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Property:Outcome specification

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'''Tension''' Assessed by the investigator with a four point rating scale: 0 = no tension 1 = slight tension 2 = moderate tension 3 = severe tension  +
'''Skinfold thickness''' (Parameter of fibrosis) was measured with a calliper in mm and devided by 2 for the normal measurement of the skinfold in not fibrotically changed skin. Measures of the absolute values were taken from the upper arm, the lower arm, the hand and from the third finger. The absolute reference value is 2 mms for the healthy skin.  +
'''Volume reduction''' measured by Volometer = opto-electronic device measures the arm circumference 2-dimensionally along a distance of 45cm on the entire arm according to the kuhnke formula. As reference the healthy arm of each individual is measured.  +
Specifically tumor clearance, i.e. the proportion of patients with complete histological tumor clearance after eight weeks (time point 3)  +
Specifically tumor size, examination after three weeks (time point 1), six weeks (time point 2) and eight weeks (time point 3)  +
Evidenced by any of the following three events: an increase in the HAQ-II score of 0.25 or more; an increase in CPIS score; or discontinuation of letrozole specifically due to aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)  +