of efficacy n=1&lt;br /&gt;
&lt;br /&gt;
Died during treatment n=23&lt;br /&gt;
&lt;br /&gt;
Died post-treatment but before follow-up n=8&lt;br /&gt;
&lt;br /&gt;
Died post follow-up n=3&lt;br /&gt;
|Intervention=Sativex&lt;br /&gt;
|Dosage and regime=Sativex® (nabiximol, THC 27 mg/mL, CBD, 25 mg/mL) via oral spray (self-applied by patient)&lt;br /&gt;
&lt;br /&gt;
Week 1: dose finding; week 2-5: stable dose, max. 10 sprays&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Part A&lt;br /&gt;
&lt;br /&gt;
First week average number of sprays = 3.6; Second week = 6.4&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Part B&lt;br /&gt;
&lt;br /&gt;
Average daily number = 6.5&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=36&lt;br /&gt;
|Side Effects / Interactions=Part A&lt;br /&gt;
&lt;br /&gt;
Overall 60% at least one event, assessed as probably intervention-associated with frequency ≥ 5%: Total n = 128, 31.7%, somnolence (n = 42, 10.4%), nausea (n = 21, 5.2%) and dizziness (n = 21, 5.2%)&lt;br /&gt;
&lt;br /&gt;
Part B&lt;br /&gt;
&lt;br /&gt;
Overall 72% at least one event; assessed as probably intervention-associated with frequency ≥ 5%: Total n = 16, 15.5%; somnolence (n = 6, 5.8%)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
More than twice as many patients in Sativex arm discontinued study due to side effects (n = 14, 13.6% vs. n = 6, 5.8%); no statistical comparison given)&lt;br /&gt;
&lt;br /&gt;
None of the deaths related to intervention&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Placebo&lt;br /&gt;
|Number of participants (arm)=103&lt;br /&gt;
|Drop-out=Discontinued n=15&lt;br /&gt;
&lt;br /&gt;
Died during study n=9&lt;br /&gt;
&lt;br /&gt;
Study completed n=88&lt;br /&gt;
|Drop-out reasons=Adverse Events n=13&lt;br /&gt;
&lt;br /&gt;
Withdrawn by investigator n=1&lt;br /&gt;
&lt;br /&gt;
Lack of efficacy n=1&lt;br /&gt;
&lt;br /&gt;
Died during treatment n=9&lt;br /&gt;
|Intervention=Placebo&lt;br /&gt;
|Dosage and regime=Week 1: dose finding; week 2-5: stable dose, max. 10 sprays&lt;br /&gt;
&lt;br /&gt;
Part A&lt;br /&gt;
&lt;br /&gt;
First week average number of sprays = 3.6, Second week = 6.4&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Part B&lt;br /&gt;
&lt;br /&gt;
Average daily number = 6.3&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=36&lt;br /&gt;
|Side Effects / Interactions=Part A&lt;br /&gt;
&lt;br /&gt;
Overall 60% at least one event, assessed as probably intervention-associated with frequency ≥ 5%: Total n = 128, 31.7%, somnolence (n = 42, 10.4%), nausea (n = 21, 5.2%) and dizziness (n = 21, 5.2%)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Part B&lt;br /&gt;
&lt;br /&gt;
Overall 62% at least one event; assessed as probably intervention-associated with frequency ≥ 5%: Total n = 12, 11.7%; somnolence n = 0&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm Overview}}&lt;br /&gt;
=Outcomes=&lt;br /&gt;
&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Primary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Change in NRS value for moderate pain&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=Deterioration in both arms after 5 weeks: &lt;br /&gt;
* Sativex arm: from 3.2 to 3.7, Placebo arm: 3.1 to 3.6. (treatment effect -0.02; 95% CI: -0.42, 0.38; p = 0.917)&lt;br /&gt;
* No differences for individual subgroups (no US patients in this study)&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Median improvement in pain with NRS in %&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No arm differences after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Change in NRS value for the worst pain&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No arm differences after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=3&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Sleep&lt;br /&gt;
|Outcome specification=Extent of sleep disturbance (assessed with NRS)&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No arm differences after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=4&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Additional medication&lt;br /&gt;
|Outcome specification=General intake, appropriate opioid intake for breakthrough pain and total opioid intake per day in morphine equivalents&lt;br /&gt;
|Type of measurement=Observation&lt;br /&gt;
|Results during intervention=No arm differences after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=5&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Others&lt;br /&gt;
|Outcome name=Quality of life&lt;br /&gt;
|Outcome specification=Specification NRS: constipation NRS&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale), SGIC (Subject Global Impression of Change), PSQ (Patient Satisfaction Questionnaire), PGIC (Physician Global Impression of Change)&lt;br /&gt;
|Results during intervention=No arm differences after 5 weeks (no p-value).&lt;br /&gt;
|Results after intervention=NI&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=?&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=some concerns&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=6&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome Overview}}&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
&lt;br /&gt;
{{Funding and Conflicts of Interest&lt;br /&gt;
|Funding=Funding for the study was obtained from Otsuka Pharmaceutical Development &amp;amp; Commercialization, Inc., Rockville, MD, USA.&lt;br /&gt;
|Conflicts of Interest=According to authors no conflict of interest.&lt;br /&gt;
}}&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
&lt;br /&gt;
{{Further points for assessing the study&lt;br /&gt;
|power analysis performed=Yes&lt;br /&gt;
|Sample size corresponds to power analysis=No&lt;br /&gt;
|Reasons given for samples being too small according to power analysis=* high drop-out due to side effects or withdrawal of consent in Phase A &lt;br /&gt;
* not fitting the inclusion criteria (failure to demonstrate a 15% improvement in average pain NRS score during titration)&lt;br /&gt;
|Samples sufficiently large=NA&lt;br /&gt;
|Ethnicity mentioned=Yes&lt;br /&gt;
|Other explanations for an effect besides the investigated intervention=Yes&lt;br /&gt;
|Possibility of attention effects=NA&lt;br /&gt;
|Possibility of placebo effects=NA&lt;br /&gt;
|Other reasons=* More and cannabinoid typical side effects in intervention arms, knowledge of assignment could have influenced the result.&lt;br /&gt;
* No information whether centers were comparable in treatment of patients; especially “optimized” opioid treatment may vary from country to country&lt;br /&gt;
|Correct use of parametric and non-parametric tests=Yes&lt;br /&gt;
|Correction for multiple testing=Yes&lt;br /&gt;
|Measurement of compliance=NI&lt;br /&gt;
|Consistent reporting in numbers=Yes&lt;br /&gt;
|Comprehensive and coherent reporting=Yes&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|sufficient washout period=NA&lt;br /&gt;
|Tested for carry-over effects=NA&lt;br /&gt;
|Were sequence effects tested=NA&lt;br /&gt;
|Effect sizes reported=No&lt;br /&gt;
|Were side effects systematically recorded=Yes&lt;br /&gt;
|Side effects taken into account in the interpretation of the results=Yes&lt;br /&gt;
|Ethics / CoI / Funding=Yes&lt;br /&gt;
|Blinding reliable=?&lt;br /&gt;
|Check whether blinding was successful=?&lt;br /&gt;
|reasons given for samples being too small according to power analysis=?&lt;br /&gt;
|Testing for normal distribution=?&lt;br /&gt;
|Correct application of statistical tests=?&lt;br /&gt;
|mono- or multicentric=?&lt;br /&gt;
}}&lt;br /&gt;
{{Additional Notes&lt;br /&gt;
|Additional Notes=PRO:&lt;br /&gt;
* Ethical approval obtained&lt;br /&gt;
* Arms comparable at baseline&lt;br /&gt;
* Power analysis conducted&lt;br /&gt;
* Multiple testing controlled for endpoints pain and sleep disruption&lt;br /&gt;
* Intent-to-Treat analysis performed&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
CONTRA:&lt;br /&gt;
* High dropout rate (due to study discontinuation or death)&lt;br /&gt;
* No information on whether centers were comparable in patient treatment; particularly, &amp;quot;optimal&amp;quot; opioid treatment may vary between countries&lt;br /&gt;
* Multiple testing only controlled for pain and sleep disruption&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Grimison_et_al._(2020):_Oral_THC:CBD_cannabis_extract_for_refractory_chemotherapy-induced_nausea_and_vomiting:_a_randomised,_placebo-controlled,_phase_II_crossover_trial&amp;diff=6983</id>
		<title>Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Grimison_et_al._(2020):_Oral_THC:CBD_cannabis_extract_for_refractory_chemotherapy-induced_nausea_and_vomiting:_a_randomised,_placebo-controlled,_phase_II_crossover_trial&amp;diff=6983"/>
		<updated>2024-11-22T08:20:38Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{Reference&lt;br /&gt;
|Reference=Publication: Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial&lt;br /&gt;
}}&lt;br /&gt;
{{Study Note}}&lt;br /&gt;
=Brief summary=&lt;br /&gt;
The study included 81 patients with different types of cancer and a history of nausea and vomiting due to chemotherapy. They were randomly divided into tweo arms, one arm received THC and CBD daily and the other arm a placebo. After one cycle of chemotherapy, the arms were switched. At the end of two cycles (so that everyone was in each arm), there was overall less and less severe nausea and vomiting in the THC/CBD arm and an improvement on some quality of life measurement scales. However, the patients receiving THC/CBD had more side effects, such as dizziness and sedation, which were tolerable, according to the authors. The study has an elaborate study design. The statistics seem well thought out and take many factors into account, but a few methodological decisions remain unexplained. It should be noted in particular that many of the people involved in the article have direct contacts with the pharmaceutical industry.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
In der Studie wurden 81 Patienten mit verschiedenen Krebsarten und Vorgeschichte von Übelkeit und Erbrechen durch Chemotherapie eingeschlossen. Diese wurden zufällig in zwei Gruppen eingeteilt, eine Gruppe bekam täglich THC und CBD und die andere Gruppe ein Placebo. Nach einem Zyklus Chemotherapie wurden die Gruppen getauscht. Am Ende von zwei Zyklen (sodass jeder in jeder Gruppe war) zeigte sich insgesamt weniger und weniger schwere Übelkeit und Erbrechen in der Gruppe mit THC/CBD und eine Verbesserung auf einigen Skalen der Messung der Lebensqualität. Jedoch hatten die Patienten die THC/CBD bekamen mehr Nebenwirkungen, wie Schwindel und Sedierung, die laut den Autoren jedoch tolerierbar waren. Die Studie hat ein aufwändiges Studiendesign. Die Statistik wirkt gut durchdacht und bezieht viele Faktoren mit ein, jedoch bleiben ein paar methodische Entscheidungen unerklärt. Besonders anzumerken ist, dass viele beteiligten Personen in dem Artikel direkte Kontakte zu Pharmaindustrien aufweisen.&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
&lt;br /&gt;
{{Study Design (RCT)&lt;br /&gt;
|Perspective=Prospective&lt;br /&gt;
|Centralized=Multicentric&lt;br /&gt;
|Blinding=Double&lt;br /&gt;
|Is randomized=Yes&lt;br /&gt;
|Cross-over=Yes&lt;br /&gt;
|Number of arms=2&lt;br /&gt;
}}&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
&lt;br /&gt;
{{RCT study general properties&lt;br /&gt;
|Inclusion criteria=Aged ≥18 years; any malignancy of any stage; receiving intravenous&lt;br /&gt;
chemotherapy of moderate or high emetogenic risk; receive at least two more consecutive cycles; refractory CINV (defined as emesis, and/or nausea of moderate severity on a 5-point rating scale, and/or requiring use of rescue medications) in earlier chemotherapy cycles despite guideline-consistent antiemetic prophylaxis consisting of corticosteroids, a 5-HT3 antagonist,&lt;br /&gt;
and an NK-1 antagonist with or without olanzapine where indicated&lt;br /&gt;
|Exclusion criteria=Eastern Cooperative Oncology Group (ECOG) performance status of &amp;gt;2; a contraindication to medicinal cannabis such as unstable cardiovascular disease, substance use disorder, or significant mental health disorder; experiencing disease-related nausea and vomiting; receiving concomitant oral chemotherapy; had received/were planned to receive radiotherapy to the brain or gastrointestinal tract during the study period&lt;br /&gt;
|N randomized=81&lt;br /&gt;
|Analysis=PP Analysis&lt;br /&gt;
|Specifications on analyses=Only participants who have received both interventions have been included in the efficacy analyses. Data on safety were sourced from the safety population (all participants who received  ≥1 dose of study drug). The primary analysis was a comparison of the proportion of participants with complete response between the two treatment arms during two overall phases of treatment (0-120 h) of cycles A and B, using McNemar’s test to account for the within-patient correlation. Continuous outcomes were analysed with a linear model, and accounted for the correlation within a participant. All tests used a two-sided significance level of 10%. Secondary analyses have not been adjusted for multiple comparisons.&lt;br /&gt;
|Countries of data collection=Australia&lt;br /&gt;
|LoE=Level 2 Oxford 2011&lt;br /&gt;
|Outcome timeline=T0: baseline &lt;br /&gt;
&lt;br /&gt;
T1: one day before chemotherapy &lt;br /&gt;
&lt;br /&gt;
T2: day 8 of each cycle &lt;br /&gt;
&lt;br /&gt;
T3: between 30-42 days after end of intervention&lt;br /&gt;
}}&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
&lt;br /&gt;
{{Characteristics of participants&lt;br /&gt;
|Setting=Curative, Palliative&lt;br /&gt;
|Types of cancer=Breast Cancer, Colorectal Cancer, Gastrointestinal Cancers, Gastrointestinal Cancers - Pancreatic Cancer, Genitourinary Cancers - Testicular Cancer, Gynecologic Cancers, Hematologic Cancers, Lung Cancer, Other Cancers&lt;br /&gt;
|Stage cancer=NI&lt;br /&gt;
|Cancer stage specification=Any malignancy of any stage&lt;br /&gt;
|Comorbidity=NI&lt;br /&gt;
|Current cancer therapy=Chemotherapy&lt;br /&gt;
|Specifications on cancer therapies=Moderate-to-high emetogenic intravenous chemotherapy&lt;br /&gt;
&lt;br /&gt;
Chemotherapy regimen, n(%):&lt;br /&gt;
&lt;br /&gt;
Doxorubicin + cyclophosphamide = 20 (26)&lt;br /&gt;
&lt;br /&gt;
FOLFOX ± biological = 13 (17)&lt;br /&gt;
&lt;br /&gt;
Cisplatin based = 12 (15)&lt;br /&gt;
&lt;br /&gt;
FOLFIRINOX = 6 (8)&lt;br /&gt;
&lt;br /&gt;
Other = 27 (35)&lt;br /&gt;
|Previous cancer therapies=NI&lt;br /&gt;
|Gender=Mixed&lt;br /&gt;
|Gender specifications=Female : 61 (78%)&lt;br /&gt;
Male: 17 (22%)&lt;br /&gt;
|Age groups=Adults (18+)&lt;br /&gt;
|Age groups specification=Median age (range): 55 (29-80) years&lt;br /&gt;
}}&lt;br /&gt;
=Arms=&lt;br /&gt;
&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Intervention&lt;br /&gt;
|Number of participants (arm)=40&lt;br /&gt;
|Drop-out=4&lt;br /&gt;
|Drop-out reasons=Discontinued after THC:CBD (n = 4):&lt;br /&gt;
Death (n = 1); failure to comply (n = 1); chemotherapy stopped (n = 1); patient preference (n = 1)&lt;br /&gt;
|Intervention=THC:CBD&lt;br /&gt;
|Dosage and regime=1-4 capsules THC 2.5mg/CBD 2.5mg each 3x daily (one day before chemotherapy to day 5)&lt;br /&gt;
&lt;br /&gt;
Median (SD) number of capsules = 2 (1-3)&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=-999&lt;br /&gt;
|Side Effects / Interactions=Moderate or severe cannabinoid-related side effects in intervention arm (31%) and placebo arm (7%) (p=0.002):&lt;br /&gt;
* Significant differences for sedation (19% vs. 4%, p=0.002), dizziness (10% vs. 1%, p=0.03)&lt;br /&gt;
* No differences for disorientation (3% vs. 0%, p=0.5), anxiety (1% vs. 1%, p=1.00)&lt;br /&gt;
* No cannabinoid-related serious adverse events were reported.&lt;br /&gt;
&lt;br /&gt;
83% of the participants preferred cannabis over placebo and 15% had a preference for placebo (p&amp;lt;0.001).&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Placebo&lt;br /&gt;
|Number of participants (arm)=41&lt;br /&gt;
|Drop-out=2&lt;br /&gt;
|Drop-out reasons=Discontinued after placebo (n = 2):&lt;br /&gt;
chemotherapy stopped (n = 1); patient preference (n = 1)&lt;br /&gt;
|Intervention=Placebo&lt;br /&gt;
|Dosage and regime=Median (SD) number of capsules = 3 (2-4)&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=-999&lt;br /&gt;
|Side Effects / Interactions=Moderate or severe cannabinoid-related side effects in intervention arm (31%) and placebo arm (7%) (p=0.002):&lt;br /&gt;
* Significant differences for sedation (19% vs. 4%, p=0.002), dizziness (10% vs. 1%, p=0.03)&lt;br /&gt;
* No differences for disorientation (3% vs. 0%, p=0.5), anxiety (1% vs. 1%, p=1.00)&lt;br /&gt;
* No cannabinoid-related serious adverse events were reported.&lt;br /&gt;
&lt;br /&gt;
83% of the participants preferred cannabis over placebo and 15% had a preference for placebo (p&amp;lt;0.001).&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm Overview}}&lt;br /&gt;
=Outcomes=&lt;br /&gt;
&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Primary&lt;br /&gt;
|Outcome name=CINV (Chemotherapy-Induced Nausea and Vomiting)&lt;br /&gt;
|Outcome specification=Complete response, no vomiting or emergency medication 0-120h of chemotherapy&lt;br /&gt;
|Type of measurement=Observation&lt;br /&gt;
|Results during intervention=Results after 2 cycles, after switching to the other arm: &lt;br /&gt;
* Significant advantage for intervention arm (25%) compared to placebo arm (14%): RR=1.77; 90% CI=1.12,2.79; p=0.041.&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=CINV (Chemotherapy-Induced Nausea and Vomiting)&lt;br /&gt;
|Outcome specification=Self-reported &amp;quot;complete response&amp;quot; (&amp;quot;no vomiting&amp;quot;, &amp;quot;no clinically significant nausea&amp;quot;, defined as nausea &amp;lt;2 on a 10-point scale, and &amp;quot;no use of emergency medication&amp;quot;) during the acute (0-24 h), delayed (24-120 h) and general phase (0-120 h) of chemotherapy with diary day -1 to 6 of each cycle)&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=Results after 2 cycles, after switching to the other arm: &lt;br /&gt;
* Advantage for intervention arm for percentage for CR (p=0.04), for scales &amp;quot;no vomiting&amp;quot; (p=0.05), &amp;quot;no emergency medication&amp;quot; p=0.04), &amp;quot;no significant nausea&amp;quot; (p=0.03), mean and maximum number of vomiting per day (p=0.003, p=0.001), mean/maximum nausea values (p&#039;s&amp;lt;0.001).&lt;br /&gt;
* No difference for complete response and &amp;quot;no significant nausea&amp;quot; (p=0.12)&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=high risk&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Quality of life&lt;br /&gt;
|Outcome specification=Quality of life (nausea &amp;amp; vomiting scales) at baseline, day -1, end of treatment&lt;br /&gt;
|Type of measurement=AQoL-8D (Assessment of Quality of Life), FLIE (Functional Living Index for Emesis)&lt;br /&gt;
|Results during intervention=FLIE: &lt;br /&gt;
* significant advantage for intervention arm for nausea scale (mean difference: 20.9 on 100-point scale, p &amp;lt; 0.001) and vomiting scale (mean difference: 11.9, p &amp;lt; 0.001)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
AQOL-8D: &lt;br /&gt;
* significant advantage for intervention arm in use-related QoL (mean difference: 0.04, 95% CI 0.01,0.07; p=0.019)&lt;br /&gt;
* physical health (mean difference: 0.06, 95% CI 0.03-0.09, p &amp;lt; 0.001)&lt;br /&gt;
* mental health (mean difference: 0.04, 95% CI 0.01, 0.06, p=0.004)&lt;br /&gt;
* pain (mean difference: 0.08, 95% CI 0.03, 0.13, p=0.003)&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=high risk&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=3&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Toxicity&lt;br /&gt;
|Outcome specification=Self-developed measurement instrument: structured checklist of cannabinoid-specific adverse events&lt;br /&gt;
|Type of measurement=CTCAE (Common Terminology Criteria of Adverse Events), Self-developed measurement instrument&lt;br /&gt;
|Results during intervention=Moderate or severe cannabinoid-related side effects in intervention arm (31%) and placebo arm (7%) (p=0.002):&lt;br /&gt;
* Significant differences for sedation (19% vs. 4%, p=0.002), dizziness (10% vs. 1%, p=0.03)&lt;br /&gt;
* No differences for disorientation (3% vs. 0%, p=0.5), anxiety (1% vs. 1%, p=1.00)&lt;br /&gt;
* No cannabinoid-related serious adverse events were reported.&lt;br /&gt;
&lt;br /&gt;
83% of the participants preferred cannabis over placebo and 15% had a preference for placebo (p&amp;lt;0.001).&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=high risk&lt;br /&gt;
|Bias in selection of the reported result=low risk&lt;br /&gt;
|Other sources of bias=NA&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=4&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome Overview}}&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
&lt;br /&gt;
{{Funding and Conflicts of Interest&lt;br /&gt;
|Funding=This work was supported by the Department of Health, NSW Government, Australia. Tilray supplied and covered the cost of study treatments and were given the opportunity to review the study protocol and manuscript, but had no role in data analysis.&lt;br /&gt;
|Conflicts of Interest=Conflict of interest can be seen in the article, many contacts to pharmaceutical industries.&lt;br /&gt;
}}&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
&lt;br /&gt;
{{Further points for assessing the study&lt;br /&gt;
|power analysis performed=Yes&lt;br /&gt;
|Sample size corresponds to power analysis=Yes&lt;br /&gt;
|Reasons given for samples being too small according to power analysis=NA&lt;br /&gt;
|Samples sufficiently large=NA&lt;br /&gt;
|Ethnicity mentioned=No&lt;br /&gt;
|Other explanations for an effect besides the investigated intervention=Yes&lt;br /&gt;
|Possibility of attention effects=NA&lt;br /&gt;
|Possibility of placebo effects=NA&lt;br /&gt;
|Other reasons=Knowledge of assignment and believe in positive influence in outcomes assessed with self-report-questionnaires&lt;br /&gt;
|Correct use of parametric and non-parametric tests=NI&lt;br /&gt;
|Correction for multiple testing=Yes&lt;br /&gt;
|Measurement of compliance=Yes&lt;br /&gt;
|Consistent reporting in numbers=No&lt;br /&gt;
|Comprehensive and coherent reporting=No&lt;br /&gt;
|Cross-over=Yes&lt;br /&gt;
|sufficient washout period=NA&lt;br /&gt;
|Tested for carry-over effects=NA&lt;br /&gt;
|Were sequence effects tested=NA&lt;br /&gt;
|Effect sizes reported=No&lt;br /&gt;
|Were side effects systematically recorded=Yes&lt;br /&gt;
|Side effects taken into account in the interpretation of the results=Yes&lt;br /&gt;
