Publication: Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial

Reference
Title	Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial
Topic	Vitamin D
Author	Brown, JC, Rosenthal, MH, Ma, C, Zhang, S, Nimeiri, HS, McCleary, NJ, Abrams, TA, Yurgelun, MB, Cleary, JM, Rubinson, DA, Schrag, D, Bullock, AJ, Allen, J, Zuckerman, D, Chan, E, Chan, JA, Wolpin, BM, Constantine, M, Weckstein, DJ, Faggen, MA, Thomas, CA, Kournioti, C, Yuan, C, Zheng, H, Hollis, BW, Fuchs, CS, Ng, K, Meyerhardt, JA
Year	2019
Journal	Cancers
DOI	https://doi.org/10.3390/cancers12113451

Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.

Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D3 (4000 IU) or standard-dose (400 IU) vitamin D3. Body composition was measured with abdominal computed tomography at enrollment (baseline) and after cycle 8 of chemotherapy (16 weeks). As compared with standard-dose vitamin D3, high-dose vitamin D3 did not significantly change body weight (−0.7 kg; (95% CI: −3.5, 2.0)), body mass index (−0.2 kg/m2; (95% CI: −1.2, 0.7)), muscle area (−1.7 cm2; (95% CI: −9.6, 6.3)), muscle attenuation (−0.4 HU; (95% CI: −4.2, 3.2)), visceral adipose tissue area (−7.5 cm2; (95% CI: −24.5, 9.6)), or subcutaneous adipose tissue area (−8.3 cm2; (95% CI: −35.5, 18.9)) over the first 8 cycles of chemotherapy. Among patients with advanced or metastatic colorectal cancer, the addition of high-dose vitamin D3, vs standard-dose vitamin D3, to standard chemotherapy did not result in any changes in body composition.

This publication is referenced in the following studies:

1. Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial