Study Overview

This page lists all studies currently in the wiki under the Category Study.

Aloe vera

	Category	Publication year	DOI
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue	RCT study	2002	https://doi.org/10.1097/00002820-200212000-00007
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy	RCT study	2015	https://doi.org/10.1016/j.clbc.2014.12.006
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms	RCT study	1998	https://doi.org/10.1159/000069427
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer	RCT study	2009	https://iv.iiarjournals.org/content/23/1/171.short
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial	RCT study	2016	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876780/
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer	RCT study	2017	https://doi.org/10.1002/hed.24832
Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy	RCT study	2001	https://pubmed.ncbi.nlm.nih.gov/11338761/
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study	RCT study	2009	https://mahidol.elsevierpure.com/en/publications/the-efficacy-of-oral-aloe-vera-juice-for-radiation-induced-mucosi
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial	RCT study	2015	https://doi.org/0.3290/j.ohpd.a33091
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial	RCT study	2017	https://doi.org/10.1089/acm.2017.0047
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms	RCT study	2004	https://doi.org/10.1016/j.ijrobp.2004.02.012
Williams et al. (1996): Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity	RCT study	1996	https://doi.org/10.1016/s0360-3016(96)00320-3

Cannabinoids

	Category	Publication year	DOI
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial	RCT study	2016	https://doi.org/10.1177/0003489415612801
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies	RCT study	2017	https://doi.org/10.1177/2049463717710042
Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies	RCT study	2017	https://doi.org/10.1177/2049463717710042
Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial	RCT study	2020	https://doi.org/10.1016/j.annonc.2020.07.020
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study	RCT study	2002	https://doi.org/10.1200/JCO.2002.20.2.567
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain	RCT study	2010	https://doi.org/10.1016/j.jpainsymman.2009.06.008
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain	RCT study	2018	https://doi.org/10.1016/j.jpainsymman.2017.09.001
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial	RCT study	2012	https://doi.org/10.1016/j.jpain.2012.01.003
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)	RCT study	2006	https://doi.org/10.1200/JCO.2005.05.1847

Carnitine

	Category	Publication year	DOI
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy	RCT study	2005	https://doi.org/10.1016/j.urology.2005.05.014
Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study	RCT study	2009	https://doi.org/10.1016/j.jpainsymman.2008.03.021
Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial	RCT study	2012	https://doi.org/10.1200/JCO.2011.40.2180
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy	RCT study	2013	https://doi.org/10.1200/JCO.2012.44.8738
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine	RCT study	2018	https://doi.org/10.1093/jnci/djx259
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients	RCT study	2017	https://doi.org/10.14740/jocmr3113w
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial	RCT study	2012	http://www.nutritionj.com/content/11/1/52
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia	RCT study	2010	https://doi.org/10.1634/theoncologist.2009-0153
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy	RCT study	2014	https://doi.org/10.4103/2278-0513.132113
Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients	RCT study	2020	https://doi.org/10.1002/jpen.1720
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy	RCT study	2016	https://doi.org/10.3892/etm.2016.3871
Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy	RCT study	2020	https://doi.org/10.21608/jbaar.2020.119755

Curcumin

	Category	Publication year	DOI
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer	RCT study	2013	http://dx.doi.org/10.4172/1948-5956.1000223
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study	RCT study	2016	https://doi.org/10.1080/01635581.2016.1115527
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer	RCT study	2015	https://doi.org/10.7508/ijrr.2015.03.011
Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study	RCT study	2014	https://doi.org/10.1177/1534735413503549
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients	RCT study	2013	https://doi.org/10.1667/RR3255.1

Enzymes (bromelain papain)

	Category	Publication year	DOI
Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects	RCT study	2001	https://doi.org/10.1007/s002800170006
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy	RCT study	2007	https://doi.org/10.1007/s00066-007-1634-0
Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers	RCT study	2001	https://doi.org/10.1007/s002800170005
Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer	RCT study	2003
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial	RCT study	2002	https://doi.org/10.1016/S0167-8140(02)00192-5 Get rights and content
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme	RCT study	1991
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor	RCT study	2018	https://doi.org/10.3892/ol.2017.7673
Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen	RCT study	1992	https://link.springer.com/chapter/10.1007/978-3-7091-9087-6 34
Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente	RCT study	1978

Folic acid

	Category	Publication year	DOI
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...)	RCT study	2014	https://doi.org/10.1136/ bmjresp-2014-000061

