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- Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (Intervention arm: median and interquartile ranges of age at diagnosis: 60.5 (55-71) Placebo arm: median and interquartile ranges of age at diagnosis: 62 (54-69))