|Ethics / CoI / Funding=Yes&lt;br /&gt;
|Blinding reliable=No&lt;br /&gt;
|Check whether blinding was successful=No&lt;br /&gt;
|reasons given for samples being too small according to power analysis=?&lt;br /&gt;
|Testing for normal distribution=?&lt;br /&gt;
|Correct application of statistical tests=?&lt;br /&gt;
|mono- or multicentric=?&lt;br /&gt;
}}&lt;br /&gt;
{{Additional Notes&lt;br /&gt;
|Additional Notes=PRO:&lt;br /&gt;
* Ethical approval&lt;br /&gt;
* Power analysis&lt;br /&gt;
* Daily contact with staff on days of administration&lt;br /&gt;
* Structured assessment of side effects using a checklist&lt;br /&gt;
* Adherence monitored through diary entries and capsule counts&lt;br /&gt;
* McNemar’s test used to control for within-patient correlation&lt;br /&gt;
* Control for order effects (p=0.29)&lt;br /&gt;
* Comparability at baseline ensured by study design&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
CONTRA:&lt;br /&gt;
* Correction for multiple testing only for primary endpoints&lt;br /&gt;
* 90% confidence interval (CI) (p=0.1) used for primary endpoints and 95% CI for secondary endpoints due to pilot study design (primary endpoint was also significant at 95%)&lt;br /&gt;
* No differentiation of primary endpoint into acute or delayed responses, despite being listed in the methodology&lt;br /&gt;
* Unclear presentation of when and how each endpoint is measured&lt;br /&gt;
* Numerous interactions with pharmaceutical companies&lt;br /&gt;
* Capsule dosing individualized, with no subgroup analyses for high vs. low doses&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Johnson_et_al._(2010):_Multicenter,_double-blind,_randomized,_placebo-controlled,_parallel-group_study_of_the_efficacy,_safety,_and_tolerability_of_THC:CBD_extract_and_THC_extract_in_patients_with_intractable_cancer-related_pain&amp;diff=6982</id>
		<title>Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Johnson_et_al._(2010):_Multicenter,_double-blind,_randomized,_placebo-controlled,_parallel-group_study_of_the_efficacy,_safety,_and_tolerability_of_THC:CBD_extract_and_THC_extract_in_patients_with_intractable_cancer-related_pain&amp;diff=6982"/>
		<updated>2024-11-22T08:19:58Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{Reference&lt;br /&gt;
|Reference=Publication: Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain&lt;br /&gt;
}}&lt;br /&gt;
{{Study Note}}&lt;br /&gt;
=Brief summary=&lt;br /&gt;
In this study, 177 patients with advanced cancer were randomly divided into three arms. One arm received THC and CBD for two weeks, the other arm only THC and the third arm a placebo. The daily dose varied from person to person depending on their needs. All patients also received opioids for pain management. After two weeks, the THC plus CBD arm showed an advantage in general pain perception compared to the placebo arm. Measured with a different instrument, the THC arm showed an advantage over the placebo arm for pain in the last 24 hours. No differences were found between the THC arm and the placebo arm. There were no differences for number of days or dose of opioid use, as well as sleep quality or nausea. There was a deterioration in appetite, memory and concentration in the THC plus CBD and THC arms compared to the placebo arm. For the measurement of quality of life, there was also an advantage for the placebo arm over the other two arms in the categories &amp;quot;cognitive functions&amp;quot; and an advantage for the placebo arm over the THC plus CBD arm for &amp;quot;nausea and vomiting&amp;quot;. A large number of symptoms were recorded in this study, but no correction was made in the analysis. This increases the risk of finding an effect even though it is not there. This alone means, that the results should be interpreted with caution. This is also supported by the fact, that the results for the same symptoms such as nausea and pain differ depending on the measurement instrument. In addition, little information is given about the patients. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
In dieser Studie wurden 177 Patienten mit fortgeschrittenen Krebserkrankungen zufällig in drei Gruppen eingeteilt. Die eine Gruppe erhielt über zwei Wochen THC und CBD, die andere Gruppe nur THC und die dritte Gruppe ein Placebo. Die tägliche Dosis variierte von Person zu Person je nach Bedürfnissen. Alle Patienten erhielten zusätzlich noch Opioide zur Schmerzbehandlung. Nach zwei Wochen zeigte sich ein Vorteil für das allgemeine Schmerzempfinden für die THC plus CBD Gruppe im Vergleich zur Placebogruppe. Gemessen mit einem anderen Instrument zeigte sich ein Vorteil der THC Gruppe gegenüber der Placebogruppe für Schmerz in den letzten 24 Stunden. Keine Unterschiede wurden gefunden zwischen der THC Gruppe und der Placebogruppe. Es gab keine Unterschiede für Anzahl der Tage oder Dosis von Opioidnutzung, sowie Schlafqualität oder Übelkeit. Bezüglich Appetit, Gedächtnis und Konzentration zeigte sich eine Verschlechterung in der THC plus CBD Gruppe und THC Gruppe im Vergleich zur Placebogruppe. Für die Messung der Lebensqualität zeigte sich in den Kategorien „kognitive Funktionen“ ebenfalls ein Vorteil für die Placebogruppe gegenüber den anderen beiden Gruppen und für „Übelkeit und Erbrechen“ ein Vorteil für die Placebogruppe gegenüber der THC plus CBD Gruppe. In dieser Studie wurden sehr viele Symptome erhoben, jedoch keine Korrektur dessen in der Analyse vorgenommen. Dies erhöht die Gefahr, einen Effekt zu finden, obwohl dieser nicht da ist. Dies allein führt dazu, dass die Ergebnisse mit Vorsicht interpretiert werden sollten. Gestützt wird dieses auch dadurch, dass sich die Ergebnisse für gleiche Symptome wie Übelkeit und Schmerz je nach Messinstrument unterscheiden. Zudem werden wenig Informationen zu den Patienten gegeben.&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
&lt;br /&gt;
{{Study Design (RCT)&lt;br /&gt;
|Perspective=Prospective&lt;br /&gt;
|Centralized=Multicentric&lt;br /&gt;
|Blinding=Double&lt;br /&gt;
|Is randomized=Yes&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|Number of arms=3&lt;br /&gt;
}}&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
&lt;br /&gt;
{{RCT study general properties&lt;br /&gt;
|Inclusion criteria=Adult male or female patients, who had been using strong opioids for at least one week to relieve pain associated with incurable malignancy; pain severity score of 4 or above on a 0-10 Numerical Rating Scale (NRS) on both days of the two-day baseline period&lt;br /&gt;
|Exclusion criteria=Cancers affecting the oral cavity; radiotherapy to the floor of the mouth; major psychiatric or cardiovascular disorders; epilepsy; renal or hepatic impairment; pregnant, lactating, or not using adequate contraception; therapies expected to confound the study outcome (epidural analgesia within 48 hours of screening; palliative radio-, chemo-, or hormonal therapy within two weeks of screening; CBs within seven days of randomization); use of levodopa, sildenafil, or fentanyl; hypersensitivity to CBs&lt;br /&gt;
|N randomized=177&lt;br /&gt;
|Analysis=PP Analysis, ITT Analysis&lt;br /&gt;
|Specifications on analyses=For the two coprimary efficacy variables (NRS pain score and use of break-through medication), the Hochberg method was used to test the global hypothesis for a treatment effect on pain.&lt;br /&gt;
The daily pain NRS score was the mean of the three daily assessments. The change in mean NRS pain score from baseline (all days in run-in period) to the end of treatment (last three days on treatment) was analyzed using analysis of covariance (ANCOVA), with baseline pain as a covariate and grouped study center and treatment as factors. The proportions of responders (patients with ≥30% improvement from baseline to end of study NRS pain score) were compared between treatments. Use of breakthrough medication (number of days of use during last three days on treatment) was analyzed using logistic regression with a cumulative logit model. In addition, the change from baseline in mean number of doses of escape medication was analyzed using ANCOVA.&lt;br /&gt;
|Countries of data collection=Europe&lt;br /&gt;
|LoE=Level 2 Oxford 2011&lt;br /&gt;
|Outcome timeline=T0: baseline (2 days)&lt;br /&gt;
&lt;br /&gt;
T1: after 7-10 days &lt;br /&gt;
&lt;br /&gt;
T2: after 14-20 days&lt;br /&gt;
}}&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
&lt;br /&gt;
{{Characteristics of participants&lt;br /&gt;
|Setting=Palliative&lt;br /&gt;
|Types of cancer=Breast Cancer, Lung Cancer, Prostate Cancer&lt;br /&gt;
|Stage cancer=Advanced Stage&lt;br /&gt;
|Cancer stage specification=Mean (SD) duration of cancer: 3.5 (4.4) years&lt;br /&gt;
|Comorbidity=NI&lt;br /&gt;
|Current cancer therapy=No therapy&lt;br /&gt;
|Specifications on cancer therapies=No therapy in the last 2 weeks&lt;br /&gt;
|Previous cancer therapies=NI&lt;br /&gt;
|Gender=Mixed&lt;br /&gt;
|Gender specifications=Female n (%): 82 (46)&lt;br /&gt;
&lt;br /&gt;
Male n (%): 95 (54)&lt;br /&gt;
|Age groups=Adults (18+)&lt;br /&gt;
|Age groups specification=Mean (SD) Age: 60.2 (12.3) years&lt;br /&gt;
}}&lt;br /&gt;
=Arms=&lt;br /&gt;
&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Intervention&lt;br /&gt;
|Number of participants (arm)=60&lt;br /&gt;
|Drop-out=12&lt;br /&gt;
|Drop-out reasons=Adverse event (n=10); consent withdrawal (n=1); other (n=1)&lt;br /&gt;
|Intervention=THC:CBD&lt;br /&gt;
|Dosage and regime=THC:CBD via oral spray (self-applied by patient, one dose 2.7mg THC and 2.5mg CBD) &lt;br /&gt;
&lt;br /&gt;
Week 1: dose finding&lt;br /&gt;
&lt;br /&gt;
Week 2: stable dose, maximum of 8 sprays every 3 hours and 48 sprays in 24 hours: dose was determined by patients themselves&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=14&lt;br /&gt;
|Side Effects / Interactions=Intervention-associated events in n=106 (60%): drowsiness, dizziness, nausea, confusion, vomiting, hypotension, hypercalcemia, increased gamma GT&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Most side effects were mild/moderate; no statistical comparisons given; one case of syncope probably related to THC; other events not associated with intervention&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Intervention&lt;br /&gt;
|Number of participants (arm)=58&lt;br /&gt;
|Drop-out=13&lt;br /&gt;
|Drop-out reasons=Adverse event (n=7); consent withdrawal (n=2); sponsor decision (n=1); protocol violation (n=1); other (n=2)&lt;br /&gt;
|Intervention=THC&lt;br /&gt;
|Dosage and regime=THC extract via oral spray (2.7 mg), dosage variable;&lt;br /&gt;
Week 1: dose finding&lt;br /&gt;
&lt;br /&gt;
Week 2: stable dose, maximum of 8 sprays every 3 hours and 48 sprays in 24 hours: dose was determined by patients themselves&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=14&lt;br /&gt;
|Side Effects / Interactions=Intervention-associated events in n=106 (60%): drowsiness, dizziness, nausea, confusion, vomiting, hypotension, hypercalcemia, increased gamma GT; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Most side effects were mild/moderate; no statistical comparisons given; one case of syncope probably related to THC; other events not associated with intervention&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm&lt;br /&gt;
|Arm type=Placebo&lt;br /&gt;
|Number of participants (arm)=59&lt;br /&gt;
|Drop-out=8&lt;br /&gt;
|Drop-out reasons=Adverse event (n=3); consent withdrawal (n=2); other (n=3)&lt;br /&gt;
|Intervention=Placebo&lt;br /&gt;
|Dosage and regime=NI&lt;br /&gt;
|One-time application=No&lt;br /&gt;
|Duration in days=14&lt;br /&gt;
|Side Effects / Interactions=NI&lt;br /&gt;
|Order number=3&lt;br /&gt;
|Arm topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Arm Overview}}&lt;br /&gt;
=Outcomes=&lt;br /&gt;
&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Primary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Number of responders (≥ 30% pain reduction NRS scale baseline vs. 14-20 days)&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=Significant advantage for THC:CBD arm compared to placebo arm after 14-20 days (mean improvement = -1.37 vs. -0.69; p=0.014), no significant difference between THC arm and placebo arm after 14-20 days (mean improvement = -1.01 vs. -0.69; p=0.245)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Same results for median differences (THC:CBD arm vs. placebo arm = 0.55, p=0.024; THC arm vs. placebo arm = 0.24, p=0.204) &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Responders: &lt;br /&gt;
&lt;br /&gt;
More patients in THC:CBD arm compared to placebo arm showed improvement of more than 30% from baseline to 14-20 days (n=23 (43%) vs. n=12 (21%); Odds Ratio = 2.81; 95% CI=1.22, 6.50; p=0.006). &lt;br /&gt;
&lt;br /&gt;
No difference between THC arm and placebo arm (n=12 (23%) vs. n=12 (21%); Odds Ratio 1.10 (95% CI=0.44, 2.73; p=0.28).&lt;br /&gt;
&lt;br /&gt;
No data for comparison between THC:CBD arm and THC arm.&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=1&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Primary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Breakthrough pain and corresponding opioid intake and daily opioid use with diary Numeric Rating Scale (NRS) over the last 24h&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=Background medication opioids baseline to 14-21 days (median to baseline 271mg daily morphine equivalents): no significant changes in dosage&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Breakthrough pain and corresponding opioid use at 14-21 days: &lt;br /&gt;
&lt;br /&gt;
No difference between arms for number of days used (THC:CBD arm vs. placebo arm, p=0.697; THC arm vs. placebo arm, p=0.555); non-significant reduction in each arm (THC:CBD arm = -0.19 vs. THC arm = -0.14; placebo arm = -0.15) with no difference between arms (THC:CBD arm vs. placebo arm, p=0.688; THC arm vs. placebo arm; p=0.899); more patients in placebo arm (n=7) with increased dosage compared to THC:CBD arm (p=0.004)&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=some concerns&lt;br /&gt;
|Order number=2&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Sleep&lt;br /&gt;
|Outcome specification=Sleep quality&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No significant differences between THC:CBD arm/THC arm and placebo arm.&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=low risk&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=3&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Nausea&lt;br /&gt;
|Outcome specification=Nausea&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=No significant differences between THC:CBD arm/THC arm and placebo arm&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=4&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Cognitive functioning&lt;br /&gt;
|Outcome specification=Memory&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=Placebo arm with no change (0.01), THC:CBD arm and THC arm with deterioration compared to placebo arm (THC:CBD arm = 0.63 vs. placebo arm = 0.01, p=0.045; THC arm = 0.66 vs. placebo arm = 0.01, p=0.053).&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=5&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Cognitive functioning&lt;br /&gt;
|Outcome specification=Concentration&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=Placebo arm with improvement, THC:CBD arm and THC arm with deterioration (placebo arm = -0.35 vs. THC:CBD arm = 0.33, p=0.021; placebo arm = -0.35 vs. THC arm = 0.29, p=0.028)&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=6&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Appetite&lt;br /&gt;
|Outcome specification=Appetite&lt;br /&gt;
|Type of measurement=NRS (Numeric Rating Scale)&lt;br /&gt;
|Results during intervention=Improvement in placebo arm, deterioration in THC:CBD arm and THC arm (placebo arm = -0.59 vs. THC:CBD arm = 0.24, p=0.016; placebo group = -0.59 vs. THC group = 0.06, p=0.056).&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=7&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Quality of life&lt;br /&gt;
|Outcome specification=Quality of life at baseline and 14-21 days after&lt;br /&gt;
|Type of measurement=EORTC QLQ (European Organisation for Research and Treatment of Cancer Core/ Quality of Life questionnaire)&lt;br /&gt;
|Results during intervention=At days 14-21: Effects for reduction of &amp;quot;cognitive function&amp;quot; in THC:CBD arm and THC arm compared to placebo arm (THC:CBD arm = -5.33 vs. placebo arm = 3.68, p=0.02; THC arm = -6.77 vs. placebo arm = 3.68, p=0.01) &lt;br /&gt;
&lt;br /&gt;
Worsening of &amp;quot;nausea and vomiting&amp;quot; in THC:CBD arm compared to placebo arm (THC:CBD arm = 5.13 vs. placebo arm = -3.43, p=0.02; THC arm = -3.41 vs. placebo arm = -3.43; p=1.0).&lt;br /&gt;
&lt;br /&gt;
For &amp;quot;pain&amp;quot; no difference between THC:CBD arm/THC arm and placebo arm.&lt;br /&gt;
&lt;br /&gt;
For &amp;quot;social function&amp;quot; significant advantage for THC arm over placebo arm (9.66 vs. 1.58; p=0.038).&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=8&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome&lt;br /&gt;
|Outcome type=Secondary&lt;br /&gt;
|Outcome name=Pain&lt;br /&gt;
|Outcome specification=Pain at baseline and 14-21 days after&lt;br /&gt;
|Type of measurement=BPI-SF (Brief Pain Inventory - Short Form)&lt;br /&gt;
|Results during intervention=Pain in the last 24h: significant advantage for THC arm over placebo arm (-3.20 vs. 0.87; p=0.048), no difference for interference pain.&lt;br /&gt;
|Results after intervention=NA&lt;br /&gt;
|Bias arising from the randomization process=some concerns&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)=high risk&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)=NA&lt;br /&gt;
|Bias due to missing outcome data=low risk&lt;br /&gt;
|Bias in measurement of the outcome=some concerns&lt;br /&gt;
|Bias in selection of the reported result=some concerns&lt;br /&gt;
|Other sources of bias=some concerns&lt;br /&gt;
|Overall RoB judgment=high risk&lt;br /&gt;
|Order number=9&lt;br /&gt;
|Outcome topic=Cannabinoids&lt;br /&gt;
}}&lt;br /&gt;
{{Outcome Overview}}&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
&lt;br /&gt;
{{Funding and Conflicts of Interest&lt;br /&gt;
|Funding=This study was sponsored by GW Pharma Ltd. All study medication was supplied by GW Pharma Ltd., and it also funded all sites involved in the study by means of per-patient payments based on recruitment. GW Pharma Ltd. has funded J. R. Johnson (primary author) to attend two conferences to present the results of this study.&lt;br /&gt;
|Conflicts of Interest=NI&lt;br /&gt;
}}&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
&lt;br /&gt;
{{Further points for assessing the study&lt;br /&gt;
|power analysis performed=Yes&lt;br /&gt;
|Sample size corresponds to power analysis=Yes&lt;br /&gt;
|Reasons given for samples being too small according to power analysis=NA&lt;br /&gt;
|Samples sufficiently large=NA&lt;br /&gt;
|Ethnicity mentioned=Yes&lt;br /&gt;
|Other explanations for an effect besides the investigated intervention=Yes&lt;br /&gt;
|Possibility of attention effects=No information whether centers were comparable in treatment of patients; especially “optimized” opioid treatment may vary from country to country&lt;br /&gt;
|Possibility of placebo effects=NA&lt;br /&gt;
|Other reasons=No information whether centers were comparable in treatment of patients; especially “optimized” opioid treatment may vary from country to country&lt;br /&gt;
|Correct use of parametric and non-parametric tests=Yes&lt;br /&gt;
|Correction for multiple testing=No&lt;br /&gt;
|Measurement of compliance=NI&lt;br /&gt;
|Consistent reporting in numbers=Yes&lt;br /&gt;
|Comprehensive and coherent reporting=No&lt;br /&gt;
|Cross-over=No&lt;br /&gt;
|sufficient washout period=NA&lt;br /&gt;
|Tested for carry-over effects=NA&lt;br /&gt;
|Were sequence effects tested=NA&lt;br /&gt;
|Effect sizes reported=No&lt;br /&gt;
|Were side effects systematically recorded=Yes&lt;br /&gt;
|Side effects taken into account in the interpretation of the results=Yes&lt;br /&gt;
|Ethics / CoI / Funding=Yes&lt;br /&gt;
}}&lt;br /&gt;
{{Additional Notes&lt;br /&gt;
|Additional Notes=PRO:&lt;br /&gt;
* Ethical approval&lt;br /&gt;
* Intent-to-treat analysis&lt;br /&gt;
* Power analysis&lt;br /&gt;
* Arms comparable at baseline&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
CONTRA:&lt;br /&gt;
* No information on whether centers were comparable in patient treatment; especially as “optimal” opioid treatment may vary from country to country.&lt;br /&gt;
* Baseline data: cancer type not specified for 104 patients.&lt;br /&gt;
* No control for multiple testing.&lt;br /&gt;
* Reported results in the text are unclear.&lt;br /&gt;
* No information on cancer stage.&lt;br /&gt;
* No explanation of how randomization was conducted or how blinding was ensured.&lt;br /&gt;
* Most comparisons are between the interventionarms and the placeboarm, but there are few comparisons between the interventionarms &lt;br /&gt;
* No elaboration of the intent-to-treat analysis in the methodology&lt;br /&gt;
}}&lt;br /&gt;
=Additional Notes=&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6981</id>
		<title>Example Queries II</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6981"/>
		<updated>2024-11-22T08:19:12Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== What effects of selenium have been investigated? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? - outcome-based ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Selenium]]&lt;br /&gt;
 [[Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |?Results after intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Which intervention for depression in cancer was investigated in studies with a placebo arm? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Outcome name::Depression]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Reference.Topic&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies -- study-based ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabinoids]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |?Were side effects systematically recorded&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies -- arm-based ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Topic::Cannabinoids]]&lt;br /&gt;
 [[Arm type::Placebo]]&lt;br /&gt;
 |?Intervention&lt;br /&gt;
 |?Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:Arm&amp;diff=6980</id>
		<title>Template:Arm</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:Arm&amp;diff=6980"/>
		<updated>2024-11-22T08:14:53Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
