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- Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + ('''Side effects of tooth extraction: Mouth … '''Side effects of tooth extraction: Mouth opening'''</br></br>Distance from the upper central incisor margin to the lower at the biggest positive mouth opening state before and after surgery; distance differences before and after surgery indicated the limitation of mouth opening degree.ed the limitation of mouth opening degree.)