Property:Inclusion criteria
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Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study +
Malignancy confirmed by histopathology, combination chemotherapy including cyclophosphamide, occurrence of at least 2 episodes of vomiting in previous chemotherapy cycle and age above 18 years.
All patients received cyclophosphamide 500-1000 mg I.V. in combination with other chemotherapeutic agents. +
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme +
NI +
Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors +
Women aged 18–80 years at the time of study enrolment; body mass index (BMI) in the range 25–40 kg/m<sup>2</sup> ; received chemotherapy (neo-adjuvant or adjuvant with any medically-prescribed gent/regime) for treatment of invasive breast cancer; reported no current use of tobacco (past 12 months); no chronic illness such as diabetes, cardiovascular disease (or to be taking medications to control blood glucose and/or blood lipids) or cancer other than the previously treated breast cancer; willing to refrain from all weight loss diets and supplements for a study period of 6 month +
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. +
Lung or breast cancer, 21 years or older;
Patients who speak english and give informed consent +
Presence of any type of metastatic cancer and a pain score of 2 or higher on the 0–10 pain scale during the current hospitalization. Additional criteria for the patient-partner dyad were being 21 years of age or older; living together as spouses or domestic partners, family members, or friends; English speaking; living within a 75- to 100-mile radius of the hospital; partner availability for 30 minutes from 2–10 pm; and willingness to participate as evidenced by verbalizing understanding and signing an informed consent form. +
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) +
Advanced, incurable cancer; cancer-related anorexia-cachexia syndrome; weight loss (≥ 5% over 6 months), not explained by other diseases or recent surgery; Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤ 2: estimated life expectancy of 3 months; Creatinine, bilirubin, and transaminase values no higher than 3x the maximum normal value; Unchanged antineoplastic therapy for 4 weeks and unchanged supportive treatment (analgesics, sedatives, tranquilizers, and anticholinergics) for 1 week before baseline assessments +
Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer +
Biopsy-proven localized (nonmetastatic) prostate cancer documented within 48 months before enrolling in the trial, Gleason score of <8, serum PSA level of <50 ng/mL, age <85 years, life expectancy of ≥3 years, elected to forgo front-line therapy and chose to be followed by active surveillance, limited daily selenium supplementation to no more than 50 μg from non-study sources +
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms +
Stage II-IVM0 carcinoma in the head-neck-area; radiotherapy (at least 50 Gy); Karnofsky power > 60; both primary radical radiotherapy and postoperative radiotherapy patients were eligible +
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy +
Aged 18–75 years, Grade ≥3 neuropathy, as determined by NCI-CTC criteria version 3.0, while receiving paclitaxel, cisplatin or vinblastine treatment, and/or grade ≥2 neuropathy persisting for at least one month after the discontinuation of either drug, and neurotoxicity for <6 months; at least one abnormality on electrophysiological examination; Karnofsky physical score (KPS) of ≥60; absolute neutrophil count of ≥1.5×10<sup>9</sup>/l, hemoglobin count of ≥80 g/l, platelet count of ≥75×10<sup>9</sup>/l, total bilirubin counts of 1.5-fold less than normal value, glutamic-pyruvic transaminase (GPT/ALT) and glutamic-oxalacetic transaminease (GOT/AST) no more than 2.5-fold greater than the normal value; normal blood urea nitrogen, serum creatinine and electrocardiogram (ECG) findings. During the study, the use of steroids, analgesic or neuroprotectant drugs was not permitted. +
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Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor +
Diagnosis of hematological tumor; white blood cell count 3–12×10<sup>9</sup>/l, platelet count ≥60×10<sup>9</sup> /l, absolute neutrophil count ≥10<sup>9</sup> /l; average score of the difficulty of mandibular impacted third molar extraction ≥14, patients had difficulties with tooth extraction; informed consent form signed by patients +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
Women aged 18 years or older with documented breast cancer who had received a first cycle of AC chemotherapy and who experienced vomiting or moderate to severe nausea, defined as a nausea score of ≥40 on a visual analog scale of 0 (no nausea) to 100 (unbearable nausea). Their treatment plan included at least two more cycles of AC +
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial +
Breast cancer patients undergoing adjuvant radiotherapy after surgery +
Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial +
- Histologically confirmed HNSCC classified as stage I or II baccording to criteria of American Joint Committee on Cancer and radically treated with surgery and/or radiotherapy
- Performance status 0-2
- Adequate liver, kidley, cardiac function +
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. +
18 years or older, had major abdominal surgery for mainly hepatocellular cancer and gastric cancer in the 24 hours prior, alert, awake, in a stable medical condition, able to verbally communicate, received general anesthetics, and used PCAs for pain +
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Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial +
Definite pathological diagnosis of differentiated thyroid cancer (DTC), presented to department for <sup>131</sup>I treatment +
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial +
A histopathological diagnosis of epithelial carcinoma of the digestive tract (esophagus, stomach, small intestine, colon, and rectum), clinical stages I to III; aged 30 to 90 years at entry; diagnosis and initial surgery at the International University of Health and Welfare Hospital; not taking vitamin D supplements or active vitamin D; and no history of urinary tract stones +
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study +
Patients with gynecological cancers (ovarian, cervical, endometrial, vulvar carcinoma; stage 1-4, recurrence), ECOG status 0-2, carboplatin-paclitaxel chemotherapy +
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial +
Patients who were older than 18 years; were examined with second and third stage colorectal cancer; received CRT during postoperative and preoperative periods; were able to speak, read, and understand Turkish; and had agreed to participate in the study. +
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Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer +
- Non-small-cell lung cancer (stages pT1–2, N0–1, and T3N0), cancer of the larynx (Tis, T1–3, and N0–1), or cancer of the oral cavity (T1–2 and N0–1)
- Performance status 0–2
- Treated with curative intent +
Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial +
Patients with solid malignancies and good functional status (Karnofsky Performance Status 70–100) candidates to receive Cisplatin-chemotherapy +