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- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (Carnitine deficiency (free carnitine < … Carnitine deficiency (free carnitine < 35 µmol/L for men or < 25 µmol/L for women or acyl/free carnitine ratio > 0.4; Baseline: intervention arm: 34% and placebo arm: 32%)</br></br>Medication (intervention/placebo arm)</br>Psychostimulants 2.1/ 3.2%</br>Analgesics 44.4/ 33.7% </br>Antidepressants 28.6/ 27.8%s 44.4/ 33.7% Antidepressants 28.6/ 27.8%)