{{#template_params:Arm type (list;property=Arm type)|Number of participants (property=Number of participants (arm))|Drop-out (property=Drop-out)|Drop-out reasons (property=Drop-out reasons)|Intervention (property=Intervention)|Dosage and regime (property=Dosage and regime)|One-time application (property=One-time application)|Duration in days (property=Duration in days)|Side Effects / Interactions (property=Side Effects / Interactions)|Order number (property=Order number)}}&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&amp;lt;includeonly&amp;gt;&lt;br /&gt;
{{#subobject:|&lt;br /&gt;
|Arm type={{{Arm type|}}}|+sep=,&lt;br /&gt;
|Number of participants (arm)={{{Number of participants (arm)|}}}&lt;br /&gt;
|Drop-out={{{Drop-out|}}}&lt;br /&gt;
|Drop-out reasons={{{Drop-out reasons|}}}&lt;br /&gt;
|Intervention={{{Intervention|}}}&lt;br /&gt;
|Dosage and regime={{{Dosage and regime|}}}&lt;br /&gt;
|One-time application={{{One-time application|}}}&lt;br /&gt;
|Duration in days={{{Duration in days|}}}&lt;br /&gt;
|Side Effects / Interactions={{{Side Effects / Interactions|}}}&lt;br /&gt;
|Order number={{{Order number|}}}&lt;br /&gt;
|Arm topic={{{Arm topic|}}}&lt;br /&gt;
}}&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=6979</id>
		<title>Form:RCT Study</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=6979"/>
		<updated>2024-11-22T08:06:26Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
This is the &amp;quot;RCT Study&amp;quot; form.&lt;br /&gt;
To create a page with this form, enter the page name below;&lt;br /&gt;
if a page with that name already exists, you will be sent to a form to edit that page.&lt;br /&gt;
&lt;br /&gt;
{{#forminput:form=RCT Study}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&amp;lt;includeonly&amp;gt;&lt;br /&gt;
&lt;br /&gt;
=Publication=&lt;br /&gt;
&lt;br /&gt;
{{{for template|Reference}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Publication: &lt;br /&gt;
| {{{field|Reference|input type=text|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Note}}}&lt;br /&gt;
==Study Note==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Study Note|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Brief summary=&lt;br /&gt;
{{{section|Brief summary|level=1}}}&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
{{{section|Study Design|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Design (RCT)}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Prospective / Retrospective: {{#info: Prospective: forward-looking, examples include clinical trials, cohort studies, and long-term observational studies; &lt;br /&gt;
Retrospective: backward-looking, relying on existing data, examples include case-control studies and retrospective cohort studies|note}}&lt;br /&gt;
| {{{field|Perspective|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Monocentric / Multicentric:  {{#info: Monocentric: conducted in one center/ hospital; &lt;br /&gt;
Multicentric: conducted in multiple centers/ hospitals|note}}&lt;br /&gt;
| {{{field|Centralized|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Blinding: {{#info: No: Open, all parties are aware of group assignments; &lt;br /&gt;
Single: one party is unaware of group assignments (generally participants); &lt;br /&gt;
Double: two parties are unaware of group assignments (generally the participants and the researchers); &lt;br /&gt;
Triple: concealing group assignment from additional parties|note}}&lt;br /&gt;
| {{{field|Blinding|input type=radiobutton|mandatory|default=?|values=?,No,Single,Double,Triple,NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Is randomized: &lt;br /&gt;
| {{{field|Is randomized|input type=checkbox|default=Yes}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-over: {{#info: Participants alternate between different treatment groups or conditions over a specified period, allowing each participant to serve as their own control|note}}&lt;br /&gt;
| {{{field|Cross-over|input type=checkbox|default=No}}}&lt;br /&gt;
|-&lt;br /&gt;
! Number of arms: &lt;br /&gt;
| {{{field|Number of arms|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
{{{section|Study characteristics|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|RCT study general properties}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Inclusion criteria: &lt;br /&gt;
| {{{field|Inclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Exclusion criteria: &lt;br /&gt;
| {{{field|Exclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! N randomized: &lt;br /&gt;
| {{{field|N randomized|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|-&lt;br /&gt;
! Analysis: {{#info: PP: Per Protocol analysis, i.e. only participants included who adhered to the study protocol.&lt;br /&gt;
ITT: Intention-to-treat analysis, i.e. all randomized participants included regardless of any drop-outs or changes in assignment.&lt;br /&gt;
mITT: modified Intention-to-treat analysis can refer to analyses in which participants with missing outcome data are excluded or it can refer to analyses in which only participants who received at least one treatment dose are included. In this case, participants dropped out of the study prematurely for reasons unrelated to the treatment.|note}}&lt;br /&gt;
| {{{field|Analysis|input type=checkboxes|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on analyses:&lt;br /&gt;
| {{{field|Specifications on analyses|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Countries of data collection: &lt;br /&gt;
| {{{field|Countries of data collection|input type=text with autocomplete|delimiter=,|values=Afghanistan,Albania,Algeria,Andorra,Angola,Antigua &amp;amp; Deps,Argentina,Armenia,Australia,Austria,Azerbaijan,Bahamas,Bahrain,Bangladesh,Barbados,Belarus,Belgium,Belize,Benin,Bhutan,Bolivia,Bosnia Herzegovina,Botswana,Brazil,Brunei,Bulgaria,Burkina,Burundi,Cambodia,Cameroon,Canada,Cape Verde,Central African Rep,Chad,Chile,China,Colombia,Comoros,Congo,Congo {Democratic Rep},Costa Rica,Croatia,Cuba,Cyprus,Czech Republic,Denmark,Djibouti,Dominica,Dominican Republic,East Timor,Ecuador,Egypt,El Salvador,Equatorial Guinea,Eritrea,Estonia,Ethiopia,Europe,Fiji,Finland,France,Gabon,Gambia,Georgia,Germany,Ghana,Greece,Grenada,Guatemala,Guinea,Guinea-Bissau,Guyana,Haiti,Honduras,Hungary,Iceland,India,Indonesia,Iran,Iraq,Ireland {Republic},Israel,Italy,Ivory Coast,Jamaica,Japan,Jordan,Kazakhstan,Kenya,Kiribati,Korea North,Korea South,Kosovo,Kuwait,Kyrgyzstan,Laos,Latin America,Latvia,Lebanon,Lesotho,Liberia,Libya,Liechtenstein,Lithuania,Luxembourg,Macedonia,Madagascar,Malawi,Malaysia,Maldives,Mali,Malta,Marshall Islands,Mauritania,Mauritius,Mexico,Micronesia,Moldova,Monaco,Mongolia,Montenegro,Morocco,Mozambique,Myanmar,{Burma},Namibia,Nauru,Nepal,Netherlands,New Zealand,Nicaragua,Niger,Nigeria,North America,Norway,Oman,Pakistan,Palau,Panama,Papua New Guinea,Paraguay,Peru,Philippines,Poland,Portugal,Qatar,Romania,Russian Federation,Rwanda,St Kitts &amp;amp; Nevis,St Lucia,Saint Vincent &amp;amp; the Grenadines,Samoa,San Marino,Sao Tome &amp;amp; Principe,Saudi Arabia,Senegal,Serbia,Seychelles,Sierra Leone,Singapore,Slovakia,Slovenia,Solomon Islands,Somalia,South Africa,South Sudan,Spain,Sri Lanka,Sudan,Suriname,Swaziland,Sweden,Switzerland,Syria,Taiwan,Tajikistan,Tanzania,Thailand,Togo,Tonga,Trinidad &amp;amp; Tobago,Tunisia,Turkey,Turkmenistan,Tuvalu,Uganda,Ukraine,United Arab Emirates,United Kingdom,United Kingdom - Great Britain,United States,United States - New York,United States - Texas,Uruguay,Uzbekistan,Vanuatu,Vatican City,Venezuela,Vietnam,Yemen,Zambia,Zimbabwe,NI,?|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! LoE: {{#info: Level of evidence|note}}&lt;br /&gt;
| {{{field|LoE|input type=dropdown|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Outcome timeline: {{#info: Data collection times|note}}&lt;br /&gt;
| {{{field|Outcome timeline|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
{{{section|Characteristics of participants|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Characteristics of participants}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Setting: {{#info: Refers to cancer therapy setting.&lt;br /&gt;
- Curative therapy: aims to completely eradicate a disease and achieve a full recovery; &lt;br /&gt;
- Neo-adjuvant therapy: form of curative therapy, given before the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Adjuvant therapy: form of curative therapy, given after the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Palliative therapy: focuses on providing relief from symptoms and improving the quality of life for patients, without necessarily targeting the underlying disease; &lt;br /&gt;
- Active surveillance: involves close monitoring of disease progression without any intervention (typically used for prostate cancer);&lt;br /&gt;
- No therapy setting: Patients who completed therapy/are currently not in cancer treatment, cancer survivors.|note}}&lt;br /&gt;
| {{{field|Setting|input type=checkboxes|delimiter=,|default=?|mandatory|values=?, Curative, Neo-adjuvant, Adjuvant, Palliative, Active surveillance, No therapy setting, NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Types of cancer: {{#info: &amp;quot;Other Cancers&amp;quot; means that only a subpopulation was specified, but further unspecified cancer types were included|note}}&lt;br /&gt;
| {{{field|Types of cancer|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Adrenal Cancer,Anal Cancer,Bile Duct Cancer,Bone and Soft Tissue Cancers, Bone and Soft Tissue Cancers - Osteosarcoma,Bone and Soft Tissue Cancers - Ewing Sarcoma,Bone and Soft Tissue Cancers - Chondrosarcoma,Bone and Soft Tissue Cancers - Rhabdomyosarcoma,Bone and Soft Tissue Cancers – Liposarcoma,Brain and Central Nervous System (CNS) Cancers,Brain and Central Nervous System (CNS) Cancers - Astrocytoma,Brain and Central Nervous System (CNS) Cancers - Glioblastoma,Brain and Central Nervous System (CNS) Cancers - High-Grade Glioma,Brain and Central Nervous System (CNS) Cancers - Meningioma,Breast Cancer,Breast Cancer - Ductal Carcinoma,Breast Cancer - Lobular Carcinoma,Breast Cancer - Inflammatory Breast Cancer,Breast Cancer - Triple-Negative Breast Cancer,Carcinosarcoma,Chest Cancer,Colorectal Cancer,Colorectal Cancer - Colon Cancer,Colorectal Cancer - Rectal Cancer,Eye Cancer,Eye Cancer - Retinoblastoma,Gastrointestinal Cancers,Gastrointestinal Cancers - Gallbladder Cancer,Gastrointestinal Cancers - Gastric (Stomach) Cancer,Gastrointestinal Cancers - Esophageal Cancer,Gastrointestinal Cancers - Pancreatic Cancer,Gastrointestinal Cancers - Liver Cancer,Genitourinary Cancers,Genitourinary Cancers - Bladder Cancer,Genitourinary Cancers - Kidney (Renal) Cancer,Genitourinary Cancers - Testicular Cancer,Genitourinary Cancers - Urethral Cancer,Gynecologic Cancers,Gynecologic Cancers - Ovarian Cancer,Gynecologic Cancers - Cervical Cancer,Gynecologic Cancers - Uterine Cancer,Gynecologic Cancers - Endometrial Cancer,Gynecologic Cancers - Vulvar Cancer,Head and Neck Cancers, Head and Neck Cancers - Oral Cancer,Head and Neck Cancers - Oropharyngeal Cancer,Head and Neck Cancers - Laryngeal Cancer,Head and Neck Cancers - Nasopharyngeal Cancer,Head and Neck Cancers - Tongue Cancer,Head and Neck Cancers - Thyroid Cancer,Head and Neck Cancers - Ethmoid Sinus Cancer,Hematologic Cancers, Hematologic Cancers - Leukemia (Acute Lymphocytic/Acute Myeloid/Chronic Lymphocytic/Chronic Myeloid), Hematologic Cancers - Lymphoma (Hodgkin and Non-Hodgkin),Hematologic Cancers - Multiple Myeloma,Lung Cancer,Lung Cancer - Small Cell Lung Cancer,Lung Cancer - Non-Small Cell Lung Cancer,Mesothelioma,Neuroblastoma,Prostate Cancer,Skin Cancer,Skin Cancer - Basal Cell Carcinoma,Skin Cancer - Squamous Cell Carcinoma,Skin Cancer – Melanoma,Stomach Cancer,Solid Malignancies,Thymoma and Thymic Carcinoma,Unspecified Sarcoma,Other Cancers,NI,?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage: {{#info: Early Stage: generally refers to cancer that is localized to the area where it started, mostly stages I and II;&lt;br /&gt;
Advanced Stage: cancer that has spread beyond its original site, mostly stages III and IV, with stage IV indicating distant metastasis|note}}&lt;br /&gt;
| {{{field|Stage cancer|input type=checkboxes|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage specification: &lt;br /&gt;
| {{{field|Cancer stage specification|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comorbidity: &lt;br /&gt;
| {{{field|Comorbidity|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Current cancer therapy: &lt;br /&gt;
| {{{field|Current cancer therapy|input type=text with autocomplete|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on cancer therapies: &lt;br /&gt;
| {{{field|Specifications on cancer therapies|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Previous cancer therapies: &lt;br /&gt;
| {{{field|Previous cancer therapies|input type=text with autocomplete|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender: &lt;br /&gt;
| {{{field|Gender|input type=radiobutton|mandatory|values=?, Male, Female, Mixed, NI|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender specifications: &lt;br /&gt;
| {{{field|Gender specifications|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups: &lt;br /&gt;
| {{{field|Age groups|input type=checkboxes|values=?, Children (0-15), Adolescents and young adults (15-39), Adults (18+), Elderly (65+), NI|default=adults (18+)}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups specification: &lt;br /&gt;
| {{{field|Age groups specification|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
=Arms=&lt;br /&gt;
{{{section|Arms|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Arm type:&#039;&#039;&#039; {{#info: Active control: group receives active treatment; &lt;br /&gt;
Passive control: for example: treatment as usual, waiting control, no treatment|note}}&lt;br /&gt;
{{{field|Arm type|input type=checkboxes|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Number of participants (arm):&#039;&#039;&#039; {{{field|Number of participants (arm)|input type=text|mandatory|default=-999}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out:&#039;&#039;&#039; {{#info: Number of participants who left the study for any reason or did not provide information on every data collection date|note}} {{{field|Drop-out|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out reasons:&#039;&#039;&#039; {{{field|Drop-out reasons|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Intervention:&#039;&#039;&#039; {{{field|Intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Dosage and regime:&#039;&#039;&#039; {{{field|Dosage and regime|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;One-time application:&#039;&#039;&#039; {{{field|One-time application|input type=checkbox|mandatory|default=No}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Duration in days:&#039;&#039;&#039; {{#info: For long-term interventions, the number of days is an estimate.&lt;br /&gt;
A value of -999 indicates that the exact duration cannot be extracted from the study due to ambiguous or incomplete information. See &#039;&#039;Outcome timeline&#039;&#039; or &#039;&#039;Dosage and regime&#039;&#039; for further information. |note}}&lt;br /&gt;
{{{field|Duration in days|input type=regexp|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Side Effects / Interactions:&#039;&#039;&#039; {{{field|Side Effects / Interactions|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&#039;&#039;&#039;Arm topic:&#039;&#039;&#039; {{{field|Arm topic|input type=text with autocomplete|mandatory|delimiter=,|values=Acai berries,Acupuncture,Agaricus,Aloe vera,Amygdalin,Angelica sinensis,Annona muricata,Antrodia,Apigenin,Argan oil,Aromatherapy,Artemisia,Astragalus,Berberine,Biobran,Boswellia serrata,Breuss diet,Broccoli sprouts,Budwig diet,Cannabinoids,Capsaicin,Carnitine,Chlorella,Chronomedicine and Oncology,Chrysin,Cimicifuga,Co-enzyme Q10/ubiquinol,Colostrum,Cranberry,Curcumin,Dichloroacetate,Electroacupuncture,Enzymes (bromelain papain),Essiac,FactorAF2,Fasting,Fermented wheat germ extract,Flor Essence,Folic acid,Galavit,Gammalinolenic acid,Germanium,Ginger (also contains zerumbone),Ginkgo,Ginseng,Glutamine,Glutathione,Glycyrrhiza glabra,Graviola,Green tea (EGCG),Guarana,Hericium erinaceus,Homeopathy,Honey,Hops,Hydrazine sulphate,Hyperthermia (whole body and electrotherapy),Indole-3-carbinol,Insulin potentiation therapy,Isoflavones and equol,Kaempferol,Kavakava,Kombucha,Lapacho,Linseed,Low-carbohydrate or ketogenic diet,Lutein,Lycopene,Macrobiotics,Magnolia,Massage,Medical mushrooms (coriolus/Maitake/Ganoderma/reishi),Melatonin,Metadon,Methylsulfonylmethane (MSM),Mind-body therapies,Mistletoe,Neem,Nigella sativa,Noni,Omega 6 fatty acids,Omega-3 fatty acids,OPC (grape seed extract),Phellinus,Piper nigra,Polyerga,Pomegranate,Probiotics,Propolis,Prostasol,Qigong and Tai Chi,Quercetin,Reflexology,Reiki (Therapeutic Touch/Healing Touch/Polarity),Resveratrol,Rhodiola,Rhubarb,Rooibos,Selenium,Shiitake,Silymarin/marigold thistle,Soy,Spirulina,St. John&#039;s wort,Supportive therapy (NW),TCM,Thymus therapy,Ukrain,Uncaria (cat&#039;s claw),Valerian,Vitamin A (beta-carotene),Vitamin B1,Vitamin B12,Vitamin B2,Vitamin B6,Vitamin C,Vitamin D,Vitamin E,Wheatgrass,Yoga,Zeolites,Zinc}}}&lt;br /&gt;
&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Outcomes=&lt;br /&gt;
{{{section|Outcomes|level=1}}}&lt;br /&gt;
{{{for template|Outcome|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Outcome type:&#039;&#039;&#039; {{#info: As specificed by the authors| note}} {{{field|Outcome type|input type=radiobutton|mandatory|default=?|values=?,Primary,Secondary,Others,NI}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome name:&#039;&#039;&#039; {{{field|Outcome name|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Additional medication,Anorexia/Cachexia,Antibodies,Anxiety,Appetite,Arterial inflow,BMD (Bone Mineral Density),Body composition,Carnitine level,Carotenoid concentration,Cerebral oedema,CINV (Chemotherapy-Induced Nausea and Vomiting),Cognitive functioning,Cognitive impairment,Depression,Dermatitis,DFS (Disease-Free Survival),Diarrhoe,Distress,Dysgeusia,EFS (Event-Free Survival),Ejection fraction,Emesis,Erectile dysfunction,Erythema,Esophagitis,Fatigue,Fever,Fibrosis,Folic acid level,Frequency of rescue analgesics,Functionality,Haematological indices,Haematological toxicity,Hand-foot syndrome,Hand grip strength,Hepatotoxicity,Hot flushes,Hormone level,Ileus (intestinal obstruction),Incidence of acute GVHD (Graft-Versus-Host Disease),Infection,Interaction with cancer treatment,Laboratory parameters,Length of hospital stay,LFS (Local-Free Survival),Lymphedema,Menopausal symptoms,Mental status/ function,MFS (Metastases-Free Survival),Mood/Affect,Mortality rate,MTD (Maximum Tolerated Dose),Mucositis,Musculoskeletal symptoms,Nausea,Nausea and Vomiting,Nerve conduction velocity,Neurotoxicity,Neutropenia,Non-haematological indices,Nutrition status,Objective signs and subjective symptoms,Oral ulcus,OS (Overall Survival),Ototoxicity,Pain,PD (Pharmacodynamics),Performance Status,Peripheral neuropathy,PFS (Progression-Free Survival),Pharyngitis,Physical functioning,PK (Pharmacokinetics),Postoperative morbidity/ complications,Postoperative opiate consumption,PSADT (Prostate-Specific Antigen Doubling Time),PSA level (Prostate-Specific Antigen),Quality of life,Recurrence rate,Reduction of complication rates,REE (Resting Energy Expenditure),Relaxation,Restoration of bowel function after surgery,RFS (Recurrence-Free Survival),Salivary gland function,Selenium level,Seroconversion,Shoulder mobility,Side effects of androgen deprivation/suppression,Side effects of tooth extraction,Skeletal morbidity-free survival,Sleep,Stomatitis,Stress,Symptom load,Taste alteration,Tea polyphenol uptake,Thromboembolic event rates,Toxicity,Treatment interruption,Tumor progression,Tumor response,Vaginal atrophy,Vitamin A level,Vitamin B6 level,Vitamin B12 level,Vitamin B17 level,Vitamin C level,Vitamin D level,Vitamin E level,Vomiting,Weight,Well-being,Wound healing,Wound odour,Xerostomia,Zinc level,Unspecified effects,NI,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome specification:&#039;&#039;&#039; {{{field|Outcome specification|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Type of measurement:&#039;&#039;&#039; {{{field|Type of measurement|input type=tokens|mandatory|default=?|delimiter=,|values=AQoL-8D (Assessment of Quality of Life),ASAT (Auditory Sustained Attention Test),Atomic absorption,Audiogram,AUSCAN (Australian/Canadian Osteoarthritis Hand Index),BCPT (Breast Cancer Prevention Symptom Scales),BDI (Beck Depression Inventory),BFI (Brief Fatigue Inventory),BIA (Bioelectrical impedance analysis),Blood Test,BPI-SF (Brief Pain Inventory - Short Form),CES-D (Center for Epidemiologic Studies - Depression Scale),Chemiluminescent immunoassay,CNPI (Checklist of Non-Verbal Pain Indicators),CSSP (Catterall Skin Scoring Profile),CT (Computed Tomography),CTCAE (Common Terminology Criteria of Adverse Events),Cystoscopy,Diary questionnaire,DXA (Dual energy X-ray Absorptiometry),Dynamometer,Echo-color Doppler,ECOG Performance Status Scale (Eastern Cooperative Oncology Group),Electronic monitoring device,Electrophysiological evaluation,ELISA protocol (Enzyme-Linked Immunoabsorbent Assay),EORTC QLQ (European Organisation for Research and Treatment of Cancer Core/ Quality of Life questionnaire),ESAS (Edmonton Symptom Assessment Scale),FAACT (Functional Assessment of Anorexia-Cachexia Therapy),FACIT (Functional Assessment of Chronic Illness Therapy),FACT (Functional Assessment of Cancer Therapy),FGS (Hughes&#039; Functional Grading Scale),FIQ (Fibromyalgia Impact Questionnaire),FLIE (Functional Living Index for Emesis),Genitourinary atrophy self-assessment tool,GFAAS (Graphite Furnace Atomic Absorption Spectrometry),Global Charter Fatigue Scale,HADS (Hospital Anxiety and Depression Scale),HAQ-DI (Health Assessment Questionnaire-Disability Index),HFRDIS (Hot Flash Related Daily Interference Scale),HFS (Hot Flush Score),HGST Maximum (Handgrip Strength Test),Histological examination,HNQR (Head and Neck Radiotherapy Questionnaire),HSCS (High Sensitivity Cognitive Screen),ICI Test (Intracavernosal Injection Test),IIEF (International Index of Erectile Function),Interview,KPS (Karnofsky Performance Status),LASA (Linear Analogue Self-Assessment),LENT SOMA Scale (Late Effects on Normal Tissues/ Subjective Objective Management Analysis),MADRS (Montgomery-Asberg Depression Rating Scale),MAT (Multinational Association of Supportive Care in Cancer-Antiemesis Tool),McDonald criteria,MDASI (M. D. Anderson Symptom Inventory),Measuring tape,MENQOL (Menopause-Specific Quality of Life),MFI-20 (Multidimensional Fatigue Inventory-20),MMSE (Mini-Mental State Exam),Morbidity rating scale (by Dische),MOS SF-12 (Medical Outcomes Study/ 12-Item Short Form Health Survey),MPQ-SF (McGill Pain Questionnaire - Short Form),MRI (Magnetic Resonance Imaging),MRS (Mood Rating Scale),MYCaW (Measure Yourself Concerns and Wellbeing),NCI-CTC v.2 (National Cancer Institute-Common Toxic Criteria),NCI Grading Scale (National Cancer Institute),NDS (Neurological Disability Score),Neurologic examination,Neuropathy specific question,NRS (Numeric Rating Scale),NRS (Nutritional Risk Screening),NSS (Neurological Symptom Score),Observation,OMAS (Oral Mucositis Assessment Scale),Otoacoustic Emissions Testing,PAC-QoL (Patient Assessment of Constipation - Quality of Life),PGIC (Physician Global Impression of Change),PG-SGA (Patient-Generated Subjective Global Assessment),PHLF (Post Hepatectomy Liver Failure),PHS (Cognitive subscale of the Perceived Health Scale),pH-value,Physical examination,Physical functioning (grip strength;6 minute walk;leg extension),POMS (Profile of Mood States),PoSSe (Postoperative Symptom Severity Scale),Postoperative morbidity/complications (classification according to Clavien-Dindo),PROMIS (Patient-Reported Outcomes Measurement Information System),PSQ (Patient Satisfaction Questionnaire),PSQI (Pittsburgh Sleep Quality Index),QoR-40 (Quality of Recovery-40 Questionnaire),RDS (Radiation Dermatitis Severity),RECIST 1.0 Criteria (Response Evaluation Criteria in Solid Tumors),Reidel-Seiffer tuning fork,Rhodes Inventory of Nausea,RPSAS (Radiation Proctopathy System Assessment Scale),RTOG Acute Radiation Morbidity Scoring Criteria (Radiation Therapy Oncology Group),Scale,SCID (Structured Clinical Interview for DSM IV),Scintigraphy,Self-developed measurement instrument,SF-36 (Short Form-36 Health Survey),SF-MPQ (Short-Form McGill Pain Questionnaire),SGIC (Subject Global Impression of Change),SI (Symptom Inventory questionnaire),SOMA (Subjective Objective Medical management and Analytic evaluation of injury),SPECT (Single Photon Emission Computed Tomography),Spectrophotometry,SPPB (Short Physical Performance Battery),STAI (State-Trait-Anxiety-Inventory),Symptom experience diary (NCCTG),Thermometer,Three-stimulus drop technique (by Henkin),Tissue testing,TMT (Trail Making Test),TNS (Total Neuropathy Score),Ultrasonography,Unspecified questionnaire,Urinalysis,VAS (Visual Analogue Scale),VMI (Vaginal Maturation Index),VNS (Verbal Numerical Scale),Volometer,Western Ontario and McMaster Osteoarthritis Index,WHO-Scale (World Health Organisation),Wound volume,NI,NA,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Results during intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results during intervention&#039;&#039; means that the time of data collection is during or shortly after the period of the intervention (e.g. on the last day or a few days after). The results therefore still relate to the direct effects of the intervention.|note}}&lt;br /&gt;
