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List of results

Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Aloe was well tolerated in all patients and no metabolic undesirable effects were observed. In addition, no aloe-related toxicity occurred, including vomiting and diarrhoea.)
Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (As reported, no adverse effects were observed (no significant differences in headaches, nausea, fatigue, and other symptoms between placebo and Vitamin E (all p > 0.05))
Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (As reported, no adverse effects were observed (no significant differences in headaches, nausea, fatigue, and other symptoms between placebo and Vitamin E (all p > 0.05))
Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients + (Authors: “L-carnitine was well tolerated by all patients.” No differences in mortality as of March 2018.)
Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients + (Authors: “L-carnitine was well tolerated by all patients.” No differences in mortality as of March 2018.)
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (Caused by taxane therapy, Grade 3 Toxicities (CTCAE): Sleep disturbance: 1 instance Neuropathy (caused by taxanes): 1 instance)
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (Caused by taxane therapy, Grade 3 Toxicities (CTCAE): Vomiting: 1 instance Neuropathy (caused by taxanes): 8 instances)
Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9 + (Change in side effects of chemotherapy (scale 0-10), sign. reduction of nausea within the Ginkgo arm (Mean=-0.1, SD=2.78) compared to the placebo arm (Mean=-0.9, SD=2.67), p=0.05)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Cognitive functions: negative effect of na … Cognitive functions: negative effect of nabiximols (no values given); nausea and vomiting; dizziness; drowsiness; disorientation; anorexia, constipation; dry mouth; anemia; diarrhea; dysgeusia headache; asthenia hallucinations; reduced appetite; fatigue; pain; insomnia; stomatitis weight lossue; pain; insomnia; stomatitis weight loss)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Cognitive functions: negative effect of na … Cognitive functions: negative effect of nabiximols (no values given); nausea and vomiting; dizziness; drowsiness; disorientation; anorexia, constipation; dry mouth; anemia; diarrhea; dysgeusia headache; asthenia hallucinations; reduced appetite; fatigue; pain; insomnia; stomatitis; weight losse; pain; insomnia; stomatitis; weight loss)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Cognitive functions: negative effect of na … Cognitive functions: negative effect of nabiximols (no values given); nausea and vomiting; dizziness; drowsiness; disorientation; anorexia, constipation; dry mouth; anemia; diarrhea; dysgeusia headache; asthenia hallucinations; reduced appetite; fatigue; pain; insomnia; stomatitis; weight losse; pain; insomnia; stomatitis; weight loss)
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Comparison of number of side effects p = 0.88 (mainly nausea, vomiting and hair loss), no side effects associated with vitamin E, no deaths due to vitamin E)
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Digestive disorder (n=2), migraine (n=1))
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Discomfort (including hot flushes, nausea, asthenia, headaches, dizziness) in n=2)
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Discomfort (including hot flushes, nausea, asthenia, headaches, dizziness) in n=4)
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Discomfort (including hot flushes, nausea, asthenia, headaches, dizziness) in n=4)
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Discomfort (including hot flushes, nausea, asthenia, headaches, dizziness) in n=0)
Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients + (Gastrointestinal complaints with dizziness and occasional vomiting (was controlled with antiemetic medication) - no numbers given)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (Gastrointestinal symptoms, such as stage 2 heartburn, bruising/redness and skin rash)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Grade ≥2 creatinine, neohrolithiasis, neutropenia)
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Headache (25%), flushing (21.8%), drowsiness (9.4%), nausea (6.2%), rhinitis (6.2%), euphoria (6.2%), according to authors caused by sildenafil (no difference in side effects between both sildenafil arms))
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Headache (28.1%), flushing (22.8%), drowsiness (8.5%), rhinitis (8.5%), nausea (5.7%), according to authors caused by sildenafil (no difference in side effects between sildenafil arms))
Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Heartburn, headache, vertigo)
Yekta et al. (2012): Ginger as a miracle against chemotherapy-induced vomiting + (Heartburn, no significant difference between arms: * anticipatory: p= 0.2 * acute: p= 0.06 * delayed: p= 0.5)
Yekta et al. (2012): Ginger as a miracle against chemotherapy-induced vomiting + (Heartburn, no significant difference between arms: * anticipatory: p= 0.2 * acute: p= 0.06 * delayed: p= 0.5)

Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Hypercalcemia, grade ≥2 calcium, nephrolithiasis, diarrhea)

Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Hyperphosphatemia (>4.5 mg/dl) in 11/40 … Hyperphosphatemia (>4.5 mg/dl) in 11/40 (27.5%), no significant differences;hypercalcemia (>10.5 mg/dl) in 1/40 (2.5%)All side effects were “non-serious” and “mild-level-1,” except for 1/40 (2.5%) recorded as “mild-level-2” due to temporarily holding the intervention for a few doses to successfully reduce the serum calcium and phosphorous and restart calcitriolm calcium and phosphorous and restart calcitriol)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Hyperphosphatemia (>4.5 mg/dl) in 12/40 … Hyperphosphatemia (>4.5 mg/dl) in 12/40 (30.0%), no significant differences;hypercalcemia (>10.5 mg/dl) in 1/40 (2.5%);All side effects were “non-serious” and “mild-level-1,” except for 3/40 (7.5%) recorded as “mild-level-2” due to temporarily holding the intervention for a few doses to successfully reduce the serum cal- cium and phosphorous and restart placeboum cal- cium and phosphorous and restart placebo)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Impotence in 14% of men; vomiting; fluid retention; confused thinking; drowsiness; loss of coordination; inappropriate behavior)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Impotence in 18 % of men; vomiting; fluid retention; confused thinking; drowsiness; loss of coordination; inappropriate behavior)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Impotence in 4% of men; vomiting; fluid retention; confused thinking; drowsiness; loss of coordination; inappropriate behavior)
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (Incidence of nausea (44.4%) and diarrhea (11.1%) was the same in the two groups, 1 patient per group had fever > 100.4 °F at home)
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (Incidence of nausea (44.4%) and diarrhea (11.1%) was the same in the two groups, 1 patient per group had fever > 100.4 °F at home)
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Insomnia: Guarana: n = 22, placebo: n = 31, Palpitation: Guarana: n = 10, placebo: n = 12, Nausea: Guarana: n = 25, placebo: n = 35, Anxiety: Guarana: n = 17, placebo: n = 25, Dermatologic: Guarana: n = 1, placebo: n = 3)
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Insomnia: Guarana: n = 22, placebo: n = 31 … Insomnia: Guarana: n = 22, placebo: n = 31, Palpitation: Guarana: n = 10, placebo: n = 12, Nausea: Guarana: n = 25, placebo: n = 35, Anxiety: Guarana: n = 17, placebo: n = 25, Dermatologic: Guarana: n = 1, placebo: n = 3Total Guarana n=30, Placebo n=45, no statistical comparison conducted n=45, no statistical comparison conducted)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Intervention-associated events in n=106 (6 … Intervention-associated events in n=106 (60%): drowsiness, dizziness, nausea, confusion, vomiting, hypotension, hypercalcemia, increased gamma GT; Most side effects were mild/moderate; no statistical comparisons given; one case of syncope probably related to THC; other events not associated with interventioner events not associated with intervention)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Intervention-associated events in n=106 (6 … Intervention-associated events in n=106 (60%): drowsiness, dizziness, nausea, confusion, vomiting, hypotension, hypercalcemia, increased gamma GTMost side effects were mild/moderate; no statistical comparisons given; one case of syncope probably related to THC; other events not associated with interventioner events not associated with intervention)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Melatonin was well tolerated, no related toxicities.)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (Mild hypercalcemia at 12 week assessment)
Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (Moderate nausea; diarrhea, constipation, headache, fatigue, feeling of weakness (asthenia))
Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Moderate or severe cannabinoid-related sid … Moderate or severe cannabinoid-related side effects in intervention arm and placebo arm (31% vs. 7%, p=0.002):* Significant differences for sedation (19% vs. 4%, p=0.002) and dizziness (10% vs. 1%, p=0.03)* No differences for disorientation (p=0.5) and anxiety (p=1.00)* No cannabinoid-related serious adverse events reported83% of the participants preferred cannabis over placebo and 15% had a preference for placebo (p<0.001)15% had a preference for placebo (p<0.001))
Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Moderate or severe cannabinoid-related sid … Moderate or severe cannabinoid-related side effects in intervention arm and placebo arm (31% vs. 7%, p=0.002):* Significant differences for sedation (19% vs. 4%, p=0.002) and dizziness (10% vs. 1%, p=0.03)* No differences for disorientation (p=0.5) and anxiety (p=1.00)* No cannabinoid-related serious adverse events reported83% of the participants preferred cannabis over placebo and 15% had a preference for placebo (p<0.001)15% had a preference for placebo (p<0.001))
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Most common adverse events: neutropenia (2 … Most common adverse events: neutropenia (24 patients (35%)) and hypertension (9 patients (13%)), diarrhea (1 patient (1%)),the only adverse events that were reported as possibly related to vitamin D3 were hyperphosphatemia (1 patient in intervention arm) and kidney stones (1 patient in the placebo arm)dney stones (1 patient in the placebo arm))
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Most common adverse events: neutropenia (21 patients (31%)) and hypertension (11 patients (16%)), diarrhea (8 patient (12%)))
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Most common: Gastrointestinal reactions (v … Most common: Gastrointestinal reactions (vomiting, diarrhea, bloating), p>0.05;Second most common: Reduced white blood cell count (only in intervention arm), liver dysfunction, and sleep disturbancesFor severe adverse events: no connection with administered medications; p>0.05No difference between arms for adverse reactions and events (p=0.5816; p=0.3903)dverse reactions and events (p=0.5816; p=0.3903))
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Most common: Gastrointestinal reactions (v … Most common: Gastrointestinal reactions (vomiting, diarrhea, bloating), p>0.05;Second most common: Reduced white blood cell count (only in intervention arm), liver dysfunction, and sleep disturbancesFor severe adverse events: no connection with administered medications; p>0.05No difference between arms for adverse reactions and events (p=0.5816; p=0.3903)dverse reactions and events (p=0.5816; p=0.3903))
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (Most frequently nausea (n=10) and dizziness (n=5); 1 case of vomiting)
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (Most frequently nausea (n=17) and dizziness (n=15); 1 case of disorientation and 1 case of visual hallucinations)
Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients + (N of side effects of any grade attributed to the supplementation (n=32) - Gastrointestinal: 23 - Genitourinary: 1 - Neurologic: 2 - Skin: 6)
Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients + (N of side effects of any grade attributed to the supplementation (n=32) - Gastrointestinal: 23 - Genitourinary: 1 - Neurologic: 2 - Skin: 6)
Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients + (N of side effects of any grade attributed to the supplementation (n=32) - Gastrointestinal: 23 - Genitourinary: 1 - Neurologic: 2 - Skin: 6)