Ginger

	Category	Publication year	DOI
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy	RCT study	2016	https://doi.org/10.14456/apjcp.2016.186/APJCP.2016.17.8.3877
Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer	RCT study	2015	https://doi.org/10.1188/15.CJON.E92-E97
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin	RCT study	2017	https://doi.org/10.1093/annonc/mdx315
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens	RCT study	2011	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828901/
Kadhim et al. (2021): Effect of Ginger Tea on Chemotherapy-Induced Nausea and Vomiting among Patients Attending the Oncology Teaching Hospital, Baghdad 2020	RCT study	2021	https://doi.org/10.37506/ijfmt.v15i3.15511
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy	RCT study	2017	https://doi.org/10.1007/s12032-017-0931-4
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial	RCT study	2018	https://doi.org/10.1177/153473541775354
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer	RCT study	2015	http://dx.doi.org/10.1016/j.ctim.2015.03.009
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial	RCT study	2017	https://doi.org/10.3390/nu9080867
Montazeri et al. (2013): Effect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients	RCT study	2013	https://doi.org/10.5812/ircmj.4392
Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial	RCT study	2012	https://doi.org/10.1177/15347354114332
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients	RCT study	2013	https://doi.org/10.5812/ircmj.4392
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients	RCT study	2011	https://doi.org/10.1007/s00520-011-1236-3
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting	RCT study	2016	https://doi.org/10.1111/fct.12236
Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer	RCT study	2016	https://doi.org/10.14456/apjcp.2016.225/APJCP.2016.17.8.4125
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients	RCT study	2017	https://doi.org/10.15296/ijwhr.2017.55
Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study	RCT study	2016	https://www.researchgate.net/profile/Mohammad-Shooriabi/publication/309204156 The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia A double-blind controlled study/links/5805266408aee314f68e2109/The-effect-of-ginger-extract-on-radiotherapy-oriented-salivation-in-patients-with-xerostomia-A-double-blind-controlled-study.pdf
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study	RCT study	2003	https://academy.miloa.eu/wp-content/uploads/2020/06/S.-Sontakke-M.-S.-Naik-al-2003.pdf
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study	RCT study	2017	https://doi.org/10.1007/s00520-016-3423-8
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study	RCT study	2020	https://doi.org/10.1007/s00520-019-05201-5
Yekta et al. (2012): Ginger as a miracle against chemotherapy-induced vomiting	RCT study	2012	https://www.researchgate.net/publication/249321809 Ginger as a miracle against chemotherapy-induced vomiting
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting	RCT study	2008	https://doi.org/10.1007/s00520-008-0528-8

Ginkgo

	Category	Publication year	DOI
Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9	RCT study	2013	https://doi.org/10.1007/s00520-012-1647-9
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131	RCT study	2012	https://doi.org/10.1089/thy.2010.0398
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study	RCT study	2015	https://doi.org/10.5935/0946-5448.20150003

Green tea (EGCG)

	Category	Publication year	DOI
Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer	RCT study	2012	https://doi.org/10.1158/1940-6207.CAPR-12-0117
Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy	RCT study	2014	http://PMC4116577
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy	RCT study	2015	https://doi.org/10.1002/pros.22943
Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial	RCT study	2017	https://doi.org/10.1001/jamadermatol.2017.2529
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study	RCT study	2014	https://doi.org/10.1177/201010581402300102
Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities	RCT study	2012	https://doi.org/10.1158/1940-6207.CAPR-11-0306
Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors	RCT study	2010	https://doi.org/10.1111/j.1365-277X.2010.01078.x

Guarana

	Category	Publication year	DOI
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy	RCT study	2011	https://doi.org/10.1089/acm.2010.0571
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study	RCT study	2009	https://doi.org/10.1089/acm.2008.0324
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study	RCT study	2013	https://doi.org/10.3109/19390211.2013.830676
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life	RCT study	2016	https://doi.org/10.1080/19390211.2016.1193081

Low-carbohydrate or ketogenic diet

	Category	Publication year	DOI
Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial	RCT study	2018	https://doi.org/10.3390/nu10091187
Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2)	RCT study	2020	https://doi.org/10.1158/1078-0432.CCR-19-3873
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study	RCT study	2019	https://doi.org/10.1080/01635581.2019.1650942

Lycopene

	Category	Publication year	DOI
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer	RCT study	2011	https://doi.org/10.1007/s10552-010-9684-5
Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients	RCT study	2017	https://doi.org/10.15171/jnp.2017.25
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA	RCT study	2017	https://doi.org/10.1016/j.clnu.2016.06.014
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study	RCT study	2010	https://doi.org/10.4103/0028-3886.60389

