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List of results

Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (Age over 18 years, a dose of radiation rec … Age over 18 years, a dose of radiation received over 4,500 cGy, the radiation received during the period 6 to 7 weeks, minor and major salivary glands involvement, one or two sides of the face in the field of radiation, and over the last three months of receiving radiation. last three months of receiving radiation.)
Montazeri et al. (2013): Eﬀect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients + (Age over 18, having the experience of chem … Age over 18, having the experience of chemotherapy with nausea and vomiting, having at least two chemotherapy episodes. Consists of 50-100 mg Cisplatin, with or without other chemotherapy agents with similar amount and prescription in two chemotherapy cycles without having any plans for radiotherapy among cycles, presence in ward for 24 hours ( in order to investigate the PRN), having no nausea and vomiting experiences for some reasons except for chemotherapy, lack of receiving PRN in 24 past hours, lack of treatment with corticosteroid drugs during considered cycles, lack of aﬄictions to hepatitis, digestion system block-age, brain malignancy and cerebral metastasis and clotting disorder on the basis of recorded information in ﬁles, lack of using the anti-clot drug in ﬁles, lack of using the anti-clot drug)
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (Age over 18, having the experience of chem … Age over 18, having the experience of chemotherapy with nausea and vomiting, having at least two chemotherapy episodes. Consists of 50-100 mg Cisplatin, with or without other chemotherapy agents with similar amount and prescription in two chemotherapy cycles without having any plans for radiotherapy among cycles; presence in ward for 24 hours ( in order to investigate the PRN; having no nausea and vomiting experiences for some reasons except for chemotherapy; lack of receiving PRN in 24 past hours; lack of treatment with corticosteroid drugs during considered cycles; lack of afflictions to hepatitis, digestion system blockage, brain malignancy and cerebral metastasis and clotting disorder on the basis of recorded information in files; lack of using the anti-clot drugin files; lack of using the anti-clot drug)
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (Age ≥18 years; cancer in the pelvic area, radiotherapy and acute proctitis (ARP))
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Aged 18–75 years, Grade ≥3 neuropathy, as … Aged 18–75 years, Grade ≥3 neuropathy, as determined by NCI-CTC criteria version 3.0, while receiving paclitaxel, cisplatin or vinblastine treatment, and/or grade ≥2 neuropathy persisting for at least one month after the discontinuation of either drug, and neurotoxicity for <6 months; at least one abnormality on electrophysiological examination; Karnofsky physical score (KPS) of ≥60; absolute neutrophil count of ≥1.5×109/l, hemoglobin count of ≥80 g/l, platelet count of ≥75×109/l, total bilirubin counts of 1.5-fold less than normal value, glutamic-pyruvic transaminase (GPT/ALT) and glutamic-oxalacetic transaminease (GOT/AST) no more than 2.5-fold greater than the normal value; normal blood urea nitrogen, serum creatinine and electrocardiogram (ECG) findings. During the study, the use of steroids, analgesic or neuroprotectant drugs was not permitted.se of steroids, analgesic or neuroprotectant drugs was not permitted.)
Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (Aged 75 years or younger with recent resected stage II cutaneous malignant melanoma; Hematopoietic, hepatic, and renal functionality within normal ranges)
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa)
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Aged >18 years, pathologically established stages III and IV advanced nasopharyngeal carcinoma (NPC), concomitant chemotherapy and radiotherapy (CCRT))
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (Aged less than 55 years, who were referred … Aged less than 55 years, who were referred to our institute for 131I therapy to ablate the remnant thyroid tissue or to treat metastatic tumor, were enrolled in this study; all patients were in a hypothyroid state with serum thyroid stimulating hormone levels higher than 25 mIU/llating hormone levels higher than 25 mIU/l)
Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Aged ≥18 years; any malignancy of any stag … Aged ≥18 years; any malignancy of any stage; receiving intravenouschemotherapy of moderate or high emetogenic risk; receive at least two more consecutive cycles; refractory CINV (defined as emesis, and/or nausea of moderate severity on a 5-point rating scale, and/or requiring use of rescue medications) in earlier chemotherapy cycles despite guideline-consistent antiemetic prophylaxis consisting of corticosteroids, a 5-HT3 antagonist,and an NK-1 antagonist with or without olanzapine where indicatedwith or without olanzapine where indicated)
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (All hospitalised patients with malodorous fungating malignant wounds were eligible to participate in the study)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (At least 18 years of age with newly diagnosed brain tumor with serum level of 25 (OH) vitamin D ≤20 ng/dL)
Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis + (At least 18 years of age, diagnosis of a hematologic cancer (leukemia or lymphoma), and non-smoker and non-alcoholic.)
