Example Queries
Welche Indikationen gibt es für die Einnahme von Selen?
Hilft Vitamin C gegen Fatigue?
| Results after intervention | |
|---|---|
| Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial | Estimated mean (SD) from graphic:
2, 6 and 24h post-op: at rest significantly lower in intervention compared to placebo; p's<0.05 (no values reported, only graphs) While coughing: no significant difference at any time point; p's>0.05 Frequency as Mean(SD): Intervention: 0.8(0.8) Placebo: 1.4(1.0) |
Welche Evidenz gibt es für Vitamin C hochdosiert?
Welche Nebenwirkungen hat Curcumin?
Hilft Curcumin gegen Übelkeit?
Outcome Übelkeit kommt bei Topic Curcumin nicht vor.
Verbessert Vitamin D die Osteoporose?
In welcher Dosis sollte Vitamin D eingenommen werden?
| Dosage and regime | |
|---|---|
| Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial | Two capsules of vitamin D3 (total 1,200 IU/day), for 12 months Two capsule form and identical in appearance and taste, containing sesame oil, gelatin derived from swine, and glycerin, for 12 months |
| Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer | Cholecalciferol 2000 IU daily, for 2 years or until death, whichever came first Only standard chemotherapy |
| Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer | Supplied by Genzyme as 2.5 μg soft gel capsules,10 μg (i.e., four capsules of 2.5 μg) of doxercalciferol orally each day of the chemotherapy cycles before breakfast and at the same time,
Duration: for 1-12 cycles of chemotherapy (each cycle: 28 days), median duration: 6 cycles |
| ... further results | |
Für/gegen was ist die Einnahme von Aloe empfehlenswert?
Hilft Aloe bei Mukositis?
| Results after intervention | Overall RoB judgment | |
|---|---|---|
| Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial | NA No difference between selenium arm (26.92±6.26 days) and placebo arm (25.81±4.33 days); p=0.38 Overall: No difference between the arms; p= 0.35 No difference between the arms; p= 0.69 Overall: No difference between arms for increase in serum creatinine; p=0.31 or increase in aspartate aminotransferase and alanine transaminase: p=0.62 Significant difference in mean serum selenium level between two arms at 14 days after transplantation (8.34 mcg/dL in the selenium arm vs 7.36 mcg/dL in the placebo arm), p=0.018 Overall: Cumulative incidence (grade 1-4) comparable in both selenium arm (83.8%) and placebo arm (81.1%); p=0.76; grade 3-4 mucositis significantly lower in selenium arm (10.8%) compared to placebo arm (35.1%); p=0.013 (grade 4: 2x in placebo arm, 0x in selenium arm)
NA | some concerns some concerns some concerns some concerns some concerns some concerns high risk some concerns |
| Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer | At the end of radiation (after 7 weeks) there was no difference in the mean serum selenium level between the selenium arm and placebo arm (p=0.24)
Based on the selenium level before radiation, developing severe oral mucositis was statistically significant postponed in patients who had selenium levels ≥ 65 mcg/L (p=0.04)
| NA high risk |
| Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck | Overall: No significant differences between arms (grade 3 intervention arm 2x, placebo arm 3x, no grade 4) Only one patient from the intervention arm did not reach CR and died After 12 months: No significant differences between arms After 12 months: No significant differences between arms No significant difference for week 6-8 post-treatment and Follow-up within a year Overall:
| some concerns low risk low risk low risk some concerns some concerns |
Schützt Aloe vor Hautentzündungen?
In welcher Dosis sollte man Ingwer bei Übelkeit einsetzen?
| Outcome name | Dosage and regime | |
|---|---|---|
| Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy | Nausea Vomiting | Daily dose 2x2 ginger capsules (250mg ginger powder each), every 12h for 3 days over 3 cycles, start not specified Daily dose 2x2 capsules, every 12h for 3 days over 3 cycles, start not specified |
| Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens | Nausea Vomiting | Four capsules of powdered ginger (Zintoma®, Gol Daru) daily (each capsule contained 250 mg of ginger) Four capsules of placebo (lactose) |
| Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer | Nausea Quality of life Unspecified effects | Antiemetics + bottle with 2 drops of ginger oil
Glass pendant (in the form of a small flask), to be hung approx. 20 cm from the nose, the bottle was held directly under the nose and inhaled deeply at least 3 times a day for 2 minutes each time Start: Day 1 of chemotherapy |
| Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial | Nausea and Vomiting Nausea and Vomiting Nausea and Vomiting | Daily dose 3x0.5g
Every 8h, starting 30min after chemotherapy Every 8h, starting 30min after Chemotherapy |
| Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients | Nausea Nausea Quality of life Vomiting | 250mg 2x3 ginger capsules (liquid extract from ginger root in virgin olive oil + excipients, 1.5g ginger daily)
1.5g daily 2x3 placebo capsules |
| Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study | Nausea Vomiting Vomiting Toxicity | Two capsules, each containing 500 mg of gin- ger powder, orally, 2 ml of normal saline IV, 20 min prior to chemotherapy. Two capsules of ginger were repeated after 6 h of cancer chemotherapy. 2 capsules of lactulose orally and injection metoclopramide 20 mg IV, 20 min prior to chemotherapy. Two capsules of 5 mg metoclopramide each, orally after 6 h 2 capsules of lactulose orally and injection ondansetron 4 mg IV, 20 min prior to chemotherapy and two capsules of ondansetron, 2 mg each, orally after 6 h. |
| Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study | Nausea Nausea Vomiting Toxicity | Daily dose 4x500mg before meals and one in the evening from day 1 to day 5 of chemotherapy
+ standard antiemetic medication included 20 mg of dexamethasone, 8 mg of ondansetron, and 50 mg of ranitidine which were injected 30 min before chemotherapy administration; if necessary 50mg dimenhydrinate before chemotherapy and 5 days at home |
| Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting | Unspecified effects Nausea and Vomiting Nausea and Vomiting Toxicity | 8 capsules daily 1.0-g ginger dose, - Each capsule contained 250 mg dry extract of ginger root [10:1 (v/v) extraction solvent (ethanol 50%)/root] standard- ized to 15 mg (5%) of total gingerols
- four capsules ginger and four capsules placebo daily |