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- Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (There was no significant difference betwee … There was no significant difference between the two treatment arms in terms of cumulative probability, prevalence, or duration of erythema.</br></br>For subjects who did not have chemotherapy, those in the placebo arm had a significantly greater incidence of grade 2 or more erythema than those in the aloe vera arm (71% vs. 51%) (p = 0.02).he aloe vera arm (71% vs. 51%) (p = 0.02).)