{{{field|Results during intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&#039;&#039;&#039;Results after intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results after intervention&#039;&#039; means there is a longer break between the time of data collection and the end of the intervention, e.g. more than a week. The results relate more to long-term effects. &lt;br /&gt;
If a categorization in &#039;&#039;Results during vs. after intervention&#039;&#039; is not possible (e.g. survival data), the results are summarized under &#039;&#039;Results after intervention&#039;&#039; under the headline &amp;quot;Overall&amp;quot;.|note}}&lt;br /&gt;
{{{field|Results after intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
==Risk of Bias Assessment: Cochrane RoB tool 2.0==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Bias arising from the randomization process&lt;br /&gt;
| {{{field|Bias arising from the randomization process|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (assignment to intervention) &lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (assignment to intervention)|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (adhering to intervention)&lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (adhering to intervention)|input type=radiobutton|mandatory|default=NA|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to missing outcome data&lt;br /&gt;
| {{{field|Bias due to missing outcome data|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in measurement of the outcome&lt;br /&gt;
| {{{field|Bias in measurement of the outcome|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in selection of the reported result&lt;br /&gt;
| {{{field|Bias in selection of the reported result|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Other sources of bias&lt;br /&gt;
| {{{field|Other sources of bias|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Overall RoB judgment&lt;br /&gt;
| {{{field|Overall RoB judgment|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&#039;&#039;&#039;Outcome topic:&#039;&#039;&#039; {{{field|Outcome topic|input type=text with autocomplete|mandatory|delimiter=,|values=Acai berries,Acupuncture,Agaricus,Aloe vera,Amygdalin,Angelica sinensis,Annona muricata,Antrodia,Apigenin,Argan oil,Aromatherapy,Artemisia,Astragalus,Berberine,Biobran,Boswellia serrata,Breuss diet,Broccoli sprouts,Budwig diet,Cannabinoids,Capsaicin,Carnitine,Chlorella,Chronomedicine and Oncology,Chrysin,Cimicifuga,Co-enzyme Q10/ubiquinol,Colostrum,Cranberry,Curcumin,Dichloroacetate,Electroacupuncture,Enzymes (bromelain papain),Essiac,FactorAF2,Fasting,Fermented wheat germ extract,Flor Essence,Folic acid,Galavit,Gammalinolenic acid,Germanium,Ginger (also contains zerumbone),Ginkgo,Ginseng,Glutamine,Glutathione,Glycyrrhiza glabra,Graviola,Green tea (EGCG),Guarana,Hericium erinaceus,Homeopathy,Honey,Hops,Hydrazine sulphate,Hyperthermia (whole body and electrotherapy),Indole-3-carbinol,Insulin potentiation therapy,Isoflavones and equol,Kaempferol,Kavakava,Kombucha,Lapacho,Linseed,Low-carbohydrate or ketogenic diet,Lutein,Lycopene,Macrobiotics,Magnolia,Massage,Medical mushrooms (coriolus/Maitake/Ganoderma/reishi),Melatonin,Metadon,Methylsulfonylmethane (MSM),Mind-body therapies,Mistletoe,Neem,Nigella sativa,Noni,Omega 6 fatty acids,Omega-3 fatty acids,OPC (grape seed extract),Phellinus,Piper nigra,Polyerga,Pomegranate,Probiotics,Propolis,Prostasol,Qigong and Tai Chi,Quercetin,Reflexology,Reiki (Therapeutic Touch/Healing Touch/Polarity),Resveratrol,Rhodiola,Rhubarb,Rooibos,Selenium,Shiitake,Silymarin/marigold thistle,Soy,Spirulina,St. John&#039;s wort,Supportive therapy (NW),TCM,Thymus therapy,Ukrain,Uncaria (cat&#039;s claw),Valerian,Vitamin A (beta-carotene),Vitamin B1,Vitamin B12,Vitamin B2,Vitamin B6,Vitamin C,Vitamin D,Vitamin E,Wheatgrass,Yoga,Zeolites,Zinc}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
{{{for template|Outcome Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
{{{section|Funding and Conflicts of Interest|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Funding and Conflicts of Interest}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Funding: &lt;br /&gt;
| {{{field|Funding|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Conflicts of Interest: &lt;br /&gt;
| {{{field|Conflicts of Interest|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
{{{section|Further points for assessing the study|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Further points for assessing the study}}}&lt;br /&gt;
==Sample==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Power analysis performed&lt;br /&gt;
| {{{field|power analysis performed|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sample size corresponds to power analysis&lt;br /&gt;
| {{{field|Sample size corresponds to power analysis|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Reasons for insufficient sample size based on power analysis&lt;br /&gt;
| {{{field|Reasons given for samples being too small according to power analysis|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! If no power analysis performed: at least moderate sample size (n &amp;gt;= 30 per arm)&lt;br /&gt;
| {{{field|Samples sufficiently large|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethnicity mentioned&lt;br /&gt;
| {{{field|Ethnicity mentioned|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Alternative Explanation==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Other explanations for an effect besides the investigated intervention&lt;br /&gt;
| {{{field|Other explanations for an effect besides the investigated intervention|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of attention effects {{#info: e.g. due to lack of a placebo arm|note}}&lt;br /&gt;
| {{{field|Possibility of attention effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of placebo effects&lt;br /&gt;
| {{{field|Possibility of placebo effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Other reasons&lt;br /&gt;
| {{{field|Other reasons|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Statistics==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Correct use of parametric and non-parametric tests {{#info: Testing for normal distribution only necessary if parametric tests are used, NI: use of parametric tests without report of normal distribution testing|note}} &lt;br /&gt;
| {{{field|Correct use of parametric and non-parametric tests|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Correction for multiple testing&lt;br /&gt;
| {{{field|Correction for multiple testing|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Measurement of compliance&lt;br /&gt;
| {{{field|Measurement of compliance|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Consistent reporting in numbers (figures, flowchart, abstract, results)&lt;br /&gt;
| {{{field|Consistent reporting in numbers|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comprehensive and coherent reporting&lt;br /&gt;
| {{{field|Comprehensive and coherent reporting|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-Over study&lt;br /&gt;
| {{{field|Cross-over|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sufficient washout period&lt;br /&gt;
| {{{field|sufficient washout period|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for carry-over effects&lt;br /&gt;
| {{{field|Tested for carry-over effects|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for sequence effects&lt;br /&gt;
| {{{field|Were sequence effects tested|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Interpretation of results==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Effect sizes reported (clinical vs. statistical significance)&lt;br /&gt;
| {{{field|Effect sizes reported|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects systematically recorded&lt;br /&gt;
| {{{field|Were side effects systematically recorded|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects considered in result interpretation&lt;br /&gt;
| {{{field|Side effects taken into account in the interpretation of the results|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethics votum&lt;br /&gt;
| {{{field|Ethics / CoI / Funding|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Additional Notes}}}&lt;br /&gt;
==Additional Notes==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Additional Notes|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Property:Arm_topic&amp;diff=6978</id>
		<title>Property:Arm topic</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Property:Arm_topic&amp;diff=6978"/>
		<updated>2024-11-22T08:05:03Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;This is a property of type [[Has type::Text]].&lt;br /&gt;
&lt;br /&gt;
The allowed values for this property are:&lt;br /&gt;
* [[Allows value::Acai berries]]&lt;br /&gt;
* [[Allows value::Acupuncture]]&lt;br /&gt;
* [[Allows value::Agaricus]]&lt;br /&gt;
* [[Allows value::Aloe vera]]&lt;br /&gt;
* [[Allows value::Amygdalin]]&lt;br /&gt;
* [[Allows value::Angelica sinensis]]&lt;br /&gt;
* [[Allows value::Annona muricata]]&lt;br /&gt;
* [[Allows value::Antrodia]]&lt;br /&gt;
* [[Allows value::Apigenin]]&lt;br /&gt;
* [[Allows value::Argan oil]]&lt;br /&gt;
* [[Allows value::Aromatherapy]]&lt;br /&gt;
* [[Allows value::Artemisia]]&lt;br /&gt;
* [[Allows value::Astragalus]]&lt;br /&gt;
* [[Allows value::Berberine]]&lt;br /&gt;
* [[Allows value::Biobran]]&lt;br /&gt;
* [[Allows value::Boswellia serrata]]&lt;br /&gt;
* [[Allows value::Breuss diet]]&lt;br /&gt;
* [[Allows value::Broccoli sprouts]]&lt;br /&gt;
* [[Allows value::Budwig diet]]&lt;br /&gt;
* [[Allows value::Cannabinoids]]&lt;br /&gt;
* [[Allows value::Capsaicin]]&lt;br /&gt;
* [[Allows value::Carnitine]]&lt;br /&gt;
* [[Allows value::Chlorella]]&lt;br /&gt;
* [[Allows value::Chronomedicine and Oncology]]&lt;br /&gt;
* [[Allows value::Chrysin]]&lt;br /&gt;
* [[Allows value::Cimicifuga]]&lt;br /&gt;
* [[Allows value::Co-enzyme Q10/ubiquinol]]&lt;br /&gt;
* [[Allows value::Colostrum]]&lt;br /&gt;
* [[Allows value::Cranberry]]&lt;br /&gt;
* [[Allows value::Curcumin]]&lt;br /&gt;
* [[Allows value::Dichloroacetate]]&lt;br /&gt;
* [[Allows value::Electroacupuncture]]&lt;br /&gt;
* [[Allows value::Enzymes (bromelain papain)]]&lt;br /&gt;
* [[Allows value::FactorAF2]]&lt;br /&gt;
* [[Allows value::Fasting]]&lt;br /&gt;
* [[Allows value::Fermented wheat germ extract]]&lt;br /&gt;
* [[Allows value::Flor Essence, Essiac]]&lt;br /&gt;
* [[Allows value::Folic acid]]&lt;br /&gt;
* [[Allows value::Galavit]]&lt;br /&gt;
* [[Allows value::Gammalinolenic acid]]&lt;br /&gt;
* [[Allows value::Germanium]]&lt;br /&gt;
* [[Allows value::Ginger]]&lt;br /&gt;
* [[Allows value::Ginkgo]]&lt;br /&gt;
* [[Allows value::Ginseng]]&lt;br /&gt;
* [[Allows value::Glutamine]]&lt;br /&gt;
* [[Allows value::Glutathione]]&lt;br /&gt;
* [[Allows value::Glycyrrhiza glabra]]&lt;br /&gt;
* [[Allows value::Graviola]]&lt;br /&gt;
* [[Allows value::Green tea (EGCG)]]&lt;br /&gt;
* [[Allows value::Guarana]]&lt;br /&gt;
* [[Allows value::Hericium erinaceus]]&lt;br /&gt;
* [[Allows value::Homeopathy]]&lt;br /&gt;
* [[Allows value::Honey]]&lt;br /&gt;
* [[Allows value::Hops]]&lt;br /&gt;
* [[Allows value::Hydrazine sulphate]]&lt;br /&gt;
* [[Allows value::Hyperthermia (whole body and electrotherapy)]]&lt;br /&gt;
* [[Allows value::Indole-3-carbinol]]&lt;br /&gt;
* [[Allows value::Insulin potentiation therapy]]&lt;br /&gt;
* [[Allows value::Isoflavones and equol]]&lt;br /&gt;
* [[Allows value::Kaempferol]]&lt;br /&gt;
* [[Allows value::Kavakava]]&lt;br /&gt;
* [[Allows value::Kombucha]]&lt;br /&gt;
* [[Allows value::Lapacho]]&lt;br /&gt;
* [[Allows value::Linseed]]&lt;br /&gt;
* [[Allows value::Low-carbohydrate or ketogenic diet]]&lt;br /&gt;
* [[Allows value::Lutein]]&lt;br /&gt;
* [[Allows value::Lycopene]]&lt;br /&gt;
* [[Allows value::Macrobiotics]]&lt;br /&gt;
* [[Allows value::Magnolia]]&lt;br /&gt;
* [[Allows value::Massage]]&lt;br /&gt;
* [[Allows value::Medical mushrooms (coriolus/Maitake/Ganoderma/reishi)]]&lt;br /&gt;
* [[Allows value::Melatonin]]&lt;br /&gt;
* [[Allows value::Metadon]]&lt;br /&gt;
* [[Allows value::Methylsulfonylmethane (MSM)]]&lt;br /&gt;
* [[Allows value::Mind-body therapies]]&lt;br /&gt;
* [[Allows value::Mistletoe]]&lt;br /&gt;
* [[Allows value::Neem]]&lt;br /&gt;
* [[Allows value::Nigella sativa]]&lt;br /&gt;
* [[Allows value::Noni]]&lt;br /&gt;
* [[Allows value::Omega 6 fatty acids]]&lt;br /&gt;
* [[Allows value::Omega-3 fatty acids]]&lt;br /&gt;
* [[Allows value::OPC (grape seed extract)]]&lt;br /&gt;
* [[Allows value::Phellinus]]&lt;br /&gt;
* [[Allows value::Piper nigra]]&lt;br /&gt;
* [[Allows value::Polyerga]]&lt;br /&gt;
* [[Allows value::Pomegranate]]&lt;br /&gt;
* [[Allows value::Probiotics]]&lt;br /&gt;
* [[Allows value::Propolis]]&lt;br /&gt;
* [[Allows value::Prostasol]]&lt;br /&gt;
* [[Allows value::Qigong and Tai Chi]]&lt;br /&gt;
* [[Allows value::Quercetin]]&lt;br /&gt;
* [[Allows value::Reflexology]]&lt;br /&gt;
* [[Allows value::Reiki (Therapeutic Touch/Healing Touch/Polarity)]]&lt;br /&gt;
* [[Allows value::Resveratrol]]&lt;br /&gt;
* [[Allows value::Rhodiola]]&lt;br /&gt;
* [[Allows value::Rhubarb]]&lt;br /&gt;
* [[Allows value::Rooibos]]&lt;br /&gt;
* [[Allows value::Selenium]]&lt;br /&gt;
* [[Allows value::Shiitake]]&lt;br /&gt;
* [[Allows value::Silymarin/marigold thistle]]&lt;br /&gt;
* [[Allows value::Soy]]&lt;br /&gt;
* [[Allows value::Spirulina]]&lt;br /&gt;
* [[Allows value::St. John&#039;s wort]]&lt;br /&gt;
* [[Allows value::Supportive therapy (NW)]]&lt;br /&gt;
* [[Allows value::TCM]]&lt;br /&gt;
* [[Allows value::Thymus therapy]]&lt;br /&gt;
* [[Allows value::Ukrain]]&lt;br /&gt;
* [[Allows value::Uncaria (cat&#039;s claw)]]&lt;br /&gt;
* [[Allows value::Valerian]]&lt;br /&gt;
* [[Allows value::Vitamin A (beta-carotene)]]&lt;br /&gt;
* [[Allows value::Vitamin B1]]&lt;br /&gt;
* [[Allows value::Vitamin B12]]&lt;br /&gt;
* [[Allows value::Vitamin B2]]&lt;br /&gt;
* [[Allows value::Vitamin B6]]&lt;br /&gt;
* [[Allows value::Vitamin C]]&lt;br /&gt;
* [[Allows value::Vitamin D]]&lt;br /&gt;
* [[Allows value::Vitamin E]]&lt;br /&gt;
* [[Allows value::Wheatgrass]]&lt;br /&gt;
* [[Allows value::Yoga]]&lt;br /&gt;
* [[Allows value::Zeolites]]&lt;br /&gt;
* [[Allows value::Zinc]]&lt;br /&gt;
* [[Allows value::NI]]&lt;br /&gt;
* [[Allows value::?]]&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Property:Arm_topic&amp;diff=6977</id>
		<title>Property:Arm topic</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Property:Arm_topic&amp;diff=6977"/>
		<updated>2024-11-22T08:03:45Z</updated>

		<summary type="html">&lt;p&gt;Cotto: Created a property of type Text&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;This is a property of type [[Has type::Text]].&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=6976</id>
		<title>MediaWiki:Common.css</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=6976"/>
		<updated>2024-11-22T08:00:07Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;/* CSS placed here will be applied to all skins */&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(n) {&lt;br /&gt;
    text-align: justify;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
// weiße Reference Überschrift&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:visited {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:link{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:hover{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:active {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
// Tabellen Todos Ende&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;low risk&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;some concerns&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
input[value=&amp;quot;high risk&amp;quot;]  {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(2) {&lt;br /&gt;
    color: green;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(3) {&lt;br /&gt;
    color: orange;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(4) {&lt;br /&gt;
    color: red;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.low-risk {&lt;br /&gt;
    color: green;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.some-concerns {&lt;br /&gt;
    color: orange;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.high-risk {&lt;br /&gt;
    color: red;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(2) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(4) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#bodyContent &amp;gt; div.mw-body-subheader {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(1) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.uniform-width-table {&lt;br /&gt;
  width:100%;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(1), .wikitable.uniform-width-table td:nth-child(1){&lt;br /&gt;
  width: 60%; /* Width for the first column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(2), .wikitable.uniform-width-table td:nth-child(2){&lt;br /&gt;
  width: 5%; /* Width for the second column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(3), .wikitable.uniform-width-table td:nth-child(3){&lt;br /&gt;
  width: 5%; /* Width for the third column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(4), .wikitable.uniform-width-table td:nth-child(4){&lt;br /&gt;
  width: 30%; /* Width for the fourth column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.vector-body p {&lt;br /&gt;
  margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable {&lt;br /&gt;
        background-color: #ffffff;&lt;br /&gt;
        color: #202122;&lt;br /&gt;
        margin: 1em 0;&lt;br /&gt;
        border: 1px solid #a2a9b1;&lt;br /&gt;
        border-collapse: collapse&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; tbody &amp;gt; tr:nth-child(n) &amp;gt; th {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; thead &amp;gt; tr &amp;gt; th:nth-child(n) {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:Publication&amp;diff=6975</id>
		<title>Template:Publication</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:Publication&amp;diff=6975"/>
		<updated>2024-11-22T07:59:40Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
{{#template_params:Title (property=Title)|Topic (list;property=Topic)|Author (property=Author)|Year (property=Publication year)|Journal (property=Journal)|DOI (property=DOI)|Authors Abstract (property=Authors Abstract)}}&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&amp;lt;includeonly&amp;gt;&lt;br /&gt;
{|class=&amp;quot;wikitable&amp;quot; style=&amp;quot;width: 40em; font-size: 90%; border: 2px solid #3366cc; color: black; margin-bottom: 0.5em; margin-top: 0.2em; clear: right; text-align:left;&amp;quot;&lt;br /&gt;
!style=&amp;quot;text-align: center; color: #ffffff; background-color: #3366cc;&amp;quot; colspan=&amp;quot;2&amp;quot;|&amp;lt;span style=&amp;quot;font-size: larger;&amp;quot;&amp;gt;Reference&amp;lt;/span&amp;gt;&lt;br /&gt;
|- &lt;br /&gt;
! style=&amp;quot;width:20%;&amp;quot; |Title&lt;br /&gt;
| [[Title::{{{Title|}}}]]&lt;br /&gt;
|-&lt;br /&gt;
! Topic&lt;br /&gt;
| {{#arraymap:{{{Topic|}}}|,|x|[[Topic::x]]}}&lt;br /&gt;
|-&lt;br /&gt;
!  Author&lt;br /&gt;
| [[Author::{{{Author|}}}|]]|{{#arraymap:{{{Author|}}}|;|x|[[x]]}}&lt;br /&gt;
|-&lt;br /&gt;
! Year&lt;br /&gt;
| [[Publication year::{{{Year|}}}]]&lt;br /&gt;
|-&lt;br /&gt;
! Journal&lt;br /&gt;
| [[Journal::{{{Journal|}}}]]&lt;br /&gt;
|-&lt;br /&gt;
! DOI &lt;br /&gt;
| [[DOI::{{{DOI|}}}]]&lt;br /&gt;
|}&lt;br /&gt;
[[Category:Publication]]&lt;br /&gt;
= Author&#039;s Abstract {{#info: The abstract and the information and conclusions contained therein were written by the authors of the publication.|note}} =&lt;br /&gt;
{| class=&amp;quot;text&amp;quot;&lt;br /&gt;
| style=&amp;quot;text-align: justify&amp;quot;| [[Authors Abstract::{{{Authors Abstract|}}}]]&lt;br /&gt;
