Example Queries - Curcumin

How does curcumin influence mucositis in cancer patients?

	Outcome specification	Results during intervention	Overall RoB judgment
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer	Burning Sensation in the mouth	Significant difference between intervention vs. placebo arm in mean (SD): intervention 3.7 (2.1) vs. placebo 7.9 (2.0); p < 0.001	some concerns
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer	Max. degree of mucositis	Max. degree of mucositis (number (%) of patients): Grade 1: Intervention arm: 15 (78.9%), Placebo arm: 3 (16.7%) Grade 2: Intervention arm: 4 (21.1%), Placebo arm: 8 (44.4%) Grade 3: Intervention arm: 0 (0%), Placebo arm: 7 (38.9%) Grade 4: Intervention arm and Placebo arm: 0 Difference between arms in distribution of grades: p < 0.001 Time between T0 and onset of max. mucositis: no numbers given; p = 0.315 Incidence of max. mucositis (number (%)): 7 days: Intervention arm: 4 (21.1%), Placebo arm: 8 (44.4%) 14 days: Intervention arm: 6 (31.6%), Placebo arm: 4 (22.2%) 21 days: Intervention arm: 9 (47.4%), Placebo arm: 6 (33.3%)	some concerns
Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study	Oral Mucositis	Weeks 1-7: Curcumin arm < Povidone-iodine arm; p < 0.001 (derived from graph only, no values provided) Cases of intolerable mucositis: Curcumin arm: 14/39 vs. Povidone-iodine arm: 34/40; p < 0.0001	some concerns

What helps against mucositis in cancer?

	Outcome topic	Results during intervention	Results after intervention	Overall RoB judgment
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial	Selenium	Onset of mucositis after transplantation comparable in both selenium and placebo arm; p=0.81	Overall: Cumulative incidence (grade 1-4) comparable in both selenium arm (83.8%) and placebo arm (81.1%); p=0.76; grade 3-4 mucositis significantly lower in selenium arm (10.8%) compared to placebo arm (35.1%); p=0.013 (grade 4: 2x in placebo arm, 0x in selenium arm) Mean duration comparable (p=0.048), only duration of objective mucositis from grade 2 to 4 and back was significantly shorter in the selenium arm (3.6±1.84 days) than in the placebo arm (5.3±2.2 days); p=0.014	high risk
Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer	Selenium	Significant difference for incidence of severe mucositis at week 3: selenium arm 9.8% vs. placebo arm 42.0% (p=0.017)	After 7 weeks no significant differences between the selenium arm and the placebo arm for: mean duration of oral mucositis (grade 1–4) (p=0.27) onset of oral mucosits (p =0.31) recovery (day after radiation completion (p=0.80) cumulative incidence of oral mucusitis (grade 1–4) (p=0.79) Severe oral mucositis (grade 3 or 4) was seen in 25 patients in the selenium arm and in 20 patients in the placebo arm. Addition: Development of oral mucositis in patients with selenium levels >65 mcg/l significantly delayed from baseline (p=0.04, no further explanation given)	high risk
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer	Curcumin	Significant difference between intervention vs. placebo arm in mean (SD): intervention 3.7 (2.1) vs. placebo 7.9 (2.0); p < 0.001	NA	some concerns
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer	Curcumin	Max. degree of mucositis (number (%) of patients): Grade 1: Intervention arm: 15 (78.9%), Placebo arm: 3 (16.7%) Grade 2: Intervention arm: 4 (21.1%), Placebo arm: 8 (44.4%) Grade 3: Intervention arm: 0 (0%), Placebo arm: 7 (38.9%) Grade 4: Intervention arm and Placebo arm: 0 Difference between arms in distribution of grades: p < 0.001 Time between T0 and onset of max. mucositis: no numbers given; p = 0.315 Incidence of max. mucositis (number (%)): 7 days: Intervention arm: 4 (21.1%), Placebo arm: 8 (44.4%) 14 days: Intervention arm: 6 (31.6%), Placebo arm: 4 (22.2%) 21 days: Intervention arm: 9 (47.4%), Placebo arm: 6 (33.3%)	NA	some concerns
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck	Selenium	NA	Overall: No significant differences between arms (grade 3 intervention arm 2x, placebo arm 3x, no grade 4)	some concerns
... further results