Property:Specifications on analyses
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Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients +
The data were analyzed by SPSS 20 software. The quantitative variables were expressed as mean (standard deviation) or median (interquartile range) and qualitative variables as number (%). To compare quantitative variables, repeated measures analysis of variance (ANOVA) was used and to compare qualitative variables, chi-square +
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial +
The specific analysis method is not stated in the study, however, according to the authors, all included patients were evaluated at the end of the study. +
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer +
ITT not specified, but no drop-out reported. +
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia +
The analysis was performed on an intent-to treat basis. An interim analysis was planned every 100 randomized patients to test the efficacy (primary efficacy endpoints) and the toxicity of the different arms according to the following “early stopping rules”: the arm(s) in which the efficacy values were significantly lower (p .05), by a t-test for changes, than in the other arms would be stopped. Likewise wise, the arm(s) in which grade 3 or 4 toxicity values were significantly higher by a t-test for changes, than in the other arms would be stopped.
A very low level for the significance of p-values (p .001) was chosen considering that there are 10 possible pairs of between-arm comparisons and three endpoints, implying 30 possible candidate analyses; p-values are reported including Bonferroni’s corrections for multiple comparisons. +
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study +
- Kaplan-Meier method to estimate survival probabilities and the Mantel-Haenszel log-rank test to compare groups
- Cox proportional hazards regression to estimate crude and adjusted hazard ratios (HR) and 95% confidence intervals (CI) +
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial +
All 56 patients were evaluated according to an intent-to-treat-analysis. 8 patients finished the study prematurely at their own request, but the comparibility of the study groups was still remained. +
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer +
104 patients were analysed. +
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial +
Mann-Whitney U test +
Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer +
- Survival curves generated (Kaplan and Meier)
- Log-rank test used to compare survival distributions between the two groups
- Cox proportional hazards models used to calculate the RR (relative risk) of having an end point in the b-carotene group relative to those taking placebo, adjusted for other covariates +
Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial +
NI +
Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial +
- Distributions of progression-free survival estimated by method of Kaplan and Meier
- Effects of treatment/patient and disease characteristics analyzed using proportional hazards regression model of Cox
- Magnitude of treatment differences was expressed as the relative risk, for busulfan alone relative to the busulfan plus vitamin A +
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...) +
- Analyzed: N = 77 for primary endpoint, 78 for secondary endpoints (n=5 patients did not receive any treatment, n=1 data set missing for primary endpoint)
- 1% level of significance used because of the large number of treatment comparisons +
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck +
Three interim analyses were planned: the first after 20 patients have completed Chemo-Radiotherapy to ensure toxicity in the selenium arm was not unacceptably high and the second and third after one third and two thirds of the patients had been followed for at least 18 months +
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy +
Patients receiving < 4 cycles of paclitaxel or any dose curtailments were excluded from the analysis +
Montazeri et al. (2013): Effect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients +
Kolmogorov-Smirnov Test +
Montazeri et al. (2013): Iranian Red Crescent Medical JournalEffect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients. +
? +
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial +
NI +
Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology +
No information about possible drop-out +