Reflexology

	Category	Publication year	DOI
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population?	RCT study	2013	http://dx.doi.org/10.1016/j.ctcp.2013.03.002
Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial.	RCT study	2012	https://doi.org/10.1155/2012/456897
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer	RCT study	2010	https://doi.org/10.1016/j.ejca.2009.10.006
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer.	RCT study	2000	https://www.researchgate.net/publication/12653792 The effects of foot reflexology on anxiety and pain in patients with breast and lung cancer
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety.	RCT study	2007	https://doi.org/10.1188/07.ONF.127-132
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer.	RCT study	2008	https://doi.org/10.1097/01.NCC.0000305694.74754.7b
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial	RCT study	2016	https://doi.org/10.1111/ijn.12532
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer	RCT study	2012	https://doi.org/10.1188/12.ONF.568-577
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment	RCT study	2017	https://doi.org/10.1016/j.jpainsymman.2017.07.037
Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients	RCT study	2017	https://doi.org/10.4103/apjon.apjon 15 17
Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients	RCT study	2017	http://doi.org/10.1016/j.ctcp.2017.09.004

Resveratrol

	Category	Publication year	DOI
Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics	RCT study	2011	http://10.1158/1940-6207.CAPR-11-0148

Selenium

	Category	Publication year	DOI
Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients	RCT study	2006	https://link.springer.com/article/10.1385/BTER:110:1:19
Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients	RCT study	2010	https://ar.iiarjournals.org/content/30/5/1829.short
Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients	RCT study	2010	https://ar.iiarjournals.org/content/30/5/1783.short
Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial	RCT study	2016	https://doi.org/10.1016/j.ejca.2016.09.021
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial	RCT study	2013	https://doi.org/10.1038/bmt.2012.250
Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597	RCT study	2012	https://doi.org/10.1200/JCO.2013.49.2173
Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer	RCT study	2020	https://doi.org/10.3290/j.ohpd.a45080
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck	RCT study	2015	https://doi.org/10.5306/wjco.v6.i5.166
Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology	RCT study	2010	https://doi.org/10.1016/j.ijrobp.2009.08.013
Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial	RCT study	2013	https://link.springer.com/article/10.1186/1748-717X-8-72
Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization	RCT study	2014	https://doi.org/10.1177/1534735414541963
Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer	RCT study	2010	https://doi.org/10.1158/1940-6207.CAPR-09-0143

Vitamin A (beta-carotene)

	Category	Publication year	DOI
Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients	RCT study	2005	https://doi.org/10.1093/jnci/dji095
Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients	RCT study	2005	https://doi.org/10.1200/JCO.2005.05.514
Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients	RCT study	2006	https://doi.org/10.1002/ijc.22042
Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy	RCT study	2005	https://pubmed.ncbi.nlm.nih.gov/15690650/
Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer	RCT study	1996	https://doi.org/10.1016/S0964-1955(96)00010-3
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study	RCT study	2012	https://doi.org/10.1016/j.ijrobp.2011.05.032
Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer	RCT study	2001	https://pubmed.ncbi.nlm.nih.gov/11245451/
Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial	RCT study	1995	https://doi.org/10.1016/0145-2126(95)00032-J
Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial	RCT study	2003	https://doi.org/10.3892/or.10.6.1895
Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer	RCT study	2000	https://doi.org/10.1093/jnci/92.12.977

Vitamin B1

	Category	Publication year	DOI
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture	RCT study	2013	http://dx.doi.org/10.1155/2013/349653

Vitamin B12

	Category	Publication year	DOI
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...)	RCT study	2014	https://doi.org/10.1136/ bmjresp-2014-000061
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy	RCT study	2014	https://doi.org/10.4103/2278-0513.132113

Vitamin B6

	Category	Publication year	DOI
Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy	RCT study	2014	https://doi.org/10.12788/jcso.0017
Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group	RCT study	1995	https://doi.org/10.1159/000475139
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study	RCT study	2014	http://www.ncbi.nlm.nih.gov/pubmed/26158157
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture	RCT study	2013	http://dx.doi.org/10.1155/2013/349653
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial	RCT study	2017	https://doi.org/10.1001/jamaoncol.2017.1269

Vitamin C

	Category	Publication year	DOI
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer	RCT study	2016	https://doi.org/10.1177/0194599816642418
Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial	RCT study	2016	http://dx.doi.org/10.1155/2016/9147279
Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial	RCT study	2010	http://dx.doi.org/10.2967/jnumed.109.071449

