Publication: Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial
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| Title | Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial |
| Topic | Vitamin E |
| Author | Villani, V, Zucchella, C, Cristalli, G, Galie, E, Bianco, F, Giannarelli, D, Carpano, S, Spriano, G, Pace, A |
| Year | 2016 |
| Journal | Head and Neck |
| DOI | https://doi.org/10.1002/hed.24396 |
Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.
| Background.
Few studies have investigated the effect of vitamin E in reducing the cisplatin (CDDP)-induced ototoxicity. This study evaluated vitamin E supplementation as a protecting agent against CDDP-induced ototoxicity. Methods. Patients who started CDDP were randomly assigned to receive vitamin E supplementation at 400 mg per day (group 1) or placebo (group 2). Audiograms and evoked brainstem responses were obtained at baseline, and after 1, 2, and 3 months. Results. Twenty-three patients affected by solid malignancies were enrolled (13 in group 1 and 10 in group 2). At 1 month, a significant hearing loss in group 2 at both 2000 HZ (right ear: p=0.05; left ear: p=0.04) and 8000 HZ (right ear: p=0.04; left ear: p=0.03) was detected when compared to baseline values. Audiograms did not show significant changes. At 1 month, evoked brainstem responses remained unchanged in both arms without significant differences between groups. Conclusion. These preliminary findings confirm the neuroprotective properties of vitamin E against the CDDP-induced ototoxicity. |
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