Property:Side Effects / Interactions
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Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia +
No side effects reported.
No significant difference between arms (p=NI) +
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia +
No side effects reported
No significant difference between arms (p=NI) +
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia +
2x grade 3 or 4 diarrhoe
No significant difference between arms (p=NI) +
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia +
2x grade 3 or 4 diarrhoe
No significant difference between arms (p=NI) +
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia +
No side effects reported.
No significant difference between arms (p=NI) +
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study +
NI +
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study +
NI +
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study +
NI +
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial +
NI +
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial +
There is a trend towards less need for additional medication in the placebo group. +
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer +
1 patient complained of its taste or consistency +
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer +
3 patients complained of its taste or consistency +
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial +
N=2: constipation;
N=4: reflux +
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial +
NI +
Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer +
- Number of side effects ≥ grade 2 (standard toxicity grading scales): 4
- Symptoms (not separated between groups): Depression, headaches, bone pain, cheilitis, dry skin, diarrhea
- Yellowing of the skin: 8 patients (6%) +
Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer +
- Number of side effects ≥ grade 2 (standard toxicity grading scales): 5
- Symptoms (not separated between groups): Depression, headaches, bone pain, cheilitis, dry skin, diarrhea
- Yellowing of the skin: 25 patients (18%) +
Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial +
NA +
Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial +
NI +
Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial +
- Grade 4 thrombocytopenia: N = 2 (+ grade 3 leukopenia/grade 1 hyperpigmentation: N = 1, + grade 2 weight loss, anorexia and fatigue: N = 1)
- Grade 2 thrombocytopenia: N = 2
- Grade 2 or grade 3 personality change: N = 1 each
- Dry skin rashes: N = 4 (1x grade 3)
- Grade 1 abdominal cramps: N = 1
- Hepatic side effects: N = 5
- Grade 3 Dry mouth: N = 1
- Grade 2 Fatigue with pain: N = 1
- Grade 2 Anxiety: N = 1
- Grade 1 Restrictive lung disease: N = 1
- Pancreatitis (grade unknown): N = 1 +
Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial +
- Grade 3 Mucositis, ulcers in esophagus and stomach, vomiting and anorexia: N = 1
- Grade 2 Nausea and vomiting: N = 2
- Grade 1 Abdominal cramps: N = 1
- Grade 1 thrombocytopenia: N = 1
- Dizziness/fainting (grade unknown): N = 1 +