Publication: Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial
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| Title | Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial |
| Topic | Vitamin D |
| Author | Ng, K, Nimeiri, HS, McCleary, NJ, Abrams, TA, Yurgelun, MB, Cleary, JM, Rubinson, DA, Schrag, D, Miksad, R, Bullock, AJ, Allen, J, Zuckerman, D, Chan, E, Chan, JA, Wolpin, BM, Constantine, M, Weckstein, DJ, Faggen, MA, Thomas, CA, Kournioti, C, Yuan, C, Ganser, C, Wilkinson, B, Mackintosh, C, Zheng, H |
| Year | 2019 |
| Journal | JAMA |
| DOI | https://doi.org/10.1001/jama.2019.2402 |
Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.
| Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D3 (4000 IU) or standard-dose (400 IU) vitamin D3 . Body composition was measured with abdominal computed tomography at enrollment (baseline) and after cycle 8 of chemotherapy (16 weeks). As compared with standard-dose vitamin D3 , high-dose vitamin D3 did not significantly change body weight (−0.7 kg; (95% CI: −3.5, 2.0)), body mass index (−0.2 kg/m2; (95% CI: −1.2, 0.7)), muscle area (−1.7 cm2; (95% CI: −9.6, 6.3)), muscle attenuation (−0.4 HU; (95% CI: −4.2, 3.2)), visceral adipose tissue area (−7.5 cm2 ; (95% CI: −24.5, 9.6)), or subcutaneous adipose tissue area (−8.3 cm2; (95% CI: −35.5, 18.9)) over the first 8 cycles of chemotherapy. Among patients with advanced or metastatic colorectal cancer, the addition of high-dose vitamin D3 , vs standard-dose vitamin D3 , to standard chemotherapy did not result in any changes in body composition. |
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