|}&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;strong&amp;gt;This publication is referenced in the following studies:&amp;lt;/strong&amp;gt;&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
[[has subobject.Reference::{{SUBJECTPAGENAME}}]]&lt;br /&gt;
|format=ol&lt;br /&gt;
}}&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6918</id>
		<title>Example Queries II</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6918"/>
		<updated>2024-11-21T13:12:27Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* How does selenium influence survival in cancer? - outcome-based */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== What effects of selenium have been investigated? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? - outcome-based ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Selenium]]&lt;br /&gt;
 [[Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |?Results after intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Which intervention for depression in cancer was investigated in studies with a placebo arm? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Outcome name::Depression]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Reference.Topic&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies ==&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabinoids]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |?Were side effects systematically recorded&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6917</id>
		<title>Example Queries II</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6917"/>
		<updated>2024-11-21T13:11:31Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== What effects of selenium have been investigated? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? - outcome-based ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Selenium]]&lt;br /&gt;
 [[Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?Results after intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Which intervention for depression in cancer was investigated in studies with a placebo arm? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Outcome name::Depression]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Reference.Topic&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies ==&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabinoids]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |?Were side effects systematically recorded&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6916</id>
		<title>Example Queries II</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries_II&amp;diff=6916"/>
		<updated>2024-11-21T13:11:08Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== What effects of selenium have been investigated? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== How does selenium influence survival in cancer? - outcome-based ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[Outcome topic::Selenium]]&lt;br /&gt;
 [[Outcome name:DFS (Disease-Free Survival)||EFS (Event-Free Survival)||LFS (Local-Free Survival)||MFS (Metastases-Free Survival)||OS (Overall Survival)||PFS (Progression-Free Survival)||RFS (Recurrence-Free Survival)]]&lt;br /&gt;
 |?Results after intervention&lt;br /&gt;
 |?Overall RoB judgment&lt;br /&gt;
 |?Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Which intervention for depression in cancer was investigated in studies with a placebo arm? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Outcome name::Depression]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Reference.Topic&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
== Side effects of Cannabis in placebo-controlled studies ==&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Cannabinoids]]&lt;br /&gt;
 [[has subobject.Arm type::Placebo]]&lt;br /&gt;
 |?has subobject.Intervention&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |?Were side effects systematically recorded&lt;br /&gt;
 |headers=plain&lt;br /&gt;
 |limit=5&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=6770</id>
		<title>Form:RCT Study</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=6770"/>
		<updated>2024-11-21T09:33:57Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
This is the &amp;quot;RCT Study&amp;quot; form.&lt;br /&gt;
To create a page with this form, enter the page name below;&lt;br /&gt;
if a page with that name already exists, you will be sent to a form to edit that page.&lt;br /&gt;
&lt;br /&gt;
{{#forminput:form=RCT Study}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&amp;lt;includeonly&amp;gt;&lt;br /&gt;
&lt;br /&gt;
=Publication=&lt;br /&gt;
&lt;br /&gt;
{{{for template|Reference}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Publication: &lt;br /&gt;
| {{{field|Reference|input type=text|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Note}}}&lt;br /&gt;
==Study Note==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Study Note|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Brief summary=&lt;br /&gt;
{{{section|Brief summary|level=1}}}&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
{{{section|Study Design|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Design (RCT)}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Prospective / Retrospective: {{#info: Prospective: forward-looking, examples include clinical trials, cohort studies, and long-term observational studies; &lt;br /&gt;
Retrospective: backward-looking, relying on existing data, examples include case-control studies and retrospective cohort studies|note}}&lt;br /&gt;
| {{{field|Perspective|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Monocentric / Multicentric:  {{#info: Monocentric: conducted in one center/ hospital; &lt;br /&gt;
Multicentric: conducted in multiple centers/ hospitals|note}}&lt;br /&gt;
| {{{field|Centralized|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Blinding: {{#info: No: Open, all parties are aware of group assignments; &lt;br /&gt;
Single: one party is unaware of group assignments (generally participants); &lt;br /&gt;
Double: two parties are unaware of group assignments (generally the participants and the researchers); &lt;br /&gt;
Triple: concealing group assignment from additional parties|note}}&lt;br /&gt;
| {{{field|Blinding|input type=radiobutton|mandatory|default=?|values=?,No,Single,Double,Triple,NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Is randomized: &lt;br /&gt;
| {{{field|Is randomized|input type=checkbox|default=Yes}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-over: {{#info: Participants alternate between different treatment groups or conditions over a specified period, allowing each participant to serve as their own control|note}}&lt;br /&gt;
| {{{field|Cross-over|input type=checkbox|default=No}}}&lt;br /&gt;
|-&lt;br /&gt;
! Number of arms: &lt;br /&gt;
| {{{field|Number of arms|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
{{{section|Study characteristics|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|RCT study general properties}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Inclusion criteria: &lt;br /&gt;
| {{{field|Inclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Exclusion criteria: &lt;br /&gt;
| {{{field|Exclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! N randomized: &lt;br /&gt;
| {{{field|N randomized|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|-&lt;br /&gt;
! Analysis: {{#info: PP: Per Protocol analysis, i.e. only participants included who adhered to the study protocol.&lt;br /&gt;
ITT: Intention-to-treat analysis, i.e. all randomized participants included regardless of any drop-outs or changes in assignment.&lt;br /&gt;
mITT: modified Intention-to-treat analysis can refer to analyses in which participants with missing outcome data are excluded or it can refer to analyses in which only participants who received at least one treatment dose are included. In this case, participants dropped out of the study prematurely for reasons unrelated to the treatment.|note}}&lt;br /&gt;
| {{{field|Analysis|input type=checkboxes|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on analyses:&lt;br /&gt;
| {{{field|Specifications on analyses|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Countries of data collection: &lt;br /&gt;
| {{{field|Countries of data collection|input type=text with autocomplete|delimiter=,|values=Afghanistan,Albania,Algeria,Andorra,Angola,Antigua &amp;amp; Deps,Argentina,Armenia,Australia,Austria,Azerbaijan,Bahamas,Bahrain,Bangladesh,Barbados,Belarus,Belgium,Belize,Benin,Bhutan,Bolivia,Bosnia Herzegovina,Botswana,Brazil,Brunei,Bulgaria,Burkina,Burundi,Cambodia,Cameroon,Canada,Cape Verde,Central African Rep,Chad,Chile,China,Colombia,Comoros,Congo,Congo {Democratic Rep},Costa Rica,Croatia,Cuba,Cyprus,Czech Republic,Denmark,Djibouti,Dominica,Dominican Republic,East Timor,Ecuador,Egypt,El Salvador,Equatorial Guinea,Eritrea,Estonia,Ethiopia,Europe,Fiji,Finland,France,Gabon,Gambia,Georgia,Germany,Ghana,Greece,Grenada,Guatemala,Guinea,Guinea-Bissau,Guyana,Haiti,Honduras,Hungary,Iceland,India,Indonesia,Iran,Iraq,Ireland {Republic},Israel,Italy,Ivory Coast,Jamaica,Japan,Jordan,Kazakhstan,Kenya,Kiribati,Korea North,Korea South,Kosovo,Kuwait,Kyrgyzstan,Laos,Latin America,Latvia,Lebanon,Lesotho,Liberia,Libya,Liechtenstein,Lithuania,Luxembourg,Macedonia,Madagascar,Malawi,Malaysia,Maldives,Mali,Malta,Marshall Islands,Mauritania,Mauritius,Mexico,Micronesia,Moldova,Monaco,Mongolia,Montenegro,Morocco,Mozambique,Myanmar,{Burma},Namibia,Nauru,Nepal,Netherlands,New Zealand,Nicaragua,Niger,Nigeria,North America,Norway,Oman,Pakistan,Palau,Panama,Papua New Guinea,Paraguay,Peru,Philippines,Poland,Portugal,Qatar,Romania,Russian Federation,Rwanda,St Kitts &amp;amp; Nevis,St Lucia,Saint Vincent &amp;amp; the Grenadines,Samoa,San Marino,Sao Tome &amp;amp; Principe,Saudi Arabia,Senegal,Serbia,Seychelles,Sierra Leone,Singapore,Slovakia,Slovenia,Solomon Islands,Somalia,South Africa,South Sudan,Spain,Sri Lanka,Sudan,Suriname,Swaziland,Sweden,Switzerland,Syria,Taiwan,Tajikistan,Tanzania,Thailand,Togo,Tonga,Trinidad &amp;amp; Tobago,Tunisia,Turkey,Turkmenistan,Tuvalu,Uganda,Ukraine,United Arab Emirates,United Kingdom,United Kingdom - Great Britain,United States,United States - New York,United States - Texas,Uruguay,Uzbekistan,Vanuatu,Vatican City,Venezuela,Vietnam,Yemen,Zambia,Zimbabwe,NI,?|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! LoE: {{#info: Level of evidence|note}}&lt;br /&gt;
| {{{field|LoE|input type=dropdown|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Outcome timeline: {{#info: Data collection times|note}}&lt;br /&gt;
| {{{field|Outcome timeline|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
{{{section|Characteristics of participants|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Characteristics of participants}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Setting: {{#info: Refers to cancer therapy setting.&lt;br /&gt;
- Curative therapy: aims to completely eradicate a disease and achieve a full recovery; &lt;br /&gt;
- Neo-adjuvant therapy: form of curative therapy, given before the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Adjuvant therapy: form of curative therapy, given after the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Palliative therapy: focuses on providing relief from symptoms and improving the quality of life for patients, without necessarily targeting the underlying disease; &lt;br /&gt;
- Active surveillance: involves close monitoring of disease progression without any intervention (typically used for prostate cancer);&lt;br /&gt;
- No therapy setting: Patients who completed therapy/are currently not in cancer treatment, cancer survivors.|note}}&lt;br /&gt;
| {{{field|Setting|input type=checkboxes|delimiter=,|default=?|mandatory|values=?, Curative, Neo-adjuvant, Adjuvant, Palliative, Active surveillance, No therapy setting, NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Types of cancer: {{#info: &amp;quot;Other Cancers&amp;quot; means that only a subpopulation was specified, but further unspecified cancer types were included|note}}&lt;br /&gt;
| {{{field|Types of cancer|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Adrenal Cancer,Anal Cancer,Bile Duct Cancer,Bone and Soft Tissue Cancers, Bone and Soft Tissue Cancers - Osteosarcoma,Bone and Soft Tissue Cancers - Ewing Sarcoma,Bone and Soft Tissue Cancers - Chondrosarcoma,Bone and Soft Tissue Cancers - Rhabdomyosarcoma,Bone and Soft Tissue Cancers – Liposarcoma,Brain and Central Nervous System (CNS) Cancers,Brain and Central Nervous System (CNS) Cancers - Astrocytoma,Brain and Central Nervous System (CNS) Cancers - Glioblastoma,Brain and Central Nervous System (CNS) Cancers - High-Grade Glioma,Brain and Central Nervous System (CNS) Cancers - Meningioma,Breast Cancer,Breast Cancer - Ductal Carcinoma,Breast Cancer - Lobular Carcinoma,Breast Cancer - Inflammatory Breast Cancer,Breast Cancer - Triple-Negative Breast Cancer,Carcinosarcoma,Chest Cancer,Colorectal Cancer,Colorectal Cancer - Colon Cancer,Colorectal Cancer - Rectal Cancer,Eye Cancer,Eye Cancer - Retinoblastoma,Gastrointestinal Cancers,Gastrointestinal Cancers - Gallbladder Cancer,Gastrointestinal Cancers - Gastric (Stomach) Cancer,Gastrointestinal Cancers - Esophageal Cancer,Gastrointestinal Cancers - Pancreatic Cancer,Gastrointestinal Cancers - Liver Cancer,Genitourinary Cancers,Genitourinary Cancers - Bladder Cancer,Genitourinary Cancers - Kidney (Renal) Cancer,Genitourinary Cancers - Testicular Cancer,Genitourinary Cancers - Urethral Cancer,Gynecologic Cancers,Gynecologic Cancers - Ovarian Cancer,Gynecologic Cancers - Cervical Cancer,Gynecologic Cancers - Uterine Cancer,Gynecologic Cancers - Endometrial Cancer,Gynecologic Cancers - Vulvar Cancer,Head and Neck Cancers, Head and Neck Cancers - Oral Cancer,Head and Neck Cancers - Oropharyngeal Cancer,Head and Neck Cancers - Laryngeal Cancer,Head and Neck Cancers - Nasopharyngeal Cancer,Head and Neck Cancers - Tongue Cancer,Head and Neck Cancers - Thyroid Cancer,Head and Neck Cancers - Ethmoid Sinus Cancer,Hematologic Cancers, Hematologic Cancers - Leukemia (Acute Lymphocytic/Acute Myeloid/Chronic Lymphocytic/Chronic Myeloid), Hematologic Cancers - Lymphoma (Hodgkin and Non-Hodgkin),Hematologic Cancers - Multiple Myeloma,Lung Cancer,Lung Cancer - Small Cell Lung Cancer,Lung Cancer - Non-Small Cell Lung Cancer,Mesothelioma,Neuroblastoma,Prostate Cancer,Skin Cancer,Skin Cancer - Basal Cell Carcinoma,Skin Cancer - Squamous Cell Carcinoma,Skin Cancer – Melanoma,Stomach Cancer,Solid Malignancies,Thymoma and Thymic Carcinoma,Unspecified Sarcoma,Other Cancers,NI,?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage: {{#info: Early Stage: generally refers to cancer that is localized to the area where it started, mostly stages I and II;&lt;br /&gt;
Advanced Stage: cancer that has spread beyond its original site, mostly stages III and IV, with stage IV indicating distant metastasis|note}}&lt;br /&gt;
| {{{field|Stage cancer|input type=checkboxes|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage specification: &lt;br /&gt;
| {{{field|Cancer stage specification|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comorbidity: &lt;br /&gt;
| {{{field|Comorbidity|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Current cancer therapy: &lt;br /&gt;
| {{{field|Current cancer therapy|input type=text with autocomplete|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on cancer therapies: &lt;br /&gt;
| {{{field|Specifications on cancer therapies|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Previous cancer therapies: &lt;br /&gt;
| {{{field|Previous cancer therapies|input type=text with autocomplete|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender: &lt;br /&gt;
| {{{field|Gender|input type=radiobutton|mandatory|values=?, Male, Female, Mixed, NI|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender specifications: &lt;br /&gt;
| {{{field|Gender specifications|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups: &lt;br /&gt;
| {{{field|Age groups|input type=checkboxes|values=?, Children (0-15), Adolescents and young adults (15-39), Adults (18+), Elderly (65+), NI|default=adults (18+)}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups specification: &lt;br /&gt;
| {{{field|Age groups specification|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
=Arms=&lt;br /&gt;
{{{section|Arms|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Arm type:&#039;&#039;&#039; {{#info: Active control: group receives active treatment; &lt;br /&gt;
Passive control: for example: treatment as usual, waiting control, no treatment|note}}&lt;br /&gt;
{{{field|Arm type|input type=checkboxes|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Number of participants (arm):&#039;&#039;&#039; {{{field|Number of participants (arm)|input type=text|mandatory|default=-999}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out:&#039;&#039;&#039; {{#info: Number of participants who left the study for any reason or did not provide information on every data collection date|note}} {{{field|Drop-out|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out reasons:&#039;&#039;&#039; {{{field|Drop-out reasons|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Intervention:&#039;&#039;&#039; {{{field|Intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Dosage and regime:&#039;&#039;&#039; {{{field|Dosage and regime|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;One-time application:&#039;&#039;&#039; {{{field|One-time application|input type=checkbox|mandatory|default=No}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Duration in days:&#039;&#039;&#039; {{#info: For long-term interventions, the number of days is an estimate.&lt;br /&gt;
A value of -999 indicates that the exact duration cannot be extracted from the study due to ambiguous or incomplete information. See &#039;&#039;Outcome timeline&#039;&#039; or &#039;&#039;Dosage and regime&#039;&#039; for further information. |note}}&lt;br /&gt;
{{{field|Duration in days|input type=regexp|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Side Effects / Interactions:&#039;&#039;&#039; {{{field|Side Effects / Interactions|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Outcomes=&lt;br /&gt;
{{{section|Outcomes|level=1}}}&lt;br /&gt;
{{{for template|Outcome|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Outcome type:&#039;&#039;&#039; {{#info: As specificed by the authors| note}} {{{field|Outcome type|input type=radiobutton|mandatory|default=?|values=?,Primary,Secondary,Others,NI}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome name:&#039;&#039;&#039; {{{field|Outcome name|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Additional medication,Anorexia/Cachexia,Antibodies,Anxiety,Appetite,Arterial inflow,BMD (Bone Mineral Density),Body composition,Carnitine level,Carotenoid concentration,Cerebral oedema,CINV (Chemotherapy-Induced Nausea and Vomiting),Cognitive functioning,Cognitive impairment,Depression,Dermatitis,DFS (Disease-Free Survival),Diarrhoe,Distress,Dysgeusia,EFS (Event-Free Survival),Ejection fraction,Emesis,Erectile dysfunction,Erythema,Esophagitis,Fatigue,Fever,Fibrosis,Folic acid level,Frequency of rescue analgesics,Functionality,Haematological indices,Haematological toxicity,Hand-foot syndrome,Hand grip strength,Hepatotoxicity,Hot flushes,Hormone level,Ileus (intestinal obstruction),Incidence of acute GVHD (Graft-Versus-Host Disease),Infection,Interaction with cancer treatment,Laboratory parameters,Length of hospital stay,LFS (Local-Free Survival),Lymphedema,Menopausal symptoms,Mental status/ function,MFS (Metastases-Free Survival),Mood/Affect,Mortality rate,MTD (Maximum Tolerated Dose),Mucositis,Musculoskeletal symptoms,Nausea,Nausea and Vomiting,Nerve conduction velocity,Neurotoxicity,Neutropenia,Non-haematological indices,Nutrition status,Objective signs and subjective symptoms,Oral ulcus,OS (Overall Survival),Ototoxicity,Pain,PD (Pharmacodynamics),Performance Status,Peripheral neuropathy,PFS (Progression-Free Survival),Pharyngitis,Physical functioning,PK (Pharmacokinetics),Postoperative morbidity/ complications,Postoperative opiate consumption,PSADT (Prostate-Specific Antigen Doubling Time),PSA level (Prostate-Specific Antigen),Quality of life,Recurrence rate,Reduction of complication rates,REE (Resting Energy Expenditure),Relaxation,Restoration of bowel function after surgery,RFS (Recurrence-Free Survival),Salivary gland function,Selenium level,Seroconversion,Shoulder mobility,Side effects of androgen deprivation/suppression,Side effects of tooth extraction,Skeletal morbidity-free survival,Sleep,Stomatitis,Stress,Symptom load,Taste alteration,Tea polyphenol uptake,Thromboembolic event rates,Toxicity,Treatment interruption,Tumor progression,Tumor response,Vaginal atrophy,Vitamin A level,Vitamin B6 level,Vitamin B12 level,Vitamin B17 level,Vitamin C level,Vitamin D level,Vitamin E level,Vomiting,Weight,Well-being,Wound healing,Wound odour,Xerostomia,Zinc level,Unspecified effects,NI,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome specification:&#039;&#039;&#039; {{{field|Outcome specification|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Type of measurement:&#039;&#039;&#039; {{{field|Type of measurement|input type=tokens|mandatory|default=?