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- Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Event-free survival, time to second primar … Event-free survival, time to second primary tumor, and survival curves were constructed by the Kaplan–Meier technique and were compared by the log-rank test. The interaction between the effects of N-acetylcysteine and those of retinyl palmitate was tested with a proportional hazards model. Also, analyses of four arms were performed.lso, analyses of four arms were performed.)