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List of results

• Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients  + (NI)
• Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population?  + (NI)
• Montazeri et al. (2013): Effect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients  + (NI)
• Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial  + (NI)
• Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial  + (NI)
• Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial.  + (NI)
• Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial  + (NI)
• Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer.  + (NI)
• Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety.  + (NI)
• Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer.  + (NI)
• Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy  + (NI)
• Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial  + (NI)
• Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain  + (NI)
• Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens  + (NI)
• Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA  + (NO and M0)
• Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients  + (Non-Hodgkin intermediate and high grade)
• Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial  + (Not operable Pancreas carcinoma, stage IV)
• Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer  + (Number per group: - intervention: 17x I, 19x II, 14x III and IV - placebo: 18x I, 20x II, 18x III and IV)
• Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial  + (Patients in different stages of complete remission: CR1, CR2, CR3)
• Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen  + (Patients with carcinomas in the floor of the mouth)
• Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy  + (Patients with stage I/II/III in % - overall: 13/41/46 - intervention arm: 22/30/48 - placebo arm: 5/51/44 Significant difference between arms (p=0.031): intervention arm with earlier stages at diagnosis of cancer when compared with the placebo arm)
• Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms  + (Patients with untreatable locally advanced … Patients with untreatable locally advanced or metastatic solid tumors and a life expectancy <6 months</br></br></br>Tumor histotype: </br></br>Non-small cell lung cancer: Control arm = 11; Aloe arm = 12</br></br>Gastrointestinal tract tumors: Control arm = 9; Aloe arm = 7</br></br>Breast cancer: Control arm = 4; Aloe arm = 3</br></br>Brain glioblastoma: Control arm = 2; Aloe arm = 2n glioblastoma: Control arm = 2; Aloe arm = 2)
• Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme  + (People with metastases outside the abdomin … People with metastases outside the abdominal area were excluded. </br></br>Karnovsky Index >50%</br></br></br>Abdominal cancer types in enzyme arm; in control arm:</br></br>Ovarian carcinoma: 2; 2</br></br>Uterine carcinoma: 11; 15</br></br>Prostate carcinoma: 14; 2</br></br>Intestinal carcinoma: 3; 7</br></br>Hypernephroma (with pelvic metastases): 1; 1</br></br>Carcinoma of the vas deferens: 1; - </br></br>Head and neck carcinoma: 1; -</br></br>Bladder carcinoma: 1; -</br></br>Non-Hodgkin's lymphoma: -; 1</br></br>Chronic lymphocytic leukemia: -; 1</br></br>Vaginal carcinoma: 1; 2</br></br>Rectal carcinoma: - ; 1</br></br>Double carcinoma: 1; -ctal carcinoma: - ; 1 Double carcinoma: 1; -)
• Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer  + (Per arm, n stage I/n stage II/n stage III: - vit. A: 395/167/85 - NAC: 371/176/95 - vit. A + NAC: 376/182/85 - control: 382/184/77)
• Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer  + (Per group n (%) - intervention: in situ 6 (4%), I 83 (62%), II 45 (34%) - placebo: in situ 7 (5%), I 82 (64%), II 40 (31%))

• Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer  + (Radiotherapy field >33% of the buccal mucosa and ECOG 0‐2)

• Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial  + (Second- and third‐stage colorectal cancer)
• Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life  + (Stage I - IV)
• Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer  + (Stage I and II)
• Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients  + (Stage I or II)
• Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients  + (Stage I or stage II cancer, n (%) of stage II disease per arm: - intervention: 101 (37) - placebo: 107 (40))
• Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients  + (Stage I or stage II cancer, n (%) of stage II disease per arm: - intervention: 101 (37) - placebo: 107 (40))
• Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients  + (Stage I or stage II cancer, n (%) of stage II disease per arm: - intervention: 101 (37) - placebo: 107 (40))
• Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients  + (Stage I-III)
• Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients  + (Stage I-III)
• Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia  + (Stage I-III)
• Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer  + (Stage I-III (non-metastasised) hormone receptor–negative breast cancer Breast cancer stage at diagnosis: n(%) I: Poly E arm: 14(47) Placebo arm: 2(20) II Poly E arm: 9(30) Placebo arm: 6(60) III Poly E arm: 7(23) Placebo arm: 2(20))
• Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT  + (Stage I-IV)
• Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer  + (Stage I: n=5 Stage II: n=35 Stage III: n=15 Stage IV: n=5)
• Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial  + (Stage II)
• Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer  + (Stage II or III breast cancer, no significant differences between arms in cancer stage (p > 0.05))
• Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer  + (Stage II, III, or IV)
• Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study  + (Stage II-IV and recurrent cancer)
• Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia  + (Stage III and IV)
• Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics  + (Stage IV colorectal cancer and hepatic metastases)
• Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial  + (Stage I–III hormone receptor positive breast cancer)
• Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects  + (Stage of disease per arm (n): Enzyme arm: Ib = 2, IIb = 16, IIIb = 42 Control arm: Ib = 0, IIb = 19, IIIb = 41 Performance status (WHO) per arm (n): Enzyme arm: 1 = 54, 2 = 6 Control arm: 1 = 51, 2 =9)
• Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial  + (Stages I to III)
• Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study  + (Stages I-IV and primary and recurrent tumors)
• Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study  + (Stages I-IV and primary and recurrent tumors)
• Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial  + (Stages T1-3, N0-1, M0)