|delimiter=,|values=AQoL-8D (Assessment of Quality of Life),ASAT (Auditory Sustained Attention Test),Atomic absorption,Audiogram,AUSCAN (Australian/Canadian Osteoarthritis Hand Index),BCPT (Breast Cancer Prevention Symptom Scales),BDI (Beck Depression Inventory),BFI (Brief Fatigue Inventory),BIA (Bioelectrical impedance analysis),Blood Test,BPI-SF (Brief Pain Inventory - Short Form),CES-D (Center for Epidemiologic Studies - Depression Scale),Chemiluminescent immunoassay,CNPI (Checklist of Non-Verbal Pain Indicators),CSSP (Catterall Skin Scoring Profile),CT (Computed Tomography),CTCAE (Common Terminology Criteria of Adverse Events),Cystoscopy,Diary questionnaire,DXA (Dual energy X-ray Absorptiometry),Dynamometer,Echo-color Doppler,ECOG Performance Status Scale (Eastern Cooperative Oncology Group),Electronic monitoring device,Electrophysiological evaluation,ELISA protocol (Enzyme-Linked Immunoabsorbent Assay),EORTC QLQ (European Organisation for Research and Treatment of Cancer Core/ Quality of Life questionnaire),ESAS (Edmonton Symptom Assessment Scale),FAACT (Functional Assessment of Anorexia-Cachexia Therapy),FACIT (Functional Assessment of Chronic Illness Therapy),FACT (Functional Assessment of Cancer Therapy),FGS (Hughes&#039; Functional Grading Scale),FIQ (Fibromyalgia Impact Questionnaire),FLIE (Functional Living Index for Emesis),Genitourinary atrophy self-assessment tool,GFAAS (Graphite Furnace Atomic Absorption Spectrometry),Global Charter Fatigue Scale,HADS (Hospital Anxiety and Depression Scale),HAQ-DI (Health Assessment Questionnaire-Disability Index),HFRDIS (Hot Flash Related Daily Interference Scale),HFS (Hot Flush Score),HGST Maximum (Handgrip Strength Test),Histological examination,HNQR (Head and Neck Radiotherapy Questionnaire),HSCS (High Sensitivity Cognitive Screen),ICI Test (Intracavernosal Injection Test),IIEF (International Index of Erectile Function),Interview,KPS (Karnofsky Performance Status),LASA (Linear Analogue Self-Assessment),LENT SOMA Scale (Late Effects on Normal Tissues/ Subjective Objective Management Analysis),MADRS (Montgomery-Asberg Depression Rating Scale),MAT (Multinational Association of Supportive Care in Cancer-Antiemesis Tool),McDonald criteria,MDASI (M. D. Anderson Symptom Inventory),Measuring tape,MENQOL (Menopause-Specific Quality of Life),MFI-20 (Multidimensional Fatigue Inventory-20),MMSE (Mini-Mental State Exam),Morbidity rating scale (by Dische),MOS SF-12 (Medical Outcomes Study/ 12-Item Short Form Health Survey),MPQ-SF (McGill Pain Questionnaire - Short Form),MRI (Magnetic Resonance Imaging),MRS (Mood Rating Scale),MYCaW (Measure Yourself Concerns and Wellbeing),NCI-CTC v.2 (National Cancer Institute-Common Toxic Criteria),NCI Grading Scale (National Cancer Institute),NDS (Neurological Disability Score),Neurologic examination,Neuropathy specific question,NRS (Numeric Rating Scale),NRS (Nutritional Risk Screening),NSS (Neurological Symptom Score),Observation,OMAS (Oral Mucositis Assessment Scale),Otoacoustic Emissions Testing,PAC-QoL (Patient Assessment of Constipation - Quality of Life),PGIC (Physician Global Impression of Change),PG-SGA (Patient-Generated Subjective Global Assessment),PHLF (Post Hepatectomy Liver Failure),PHS (Cognitive subscale of the Perceived Health Scale),pH-value,Physical examination,Physical functioning (grip strength;6 minute walk;leg extension),POMS (Profile of Mood States),PoSSe (Postoperative Symptom Severity Scale),Postoperative morbidity/complications (classification according to Clavien-Dindo),PROMIS (Patient-Reported Outcomes Measurement Information System),PSQ (Patient Satisfaction Questionnaire),PSQI (Pittsburgh Sleep Quality Index),QoR-40 (Quality of Recovery-40 Questionnaire),RDS (Radiation Dermatitis Severity),RECIST 1.0 Criteria (Response Evaluation Criteria in Solid Tumors),Reidel-Seiffer tuning fork,Rhodes Inventory of Nausea,RPSAS (Radiation Proctopathy System Assessment Scale),RTOG Acute Radiation Morbidity Scoring Criteria (Radiation Therapy Oncology Group),Scale,SCID (Structured Clinical Interview for DSM IV),Scintigraphy,Self-developed measurement instrument,SF-36 (Short Form-36 Health Survey),SF-MPQ (Short-Form McGill Pain Questionnaire),SGIC (Subject Global Impression of Change),SI (Symptom Inventory questionnaire),SOMA (Subjective Objective Medical management and Analytic evaluation of injury),SPECT (Single Photon Emission Computed Tomography),Spectrophotometry,SPPB (Short Physical Performance Battery),STAI (State-Trait-Anxiety-Inventory),Symptom experience diary (NCCTG),Thermometer,Three-stimulus drop technique (by Henkin),Tissue testing,TMT (Trail Making Test),TNS (Total Neuropathy Score),Ultrasonography,Unspecified questionnaire,Urinalysis,VAS (Visual Analogue Scale),VMI (Vaginal Maturation Index),VNS (Verbal Numerical Scale),Volometer,Western Ontario and McMaster Osteoarthritis Index,WHO-Scale (World Health Organisation),Wound volume,NI,NA,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Results during intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results during intervention&#039;&#039; means that the time of data collection is during or shortly after the period of the intervention (e.g. on the last day or a few days after). The results therefore still relate to the direct effects of the intervention.|note}}&lt;br /&gt;
{{{field|Results during intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&#039;&#039;&#039;Results after intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results after intervention&#039;&#039; means there is a longer break between the time of data collection and the end of the intervention, e.g. more than a week. The results relate more to long-term effects. &lt;br /&gt;
If a categorization in &#039;&#039;Results during vs. after intervention&#039;&#039; is not possible (e.g. survival data), the results are summarized under &#039;&#039;Results after intervention&#039;&#039; under the headline &amp;quot;Overall&amp;quot;.|note}}&lt;br /&gt;
{{{field|Results after intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
==Risk of Bias Assessment: Cochrane RoB tool 2.0==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Bias arising from the randomization process&lt;br /&gt;
| {{{field|Bias arising from the randomization process|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (assignment to intervention) &lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (assignment to intervention)|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (adhering to intervention)&lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (adhering to intervention)|input type=radiobutton|mandatory|default=NA|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to missing outcome data&lt;br /&gt;
| {{{field|Bias due to missing outcome data|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in measurement of the outcome&lt;br /&gt;
| {{{field|Bias in measurement of the outcome|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in selection of the reported result&lt;br /&gt;
| {{{field|Bias in selection of the reported result|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Other sources of bias&lt;br /&gt;
| {{{field|Other sources of bias|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Overall RoB judgment&lt;br /&gt;
| {{{field|Overall RoB judgment|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome topic:&#039;&#039;&#039; {{{field|Outcome topic|input type=text with autocomplete|mandatory|delimiter=,|values=Acai berries,Acupuncture,Agaricus,Aloe vera,Amygdalin,Angelica sinensis,Annona muricata,Antrodia,Apigenin,Argan oil,Aromatherapy,Artemisia,Astragalus,Berberine,Biobran,Boswellia serrata,Breuss diet,Broccoli sprouts,Budwig diet,Cannabinoids,Capsaicin,Carnitine,Chlorella,Chronomedicine and Oncology,Chrysin,Cimicifuga,Co-enzyme Q10/ubiquinol,Colostrum,Cranberry,Curcumin,Dichloroacetate,Electroacupuncture,Enzymes (bromelain papain),Essiac,FactorAF2,Fasting,Fermented wheat germ extract,Flor Essence,Folic acid,Galavit,Gammalinolenic acid,Germanium,Ginger (also contains zerumbone),Ginkgo,Ginseng,Glutamine,Glutathione,Glycyrrhiza glabra,Graviola,Green tea (EGCG),Guarana,Hericium erinaceus,Homeopathy,Honey,Hops,Hydrazine sulphate,Hyperthermia (whole body and electrotherapy),Indole-3-carbinol,Insulin potentiation therapy,Isoflavones and equol,Kaempferol,Kavakava,Kombucha,Lapacho,Linseed,Low-carbohydrate or ketogenic diet,Lutein,Lycopene,Macrobiotics,Magnolia,Massage,Medical mushrooms (coriolus/Maitake/Ganoderma/reishi),Melatonin,Metadon,Methylsulfonylmethane (MSM),Mind-body therapies,Mistletoe,Neem,Nigella sativa,Noni,Omega 6 fatty acids,Omega-3 fatty acids,OPC (grape seed extract),Phellinus,Piper nigra,Polyerga,Pomegranate,Probiotics,Propolis,Prostasol,Qigong and Tai Chi,Quercetin,Reflexology,Reiki (Therapeutic Touch/Healing Touch/Polarity),Resveratrol,Rhodiola,Rhubarb,Rooibos,Selenium,Shiitake,Silymarin/marigold thistle,Soy,Spirulina,St. John&#039;s wort,Supportive therapy (NW),TCM,Thymus therapy,Ukrain,Uncaria (cat&#039;s claw),Valerian,Vitamin A (beta-carotene),Vitamin B1,Vitamin B12,Vitamin B2,Vitamin B6,Vitamin C,Vitamin D,Vitamin E,Wheatgrass,Yoga,Zeolites,Zinc}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
{{{for template|Outcome Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
{{{section|Funding and Conflicts of Interest|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Funding and Conflicts of Interest}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Funding: &lt;br /&gt;
| {{{field|Funding|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Conflicts of Interest: &lt;br /&gt;
| {{{field|Conflicts of Interest|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
{{{section|Further points for assessing the study|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Further points for assessing the study}}}&lt;br /&gt;
==Sample==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Power analysis performed&lt;br /&gt;
| {{{field|power analysis performed|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sample size corresponds to power analysis&lt;br /&gt;
| {{{field|Sample size corresponds to power analysis|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Reasons for insufficient sample size based on power analysis&lt;br /&gt;
| {{{field|Reasons given for samples being too small according to power analysis|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! If no power analysis performed: at least moderate sample size (n &amp;gt;= 30 per arm)&lt;br /&gt;
| {{{field|Samples sufficiently large|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethnicity mentioned&lt;br /&gt;
| {{{field|Ethnicity mentioned|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Alternative Explanation==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Other explanations for an effect besides the investigated intervention&lt;br /&gt;
| {{{field|Other explanations for an effect besides the investigated intervention|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of attention effects {{#info: e.g. due to lack of a placebo arm|note}}&lt;br /&gt;
| {{{field|Possibility of attention effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of placebo effects&lt;br /&gt;
| {{{field|Possibility of placebo effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Other reasons&lt;br /&gt;
| {{{field|Other reasons|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Statistics==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Correct use of parametric and non-parametric tests {{#info: Testing for normal distribution only necessary if parametric tests are used, NI: use of parametric tests without report of normal distribution testing|note}} &lt;br /&gt;
| {{{field|Correct use of parametric and non-parametric tests|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Correction for multiple testing&lt;br /&gt;
| {{{field|Correction for multiple testing|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Measurement of compliance&lt;br /&gt;
| {{{field|Measurement of compliance|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Consistent reporting in numbers (figures, flowchart, abstract, results)&lt;br /&gt;
| {{{field|Consistent reporting in numbers|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comprehensive and coherent reporting&lt;br /&gt;
| {{{field|Comprehensive and coherent reporting|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-Over study&lt;br /&gt;
| {{{field|Cross-over|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sufficient washout period&lt;br /&gt;
| {{{field|sufficient washout period|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for carry-over effects&lt;br /&gt;
| {{{field|Tested for carry-over effects|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for sequence effects&lt;br /&gt;
| {{{field|Were sequence effects tested|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Interpretation of results==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Effect sizes reported (clinical vs. statistical significance)&lt;br /&gt;
| {{{field|Effect sizes reported|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects systematically recorded&lt;br /&gt;
| {{{field|Were side effects systematically recorded|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects considered in result interpretation&lt;br /&gt;
| {{{field|Side effects taken into account in the interpretation of the results|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethics votum&lt;br /&gt;
| {{{field|Ethics / CoI / Funding|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Additional Notes}}}&lt;br /&gt;
==Additional Notes==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Additional Notes|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=6769</id>
		<title>Form:RCT Study</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Form:RCT_Study&amp;diff=6769"/>
		<updated>2024-11-21T09:32:49Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
This is the &amp;quot;RCT Study&amp;quot; form.&lt;br /&gt;
To create a page with this form, enter the page name below;&lt;br /&gt;
if a page with that name already exists, you will be sent to a form to edit that page.&lt;br /&gt;
&lt;br /&gt;
{{#forminput:form=RCT Study}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&amp;lt;includeonly&amp;gt;&lt;br /&gt;
&lt;br /&gt;
=Publication=&lt;br /&gt;
&lt;br /&gt;
{{{for template|Reference}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Publication: &lt;br /&gt;
| {{{field|Reference|input type=text|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Note}}}&lt;br /&gt;
==Study Note==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Study Note|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Brief summary=&lt;br /&gt;
{{{section|Brief summary|level=1}}}&lt;br /&gt;
&lt;br /&gt;
=Study Design=&lt;br /&gt;
{{{section|Study Design|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Study Design (RCT)}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Prospective / Retrospective: {{#info: Prospective: forward-looking, examples include clinical trials, cohort studies, and long-term observational studies; &lt;br /&gt;
Retrospective: backward-looking, relying on existing data, examples include case-control studies and retrospective cohort studies|note}}&lt;br /&gt;
| {{{field|Perspective|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Monocentric / Multicentric:  {{#info: Monocentric: conducted in one center/ hospital; &lt;br /&gt;
Multicentric: conducted in multiple centers/ hospitals|note}}&lt;br /&gt;
| {{{field|Centralized|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Blinding: {{#info: No: Open, all parties are aware of group assignments; &lt;br /&gt;
Single: one party is unaware of group assignments (generally participants); &lt;br /&gt;
Double: two parties are unaware of group assignments (generally the participants and the researchers); &lt;br /&gt;
Triple: concealing group assignment from additional parties|note}}&lt;br /&gt;
| {{{field|Blinding|input type=radiobutton|mandatory|default=?|values=?,No,Single,Double,Triple,NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Is randomized: &lt;br /&gt;
| {{{field|Is randomized|input type=checkbox|default=Yes}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-over: {{#info: Participants alternate between different treatment groups or conditions over a specified period, allowing each participant to serve as their own control|note}}&lt;br /&gt;
| {{{field|Cross-over|input type=checkbox|default=No}}}&lt;br /&gt;
|-&lt;br /&gt;
! Number of arms: &lt;br /&gt;
| {{{field|Number of arms|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Study characteristics=&lt;br /&gt;
{{{section|Study characteristics|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|RCT study general properties}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Inclusion criteria: &lt;br /&gt;
| {{{field|Inclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Exclusion criteria: &lt;br /&gt;
| {{{field|Exclusion criteria|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! N randomized: &lt;br /&gt;
| {{{field|N randomized|input type=text|mandatory|default=-999}}}&lt;br /&gt;
|-&lt;br /&gt;
! Analysis: {{#info: PP: Per Protocol analysis, i.e. only participants included who adhered to the study protocol.&lt;br /&gt;
ITT: Intention-to-treat analysis, i.e. all randomized participants included regardless of any drop-outs or changes in assignment.&lt;br /&gt;
mITT: modified Intention-to-treat analysis can refer to analyses in which participants with missing outcome data are excluded or it can refer to analyses in which only participants who received at least one treatment dose are included. In this case, participants dropped out of the study prematurely for reasons unrelated to the treatment.|note}}&lt;br /&gt;
| {{{field|Analysis|input type=checkboxes|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on analyses:&lt;br /&gt;
| {{{field|Specifications on analyses|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Countries of data collection: &lt;br /&gt;
| {{{field|Countries of data collection|input type=text with autocomplete|delimiter=,|values=Afghanistan,Albania,Algeria,Andorra,Angola,Antigua &amp;amp; Deps,Argentina,Armenia,Australia,Austria,Azerbaijan,Bahamas,Bahrain,Bangladesh,Barbados,Belarus,Belgium,Belize,Benin,Bhutan,Bolivia,Bosnia Herzegovina,Botswana,Brazil,Brunei,Bulgaria,Burkina,Burundi,Cambodia,Cameroon,Canada,Cape Verde,Central African Rep,Chad,Chile,China,Colombia,Comoros,Congo,Congo {Democratic Rep},Costa Rica,Croatia,Cuba,Cyprus,Czech Republic,Denmark,Djibouti,Dominica,Dominican Republic,East Timor,Ecuador,Egypt,El Salvador,Equatorial Guinea,Eritrea,Estonia,Ethiopia,Europe,Fiji,Finland,France,Gabon,Gambia,Georgia,Germany,Ghana,Greece,Grenada,Guatemala,Guinea,Guinea-Bissau,Guyana,Haiti,Honduras,Hungary,Iceland,India,Indonesia,Iran,Iraq,Ireland {Republic},Israel,Italy,Ivory Coast,Jamaica,Japan,Jordan,Kazakhstan,Kenya,Kiribati,Korea North,Korea South,Kosovo,Kuwait,Kyrgyzstan,Laos,Latin America,Latvia,Lebanon,Lesotho,Liberia,Libya,Liechtenstein,Lithuania,Luxembourg,Macedonia,Madagascar,Malawi,Malaysia,Maldives,Mali,Malta,Marshall Islands,Mauritania,Mauritius,Mexico,Micronesia,Moldova,Monaco,Mongolia,Montenegro,Morocco,Mozambique,Myanmar,{Burma},Namibia,Nauru,Nepal,Netherlands,New Zealand,Nicaragua,Niger,Nigeria,North America,Norway,Oman,Pakistan,Palau,Panama,Papua New Guinea,Paraguay,Peru,Philippines,Poland,Portugal,Qatar,Romania,Russian Federation,Rwanda,St Kitts &amp;amp; Nevis,St Lucia,Saint Vincent &amp;amp; the Grenadines,Samoa,San Marino,Sao Tome &amp;amp; Principe,Saudi Arabia,Senegal,Serbia,Seychelles,Sierra Leone,Singapore,Slovakia,Slovenia,Solomon Islands,Somalia,South Africa,South Sudan,Spain,Sri Lanka,Sudan,Suriname,Swaziland,Sweden,Switzerland,Syria,Taiwan,Tajikistan,Tanzania,Thailand,Togo,Tonga,Trinidad &amp;amp; Tobago,Tunisia,Turkey,Turkmenistan,Tuvalu,Uganda,Ukraine,United Arab Emirates,United Kingdom,United Kingdom - Great Britain,United States,United States - New York,United States - Texas,Uruguay,Uzbekistan,Vanuatu,Vatican City,Venezuela,Vietnam,Yemen,Zambia,Zimbabwe,NI,?|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! LoE: {{#info: Level of evidence|note}}&lt;br /&gt;
| {{{field|LoE|input type=dropdown|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Outcome timeline: {{#info: Data collection times|note}}&lt;br /&gt;
| {{{field|Outcome timeline|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
=Characteristics of participants=&lt;br /&gt;
{{{section|Characteristics of participants|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Characteristics of participants}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Setting: {{#info: Refers to cancer therapy setting.&lt;br /&gt;
- Curative therapy: aims to completely eradicate a disease and achieve a full recovery; &lt;br /&gt;
- Neo-adjuvant therapy: form of curative therapy, given before the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Adjuvant therapy: form of curative therapy, given after the primary treatment for cancer (usually surgery); &lt;br /&gt;
- Palliative therapy: focuses on providing relief from symptoms and improving the quality of life for patients, without necessarily targeting the underlying disease; &lt;br /&gt;
- Active surveillance: involves close monitoring of disease progression without any intervention (typically used for prostate cancer);&lt;br /&gt;
- No therapy setting: Patients who completed therapy/are currently not in cancer treatment, cancer survivors.|note}}&lt;br /&gt;
| {{{field|Setting|input type=checkboxes|delimiter=,|default=?|mandatory|values=?, Curative, Neo-adjuvant, Adjuvant, Palliative, Active surveillance, No therapy setting, NI}}}&lt;br /&gt;
|-&lt;br /&gt;
! Types of cancer: {{#info: &amp;quot;Other Cancers&amp;quot; means that only a subpopulation was specified, but further unspecified cancer types were included|note}}&lt;br /&gt;
| {{{field|Types of cancer|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Adrenal Cancer,Anal Cancer,Bile Duct Cancer,Bone and Soft Tissue Cancers, Bone and Soft Tissue Cancers - Osteosarcoma,Bone and Soft Tissue Cancers - Ewing Sarcoma,Bone and Soft Tissue Cancers - Chondrosarcoma,Bone and Soft Tissue Cancers - Rhabdomyosarcoma,Bone and Soft Tissue Cancers – Liposarcoma,Brain and Central Nervous System (CNS) Cancers,Brain and Central Nervous System (CNS) Cancers - Astrocytoma,Brain and Central Nervous System (CNS) Cancers - Glioblastoma,Brain and Central Nervous System (CNS) Cancers - High-Grade Glioma,Brain and Central Nervous System (CNS) Cancers - Meningioma,Breast Cancer,Breast Cancer - Ductal Carcinoma,Breast Cancer - Lobular Carcinoma,Breast Cancer - Inflammatory Breast Cancer,Breast Cancer - Triple-Negative Breast Cancer,Carcinosarcoma,Chest Cancer,Colorectal Cancer,Colorectal Cancer - Colon Cancer,Colorectal Cancer - Rectal Cancer,Eye Cancer,Eye Cancer - Retinoblastoma,Gastrointestinal Cancers,Gastrointestinal Cancers - Gallbladder Cancer,Gastrointestinal Cancers - Gastric (Stomach) Cancer,Gastrointestinal Cancers - Esophageal Cancer,Gastrointestinal Cancers - Pancreatic Cancer,Gastrointestinal Cancers - Liver Cancer,Genitourinary Cancers,Genitourinary Cancers - Bladder Cancer,Genitourinary Cancers - Kidney (Renal) Cancer,Genitourinary Cancers - Testicular Cancer,Genitourinary Cancers - Urethral Cancer,Gynecologic Cancers,Gynecologic Cancers - Ovarian Cancer,Gynecologic Cancers - Cervical Cancer,Gynecologic Cancers - Uterine Cancer,Gynecologic Cancers - Endometrial Cancer,Gynecologic Cancers - Vulvar Cancer,Head and Neck Cancers, Head and Neck Cancers - Oral Cancer,Head and Neck Cancers - Oropharyngeal Cancer,Head and Neck Cancers - Laryngeal Cancer,Head and Neck Cancers - Nasopharyngeal Cancer,Head and Neck Cancers - Tongue Cancer,Head and Neck Cancers - Thyroid Cancer,Head and Neck Cancers - Ethmoid Sinus Cancer,Hematologic Cancers, Hematologic Cancers - Leukemia (Acute Lymphocytic/Acute Myeloid/Chronic Lymphocytic/Chronic Myeloid), Hematologic Cancers - Lymphoma (Hodgkin and Non-Hodgkin),Hematologic Cancers - Multiple Myeloma,Lung Cancer,Lung Cancer - Small Cell Lung Cancer,Lung Cancer - Non-Small Cell Lung Cancer,Mesothelioma,Neuroblastoma,Prostate Cancer,Skin Cancer,Skin Cancer - Basal Cell Carcinoma,Skin Cancer - Squamous Cell Carcinoma,Skin Cancer – Melanoma,Stomach Cancer,Solid Malignancies,Thymoma and Thymic Carcinoma,Unspecified Sarcoma,Other Cancers,NI,?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage: {{#info: Early Stage: generally refers to cancer that is localized to the area where it started, mostly stages I and II;&lt;br /&gt;
