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Property:Other reasons

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* Unclear statistic: Only 45% completed questionnaires after 1 month, no information provided on intent-to-treat analyses, but according to tables all randomized patients appear to have been included in the analyses (patients who dropped out were considered treatment failure) * Different weights reported by patients and physicians * No clear indication of time course (end of study), different median times for participation in studies per arm withdrawal due to withdrawal of consent and/or side effect (45%, 58%, and 41%) or death (22%, 15% and 26%) * No flow chart, so unclear when drop-out/attrition occurred   +
No information whether centers were comparable in treatment of patients; especially “optimized” opioid treatment may vary from country to country  +
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* Subjects could continue to take supplements that contained ≤70 µg selenium and also others that did not contain selenium   +