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Being married, having stage 1 or 2 breast … Being married, having stage 1 or 2 breast cancer based on the surgery stage, age below 50, receiving tamoxifen, not undergoing chemotherapy or radiotherapy during the study, a normal Pap smear during the last 3 years, no proven malignancies in other parts of the body, being sexually active during the study, meeting at least one of the criteria set in the genitourinary atrophy self-assessment, vaginal pH ≥ 5 according to Chollet et al. study at the time of the study, and a Vaginal Maturation Index (VMI) ≤52 according to Speroff’s studydex (VMI) ≤52 according to Speroff’s study)
Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients + (Being older than 18, knowing the diagnosis of the disease, receiving no radiotherapy, receiving a epirubicin and cyclophosphamide, having received no reflexology therapy before, being literate in Turkish)
Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (Being older than 18, knowing the diagnosis … Being older than 18, knowing the diagnosis of the disease, receiving no radiotherapy, receiving an epirubicin and cyclophosphamide, having received no reflexology therapy before, literate in Turkish, having no hemorrhage, epilepsy, or fever, having no paraplegia or thrombosis, having no gall-kidney stones, having no leg varicosis and foot disease (open wound or fracture on foot), having no diagnosis of psychiatric disorder or dementia, having accepted to participate in the study.ving accepted to participate in the study.)
Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (Biopsy-proved prostate cancer; received no … Biopsy-proved prostate cancer; received no other therapy for their prostate cancer; current PSA less than 50 ng/mL; older than 18 years; no history of chemotherapy and/or radiation for any malignancy in the previous 5 years; good performance status; normal renal function (creatinine ≤ institutional upper limits of normal); normal hepatic function (total bilirubin, aspartate aminotransferase (AST; SGOT)/alanine aminotransferase (ALT; SGPT) ≤ institutional upper limits of normal)T) ≤ institutional upper limits of normal))
Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (Biopsy-proven localized (nonmetastatic) pr … Biopsy-proven localized (nonmetastatic) prostate cancer documented within 48 months before enrolling in the trial, Gleason score of <8, serum PSA level of <50 ng/mL, age <85 years, life expectancy of ≥3 years, elected to forgo front-line therapy and chose to be followed by active surveillance, limited daily selenium supplementation to no more than 50 μg from non-study sourcestation to no more than 50 μg from non-study sources)
Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Biopsy-proven squamous cell carcinoma of t … Biopsy-proven squamous cell carcinoma of the head and neck: oral cavity or oropharynx staged T1-T3 at subsites, alveolo-buccal, oral tongue, base of tongue, epiglottis/vallecula, tonsil and pharyngeal wall (lateral or posterior); previous chemotherapy was allowedterior); previous chemotherapy was allowed)
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Both sexes, age ≥ 18 years; tumors of oropharynx or oral cavity; no prior radiotherapy; primary or secondary radiotherapy; written informed consent; expected compliance)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Breast cancer patients undergoing adjuvant radiotherapy after surgery)
Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Cancer patients receiving anthracycline chemotherapy in their protocol alone (without any cardioprotective agent), aged 20-60 years)
Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Cancer patients undergoing radiotherapy)

Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (Cancer patients, age ≥ 18 years, chemotherapy with cisplatin)

Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Cancer requiring capecitabine therapy; nev … Cancer requiring capecitabine therapy; never received capecitabine before; performance status of 0 to 2, according to the Eastern Cooperative Oncology Group (ECOG) classifcation; ife expectancy longer than 6 months; not being on vitamin B supplements; no prior HFS; no contraindication to chemotherapy (ie, patient had adequate bone marrow function, including an absolute neutrophil count > 1,500 cells/L and a platelet count > 100,000/L); adequate renal function (as indicated by a serum creatinine concentration < 1.5 mg/dL); adequate liver function (as indicated by a serum bilirubin concentration < 1.5 mg/dL, a transaminase level < 3 times the upper normal limit, and a serum albumin level > 2.5 mg/dL)pper normal limit, and a serum albumin level > 2.5 mg/dL))
Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (Chemotherapy treatment by a regimen with t … Chemotherapy treatment by a regimen with the same mucositis probability, including cyclophosphamide, doxorubicin, dacarbazine, gemcitabine, methotrexate, and 5-fluorouracil; Karnofsky performance status 60 or above; life expectancy equal to or more than 6 months; white blood cell (WBC) count equal to or more than 1500cell/ml platelet counts equal to greater than 100000 μLlet counts equal to greater than 100000 μL)
Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (Colon cancer patients aged 20 to 75 years, scheduled for elective laparoscopic colectomy under general anesthesia)
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Completely functional erections before sur … Completely functional erections before surgery (corroborated by the partner and documented in the patient file), bilateral nerve-sparing radical retropubic prostatectomy (indicated on the surgical report) performed for pathologically proven organ-confined disease at least 6 months before screening, no adjuvant or neoadjuvant therapy for prostate cancer, no other treatment for ED before or after surgery, an undetectable postoperative prostate-specific antigen level, and involvement in a stable heterosexual relationship for at least 6 months before surgerynship for at least 6 months before surgery)
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Definite pathological diagnosis of differentiated thyroid cancer (DTC), presented to department for 131I treatment)
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Diagnosed with biopsy-proven Head-Neck-Cancer, treated with >4000-cGy intensity-modulated radiotherapy)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (Diagnosed with cancer, may have received ≥ … Diagnosed with cancer, may have received ≥1 chemotherapy cycle, and were scheduled for at least three additional chemotherapy cycles, chemotherapy must have been given without concurrent radiation therapy or interferon and without planned interruption by radiation therapy or surgery, must have experienced nausea of any severity in any chemotherapy cycle before study enrollment, as well as scheduled to receive a 5-HT3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone at all chemotherapy cycless dexamathasone at all chemotherapy cycles)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Diagnosed with noninflammatory breast cancer or carcinoma in situ and prescribed radiotherapy without concurrent chemotherapy at the University of Rochester Cancer Center)
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens + (Diagnosis of cancer and receiving cisplati … Diagnosis of cancer and receiving cisplatin-based regimens at least for two cycles of the chemotherapy, receiveing one of the standard antiemetic regimens [5-HT3 antagonist (granisetrone) and corticostreoid (hydrocortisone)], being able to swallow capsulesortisone)], being able to swallow capsules)
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Diagnosis of head or neck cancer; age ≥18 years; Karnofsky performance > 70 (i.e. able to carry out normal activity and work))
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (Diagnosis of hematological tumor; white bl … Diagnosis of hematological tumor; white blood cell count 3–12×109/l, platelet count ≥60×109 /l, absolute neutrophil count ≥109 /l; average score of the difficulty of mandibular impacted third molar extraction ≥14, patients had difficulties with tooth extraction; informed consent form signed by patientsd difficulties with tooth extraction; informed consent form signed by patients)
Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial + (Eastern Cooperative Oncology Group (ECOG) … Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1, diagnosed with colorectal or gastric cancer and scheduled to receive oxaliplatin-based regimens (fluouracil, leucovarine and oxaliplatin, FLOX; 5-FU/leucovarine plus axaliplatine, FOLFOX; epirubicin, oxaliplatin and capecitabine EOX; and capecitabine plus oxaliplatin, XELOX) and capecitabine plus oxaliplatin, XELOX))
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (External beam radiotherapy treatment for head and neck cancer for the first time)
Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (Female patients with histologically confirmed primary early-stage breast cancer, treated in the last 12 months with adjuvant or neoadjuvant chemotherapy, and with an ECOG performance status of <2, vitamin D deficiency)
Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer + (Female with stage II or III breast cancer, … Female with stage II or III breast cancer, having received previous surgical treatment for breast cancer, currently receiving chemotherapy with adjuvant anthracycline (chemotherapy protocols: anthracycline, cyclophosphamide [Cytoxan®], doxorubicin [Adriamycin®], and 5-ﬂuorouracil [Adrucil®]), receiving palonosetron-aprepitant antiemetic treatment, being at least in the second cycle of chemotherapy, and having experienced chemotherapy-induced nausea with a severity of 3 or higher during the previous cycles of 3 or higher during the previous cycles)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (Female; over 18 years of age; newly diagnosed histologically proven early breast cancer (T1, T2 [<3 cm], N0, N1a, M0); received breast surgery; WHO status 0 or 1; willing to give written, informed consent; and able to complete questionnaires)
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Females with approved ovarian cancer who underwent primary cytoreductive surgery, willingness to participate in the study.)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (From 18 to 68 years, in complete remission of the disease and bone marrow (NCCN guidelines), with optimal kidney and liver functions)
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 + (Had undergone near-total thyroidectomy for DTC (differentiated thyroid cancer), at enrollment considered to be free of cancer metastases (serum thyroglubin level < 10ng/ml, negative anti-TG antibody titer and negative ultrasound neck examination)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (Head and neck cancer patients scheduled to … Head and neck cancer patients scheduled to receive ≥2,000 cGy of external beam radiotherapy to ≥30% of the oral cavity; ≥18 years of age; life expectancy of ≥3 months (as determined by the physician’s judgment); Eastern Cooperative performance score of 0, 1, or 2; be able to take oral medications reliably and be alert and competent;receiving amifostine and/or concomitant chemotherapy was allowednd/or concomitant chemotherapy was allowed)
Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (Head and neck cancers who were on schedule for radiotherapy with at least 2000 Gy ot >30% of oral cavity, with or without chemotherapy)
Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (Hemoglobin ≥ 9 g/dL taken ≤ 4 weeks before registration)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Histological diagnosis of squamous cell ca … Histological diagnosis of squamous cell carcinoma of the oral cavity, the oropharynx, the hypopharynx, and/or the larynx; treated by radiotherapy alone, postoperative radiotherapy, radiochemotherapy alone, or postoperative radiochemotherapy; aged 18 to 80 years; no other cancer diagnosis in the past 5 years, except for basal cell and squamous cell carcinoma of the skinll and squamous cell carcinoma of the skin)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Histologically confirmed advanced stage tu … Histologically confirmed advanced stage tumor at any site, loss of >5% of ideal or preillness body weight in the previous 3 months with or without abnormal values of proinflammatory cytokines predictive of the onset of clinical cachexia, and a life expectancy ≥ 4 months, were eligible. Patients could be receiving concomitant antineoplastic chemotherapy or hormone therapy with palliative intent or supportive care.py with palliative intent or supportive care.)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Histologically confirmed colorectal cancer … Histologically confirmed colorectal cancer (adenocarcinoma); histological stage III colon cancer or rectosigmoid cancer resected with D2 or more lymph node dissection; age 20-80 years old; Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1; no prior chemotherapy or radiotherapy for target disease; oral intake is possible; preservation of primary organ function (white blood cell count ≥3,000 /mm3 and >12,000 /mm3, neutrophil count ≥1,500 /mm3, haemoglobin ≥9.0 g/dL, platelet count ≥100,000 /mm3; serum creatinine <1.5 mg/dL, serum total bilirubin <1.5 mg/dL, aspartate aminotransferase (ALT) <100 IU/L); able to start protocol treatment within 8 weeks of surgical procedurerotocol treatment within 8 weeks of surgical procedure)