Property:Outcome specification
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Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer +
Change over 5 years +
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms +
'''Treatment interruptions'''
Radiation interruptions because of mucositis. +
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms +
'''Incidence of severe mucositis'''
Severe mucositis = grade 2, 3 or 4 mucositis of RTOG
Biweekly, treating physicians evaluated patients for mucositis at 15 head-and-neck subsites using a 4-point grading scale. These subsites included the upper lip, lower lip, anterior oral cavity, posterior oral cavity, anterior tongue, posterior tongue, hard palate, oropharynx, nasopharynx, hypopharynx, skin, ear, salivary glands, and esophagus. +
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms +
'''Duration of mucositus'''
Biweekly, treating physicians evaluated patients for mucositis at 15 head-and-neck subsites using a 4-point grading scale. These subsites included the upper lip, lower lip, anterior oral cavity, posterior oral cavity, anterior tongue, posterior tongue, hard palate, oropharynx, nasopharynx, hypopharynx, skin, ear, salivary glands, and esophagus. +
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms +
On the biweekly examination days, patients filled out a quality of life questionnaire scoring their overall health, soreness, and the effect of soreness on daily activity (including brushing teeth, swallowing, and eating). A Scale of 1–10, with 10 best for health score and 0 worst for soreness score +
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy +
NA +
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy +
Improvement by ≥1 grade according to NCI-CTC criteria +
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy +
Electrophysiological examination and evaluation of electrophysiology +
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy +
NA +
T
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor +
Modified postoperative symptom severity scale (PoSSe): Patients were scored in 7 dimensions
(food, language, feeling, swelling, pain, nausea, and daily living) one week after surgery +
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor +
'''Side effects of tooth extraction: Mouth opening'''
Distance from the upper central incisor margin to the lower at the biggest positive mouth opening state before and after surgery; distance differences before and after surgery indicated the limitation of mouth opening degree. +
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor +
Score range = 0 (no pain) to 10 (intolerable severe pain)
No pain: 0–1 points for no pain or little pain or pain hard to feel;
Mild: 2–3 points for tolerable pain that did not affect sleep;
Moderate: 3–6 points for pain that altered normal daily activities and sleep;
Severe: ≥7 points for intolerable pain, patients took ibuprofen sustained release capsule or return for a visit +
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor +
'''Side effects of tooth extraction: Swelling'''
Value difference of CT+ ME before and after surgery indicated the swelling degree:
CT distance: distance of the skin surface from the tragion (T point) on the affected side of the cheek to the cheilion (C point) on the same side;
ME distance: distance on the skin surface from the external canthus point on the same side (E point) to the mandibular angle point (M point) +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
Scoring of vomitting +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
Reduction of the nausea score +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
Side effects +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
Emergency medication +
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study +
Dose reduction/Delay of chemotherapy +
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial +
Intensity of erythema upon radiation therapy at the 50 Gy dose +