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Property:Dosage and regime

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K
oral, 300mg, 2x daily, Start: during days 1-4 of chemotherapy Duration: until 1 month post-chemotherapy  +
Peripheral PN (PPN) 100ml (20% lipid emulsion) + carnitine, IV, -1st postoperative day OP to day 4, average administration: 72.6mg/kg daily (SD = 37.3) Duration: 4 days  +
L
2x 200 mcg tablets of selenium (Webber Naturals, Coquitlam, BC, Canada) daily from the first day until the end of radiation (including days without radiation exposure)  +
2x placebo tablets daily from the first day until the end of radiation (including days without radiation exposure)  +
Dressing Procedure 1. Irrigate wound with green tea solution with 20ml syringe until return flow is clear 2. Cover wound with absorbent pad(s) with dry green tea bag (insert within the absorbent pad) and secure with 2-inch micropore tape + Assigned nurse performs for all participants Day 1 and day 7: wound assessment; questionnaire on quality of life; photography of wound Day 1 to day 7: daily dressing; daily odour rating using VNS by patient and nurse independently  +
Dressing Procedure Irrigate wound with Normal Saline 0.9% with 20ml syringe until return flow is clear 1. Sprinkle metronidazole powder to wound bed (pound metronidazole tablet(s) finely) 2. Cover wound with absorbent pad(s) and secure with 2-inch micropore tape + Assigned nurse performs for all participants: Day 1 and day 7: wound assessment; questionnaire on quality of life; photography of wound Day 1 to day 7: daily dressing; daily odour rating using VNS by patient and nurse independently  +
Nabiximol via oral spray (self-applied by patient, 27 mg/ml THC and 25mg/ml CBD) Week 1: dose finding; week 2-5: stable dose, maximum 10 sprays Mean number of spray bursts in the 1st week: 3.7 and then stabilized: 6.4  +
Oral spray (self-applied by patient) Week 1: dose finding; week 2-5: stable dose, maximum 10 sprays Mean number of spray bursts in the 1st week: 3.8 and then stabilized: 7.3  +