Vitamin D

	Category	Publication year	DOI
Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial	RCT study	2018	https://doi.org/10.1158/1078-0432.CCR-18-0483
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer	RCT study	2018	https://doi.org/10.1080/01635581.2018.1445766
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer	RCT study	2008	https://doi.org/10.1158/1078-0432.CCR-07-4274
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators	RCT study	2007	https://doi.org/10.1200/JCO.2006.06.8197
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial	RCT study	2019	https://doi.org/10.3390/cancers12113451
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial	RCT study	2021	https://doi.org/10.3390/ cancers13153707
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial	RCT study	2019	https://doi.org/10.1016/j.wneu.2019.05.250
Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT	RCT study	2020	https://doi.org/10.1080/01635581.2020.1819348
Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study	RCT study	2016	https://doi.org/10.1093/annonc/mdw145
Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial	RCT study	2021	https://doi.org/10.3390/nu13061931
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer	RCT study	2019	https://doi.org/10.1007/s00520-019-04684-6
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial	RCT study	2017	https://doi.org/10.1007/s10549-017-4429-8
Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients	RCT study	2017	https://doi.org/10.1038/s41523-017-0006-x
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial	RCT study	2019	https://doi.org/10.1001/jama.2019.2402
Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia	RCT study	2019	https://doi.org/10.1007/s10549-019-05319-4
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial	RCT study	2019	https://doi.org/10.1007/s40199-019-00306-y
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial	RCT study	2011	https://doi.org/10.1007/s10549-011-1644-6
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer	RCT study	2011	https://doi.org/10.1200/JCO.2010.32.8815
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)	RCT study	2016	https://doi.org/10.1007/s10549-016-3710-6
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial	RCT study	2019	https://doi.org/10.1001/jama.2019.2210
Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma	RCT study	2010	https://doi.org/10.1016/j.humimm.2010.04.008

Vitamin E

	Category	Publication year	DOI
Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial	RCT study	2013	https://doi.org/10.1590/S1516-31802013000100006
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results	RCT study	2006	https://doi.org/10.1007/s00520-006-0072-3
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation	RCT study	2006	https://doi.org/10.1016/j.jpainsymman.2006.03.013
Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis	RCT study	2015	https://doi.org/10.5812/rro.2(1)2015.796
Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients	RCT study	2005	https://doi.org/10.1093/jnci/dji095
Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients	RCT study	2005	https://doi.org/10.1200/JCO.2005.05.514
Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients	RCT study	2006	https://doi.org/10.1002/ijc.22042
Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors	RCT study	1998	https://doi.org/10.1200/JCO.1998.16.2.495
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer	RCT study	2016	https://doi.org/10.1177/0194599816642418
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis	RCT study	2003	https://doi.org/10.1200/JCO.2003.06.064
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer?	RCT study	2013	https://doi.org/10.1097/MNM.0b013e328362b1f2
Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial	RCT study	2004	https://doi.org/10.1002/hed.10382
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation	RCT study	2007	https://doi.org/10.1111/j.1743-7563.2007.00111.x
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer	RCT study	2019	https://doi.org/10.1007/s00520-019-04684-6
Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial	RCT study	2011	https://doi.org/10.1007/s00520-010-1018-3
Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial	RCT study	2012	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278875/
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy	RCT study	2014	https://doi.org/10.4103/2278-0513.132113
Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy	RCT study	2003	https://doi.org/10.1200/JCO.2003.05.139
Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy	RCT study	2010	https://doi.org/10.1212/WNL.0b013e3181d5279e
Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial	RCT study	2015	https://doi.org/10.4103/2008-7802.169021
Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial	RCT study	2017	https://doi.org/10.5812/jjnpp.65027
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial	RCT study	2017	https://doi.org/10.1097/MNM.0000000000000727
Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial	RCT study	2016	https://doi.org/10.1002/hed.24396

Zeolites

	Category	Publication year	DOI
Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy	RCT study	2020	https://doi.org/10.3390/molecules25102297

Zinc

	Category	Publication year	DOI
Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial	RCT study	2012	https://journalaim.com/Article/327
Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer	RCT study	2015	https://dx.doi.org/10.1080/01635581.2015.1053497
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study	RCT study	2004	http://10.1016/S0360-3016(03)01562-1
Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer	RCT study	2013	http://ijrr.com/article-1-1036-en.html
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4)	RCT study	2007	http://10.1016/j.ijrobp.2006.10.046
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation	RCT study	2018	https://doi.org/10.1016/j.leukres.2018.04.016
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study	RCT study	2006	http://10.1016/j.ijrobp.2006.01.015
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study	RCT study	2008	http://10.1016/j.ijrobp.2007.06.073
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis	RCT study	2009	http://10.1002/lary.20524
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study	RCT study	2010	https://dx.doi.org/10.1080/01635581003605532
Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders	RCT study	2012	http://10.3109/15360288.2012.676618
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial	RCT study	2014	https://ijrr.com/browse.php?a id=1281&sid=1&slc lang=en
Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial	RCT study	2013	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724372/?report=printable
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer	RCT study	2017	https://dx.doi.org/10.1590/S1679-45082017AO3830
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation	RCT study	1998	<1938::AID-CNCR18>3.0.CO;2-U https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0142(19980515)82:10<1938::AID-CNCR18>3.0.CO;2-U
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients	RCT study	2013
Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy	RCT study	2015	https://dx.doi.org/10.1080/01635581.2015.1004735
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer	RCT study	2010	https://dx.doi.org/10.1002/ijc.25200