Publication: Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients
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| Title | Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients |
| Topic | Ginger (also contains zerumbone)"Ginger (also contains zerumbone)" is not in the list (Aloe vera, Cannabinoids, Curcumin, Enzymes (bromelain papain), Folic acid, Ginkgo, Green tea (EGCG), Low-carbohydrate or ketogenic diet, Lycopene, Selenium, ...) of allowed values for the "Topic" property. |
| Author | Ryan, JL, Heckler, CE, Roscoe, JA, Dakhil, SR, Kirshner, J, Flynn, PJ, Hickok, JT, Morrow, GR |
| Year | 2011 |
| Journal | Support Care Cancer |
| DOI | https://doi.org/10.1007/s00520-011-1236-3 |
Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.
| Purpose Despite the widespread use of antiemetics, nausea continues to be reported by over 70% of patients receiving chemotherapy.
Methods In this double blind, multicenter trial, we ran- domly assigned 744 cancer patients to four arms: 1) placebo, 2) 0.5 g ginger, 3) 1.0 g ginger, or 4) 1.5 g ginger. Nausea occurrence and severity were assessed at a baseline cycle and the two following cycles during which patients were taking their assigned study medication. All patients received a 5-HT3 receptor antagonist antiemetic on Day 1 of all cycles. Patients took three capsules of ginger (250 mg) or placebo twice daily for 6 days starting 3 days before the first day of chemotherapy. Patients reported the severity of nausea on a 7-point rating scale (“1” = “Not at all Nauseated” and “7” = “Extremely Nauseated”) for Days 1–4 of each cycle. The primary outcomes were to determine the dose and efficacy of ginger at reducing the severity of chemotherapy-induced nausea on Day 1 of chemotherapy. Results A total of 576 patients were included in final analysis (91% female, mean age = 53). Mixed model analyses demonstrated that all doses of ginger significantly reduced acute nausea severity compared to placebo on Day 1 of chemotherapy (p=0.003). The largest reduction in nausea intensity occurred with 0.5 g and 1.0 g of ginger (p=0.017 and p=0.036, respectively). Anticipatory nausea was a key factor in acute chemotherapy-induced nausea (p < 0.0001). Conclusions Ginger supplementation at a daily dose of 0.5 g– 1.0 g significantly aids in reduction of the severity of acute chemotherapy-induced nausea in adult cancer patients. |
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