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List of results

• Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial  + (Change in NRS value for moderate pain)
• Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Change in NRS value for the worst pain)
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Change in NRS value for the worst pain)
• Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial  + (Change in NRS value for the worst pain)
• Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain  + (Change in NRS value for the worst pain)
• Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial  + (Change in Plasma 25(OH)D)
• Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy  + (Change in RPSAS-value)
• Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders  + (Change in taste and smell)
• Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population?  + (Change in values across all 4 time points, arm comparison)
• Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy  + (Change of appetite score)
• Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer  + (Change over 5 years)
• Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy  + (Chemotherapy induced peripheral neuropathy with NXT from FACT)
• Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation  + (Chemotherapy-induced peripheral neuropathy; Outcome rated with PN Score: Gradations mild (1-11), moderate (12- 23) and severe (>24), summarized from the three measurement types)
• Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131  + (Chromosome-damaging properties, so called "clastogenic" factors (CFs))
• Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients  + (Classification according to Clavien-Dindo, 50-50 criteria (Prothrombin time < 50% and bilirubin level > 50 µmol/L on the 3rd and 5th postoperative days are associated with an increased risk of postoperative mortality), posthepatic liver failure (PHLF))
• Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer  + (Combined incidence of local recurrence or second primary tumor (head and neck, esophagus or lung))
• Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study  + (Complete control of vomiting with low Cth dose (500-600 mg) + low emetogenic Cth (N=20) vs. low Cth dose + high emetogenic Cth (N=7) vs. high Cth dose (900-1000 mg) with further Cth (N=23))
• Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck  + (Complete response rate (CR))
• Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial  + (Complete response, no vomiting or emergency medication 0-120h of chemotherapy)
• Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia  + (Compliance with aromatase inhibitor therapy, measured by pill counts)
• Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain  + (Concentration)
• Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer  + (Concentrations of antibodies against polysaccharides PS1, PS5, PS6, PS9, PS14, and PS18)
• Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial  + (Consumption in mg at 2h, 6h and 24h)
• Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia  + (Correlation of low- baseline vitamin D levels with development of aromatase inhibitor-induced arthralgia)
• Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study  + (Cumulative incidence of HFS)

• Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597  + (DFS Randomization until secondary tumors or recurrence and 5-year DFS)

• Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients  + (Daily life activity exposure levels)
• Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer  + (Defined as myocardial infarction, cerebrovascular accident, pulmonary embolism, deep vein thrombosis, and arterial thrombosis)
• Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators  + (Defined as the time from random assignment to a skeletal-related event or death from any cause, skeletal-related events were defined as pathologic bone fracture, spinal cord compression, surgery to the bone, or radiation to the bone)
• Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study  + (Degree of nausea Grade 0 defined as norma … Degree of nausea </br>Grade 0 defined as normal appetite; Grade 1 defined as loss of appetite without alteration in eating habits; Grade 2 defined as decreased oral intake without significant weight loss, dehydration, or malnutrition; Grade 3 defined as inadequate oral caloric or fluid intakeas inadequate oral caloric or fluid intake)
• Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients  + (Delayed, anticipatory nausea)
• Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities  + (Determine the effect of polyphenon E intervention on serum prostate-specific antigen (PSA).)
• Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial  + (Dexamethasone)
• Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology  + (Diarrhea)
• Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial  + (Diarrhea)
• Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life  + (Disease progression was observed in 63.8% of the patients, and death occurred in 53.4% of the patients treated during the 30 months of the study)
• Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life  + (Disease progression was observed in 63.8% of the patients, and death occurred in 53.4% of the patients treated during the 30 months of the study)
• Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers  + (Disease response at the end of radiation (after 8 weeks))
• Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients  + (Disease-free 12-month survival:)
• Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer  + (Disruption of daily activities due to fatigue with single item from the BFI)
• Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study  + (Distortion product otoacoustic emissions (DPOAEs), average of the amplitude of the signal and signal-noise (S/N) ratio (SNR) Tested with Scout biologic equipment from bio-logic systems®)
• Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study  + (Dose reduction/Delay of chemotherapy)
• Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study  + (Dry mouth, difficulty chewing / swallowing / speaking, burning sensation in the mouth, bad taste, waking up at night, prosthetic mesh, meeting people, talking to people, leaving the house)
• Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial  + (Duration of fever)
• Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial  + (Duration of severe neutropenia)
• Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial  + (Duration of total parenteral nutrition)
• Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study  + (Duration, severity and onset of oropharyngeal mucositis according to the dose of RT)
• Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study  + (During 1 year)
• Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial  + (During the first 2 years)
• Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer  + (During weekly visits patients underwent a … During weekly visits patients underwent a structured interview and physical examination by both a nurse and a radiation oncologist. At each visit, the following items were scored: pain control (Verbal descriptor scale).</br></br>Peak pain: </br></br>(0) None</br></br>(1) Slight </br></br>(2) Moderate </br></br>(3) Severe </br></br>(4) Extreme </br></br>(5) As bad as it can bere (4) Extreme (5) As bad as it can be)
• Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer  + (During weekly visits patients underwent a … During weekly visits patients underwent a structured interview and physical examination by both a nurse and a radiation oncologist. At each visit, the following items were scored: objective mucositis (CTCAE), functional mucositis (CTCAE) and dysphagia (CTCAE).l mucositis (CTCAE) and dysphagia (CTCAE).)