Advanced Stage: cancer that has spread beyond its original site, mostly stages III and IV, with stage IV indicating distant metastasis|note}}&lt;br /&gt;
| {{{field|Stage cancer|input type=checkboxes|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cancer stage specification: &lt;br /&gt;
| {{{field|Cancer stage specification|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comorbidity: &lt;br /&gt;
| {{{field|Comorbidity|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Current cancer therapy: &lt;br /&gt;
| {{{field|Current cancer therapy|input type=text with autocomplete|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Specifications on cancer therapies: &lt;br /&gt;
| {{{field|Specifications on cancer therapies|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Previous cancer therapies: &lt;br /&gt;
| {{{field|Previous cancer therapies|input type=text with autocomplete|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender: &lt;br /&gt;
| {{{field|Gender|input type=radiobutton|mandatory|values=?, Male, Female, Mixed, NI|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Gender specifications: &lt;br /&gt;
| {{{field|Gender specifications|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups: &lt;br /&gt;
| {{{field|Age groups|input type=checkboxes|values=?, Children (0-15), Adolescents and young adults (15-39), Adults (18+), Elderly (65+), NI|default=adults (18+)}}}&lt;br /&gt;
|-&lt;br /&gt;
! Age groups specification: &lt;br /&gt;
| {{{field|Age groups specification|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
=Arms=&lt;br /&gt;
{{{section|Arms|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Arm type:&#039;&#039;&#039; {{#info: Active control: group receives active treatment; &lt;br /&gt;
Passive control: for example: treatment as usual, waiting control, no treatment|note}}&lt;br /&gt;
{{{field|Arm type|input type=checkboxes|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Number of participants (arm):&#039;&#039;&#039; {{{field|Number of participants (arm)|input type=text|mandatory|default=-999}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out:&#039;&#039;&#039; {{#info: Number of participants who left the study for any reason or did not provide information on every data collection date|note}} {{{field|Drop-out|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Drop-out reasons:&#039;&#039;&#039; {{{field|Drop-out reasons|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Intervention:&#039;&#039;&#039; {{{field|Intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Dosage and regime:&#039;&#039;&#039; {{{field|Dosage and regime|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;One-time application:&#039;&#039;&#039; {{{field|One-time application|input type=checkbox|mandatory|default=No}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Duration in days:&#039;&#039;&#039; {{#info: For long-term interventions, the number of days is an estimate.&lt;br /&gt;
A value of -999 indicates that the exact duration cannot be extracted from the study due to ambiguous or incomplete information. See &#039;&#039;Outcome timeline&#039;&#039; or &#039;&#039;Dosage and regime&#039;&#039; for further information. |note}}&lt;br /&gt;
{{{field|Duration in days|input type=regexp|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Side Effects / Interactions:&#039;&#039;&#039; {{{field|Side Effects / Interactions|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Arm Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Outcomes=&lt;br /&gt;
{{{section|Outcomes|level=1}}}&lt;br /&gt;
{{{for template|Outcome|multiple}}}&lt;br /&gt;
&#039;&#039;&#039;Outcome type:&#039;&#039;&#039; {{#info: As specificed by the authors| note}} {{{field|Outcome type|input type=radiobutton|mandatory|default=?|values=?,Primary,Secondary,Others,NI}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome name:&#039;&#039;&#039; {{{field|Outcome name|input type=text with autocomplete|mandatory|default=?|delimiter=,|values=Additional medication,Anorexia/Cachexia,Antibodies,Anxiety,Appetite,Arterial inflow,BMD (Bone Mineral Density),Body composition,Carnitine level,Carotenoid concentration,Cerebral oedema,CINV (Chemotherapy-Induced Nausea and Vomiting),Cognitive functioning,Cognitive impairment,Depression,Dermatitis,DFS (Disease-Free Survival),Diarrhoe,Distress,Dysgeusia,EFS (Event-Free Survival),Ejection fraction,Emesis,Erectile dysfunction,Erythema,Esophagitis,Fatigue,Fever,Fibrosis,Folic acid level,Frequency of rescue analgesics,Functionality,Haematological indices,Haematological toxicity,Hand-foot syndrome,Hand grip strength,Hepatotoxicity,Hot flushes,Hormone level,Ileus (intestinal obstruction),Incidence of acute GVHD (Graft-Versus-Host Disease),Infection,Interaction with cancer treatment,Laboratory parameters,Length of hospital stay,LFS (Local-Free Survival),Lymphedema,Menopausal symptoms,Mental status/ function,MFS (Metastases-Free Survival),Mood/Affect,Mortality rate,MTD (Maximum Tolerated Dose),Mucositis,Musculoskeletal symptoms,Nausea,Nausea and Vomiting,Nerve conduction velocity,Neurotoxicity,Neutropenia,Non-haematological indices,Nutrition status,Objective signs and subjective symptoms,Oral ulcus,OS (Overall Survival),Ototoxicity,Pain,PD (Pharmacodynamics),Performance Status,Peripheral neuropathy,PFS (Progression-Free Survival),Pharyngitis,Physical functioning,PK (Pharmacokinetics),Postoperative morbidity/ complications,Postoperative opiate consumption,PSADT (Prostate-Specific Antigen Doubling Time),PSA level (Prostate-Specific Antigen),Quality of life,Recurrence rate,Reduction of complication rates,REE (Resting Energy Expenditure),Relaxation,Restoration of bowel function after surgery,RFS (Recurrence-Free Survival),Salivary gland function,Selenium level,Seroconversion,Shoulder mobility,Side effects of androgen deprivation/suppression,Side effects of tooth extraction,Skeletal morbidity-free survival,Sleep,Stomatitis,Stress,Symptom load,Taste alteration,Tea polyphenol uptake,Thromboembolic event rates,Toxicity,Treatment interruption,Tumor progression,Tumor response,Vaginal atrophy,Vitamin A level,Vitamin B6 level,Vitamin B12 level,Vitamin B17 level,Vitamin C level,Vitamin D level,Vitamin E level,Vomiting,Weight,Well-being,Wound healing,Wound odour,Xerostomia,Zinc level,Unspecified effects,NI,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Outcome specification:&#039;&#039;&#039; {{{field|Outcome specification|input type=textarea|default=?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Type of measurement:&#039;&#039;&#039; {{{field|Type of measurement|input type=tokens|mandatory|default=?|delimiter=,|values=AQoL-8D (Assessment of Quality of Life),ASAT (Auditory Sustained Attention Test),Atomic absorption,Audiogram,AUSCAN (Australian/Canadian Osteoarthritis Hand Index),BCPT (Breast Cancer Prevention Symptom Scales),BDI (Beck Depression Inventory),BFI (Brief Fatigue Inventory),BIA (Bioelectrical impedance analysis),Blood Test,BPI-SF (Brief Pain Inventory - Short Form),CES-D (Center for Epidemiologic Studies - Depression Scale),Chemiluminescent immunoassay,CNPI (Checklist of Non-Verbal Pain Indicators),CSSP (Catterall Skin Scoring Profile),CT (Computed Tomography),CTCAE (Common Terminology Criteria of Adverse Events),Cystoscopy,Diary questionnaire,DXA (Dual energy X-ray Absorptiometry),Dynamometer,Echo-color Doppler,ECOG Performance Status Scale (Eastern Cooperative Oncology Group),Electronic monitoring device,Electrophysiological evaluation,ELISA protocol (Enzyme-Linked Immunoabsorbent Assay),EORTC QLQ (European Organisation for Research and Treatment of Cancer Core/ Quality of Life questionnaire),ESAS (Edmonton Symptom Assessment Scale),FAACT (Functional Assessment of Anorexia-Cachexia Therapy),FACIT (Functional Assessment of Chronic Illness Therapy),FACT (Functional Assessment of Cancer Therapy),FGS (Hughes&#039; Functional Grading Scale),FIQ (Fibromyalgia Impact Questionnaire),FLIE (Functional Living Index for Emesis),Genitourinary atrophy self-assessment tool,GFAAS (Graphite Furnace Atomic Absorption Spectrometry),Global Charter Fatigue Scale,HADS (Hospital Anxiety and Depression Scale),HAQ-DI (Health Assessment Questionnaire-Disability Index),HFRDIS (Hot Flash Related Daily Interference Scale),HFS (Hot Flush Score),HGST Maximum (Handgrip Strength Test),Histological examination,HNQR (Head and Neck Radiotherapy Questionnaire),HSCS (High Sensitivity Cognitive Screen),ICI Test (Intracavernosal Injection Test),IIEF (International Index of Erectile Function),Interview,KPS (Karnofsky Performance Status),LASA (Linear Analogue Self-Assessment),LENT SOMA Scale (Late Effects on Normal Tissues/ Subjective Objective Management Analysis),MADRS (Montgomery-Asberg Depression Rating Scale),MAT (Multinational Association of Supportive Care in Cancer-Antiemesis Tool),McDonald criteria,MDASI (M. D. Anderson Symptom Inventory),Measuring tape,MENQOL (Menopause-Specific Quality of Life),MFI-20 (Multidimensional Fatigue Inventory-20),MMSE (Mini-Mental State Exam),Morbidity rating scale (by Dische),MOS SF-12 (Medical Outcomes Study/ 12-Item Short Form Health Survey),MPQ-SF (McGill Pain Questionnaire - Short Form),MRI (Magnetic Resonance Imaging),MRS (Mood Rating Scale),MYCaW (Measure Yourself Concerns and Wellbeing),NCI-CTC v.2 (National Cancer Institute-Common Toxic Criteria),NCI Grading Scale (National Cancer Institute),NDS (Neurological Disability Score),Neurologic examination,Neuropathy specific question,NRS (Numeric Rating Scale),NRS (Nutritional Risk Screening),NSS (Neurological Symptom Score),Observation,OMAS (Oral Mucositis Assessment Scale),Otoacoustic Emissions Testing,PAC-QoL (Patient Assessment of Constipation - Quality of Life),PGIC (Physician Global Impression of Change),PG-SGA (Patient-Generated Subjective Global Assessment),PHLF (Post Hepatectomy Liver Failure),PHS (Cognitive subscale of the Perceived Health Scale),pH-value,Physical examination,Physical functioning (grip strength;6 minute walk;leg extension),POMS (Profile of Mood States),PoSSe (Postoperative Symptom Severity Scale),Postoperative morbidity/complications (classification according to Clavien-Dindo),PROMIS (Patient-Reported Outcomes Measurement Information System),PSQ (Patient Satisfaction Questionnaire),PSQI (Pittsburgh Sleep Quality Index),QoR-40 (Quality of Recovery-40 Questionnaire),RDS (Radiation Dermatitis Severity),RECIST 1.0 Criteria (Response Evaluation Criteria in Solid Tumors),Reidel-Seiffer tuning fork,Rhodes Inventory of Nausea,RPSAS (Radiation Proctopathy System Assessment Scale),RTOG Acute Radiation Morbidity Scoring Criteria (Radiation Therapy Oncology Group),Scale,SCID (Structured Clinical Interview for DSM IV),Scintigraphy,Self-developed measurement instrument,SF-36 (Short Form-36 Health Survey),SF-MPQ (Short-Form McGill Pain Questionnaire),SGIC (Subject Global Impression of Change),SI (Symptom Inventory questionnaire),SOMA (Subjective Objective Medical management and Analytic evaluation of injury),SPECT (Single Photon Emission Computed Tomography),Spectrophotometry,SPPB (Short Physical Performance Battery),STAI (State-Trait-Anxiety-Inventory),Symptom experience diary (NCCTG),Thermometer,Three-stimulus drop technique (by Henkin),Tissue testing,TMT (Trail Making Test),TNS (Total Neuropathy Score),Ultrasonography,Unspecified questionnaire,Urinalysis,VAS (Visual Analogue Scale),VMI (Vaginal Maturation Index),VNS (Verbal Numerical Scale),Volometer,Western Ontario and McMaster Osteoarthritis Index,WHO-Scale (World Health Organisation),Wound volume,NI,NA,?}}}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Results during intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results during intervention&#039;&#039; means that the time of data collection is during or shortly after the period of the intervention (e.g. on the last day or a few days after). The results therefore still relate to the direct effects of the intervention.|note}}&lt;br /&gt;
{{{field|Results during intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
&#039;&#039;&#039;Results after intervention:&#039;&#039;&#039; {{#info: &#039;&#039;Results after intervention&#039;&#039; means there is a longer break between the time of data collection and the end of the intervention, e.g. more than a week. The results relate more to long-term effects. &lt;br /&gt;
If a categorization in &#039;&#039;Results during vs. after intervention&#039;&#039; is not possible (e.g. survival data), the results are summarized under &#039;&#039;Results after intervention&#039;&#039; under the headline &amp;quot;Overall&amp;quot;.|note}}&lt;br /&gt;
{{{field|Results after intervention|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
==Risk of Bias Assessment: Cochrane RoB tool 2.0==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Bias arising from the randomization process&lt;br /&gt;
| {{{field|Bias arising from the randomization process|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (assignment to intervention) &lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (assignment to intervention)|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to deviation from intended intervention (adhering to intervention)&lt;br /&gt;
| {{{field|Bias due to deviation from intended intervention (adhering to intervention)|input type=radiobutton|mandatory|default=NA|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias due to missing outcome data&lt;br /&gt;
| {{{field|Bias due to missing outcome data|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in measurement of the outcome&lt;br /&gt;
| {{{field|Bias in measurement of the outcome|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk, NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Bias in selection of the reported result&lt;br /&gt;
| {{{field|Bias in selection of the reported result|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Other sources of bias&lt;br /&gt;
| {{{field|Other sources of bias|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|-&lt;br /&gt;
! Overall RoB judgment&lt;br /&gt;
| {{{field|Overall RoB judgment|input type=radiobutton|mandatory|default=?|values=?,low risk,some concerns,high risk,NA}}}&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&#039;&#039;&#039;Order number:&#039;&#039;&#039; {{{field|Order number|input type=text|mandatory|default=1}}}&lt;br /&gt;
&#039;&#039;&#039;Outcome topic:&#039;&#039;&#039; {{{field|Outcome topic|input type=text with autocomplete|mandatory|delimiter=,|values=Acai berries,Acupuncture,Agaricus,Aloe vera,Amygdalin,Angelica sinensis,Annona muricata,Antrodia,Apigenin,Argan oil,Aromatherapy,Artemisia,Astragalus,Berberine,Biobran,Boswellia serrata,Breuss diet,Broccoli sprouts,Budwig diet,Cannabinoids,Capsaicin,Carnitine,Chlorella,Chronomedicine and Oncology,Chrysin,Cimicifuga,Co-enzyme Q10/ubiquinol,Colostrum,Cranberry,Curcumin,Dichloroacetate,Electroacupuncture,Enzymes (bromelain papain),Essiac,FactorAF2,Fasting,Fermented wheat germ extract,Flor Essence,Folic acid,Galavit,Gammalinolenic acid,Germanium,Ginger (also contains zerumbone),Ginkgo,Ginseng,Glutamine,Glutathione,Glycyrrhiza glabra,Graviola,Green tea (EGCG),Guarana,Hericium erinaceus,Homeopathy,Honey,Hops,Hydrazine sulphate,Hyperthermia (whole body and electrotherapy),Indole-3-carbinol,Insulin potentiation therapy,Isoflavones and equol,Kaempferol,Kavakava,Kombucha,Lapacho,Linseed,Low-carbohydrate or ketogenic diet,Lutein,Lycopene,Macrobiotics,Magnolia,Massage,Medical mushrooms (coriolus/Maitake/Ganoderma/reishi),Melatonin,Metadon,Methylsulfonylmethane (MSM),Mind-body therapies,Mistletoe,Neem,Nigella sativa,Noni,Omega 6 fatty acids,Omega-3 fatty acids,OPC (grape seed extract),Phellinus,Piper nigra,Polyerga,Pomegranate,Probiotics,Propolis,Prostasol,Qigong and Tai Chi,Quercetin,Reflexology,Reiki (Therapeutic Touch/Healing Touch/Polarity),Resveratrol,Rhodiola,Rhubarb,Rooibos,Selenium,Shiitake,Silymarin/marigold thistle,Soy,Spirulina,St. John&#039;s wort,Supportive therapy (NW),TCM,Thymus therapy,Ukrain,Uncaria (cat&#039;s claw),Valerian,Vitamin A (beta-carotene),Vitamin B1,Vitamin B12,Vitamin B2,Vitamin B6,Vitamin C,Vitamin D,Vitamin E,Wheatgrass,Yoga,Zeolites,Zinc}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
{{{for template|Outcome Overview}}}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Funding and Conflicts of Interest=&lt;br /&gt;
{{{section|Funding and Conflicts of Interest|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Funding and Conflicts of Interest}}}&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Funding: &lt;br /&gt;
| {{{field|Funding|input type=textarea|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Conflicts of Interest: &lt;br /&gt;
| {{{field|Conflicts of Interest|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
=Further points for assessing the study=&lt;br /&gt;
{{{section|Further points for assessing the study|level=1}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Further points for assessing the study}}}&lt;br /&gt;
==Sample==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Power analysis performed&lt;br /&gt;
| {{{field|power analysis performed|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sample size corresponds to power analysis&lt;br /&gt;
| {{{field|Sample size corresponds to power analysis|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Reasons for insufficient sample size based on power analysis&lt;br /&gt;
| {{{field|Reasons given for samples being too small according to power analysis|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! If no power analysis performed: at least moderate sample size (n &amp;gt;= 30 per arm)&lt;br /&gt;
| {{{field|Samples sufficiently large|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethnicity mentioned&lt;br /&gt;
| {{{field|Ethnicity mentioned|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Alternative Explanation==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Other explanations for an effect besides the investigated intervention&lt;br /&gt;
| {{{field|Other explanations for an effect besides the investigated intervention|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of attention effects {{#info: e.g. due to lack of a placebo arm|note}}&lt;br /&gt;
| {{{field|Possibility of attention effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Possibility of placebo effects&lt;br /&gt;
| {{{field|Possibility of placebo effects|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Other reasons&lt;br /&gt;
| {{{field|Other reasons|input type=textarea|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Statistics==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Correct use of parametric and non-parametric tests {{#info: Testing for normal distribution only necessary if parametric tests are used, NI: use of parametric tests without report of normal distribution testing|note}} &lt;br /&gt;
| {{{field|Correct use of parametric and non-parametric tests|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Correction for multiple testing&lt;br /&gt;
| {{{field|Correction for multiple testing|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Measurement of compliance&lt;br /&gt;
| {{{field|Measurement of compliance|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Consistent reporting in numbers (figures, flowchart, abstract, results)&lt;br /&gt;
| {{{field|Consistent reporting in numbers|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Comprehensive and coherent reporting&lt;br /&gt;
| {{{field|Comprehensive and coherent reporting|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Cross-Over study&lt;br /&gt;
| {{{field|Cross-over|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Sufficient washout period&lt;br /&gt;
| {{{field|sufficient washout period|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for carry-over effects&lt;br /&gt;
| {{{field|Tested for carry-over effects|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;text-indent:3em;&amp;quot; | - Tested for sequence effects&lt;br /&gt;
| {{{field|Were sequence effects tested|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
==Interpretation of results==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
! Effect sizes reported (clinical vs. statistical significance)&lt;br /&gt;
| {{{field|Effect sizes reported|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects systematically recorded&lt;br /&gt;
| {{{field|Were side effects systematically recorded|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Side effects considered in result interpretation&lt;br /&gt;
| {{{field|Side effects taken into account in the interpretation of the results|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|-&lt;br /&gt;
! Ethics votum&lt;br /&gt;
| {{{field|Ethics / CoI / Funding|input type=radiobutton|mandatory|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
{{{for template|Additional Notes}}}&lt;br /&gt;
==Additional Notes==&lt;br /&gt;
{| class=&amp;quot;formtable&amp;quot;&lt;br /&gt;
|{{{field|Additional Notes|input type=textarea|default=?}}}&lt;br /&gt;
|}&lt;br /&gt;
{{{end template}}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:Outcome&amp;diff=6768</id>
		<title>Template:Outcome</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:Outcome&amp;diff=6768"/>
		<updated>2024-11-21T09:28:53Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
{{#template_params:Outcome type (list;property=Outcome type)|Outcome name (list;property=Outcome name)|Outcome specification (property=Outcome specification)|Type of measurement (list;property=Type of measurement)|Timestamp measurement (property=Timestamp measurement)|Result (property=Result)|Bias arising from the randomization process (label=arising from the randomization process;property=Bias arising from the randomization process)|Bias due to deviation from intended intervention (assignment to intervention) (property=Bias due to deviation from intended intervention (assignment to intervention))|Bias due to deviation from intended intervention (adhering to intervention) (property=Bias due to deviation from intended intervention (adhering to intervention)) |Bias due to missing outcome data (property=Bias due to missing outcome data)|Bias in measurement of the outcome (property=Bias in measurement of the outcome)|Bias in selection of the reported result (property=Bias in selection of the reported result)|Other sources of bias (property=Other sources of bias)|Overall RoB judgment (property=Overall RoB judgment)}}&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
