Homeopathy vs Nausea

Erstes Ziel: Herausfinden, ob Homöopathie gegen Übelkeit hilft.

Ich brauche eine tabellarische Übersicht, aller Studien mit Homöopathie in mindestens einem Behandlungsarm, die den Endpunkt Übelkeit beschreiben.

Die verwendete Query:

{{#ask:
 [[Topic::Homeopathy]]
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 |?Title
 |?Author
 |?Publication year
 |?Is randomized
 |headers=plain
}}

Konkretisierungen

Gib mir nur randomisierte Studien

Die verwendete Query:

{{#ask:
 [[Topic::Homeopathy]]
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 [[Is randomized::Yes]]
 |?Title
 |?Author
 |?Publication year
 |?Is randomized
 |headers=plain
}}

Gib mir nur Studien, die im Kontrollarm ein Medikament gegen Übelkeit haben

Die verwendete Query:

{{#ask:
 [[Topic::Homeopathy]]
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 [[Is randomized::Yes]]
 [[Has subobject::<q>[[Arm type::active control]]</q>]]
 [[Has subobject::<q>[[Intervention::DrugAgainstNausea]]</q>]]
 |?Title
 |?Author
 |?Publication year
 |?Has subobject.Arm type
 |?Has subobject.Intervention
 |headers=plain
}}

Zeig mir an, welche Messinstrumente für Übelkeit in den Studien verwendet worden sind.

Die verwendete Query:

{{#ask:
 [[Topic::Homeopathy]]
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 [[Is randomized::Yes]]
 [[Has subobject::<q>[[Arm type::active control]]</q>]]
 [[Has subobject::<q>[[Intervention::DrugAgainstNausea]]</q>]]
 |?Author
 |?Publication year
 |?has subobject.Type of measurement
 |headers=plain
}}

Gib mir nur die Studien, die Übelkeit mit einem bestimmten Messinstrument gemessen haben

Die verwendete Query:

{{#ask:
 [[Topic::Homeopathy]]
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 [[Is randomized::Yes]]
 [[Has subobject::<q>[[Arm type::active control]]</q>]]
 [[Has subobject::<q>[[Intervention::DrugAgainstNausea]]</q>]]
 [[Has subobject::<q>[[Type of measurement::EORTC QLQ-30 (European Organisation for Research and Treatment of Cancer Core Quality of Life questionnaire)]]</q>]]
 |?Author
 |?Publication year
 |?has subobject.Type of measurement
 |headers=plain
}}

Zeig mir das nur für die letzten 10 Jahre an

The following query condition could not be considered due to this wiki's restrictions on query size or depth: <code>[[Publication year::≥1 January 2014]]</code>.

Die verwendete Query:

{{#ask:
 [[Topic::Homeopathy]]
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 [[Is randomized::Yes]]
 [[Has subobject::<q>[[Arm type::active control]]</q>]]
 [[Has subobject::<q>[[Intervention::DrugAgainstNausea]]</q>]]
 [[Has subobject::<q>[[Type of measurement::EORTC QLQ-30 (European Organisation for Research and Treatment of Cancer Core Quality of Life questionnaire)]]</q>]]
 [[Publication year::>01-01-2014]]
 |?Author
 |?Publication year
 |?has subobject.Type of measurement
 |headers=plain
}}

Zweites Ziel: Herausfinden, welche Therapien gegen Übelkeit helfen

Ich brauche eine tabellarische Übersicht aller Publikationen, die den Endpunkt Übelkeit haben und die mir anzeigt, welche Therapien gemacht wurden.

