Publication: Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study
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| Title | Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study |
| Topic | Vitamin A (beta-carotene) |
| Author | Margalit, DN, Kasperzyk, JL, Martin, NE, Sesso, HD, Gaziano, JM, Ma, J, Stampfer, MJ, Mucci, LA |
| Year | 2012 |
| Journal | International journal of radiation oncology, biology, physics |
| DOI | https://doi.org/10.1016/j.ijrobp.2011.05.032 |
Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.
| Purpose: The safety of antioxidant supplementation during radiation therapy (RT) for cancer is controversial. Antioxidants could potentially counteract the pro-oxidant effects of RT and compromise therapeutic efficacy. We performed a prospective study nested within the Physicians’ Health Study (PHS) randomized trial to determine if supplemental antioxidant use during RT for prostate cancer is associated with an increased risk of prostate cancer death or metastases.
Methods and Materials: PHS participants (383) received RT for prostate cancer while randomized to receive beta-carotene (50 mg on alternate days) or placebo. The primary endpoint was time from RT to lethal prostate cancer, defined as prostate cancer death or bone metastases. The Kaplan-Meier method was used to estimate survival probabilities and the log-rank test to compare groups. Cox proportional hazards regression was used to estimate the effect of beta-carotene compared with that of placebo during RT. Results: With a median follow-up of 10.5 years, there was no significant difference between risk of lethal prostate cancer with the use of beta-carotene during RT compared with that of placebo. |
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