Property:Dosage and regime
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Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial +
Daily supplementation with 1,000 mg of calcium carbonate and 400 IU of Vitamin D3:
Baseline 25OHD levels between 20 and 29 ng/ml were randomized to receive vitamin D2, one 50,000 IU capsule, orally once a week for a total of eight consecutive weeks, and then once a month for the rest of the study;
Baseline 25OHD levels between 10 and 19 ng/ml received Vitamin D2 50,000 IU capsule or a matching placebo orally for 16 consecutive weeks and then once a month for the rest of the study +
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer +
Placebo capsules, a capsule after breakfast and dinner +
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer +
Zinc sulfate (154mg/capsule), which corresponded to 35mg of elemental zinc, a capsule after breakfast and dinner, which amounted to 70mg of elemental zinc per day +
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation +
5-mg zinc sulfate tablets 3 times daily after meals,
Duration: from the onset of subjective perception of taste alterations (hypogeusia or dysgeusia) and continuing through radiotherapy until 1 month after radiotherapy termination +
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation +
Placebo tablets 3 times daily after meals,
Duration: from the onset of subjective perception of taste alterations (hypogeusia or dysgeusia) and continuing through radiotherapy until 1 month after radiotherapy termination +
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture +
8x ± 1 sessions for 15min
Point combinations for ...
- patients with CIPN symptoms in the lower extremities: LV3 (Taichong), SP9 (Xiongxiang), GB41 (Zulingqi),GB34 (Yanglingquan)
- patients with CIPN symptoms in the upper extremities: LI4 (Hegu), LI11 (Quchi), SI3 (Houxi), and HT3 (Shaohai)
- patients with CIPN symptoms in the upper and lower extremities: treated with complete point combination
Acupuncture needles were deeply inserted bilaterally until the deqi phenomenon was triggered; each session included 15 minutes of electrostimulation (50Hz) consisting of a combination of rectangular currents and high amplitude waves +
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture +
Same form and frequency as in Vit. B arm (oral, 3 lactose capsules daily) +
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture +
8x ± 1 sessions for 15min
- patients dipped their arms up to a hand’s width above the elbow and their feet up to a hand’s width above the ankle into a special
water basin with water at a temperature of about 35∘
- cross-galvanisation of each individual extremity by low-frequency (50Hz) faradic current (direct current impulses) up to the individual’s sensitive
threshold (i.e., the point where the tingling feeling is considered to be just acceptable) +
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture +
100mg thiamine nitrate + 100mg pyridoxine hydrochloride, oral, 3 capsules daily +
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients +
250mg 2x3 ginger capsules (liquid extract from ginger root in virgin olive oil + excipients, 1.5g ginger daily)
1.5g daily +
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients +
2x1 placebo capsules
250mg 2x2 ginger capsules ((liquid extract from ginger root in virgin olive oil + excipients and placebo capsules, 1.0g ginger daily) +
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients +
2x2 placebo capsules
250mg 2x1 ginger capsules (liquid extract from ginger root in virgin olive oil + excipients and placebo capsules, 0.5g ginger daily) +
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients +
2x3 placebo capsules +
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients +
3 times daily, 4 capsules each time
Duration: 7 weeks (entire radiationtherapy) +
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients +
500mg capsules (≥95% curcuminoids), 3 times daily, 4 capsules each time
Duration: 7 weeks (entire radiationtherapy) +
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Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial +
0.15% Benzydamine mouthwash
5mL mouthwash 3x/day from the start to the end of radiotherapy (six weeks). Patients were asked not to eat or drink for 30 minutes after mouth rinsing.
+ all patients: radiation therapy +
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial +
Aloe vera mouthwash (containing pure Aloe vera gel; 0.0009% Brilliant Blue dye; 0.0006% tartrazine yellow dye)
5mL mouthwash 3x/day from the start to the end of radiotherapy (six weeks). Patients were asked not to eat or drink for 30 minutes after mouth rinsing.
+ all patients: radiation therapy +
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial +
1g Aloe ointment (3% aloe powder, 2.3% white paraffin, 94.7% Vaseline) rectally 2x daily for 4 weeks.
+ all patients: 500mg Sulfasalazine 4x per day
+ all patients: radiotherapy +
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial +
1g Placebo ointment (without aloe vera) rectally 2x daily for 4 weeks
+ all patients: 500mg Sulfasalazine 4x per day
+ all patients: radiotherapy +
Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial +
400 mg daily
Duration: until 6. chemotherapy cycle +