{{#subobject:|&lt;br /&gt;
|Outcome name={{{Outcome name|}}}|+sep=,&lt;br /&gt;
|Outcome type={{{Outcome type|}}} &lt;br /&gt;
|Outcome specification={{{Outcome specification|}}}&lt;br /&gt;
|Type of measurement={{{Type of measurement|}}}|+sep=,&lt;br /&gt;
|Results during intervention={{{Results during intervention|}}}&lt;br /&gt;
|Results after intervention={{{Results after intervention|}}}&lt;br /&gt;
|Bias arising from the randomization process={{{Bias arising from the randomization process|}}}&lt;br /&gt;
|Bias due to deviation from intended intervention (assignment to intervention)={{{Bias due to deviation from intended intervention (assignment to intervention)|}}}&lt;br /&gt;
|Bias due to deviation from intended intervention (adhering to intervention)={{{Bias due to deviation from intended intervention (adhering to intervention) }}}&lt;br /&gt;
|Bias due to missing outcome data={{{Bias due to missing outcome data|}}}&lt;br /&gt;
|Bias in measurement of the outcome={{{Bias in measurement of the outcome|}}}&lt;br /&gt;
|Bias in selection of the reported result={{{Bias in selection of the reported result|}}}&lt;br /&gt;
|Other sources of bias={{{Other sources of bias|}}}&lt;br /&gt;
|Overall RoB judgment={{{Overall RoB judgment|}}}&lt;br /&gt;
|Outcome topic={{{Outcome topic|}}}&lt;br /&gt;
|Order number={{{Order number|}}}&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Property:Outcome_topic&amp;diff=6767</id>
		<title>Property:Outcome topic</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Property:Outcome_topic&amp;diff=6767"/>
		<updated>2024-11-21T09:25:34Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;This is a property of type [[Has type::Text]].&lt;br /&gt;
&lt;br /&gt;
The allowed values for this property are:&lt;br /&gt;
* [[Allows value::Acai berries]]&lt;br /&gt;
* [[Allows value::Acupuncture]]&lt;br /&gt;
* [[Allows value::Agaricus]]&lt;br /&gt;
* [[Allows value::Aloe vera]]&lt;br /&gt;
* [[Allows value::Amygdalin]]&lt;br /&gt;
* [[Allows value::Angelica sinensis]]&lt;br /&gt;
* [[Allows value::Annona muricata]]&lt;br /&gt;
* [[Allows value::Antrodia]]&lt;br /&gt;
* [[Allows value::Apigenin]]&lt;br /&gt;
* [[Allows value::Argan oil]]&lt;br /&gt;
* [[Allows value::Aromatherapy]]&lt;br /&gt;
* [[Allows value::Artemisia]]&lt;br /&gt;
* [[Allows value::Astragalus]]&lt;br /&gt;
* [[Allows value::Berberine]]&lt;br /&gt;
* [[Allows value::Biobran]]&lt;br /&gt;
* [[Allows value::Boswellia serrata]]&lt;br /&gt;
* [[Allows value::Breuss diet]]&lt;br /&gt;
* [[Allows value::Broccoli sprouts]]&lt;br /&gt;
* [[Allows value::Budwig diet]]&lt;br /&gt;
* [[Allows value::Cannabinoids]]&lt;br /&gt;
* [[Allows value::Capsaicin]]&lt;br /&gt;
* [[Allows value::Carnitine]]&lt;br /&gt;
* [[Allows value::Chlorella]]&lt;br /&gt;
* [[Allows value::Chronomedicine and Oncology]]&lt;br /&gt;
* [[Allows value::Chrysin]]&lt;br /&gt;
* [[Allows value::Cimicifuga]]&lt;br /&gt;
* [[Allows value::Co-enzyme Q10/ubiquinol]]&lt;br /&gt;
* [[Allows value::Colostrum]]&lt;br /&gt;
* [[Allows value::Cranberry]]&lt;br /&gt;
* [[Allows value::Curcumin]]&lt;br /&gt;
* [[Allows value::Dichloroacetate]]&lt;br /&gt;
* [[Allows value::Electroacupuncture]]&lt;br /&gt;
* [[Allows value::Enzymes (bromelain papain)]]&lt;br /&gt;
* [[Allows value::FactorAF2]]&lt;br /&gt;
* [[Allows value::Fasting]]&lt;br /&gt;
* [[Allows value::Fermented wheat germ extract]]&lt;br /&gt;
* [[Allows value::Flor Essence, Essiac]]&lt;br /&gt;
* [[Allows value::Folic acid]]&lt;br /&gt;
* [[Allows value::Galavit]]&lt;br /&gt;
* [[Allows value::Gammalinolenic acid]]&lt;br /&gt;
* [[Allows value::Germanium]]&lt;br /&gt;
* [[Allows value::Ginger]]&lt;br /&gt;
* [[Allows value::Ginkgo]]&lt;br /&gt;
* [[Allows value::Ginseng]]&lt;br /&gt;
* [[Allows value::Glutamine]]&lt;br /&gt;
* [[Allows value::Glutathione]]&lt;br /&gt;
* [[Allows value::Glycyrrhiza glabra]]&lt;br /&gt;
* [[Allows value::Graviola]]&lt;br /&gt;
* [[Allows value::Green tea (EGCG)]]&lt;br /&gt;
* [[Allows value::Guarana]]&lt;br /&gt;
* [[Allows value::Hericium erinaceus]]&lt;br /&gt;
* [[Allows value::Homeopathy]]&lt;br /&gt;
* [[Allows value::Honey]]&lt;br /&gt;
* [[Allows value::Hops]]&lt;br /&gt;
* [[Allows value::Hydrazine sulphate]]&lt;br /&gt;
* [[Allows value::Hyperthermia (whole body and electrotherapy)]]&lt;br /&gt;
* [[Allows value::Indole-3-carbinol]]&lt;br /&gt;
* [[Allows value::Insulin potentiation therapy]]&lt;br /&gt;
* [[Allows value::Isoflavones and equol]]&lt;br /&gt;
* [[Allows value::Kaempferol]]&lt;br /&gt;
* [[Allows value::Kavakava]]&lt;br /&gt;
* [[Allows value::Kombucha]]&lt;br /&gt;
* [[Allows value::Lapacho]]&lt;br /&gt;
* [[Allows value::Linseed]]&lt;br /&gt;
* [[Allows value::Low-carbohydrate or ketogenic diet]]&lt;br /&gt;
* [[Allows value::Lutein]]&lt;br /&gt;
* [[Allows value::Lycopene]]&lt;br /&gt;
* [[Allows value::Macrobiotics]]&lt;br /&gt;
* [[Allows value::Magnolia]]&lt;br /&gt;
* [[Allows value::Massage]]&lt;br /&gt;
* [[Allows value::Medical mushrooms (coriolus/Maitake/Ganoderma/reishi)]]&lt;br /&gt;
* [[Allows value::Melatonin]]&lt;br /&gt;
* [[Allows value::Metadon]]&lt;br /&gt;
* [[Allows value::Methylsulfonylmethane (MSM)]]&lt;br /&gt;
* [[Allows value::Mind-body therapies]]&lt;br /&gt;
* [[Allows value::Mistletoe]]&lt;br /&gt;
* [[Allows value::Neem]]&lt;br /&gt;
* [[Allows value::Nigella sativa]]&lt;br /&gt;
* [[Allows value::Noni]]&lt;br /&gt;
* [[Allows value::Omega 6 fatty acids]]&lt;br /&gt;
* [[Allows value::Omega-3 fatty acids]]&lt;br /&gt;
* [[Allows value::OPC (grape seed extract)]]&lt;br /&gt;
* [[Allows value::Phellinus]]&lt;br /&gt;
* [[Allows value::Piper nigra]]&lt;br /&gt;
* [[Allows value::Polyerga]]&lt;br /&gt;
* [[Allows value::Pomegranate]]&lt;br /&gt;
* [[Allows value::Probiotics]]&lt;br /&gt;
* [[Allows value::Propolis]]&lt;br /&gt;
* [[Allows value::Prostasol]]&lt;br /&gt;
* [[Allows value::Qigong and Tai Chi]]&lt;br /&gt;
* [[Allows value::Quercetin]]&lt;br /&gt;
* [[Allows value::Reflexology]]&lt;br /&gt;
* [[Allows value::Reiki (Therapeutic Touch/Healing Touch/Polarity)]]&lt;br /&gt;
* [[Allows value::Resveratrol]]&lt;br /&gt;
* [[Allows value::Rhodiola]]&lt;br /&gt;
* [[Allows value::Rhubarb]]&lt;br /&gt;
* [[Allows value::Rooibos]]&lt;br /&gt;
* [[Allows value::Selenium]]&lt;br /&gt;
* [[Allows value::Shiitake]]&lt;br /&gt;
* [[Allows value::Silymarin/marigold thistle]]&lt;br /&gt;
* [[Allows value::Soy]]&lt;br /&gt;
* [[Allows value::Spirulina]]&lt;br /&gt;
* [[Allows value::St. John&#039;s wort]]&lt;br /&gt;
* [[Allows value::Supportive therapy (NW)]]&lt;br /&gt;
* [[Allows value::TCM]]&lt;br /&gt;
* [[Allows value::Thymus therapy]]&lt;br /&gt;
* [[Allows value::Ukrain]]&lt;br /&gt;
* [[Allows value::Uncaria (cat&#039;s claw)]]&lt;br /&gt;
* [[Allows value::Valerian]]&lt;br /&gt;
* [[Allows value::Vitamin A (beta-carotene)]]&lt;br /&gt;
* [[Allows value::Vitamin B1]]&lt;br /&gt;
* [[Allows value::Vitamin B12]]&lt;br /&gt;
* [[Allows value::Vitamin B2]]&lt;br /&gt;
* [[Allows value::Vitamin B6]]&lt;br /&gt;
* [[Allows value::Vitamin C]]&lt;br /&gt;
* [[Allows value::Vitamin D]]&lt;br /&gt;
* [[Allows value::Vitamin E]]&lt;br /&gt;
* [[Allows value::Wheatgrass]]&lt;br /&gt;
* [[Allows value::Yoga]]&lt;br /&gt;
* [[Allows value::Zeolites]]&lt;br /&gt;
* [[Allows value::Zinc]]&lt;br /&gt;
* [[Allows value::NI]]&lt;br /&gt;
* [[Allows value::?]]&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Property:Outcome_topic&amp;diff=6762</id>
		<title>Property:Outcome topic</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Property:Outcome_topic&amp;diff=6762"/>
		<updated>2024-11-21T08:09:25Z</updated>

		<summary type="html">&lt;p&gt;Cotto: Created a property of type Text&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;This is a property of type [[Has type::Text]].&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6761</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6761"/>
		<updated>2024-11-20T12:35:46Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
[[Outcome topic::Selenium]]&lt;br /&gt;
|?Outcome name&lt;br /&gt;
|?Results during intervention&lt;br /&gt;
|?Overall RoB judgment&lt;br /&gt;
|limit=3&lt;br /&gt;
|headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |limit=5&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:Author&amp;diff=6730</id>
		<title>Template:Author</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:Author&amp;diff=6730"/>
		<updated>2024-11-20T12:04:01Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;includeonly&amp;gt;&lt;br /&gt;
[[Category:Author]]&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
{|&lt;br /&gt;
| &#039;&#039;&#039;This author is part of the following publications:&#039;&#039;&#039;&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
{{#ask: [[Author::~*&amp;quot;{{FULLPAGENAME}}&amp;quot;*]]&lt;br /&gt;
 | format=ol&lt;br /&gt;
}}&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=6710</id>
		<title>MediaWiki:Common.css</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=MediaWiki:Common.css&amp;diff=6710"/>
		<updated>2024-11-20T11:53:58Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;/* CSS placed here will be applied to all skins */&lt;br /&gt;
&lt;br /&gt;
// weiße Reference Überschrift&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:visited {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:link{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:hover{&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table.wikitable &amp;gt; tbody &amp;gt; tr:nth-child(1) &amp;gt; th &amp;gt; span &amp;gt; a:active {&lt;br /&gt;
    color: #ffffff;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
// Tabellen Todos Ende&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;low risk&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
input[value=&amp;quot;some concerns&amp;quot;] {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
input[value=&amp;quot;high risk&amp;quot;]  {&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(2) {&lt;br /&gt;
    color: green;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(3) {&lt;br /&gt;
    color: orange;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
#pfForm &amp;gt; div.mw-parser-output &amp;gt; div:nth-child(33) &amp;gt; div.multipleTemplateList &amp;gt; div.multipleTemplateInstance.multipleTemplate &amp;gt; table &amp;gt; tbody &amp;gt; tr &amp;gt; td.instanceMain &amp;gt; table &amp;gt; tbody &amp;gt; tr:nth-child(n+1):nth-child(-n+8) &amp;gt; td &amp;gt; span &amp;gt; label:nth-child(4) {&lt;br /&gt;
    color: red;&lt;br /&gt;
    margin: 0px;&lt;br /&gt;
    margin-right: 5px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.low-risk {&lt;br /&gt;
    color: green;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.some-concerns {&lt;br /&gt;
    color: orange;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.high-risk {&lt;br /&gt;
    color: red;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(2) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(4) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#bodyContent &amp;gt; div.mw-body-subheader {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; p:nth-child(1) {&lt;br /&gt;
    display: none;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.uniform-width-table {&lt;br /&gt;
  width:100%;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(1), .wikitable.uniform-width-table td:nth-child(1){&lt;br /&gt;
  width: 60%; /* Width for the first column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(2), .wikitable.uniform-width-table td:nth-child(2){&lt;br /&gt;
  width: 5%; /* Width for the second column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(3), .wikitable.uniform-width-table td:nth-child(3){&lt;br /&gt;
  width: 5%; /* Width for the third column */&lt;br /&gt;
  text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable.uniform-width-table th:nth-child(4), .wikitable.uniform-width-table td:nth-child(4){&lt;br /&gt;
  width: 30%; /* Width for the fourth column */&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.vector-body p {&lt;br /&gt;
  margin: 0px;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
.wikitable {&lt;br /&gt;
        background-color: #ffffff;&lt;br /&gt;
        color: #202122;&lt;br /&gt;
        margin: 1em 0;&lt;br /&gt;
        border: 1px solid #a2a9b1;&lt;br /&gt;
        border-collapse: collapse&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; tbody &amp;gt; tr:nth-child(n) &amp;gt; th {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
}&lt;br /&gt;
&lt;br /&gt;
#mw-content-text &amp;gt; div.mw-parser-output &amp;gt; table:nth-child(n) &amp;gt; thead &amp;gt; tr &amp;gt; th:nth-child(n) {&lt;br /&gt;
    background-color: #cbeeffa6;&lt;br /&gt;
    text-align: center;&lt;br /&gt;
}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:PublicationQueryTemplate&amp;diff=6708</id>
		<title>Template:PublicationQueryTemplate</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:PublicationQueryTemplate&amp;diff=6708"/>
		<updated>2024-11-20T11:53:05Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{|class=&amp;quot;wikitable&amp;quot; style=&amp;quot;width: 40em; font-size: 90%; border: 2px solid #3366cc; color: black; margin-bottom: 0.5em; margin-top: 0.2em; margin-left: 1em; padding: 0.2em; clear: right; float: right; text-align:left;&amp;quot;&lt;br /&gt;
!style=&amp;quot;text-align: center;background-color: #3366cc; color: #ffffff;&amp;quot; colspan=&amp;quot;2&amp;quot;|&amp;lt;span style=&amp;quot;font-size: larger; color: #ffffff;&amp;quot;&amp;gt;[[{{{1}}}|Reference &amp;amp;#8599;]]&amp;lt;/span&amp;gt; &lt;br /&gt;
|- &lt;br /&gt;
! style=&amp;quot;width:20%&amp;quot; |  Title&lt;br /&gt;
| {{{2}}}&lt;br /&gt;
|-&lt;br /&gt;
! Topic&lt;br /&gt;
| {{{3}}}&lt;br /&gt;
|-&lt;br /&gt;
! Author&lt;br /&gt;
| {{#arraymap:{{{4}}}|;|x|[[x]]}}&lt;br /&gt;
|-&lt;br /&gt;
! Year&lt;br /&gt;
| {{{5}}}&lt;br /&gt;
|-&lt;br /&gt;
! Journal&lt;br /&gt;
| {{{6}}}&lt;br /&gt;
|-&lt;br /&gt;
! DOI&lt;br /&gt;
| style=&amp;quot;word-break: break-all;&amp;quot; | {{{7}}}&lt;br /&gt;
|}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Template:Publication&amp;diff=6703</id>
		<title>Template:Publication</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Template:Publication&amp;diff=6703"/>
		<updated>2024-11-20T11:51:54Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&amp;lt;noinclude&amp;gt;&lt;br /&gt;
{{#template_params:Title (property=Title)|Topic (list;property=Topic)|Author (property=Author)|Year (property=Publication year)|Journal (property=Journal)|DOI (property=DOI)|Authors Abstract (property=Authors Abstract)}}&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&amp;lt;includeonly&amp;gt;&lt;br /&gt;
{|class=&amp;quot;wikitable&amp;quot; style=&amp;quot;width: 40em; font-size: 90%; border: 2px solid #3366cc; color: black; margin-bottom: 0.5em; margin-top: 0.2em; clear: right; text-align:left;&amp;quot;&lt;br /&gt;
!style=&amp;quot;text-align: center; color: #ffffff; background-color: #3366cc;&amp;quot; colspan=&amp;quot;2&amp;quot;|&amp;lt;span style=&amp;quot;font-size: larger;&amp;quot;&amp;gt;Reference&amp;lt;/span&amp;gt;&lt;br /&gt;
|- &lt;br /&gt;
! style=&amp;quot;width:20%;&amp;quot; |Title&lt;br /&gt;
| [[Title::{{{Title|}}}]]&lt;br /&gt;
|-&lt;br /&gt;
! Topic&lt;br /&gt;
| {{#arraymap:{{{Topic|}}}|,|x|[[Topic::x]]}}&lt;br /&gt;
|-&lt;br /&gt;
!  Author&lt;br /&gt;
| [[Author::{{{Author|}}}|]]|{{#arraymap:{{{Author|}}}|;|x|[[x]]}}&lt;br /&gt;
|-&lt;br /&gt;
! Year&lt;br /&gt;
| [[Publication year::{{{Year|}}}]]&lt;br /&gt;
|-&lt;br /&gt;
! Journal&lt;br /&gt;
| [[Journal::{{{Journal|}}}]]&lt;br /&gt;
|-&lt;br /&gt;
! DOI &lt;br /&gt;
| [[DOI::{{{DOI|}}}]]&lt;br /&gt;
|}&lt;br /&gt;
[[Category:Publication]]&lt;br /&gt;
= Author&#039;s Abstract {{#info: The abstract and the information and conclusions contained therein were written by the authors of the publication.|note}} =&lt;br /&gt;
{| class=&amp;quot;text&amp;quot;&lt;br /&gt;
| [[Authors Abstract::{{{Authors Abstract|}}}]]&lt;br /&gt;
|}&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;strong&amp;gt;This publication is referenced in the following studies:&amp;lt;/strong&amp;gt;&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
[[has subobject.Reference::{{SUBJECTPAGENAME}}]]&lt;br /&gt;
|format=ol&lt;br /&gt;
}}&lt;br /&gt;
&amp;lt;/includeonly&amp;gt;&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6466</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6466"/>
		<updated>2024-11-14T13:41:05Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Für/gegen was ist die Einnahme von Aloe empfehlenswert? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |limit=5&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6465</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6465"/>
		<updated>2024-11-14T13:39:11Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* In welcher Dosis sollte Vitamin D eingenommen werden? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |limit=5&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6464</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6464"/>
		<updated>2024-11-14T13:37:51Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* In welcher Dosis sollte Vitamin D eingenommen werden? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=5&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6463</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6463"/>
		<updated>2024-11-14T13:37:36Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* In welcher Dosis sollte Vitamin D eingenommen werden? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6462</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6462"/>
		<updated>2024-11-14T13:37:18Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Hilft Curcumin gegen Übelkeit? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6461</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6461"/>
		<updated>2024-11-14T13:37:02Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Verbessert Vitamin D die Osteoporose? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Outcome Übelkeit kommt bei Topic Curcumin nicht vor.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6460</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6460"/>
		<updated>2024-11-14T13:36:32Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Verbessert Vitamin D die Osteoporose? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Outcome Übelkeit kommt bei Topic Curcumin nicht vor.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6459</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6459"/>
		<updated>2024-11-14T13:36:21Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Verbessert Vitamin D die Osteoporose? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Outcome Übelkeit kommt bei Topic Curcumin nicht vor.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |default=Keine Ergebnisse gefunden.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6458</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6458"/>
		<updated>2024-11-14T13:35:49Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Verbessert Vitamin D die Osteoporose? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Outcome Übelkeit kommt bei Topic Curcumin nicht vor.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 [[has subobject.Outcome name::Bone Mineral Density (BMD)]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6457</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6457"/>
		<updated>2024-11-14T13:31:54Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Welche Evidenz gibt es für Vitamin C hochdosiert? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Outcome Übelkeit kommt bei Topic Curcumin nicht vor.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6456</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6456"/>
		<updated>2024-11-14T13:27:54Z</updated>

		<summary type="html">&lt;p&gt;Cotto: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Outcome Übelkeit kommt bei Topic Curcumin nicht vor.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
	<entry>
		<id>https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6455</id>
		<title>Example Queries</title>
		<link rel="alternate" type="text/html" href="https://camih.med.uni-jena.de/camih/index.php?title=Example_Queries&amp;diff=6455"/>
		<updated>2024-11-14T13:26:31Z</updated>

		<summary type="html">&lt;p&gt;Cotto: /* Hilft Vitamin C gegen Fatigue? */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;== Welche Indikationen gibt es für die Einnahme von Selen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Vitamin C gegen Fatigue? ==&lt;br /&gt;
&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin C]]&lt;br /&gt;
 [[has subobject.Outcome name::Fatigue]]&lt;br /&gt;
 |?has subobject.Results during intervention&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Welche Evidenz gibt es für Vitamin C hochdosiert? ==&lt;br /&gt;
== Welche Nebenwirkungen hat Curcumin? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 |?has subobject.Side Effects / Interactions&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Hilft Curcumin gegen Übelkeit? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Curcumin]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea]]&lt;br /&gt;
 |?has subobject.Outcome specification&lt;br /&gt;
 |default=Outcome Übelkeit kommt bei Topic Curcumin nicht vor.&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Verbessert Vitamin D die Osteoporose? ==&lt;br /&gt;
== In welcher Dosis sollte Vitamin D eingenommen werden? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Vitamin D]]&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |limit=3&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Für/gegen was ist die Einnahme von Aloe empfehlenswert? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Aloe vera]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
== Hilft Aloe bei Mukositis? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::Selenium]]&lt;br /&gt;
 [[has subobject.Outcome name::Mucositis]]&lt;br /&gt;
 |?has subobject.Results after intervention&lt;br /&gt;
 |?has subobject.Overall RoB judgment&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
== Schützt Aloe vor Hautentzündungen? ==&lt;br /&gt;
== In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen? ==&lt;br /&gt;
{{#ask:&lt;br /&gt;
 [[has subobject.Reference.Topic::~Ginger*]]&lt;br /&gt;
 [[has subobject.Outcome name::Nausea||Nausea and Vomiting]]&lt;br /&gt;
 |?has subobject.Outcome name&lt;br /&gt;
 |?has subobject.Dosage and regime&lt;br /&gt;
 |headers=plain&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>Cotto</name></author>
	</entry>
</feed>