Publication: Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer?
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| Title | Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? |
| Topic | Vitamin E |
| Author | Fallahi, B, Beiki, D, Abedi, SM, Saghari, M, Fard-Esfahani, A, Akhzari, F, Mokarami, B, Eftekhari, M |
| Year | 2013 |
| Journal | Nuclear medicine communications |
| DOI | https://doi.org/10.1097/MNM.0b013e328362b1f2 |
Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.
| Objectives Salivary gland impairment after high-dose radioiodine (131I) treatment is well recognized. The aim of this study was to determine the protective effect of vitamin E on radiation-induced salivary gland dysfunction in patients undergoing 131I treatment for differentiated thyroid cancer. Methods Thirty-six patients with differentiated thyroid carcinoma were enrolled in this study. They were randomly divided into two groups before postsurgical ablation therapy with 3700–5550MBq 131I: the control group, comprising 17 patients, and the vitamin E group, comprising 19 patients. All 19 patients in the experimental group received vitamin E at a dose of 800 IU/day for a duration of 1 week before to 4 weeks after 131I therapy and the 17 patients in the control group received a placebo for the same duration. Salivary gland function was assessed using salivary gland scintigraphy with intravenous injection of 370MBq 99mTc-pertechnetate in two phases, one immediately before and the other 6 months after 131I ablative therapy. First-minute uptake ratio, maximum uptake ratio, maximum secretion percentage, and excretion fraction (EF) of each salivary gland were measured and compared between the study phases for the two groups. Results There was no significant difference between preablative and postablative salivary scintigraphic indices in the experimental vitamin E group, whereas maximum secretion percentage and EF of the right submandibular gland and EF of the left parotid gland were significantly decreased in the control group. There was also a higher significant decrease in the EF of the left parotid gland in the control group compared with the vitamin E group. Conclusion Vitamin E consumption may be associated with a significant protective effect against radiation-induced dysfunction in salivary glands following single-dose 131I therapy in patients with differentiated thyroid cancer. |
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