	Intervention
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy	Ginger capsules + Antiemetic treatment: dexamethasone, aprepitant, granisetron (before each cyle + first two days of each cyle) Placebo capsules + Antiemetic treatment: dexamethasone, aprepitant, granisetron (before each cyle + first two days of each cyle)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial	Nabilon + all patients: additional administration of antiemetics (metoclopramide) and painkillers (acetaminophen (paracetamol), codeine, hydromorphone or transdermal fentanyl) possible Placebo + all patients: additional administration of antiemetics (metoclopramide) and painkillers (acetaminophen (paracetamol), codeine, hydromorphone or transdermal fentanyl) possible
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens	Ginger capsules Placebo
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain	THC:CBD THC Placebo
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer	Ginger essential oils Ginger frangance oil (placebo)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients	Ginger capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone Ginger capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone Ginger capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone Placebo capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study	Ginger capsules Placebo capsules Placebo capsules
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)	THC Cannabis extract Placebo
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study	Ginger powder capsules (certified quality) + all participants received standard antiemetic medication including dexamethasone, ondansetron, and ranitidine; if necessary dimenhydrinate Placebo in corn starch capsules + all participants received standard antiemetic medication including dexamethasone, ondansetron, and ranitidine; if necessary dimenhydrinate
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer	Reflexology Foot massage (LFM) Conventional therapy, control arm

Die verwendete Query:

{{#ask:
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 |?Has subobject.Intervention
 |headers=plain
}}

Danach möchte ich alle Studien, die Medikament A gegen B vergleichen und dazu die Übelkeitsergebnisse sehen aber auch die Nebenwirkungen der beiden Medikamente A vs B;

TODO: Vergleich A B

Die verwendete Query:

{{#ask:
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 |?has subobject.Intervention
 |?has subobject.Result
 |?has subobject.Side effects
 |headers=plain
}}

Ausserdem möchte ich wissen, welche Patientengruppen in den Studien untersucht wurden (Erwachsene, Kinder, männlich, weiblich...);

	Intervention	Result	Side effects	Number of males	Number of females	Percentage male	Mean age	Median age	Setting
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy	Ginger capsules + Antiemetic treatment: dexamethasone, aprepitant, granisetron (before each cyle + first two days of each cyle) Placebo capsules + Antiemetic treatment: dexamethasone, aprepitant, granisetron (before each cyle + first two days of each cyle)								Curative
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial	Nabilon + all patients: additional administration of antiemetics (metoclopramide) and painkillers (acetaminophen (paracetamol), codeine, hydromorphone or transdermal fentanyl) possible Placebo + all patients: additional administration of antiemetics (metoclopramide) and painkillers (acetaminophen (paracetamol), codeine, hydromorphone or transdermal fentanyl) possible								Neo-adjuvant Adjuvant Curative
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens	Ginger capsules Placebo								Curative
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain	THC:CBD THC Placebo								Palliative
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer	Ginger essential oils Ginger frangance oil (placebo)								Curative
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients	Ginger capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone Ginger capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone Ginger capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone Placebo capsules + all patients received 5-HT 3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone								Curative
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study	Ginger capsules Placebo capsules Placebo capsules								Curative
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)	THC Cannabis extract Placebo								Palliative
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study	Ginger powder capsules (certified quality) + all participants received standard antiemetic medication including dexamethasone, ondansetron, and ranitidine; if necessary dimenhydrinate Placebo in corn starch capsules + all participants received standard antiemetic medication including dexamethasone, ondansetron, and ranitidine; if necessary dimenhydrinate								Neo-adjuvant Adjuvant
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer	Reflexology Foot massage (LFM) Conventional therapy, control arm								Palliative

Die verwendete Query:

{{#ask:
 [[Has subobject::<q>[[Outcome name::Nausea]]</q>]]
 |?has subobject.Intervention
 |?has subobject.Result
 |?has subobject.Side effects
 |?Number of males
 |?Number of females
 |?Percentage male
 |?Mean age
 |?Median age
 |?Setting
 |headers=plain
}}

gibt es Unterschiede der Ergebnisse nach Alter, Geschlecht, Krebsart

Diese Art von Anfrage welche Anfrageergebnisse vergleicht und/oder hervorhebt wird nicht möglich sein. Das muss der Anwender selbst tun.

Womit mir auffällt, dass ein Endpunkt evtl. mehrfach vorkommt bei Subgruppen....