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- Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (Diagnosis of hematological tumor; white bl … Diagnosis of hematological tumor; white blood cell count 3–12×10<sup>9</sup>/l, platelet count ≥60×10<sup>9</sup> /l, absolute neutrophil count ≥10<sup>9</sup> /l; average score of the difficulty of mandibular impacted third molar extraction ≥14, patients had difficulties with tooth extraction; informed consent form signed by patientsd difficulties with tooth extraction; informed consent form signed by patients)