Property:Inclusion criteria
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Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial +
Patients with a primary histologically proven superficial BCC of 4 to 20 mm in greatest diameter +
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial +
Postmenopausal women with stage I–III hormone receptor positive breast cancer scheduled to start treatment with an adjuvant aromatase inhibitors and with a 25(OH)D level B40 ng/ml +
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study +
Patients with locally advanced (neo-adjuvant) and metastatic breast cancer refereed to a medical oncology clinic in Shohada-e-Tajrish hospital in Tehran, Iran, from July 2017 to October 2018; proven malignant biopsy; chemotherapy for at least 3 months +
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial +
Primary brain tumor/brain metastases,
Radiotherapy of whole or part of the brain (>60% of brain irradiated) with a dose of 30-60 Gray in a fractionation of 5 " 1.8-3.0 Gray/week,
No former radiotherapy in the brain +
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy +
Above 18 year-old and newly diagnosis with histology of solid tumors with Eastern Cooperative Oncology Group (ECOG) performance status B2. All patients must complete surgical resection of primary tumor and planned for at least 3 consecutive cycles of moderately to highly emetogenic adjuvant chemotherapy for curative intent +
Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial +
Patients who had all gross cancer removed (microscopic residual disease or residual margin involvement was allowed), scheduled to undergo curative-intent chemotherapy with either taxanes or platinum compounds, have a good performance status (ECOG 0-2), life expectancy ≥6 months, and not have preexisting peripheral
neuropathy from any cause +
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients +
Preoperative gastric or colorectal cancer patients without distant metastasis +
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial +
Histologically proven, advanced and irresectable adenocarcinoma of the pancreas (UICC Stage IV), had a Karnofsky performance status of >60 +
L
Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer +
Patients with head and neck cancer, who were due to receive radiation on at least two-thirds of the oral cavity; aged 18-85 years with a normal renal function (creatinine clearence > 60ml/min) and an acceptable performance status (Karnofsky performance status > 70%) without any history of radiotherapy were eligible for this study +
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial +
Age of at least 18 years; a diagnosis of lung cancer; patients receiving cisplatin-based regimens; patients receiving standard antiemetic therapy (5-HT3 RAs); the ability to swallow capsules; nonuse of self-prescribed therapies or complementary products +
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study +
All hospitalised patients with malodorous fungating malignant wounds were eligible to participate in the study +
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain +
Advanced cancer; ≥18 years of age; clinical diagnosis of cancer-related pain that was unalleviated by an optimized maintenance dose of Step 3 opioid therapy (opioid therapy considered optimized if: 1) a dose increase was clinically inappropriate due to opioid-related side effects or 2) further efficacy benefit was not expected at higher doses (for the second definition, patients had to be receiving ≥90 mg morphine equivalents/day, inclusive of maintenance, and breakthrough opioids); each of three consecutive days during the screening period: ≥four opioid breakthrough analgesic episodes per day (averaged over the three days); a stable maintenance opioid therapy dose; average pain ≥four and ≤eight on a 0-10 Numerical Rating Scale (NRS); average pain scores on the NRS that did not change by more than two points (i.e., no more than a two-point difference between the highest and lowest scores, with all scores remaining between four and eight) +
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study +
Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa +
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study +
Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa +
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis +
Aged >18 years, pathologically established stages III and IV advanced nasopharyngeal carcinoma (NPC), concomitant chemotherapy and radiotherapy (CCRT) +
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study +
Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa +
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms +
Histologically proven advanced lung cancer, gastrointestinal tract tumor, breast cancer or
brain glioblastoma; measurable neoplastic lesions; progression on classical chemotherapy, radiotherapy or endocrine therapy or poor clinical conditions precluding chemotherapy; patients were eligible after at least 1 month from the last chemotherapy course; life expectancy <6 months +
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer +
Histologically proven metastatic cancer; histological diagnosis of lung cancer or gastrointestinal tumour; measurable lesions +
Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial +
18 y old, case of recently diagnosed differentiated papillary or follicular thyroid cancer, undergone total thyroidectomy, referred to the Department of Nuclear Medicine, West China Hospital, for ablation of remnant thyroid tissue, stage pT1–T3, N0–N1, M0. For women of childbearing potential: a negative result on serum human chorionic gonadotropin pregnancy testing required +
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer +
Women with a normal sense of smell; who were diagnosed with breast cancer; who were receiving chemotherapy and experienced nausea and/or vomiting of any severity; had at least two remaining chemotherapy courses using similar chemotherapeutic agents +