Latest revision as of 11:18, 30 September 2024

Reference
Title	Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme
Topic	Enzymes (bromelain papain)
Author	Stauder, G, Beaufort, F, Streichhan, P
Year	1991
Journal	Deutsche Zeitschrift für Onkologie
DOI

Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.

In this randomized prospective clinical trial hydrolytic enzymes were given addionally to radiation in abdominal cancer patients and compared with radiation only. The concomitant oral enzyme therapy improved the tolerance of the radiation significantly. The enzyme treated patients had less deterioration of general condition and skin symptomes and less patients discontinued radiation. It reduced the number of drugs needed for the treatment od radiation avderse effects, especially antiemetics, gastrointestinal drugs, antidepressives, tranquilizers and other psychopharmaceuticals, analgetics, spamolytics, diuretics and aldosteron antagonists. In most cases the enzyme therapy was well or very well tolerated.

This publication is referenced in the following studies:

Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme

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 |Year=1991
 |Journal=Deutsche Zeitschrift für Onkologie
-|DOI=-
+|Authors Abstract=In this randomized prospective clinical trial hydrolytic enzymes were given addionally to radiation in abdominal cancer patients and compared with radiation only. The concomitant oral enzyme therapy improved the tolerance of the radiation significantly. The enzyme treated patients had less deterioration of general condition and skin symptomes and less patients discontinued radiation. It reduced the number of drugs needed for the treatment od radiation avderse effects, especially antiemetics, gastrointestinal drugs, antidepressives, tranquilizers and other psychopharmaceuticals, analgetics, spamolytics, diuretics and aldosteron antagonists. In most cases the enzyme therapy was well or very well tolerated.
-|Authors Abstract=In dieser randomisierten, prospektiven klinischen Studie wurden additiv eingesetzte hydrolytische Enzyme bei radiationstherapierten Abdominalkrebspatienten mit alleiniger Strahlentherapie verglichen. Die begleitende Oralmedikation mit dem Enzymkombinationspräparat verbesserte die Verträglichkeit der Bestrahlung. Innerhalb der strahlenbedingten Nebenwirkungen kam es bei den Enzympatienten zu deutlich geringeren Verschlechterungen des Allgemeinstatus und der Hauptsymptomatik sowie - damit einhergehend - zu weniger Therapieabbrüchen. Infolge der zumeist gut oder sehr gut vertragenen enzymatischen Begleitbehandlungen konnte die Anzahl nebenwirkungsbedingt notwendiger Medikamente reduziert werden. Insbesondere gilt dies für Antiemetika, Magen-Darm-Mittel, Antidepressiva, Tranquilizer und andere Psychopharmaka, Analgetika, Spasmolytika, Diuretika und Aldosteronantagonisten.
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