Publication: L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients
| Reference | |
|---|---|
| Title | L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients |
| Topic | Carnitine |
| Author | Okabayashi T, Sui K, Mastumoto T, Iwata J, Morita S, Iiyama T, Shimada Y |
| Year | 2020 |
| Journal | Journal of parenteral and enteral nutrition |
| DOI | https://doi.org/10.1002/jpen.1720 |
Author's Abstract The abstract and the information and conclusions contained therein were written by the authors of the publication.
| Background and aims: The effect of perioperative treatment with L-carnitine in hepatectomized patients is unclear. The objectiveof the current study is to evaluate the short-term outcomes after liver cancer surgery in patients treated with L-carnitine comparedwith nontreated patients.
Methods: Patients with primary liver malignancies scheduled to undergo a hepatectomy were randomlyassigned to receive either perioperative treatment with L-carnitine (carnitine group) or usual intake (control group). The primaryendpoint of this study was the short-term outcome after liver surgery. Results: The study participants were randomly assigned into2 groups: 106 patients in the control group and 102 patients in the perioperative L-carnitine supplementation group. The restorationof serum ammonia levels, prothrombin time, and peripheral neutrophil count at 3 days after the operation was significantly fasterin the carnitine group than in the control group. Fewer patients in the carnitine group developed grade B posthepatic liver failure,according to the grading system of the International Study Group of Liver Surgery, than patients in the control group (20% vs76%). The length of hospitalization was significantly shorter in patients in the carnitine group than in those in the control group. Conclusions: We found that perioperative treatment with L-carnitine was significantly better than ordinary treatment in reducingpostoperative serum ammonia levels, suggesting that L-carnitine may serve as a pivotal regulator of liver injury and repair andresult in shorter postoperative hospitalization |
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