Latest revision as of 09:22, 16 July 2024

Reference
Title	Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture
Topic	Vitamin B1, Vitamin B6, Electroacupuncture
Author	Rostock, M, Jaroslawski, K, Guethlin, C, Ludtke, R, Schröder, S, Bartsch, HH
Year	2013
Journal	Evidence-based Complementary and Alternative Medicine
DOI	http://dx.doi.org/10.1155/2013/349653

Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.

Purpose. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs. Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from which preliminary data showed promising results.

Methods. In a randomized trial with a group sequential adaptive design in patients with CIPN, we compared EA (LV3, SP9, GB41, GB34, LI4, LI11, SI3, and HT3; 𝑛 = 14) with hydroelectric baths (HB, 𝑛 = 14), vitamin B1/B6 capsules (300/300mg daily; VitB, 𝑛 = 15), and placebo capsules (𝑛 = 17). The statistical power in this trial was primarily calculated for proving EAonly, so results of HB and VitB are pilot data.

Results. CIPNcomplaints improved by 0.8±1.2 (EA), 1.7±1.7 (HB), 1.6±2.0 (VitB), and 1.3±1.3 points (placebo) on a 10-point numeric rating scale without significant difference between treatment groups or placebo. In addition no significant differences in sensory nerve conduction studies or quality of life (EORTC QLQ-C30) were found.

Conclusions. The used EA concept, HB, and VitB were not superior to placebo. Since, contrary to our results, studies with different acupuncture concepts showed a positive effect on CIPN, the effect of acupuncture on CIPN remains unclear. Further randomized, placebo controlled studies seem necessary.

This publication is referenced in the following studies:

Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture

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 |DOI=http://dx.doi.org/10.1155/2013/349653
 |Authors Abstract=Purpose. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs. Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from which preliminary data showed promising results.
-Methods. In a randomized trial with a group sequential adaptive design in patients with CIPN, we compared EA (LV3, SP9, GB41, GB34, LI4, LI11, SI3, and HT3; 𝑛 = 14) with hydroelectric baths (HB, 𝑛 = 14), vitamin B1/B6 capsules (300/300mg daily; VitB, 𝑛 = 15), and placebo capsules (𝑛 = 17). The statistical power in this trial was primarily calculated for proving EAonly, so results ofHB andVitB are pilot data.
+Methods. In a randomized trial with a group sequential adaptive design in patients with CIPN, we compared EA (LV3, SP9, GB41, GB34, LI4, LI11, SI3, and HT3; 𝑛 = 14) with hydroelectric baths (HB, 𝑛 = 14), vitamin B1/B6 capsules (300/300mg daily; VitB, 𝑛 = 15), and placebo capsules (𝑛 = 17). The statistical power in this trial was primarily calculated for proving EAonly, so results of HB and VitB are pilot data.
 Results. CIPNcomplaints improved by 0.8±1.2 (EA), 1.7±1.7 (HB), 1.6±2.0 (VitB), and 1.3±1.3 points (placebo) on a 10-point numeric rating scale without significant difference between treatment groups or placebo. In addition no significant differences in sensory nerve conduction studies or quality of life (EORTC QLQ-C30) were found.
 Conclusions. The used EA concept, HB, and VitB were not superior to placebo. Since, contrary to our results, studies with different acupuncture concepts showed a positive effect on CIPN, the effect of acupuncture on CIPN remains unclear. Further randomized, placebo controlled studies seem necessary.
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