Property:Results after intervention
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Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial +
NI +
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial +
NI +
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) +
NI +
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) +
NI +
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) +
NI +
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) +
? +
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue +
There was no significant difference between the two treatment arms in terms of cumulative probability, prevalence, or duration of erythema.
For subjects who did not have chemotherapy, those in the placebo arm had a significantly greater incidence of grade 2 or more erythema than those in the aloe vera arm (71% vs. 51%) (p = 0.02). +
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue +
The cumulative probability for any dry desquamation (>1%) was greater in the aloe vera arm compared with the
placebo arm (70% vs. 41%) (p<0.001)
There was no difference in the duration of reaction between the two treatment arms.
There was no significant difference between the two treatment arms in terms of cumulative probability, prevalence, or duration of moist desquamation. +
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue +
For the subjects the cumulative probability of grade 2 or more pain was greater in the aloe vera arm than in the placebo arm (26% vs. 17%) (p = 0.03).
For subjects who had drainage, those in the aloe vera arm had a significantly greater incidence of grade 2
or more pain compared with those in the placebo arm (40% vs. 20%) (p = 0.01).
For subjects who received chemotherapy, there was no difference in pain levels between the two treatment arms.
For subjects, who did not have chemotherapy, those in the aloe vera arm had a significantly greater incidence of grade 2 or more pain compared with those in the placebo arm (26% vs. 12%) (p = 0.02). +
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue +
The cumulative probability for itching toxicity (grades 1 or more, grades 2 or more, grades 3 or more) was greater in the aloe vera arm than in the placebo arm, but the difference was not significant.
There was no significant difference between the treatment arms for grade 2 or more itching according to whether or not a subject had undergone chemotherapy.
Drainage: The proportion of subjects who had lymphocele drainage was similar in both arms. Within the aloe vera arm, subjects who had lymphocele drainage experienced a significantly greater incidence of grade 2 or more itching compared with subjects who did not have lymphocele drainage (46% vs. 23%) (p = 0.01).There was no significant difference within the placebo arm for drainage versus no drainage. +
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer +
Three month after radiotherapy mean difference intervention vs. placebo arm (controlled for baseline value) (95% CI):
* Urinary symptoms: -14.1 (-24.7, -3.4); p = 0.011; intervention significantly fewer symptoms than placebo arm
* Bladder symptoms: 5.4 (-4.5, 15.4); p = 0.275
* Treatment-related symptoms: 7.9 (-3.1, 18.9); p = 0.155
* Sexual activity: -3.5 (-19.0, 12.0); p = 0.652 +
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study +
PSA level (ng/ml) within 3 months:
* Mean change (SD): Intervention arm 0.12 ( 0.16), placebo arm: 0.13 (0.06); p = 0.78
* No information on PFS within one year +
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy +
Decrease in serum PSA levels higher in the green tea arm compared to the water arm (p=0.04)
PSA mean (SD) per arm
Green tea arm (N=30): baseline= 9.6(5.2); after 33 days= 8.4(4.3)
Water arm (N=30): baseline= 9.9(8.5); after 29 dayse= 10.0(9.0)
No significant difference in changes between black tea arm and water arm (p>0.05) +
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy +
Detection of tea polyphenols in prostate tissue in 32 of 34 men in the green tea arm , but not in the other arms.
Detection of EGC, EC and methyl-EGC in early morning urine throughout the study in the green tea arm and at significantly lower concentrations in the black tea arm (p<0.01); no polyphenols in the water arm. +
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy +
NA +
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy +
NA +
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy +
NA +
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy +
NA +
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine +
Baseline to week 104 showed no differences between arms (p>0.05) +
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine +
Baseline to week 104 showed no differences between arms (p>0.05) +