Property:Side Effects / Interactions
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Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms +
No patients reported adverse effects, and none withdrew from the study because of side effects. +
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms +
No patients reported adverse effects, and none withdrew from the study because of side effects. +
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy +
Most common: Gastrointestinal reactions (vomiting, diarrhea, bloating), p>0.05;
Second most common: Reduced white blood cell count (only in intervention arm), liver dysfunction, and sleep disturbances
For severe adverse events: no connection with administered medications; p>0.05
No difference between arms for adverse reactions and events (p=0.5816; p=0.3903) +
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy +
Most common: Gastrointestinal reactions (vomiting, diarrhea, bloating), p>0.05;
Second most common: Reduced white blood cell count (only in intervention arm), liver dysfunction, and sleep disturbances
For severe adverse events: no connection with administered medications; p>0.05
No difference between arms for adverse reactions and events (p=0.5816; p=0.3903) +
T
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor +
NI +
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor +
NI +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
No significant difference in the incidence of adverse events between subjects receiving ginger and placebo.
No study-treatment-related adverse events were observed. +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
No significant difference in the incidence of adverse events between subjects receiving ginger and placebo.
No study-treatment-related adverse events were observed. +
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial +
itching, burning and epidermal changes: 49,2 % +
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial +
Patients report non-absorption of residues; typical and characteristic odor of the cream was reported as pleasant or too intense. +
Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial +
NI +
Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial +
Skin toxicity (N = 4), mucositis (N = 1) +
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. +
NI +
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. +
NI +
U
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial +
NI +
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial +
NI +
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial +
NI +
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial +
NI +
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial +
n=3 fractures (1.3%), n=2 urinary stones (0.9%);
no patients developed hypercalcemia during the follow-up period +
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial +
n=5 fractures (3.4%);
no patients developed hypercalcemia during the follow-up period +