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Property:Outcome specification

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Pittsburgh Sleep Quality Index questionnaire that inquires about frequency of sleep disturbances and subjective sleep quality  +
Specific questionnaires were used: FACIT-F that assesses self-reported QOL and fatigue with total score ranging from 0 to 160 FACIT-ES that includes a subspace evaluating menopausal symptoms, among other components that are totaled to provide an overall score ranging from 0 to 180  +
Global Chalder Fatigue Scale: Measure of fatigue severity for both physical and mental symptoms that scored in a Likert format with response options ranging from better than usual to much worse than usual, with total possible score of 26.  +
Positive ICI test - positive result was considered the ability to achieve a 30 to 40-minute full erection 10 to 15 minutes after ICI of 10 g PGE  +
Prostate specific antigen (PSA) levels before the intervention and after the intervention  +
- Patient self-assessment by xerostomia questionnaire (XQ) - Xerostomia score assessed by observer (XS) - Salivary scintigraphy (maximum accumulation, ejection fraction and prestimulatory and poststimulatory oral index)  +
Maximum tolerated dose (MTD): Toxicity level of 25% of participants with toxicity ≥ grade II according to CTCAE  +