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List of results

Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (50,000 International Units (IU) oral vitamin D3 per week for 12 weeks followed by 2000 IU daily for 40 weeks + all patients: calcium carbonate 600 mg daily)
Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial + (500 µg selenium in the form of sodium selenite [selenase®), orally on radiotherapy days and 300 µg on days without radiotherapy)
Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization + (500 µg selenium in the form of sodium selenite [selenase®), orally on radiotherapy days and 300 µg on days without radiotherapy)
Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (500 µg selenium in the form of sodium selenite (selenase®), orally on radiotherapy days and 300 µg on days without radiotherapy)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (500-mg placebo twice a day for 5 days starting on the first day of the second chemotherapy cycle; Antiemetics: Ondansetron + Dexamethason; Crossover in cycle 3)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (500mg capsules (≥95% curcuminoids), 3 times daily, 4 capsules each time Duration: 7 weeks (entire radiationtherapy))
Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients + (500µg sodium selenite 2 days before the start of radiotherapy and on days with radiotherapy; and 300 µg sodium selenite on days without radiotherapy (weekends and vacations), orally as a liquid 1 hour before radiotherapy)
Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients + (500µg sodium selenite 2 days before the start of radiotherapy and on days with radiotherapy; and 300 µg sodium selenite on days without radiotherapy (weekends and vacations), orally as a liquid 1 hour before radiotherapy)
Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer + (50mg per day orally for the duration of the study, median (range) follow-up: 51.1 (30-90) months)
Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (50mg/kg (ascorbic acid 10 g/20 mL) mixed with normal saline for a total injection volume of 50 mL; intravenous, 30 minutes)
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (6 cups of black tea (inclusive 28mg EGCG) daily until the operation (average duration = 31 days))
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (6 cups of green tea (inclusive 562mg EGCG) daily until the operation (average duration = 33 days))
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (6 cups of water daily until the operation (average duration = 29 days))
Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (6 g/day of placebo in two daily doses of 3g)
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (600 mg zinc sulfate eptahydrate per day, equivalent to 150 mg of elementary zinc per day, from day +5 post-transplant in addition to the same prophylaxis of the control arm)
Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (600mg NAC 1x/day)
Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9 + (60mg; 2x daily (daily dose 120mg))
Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (6g/day in two doses of 3g at the start of chemotherapy)
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine + (6x capsules (cellulose) daily for 24 weeks)
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (6x capsules (cellulose) daily for 24 weeks)
Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial + (75mg daily (orally), cycles of 3 months & then 1 month break + dose reduction and/or discontinuation of beta-carotene if grade II toxicity (repeatedly) reported)
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (8 capsules daily)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (8 one-hour sessions at weekly intervals for 8 weeks commencing 7 weeks after surgery.)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (8 one-hour sessions at weekly intervals for 8 weeks commencing 7 weeks after surgery. 7 weeks post surgery to 15 weeks post surgery)
Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (800 IU Vitamin D3 daily for 52 weeks + all patients: calcium carbonate 600 mg daily)

Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (800 IU daily (2x 400 IU))

Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (800 μg selenium per day (yeast selenium); Follow-up duration (mean (SD); median): 33.3 (23.3); 33.8 years)
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (84 capsules for 1 week (3x4 capsules/day starting with the first day of radiotherapy))
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (8mg daily from day 1 of radiotherapy for 6 weeks)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (8x ± 1 sessions for 15min - patients dipp … 8x ± 1 sessions for 15min- patients dipped their arms up to a hand’s width above the elbow and their feet up to a hand’s width above the ankle into a specialwater basin with water at a temperature of about 35∘- cross-galvanisation of each individual extremity by low-frequency (50Hz) faradic current (direct current impulses) up to the individual’s sensitivethreshold (i.e., the point where the tingling feeling is considered to be just acceptable)eling is considered to be just acceptable))
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (8x ± 1 sessions for 15min Point combinati … 8x ± 1 sessions for 15minPoint combinations for ...- patients with CIPN symptoms in the lower extremities: LV3 (Taichong), SP9 (Xiongxiang), GB41 (Zulingqi),GB34 (Yanglingquan) - patients with CIPN symptoms in the upper extremities: LI4 (Hegu), LI11 (Quchi), SI3 (Houxi), and HT3 (Shaohai) - patients with CIPN symptoms in the upper and lower extremities: treated with complete point combinationAcupuncture needles were deeply inserted bilaterally until the deqi phenomenon was triggered; each session included 15 minutes of electrostimulation (50Hz) consisting of a combination of rectangular currents and high amplitude wavestangular currents and high amplitude waves)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (A loading dose of 8000 IU/d of vitamin D3 (two 4000 IU capsules) for cycle 1 followed by 4000 IU/d for subsequent cycles)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (A loading dose of 8000 IU/d of vitamin D3 (two 4000 IU capsules) for cycle 1 followed by 4000 IU/d for subsequent cycles)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (All participants: 4-week run-in period with 600 IU D3 to allow serum levels to begin to normalize High-dose of 4,000 IU D3 capsules daily + all participants: 1,000 mg calcium carbonate)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (All participants: 4-week run-in period with 600 IU D3 to allow serum levels to begin to normalize Usual care dose of 600 IU D3 capsules daily + all participants: 1,000 mg calcium carbonate)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (All participants: pain medication, including intravenous injection of apotel 1 g, morphine sulfate 3 mg, and oral acet-aminophen 500 mg, depending on each patient’s need in the intensive care unit and ward)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (All patients: During the dark period of the day, Melatonin was administered orally at a dose of 20 mg/day, every day until disease progression.)
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Aloe aborescens (300g fresh aloe leaves in … Aloe aborescens (300g fresh aloe leaves in 500g honey and 40ml 40% alcohol) was given orally at a dose of 10 ml thrice daily every day without interruption, either during or after chemotherapy, until the progression of disease, starting 6 days prior to the onset of chemotherapy. + all patients: chemotherapyemotherapy. + all patients: chemotherapy)
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Aloe vera mouthwash (containing pure Aloe … Aloe vera mouthwash (containing pure Aloe vera gel; 0.0009% Brilliant Blue dye; 0.0006% tartrazine yellow dye)5mL mouthwash 3x/day from the start to the end of radiotherapy (six weeks). Patients were asked not to eat or drink for 30 minutes after mouth rinsing.+ all patients: radiation therapyinsing. + all patients: radiation therapy)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Aloe vera was administered as a tincture ( … Aloe vera was administered as a tincture (Aloe vera leaves: 10%; 40% alcohol: 90%) at a dose of 1 ml twice/day (morning and evening), every day until disease progression.All patients: During the dark period of the day, Melatonin was administered orally at a dose of 20 mg/day, every day until disease progression./day, every day until disease progression.)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (An identical-appearing placebo prescribed at the same frequency, Duration: start within 7 days of the initiation of radiotherapy and continue for another 4 weeks after radiotherapy completion)
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (Antiemetics + bottle Glass pendant (in the form of a small flask), to be hung approx. 20 cm from the nose, the bottle was held directly under the nose and inhaled deeply at least 3 times a day for 2 minutes each time Start: Day 1 of chemotherapy)
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Antiemetics + bottle with 2 drops of ginge … Antiemetics + bottle with 2 drops of ginger oilGlass pendant (in the form of a small flask), to be hung approx. 20 cm from the nose, the bottle was held directly under the nose and inhaled deeply at least 3 times a day for 2 minutes each timeStart: Day 1 of chemotherapyes each time Start: Day 1 of chemotherapy)
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (Antiemetics + bottle with 2 drops of ginge … Antiemetics + bottle with 2 drops of ginger oilGlass pendant (in the form of a small flask), to be hung approx. 20 cm from the nose, the bottle was held directly under the nose and inhaled deeply at least 3 times a day for 2 minutes each timeStart: Day 1 of chemotherapyes each time Start: Day 1 of chemotherapy)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Applied directly after radiotherapy and in the evening or on treatment-free days in the morning and evening)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Applied directly after radiotherapy and in the evening or on treatment-free days in the morning and evening)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Apply approx. 2.5 ml of cream 3 times a day to irradiated skin during radiotherapy and for one month afterwards.)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Apply approx. 2.5 ml of placebo cream 3 times a day to irradiated skin during radiotherapy and for one month afterwards.)
Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Apply the 100% aloe vera gel to the irradi … Apply the 100% aloe vera gel to the irradiated skin up 6 to 8 times a day after radiotherapy from the start of radiotherapy until the end of therpy+ all patients: advised to gently clean the irradiated skin with mild, unscented soap and dry it with a soft, clean towel, protect the skin from injury, avoid prolonged exposure to sunlight and wear loose-fitting clothing. sunlight and wear loose-fitting clothing.)
Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (Approximately 5% of energy from carbohydra … Approximately 5% of energy from carbohydrate (≤20 g/day), 25% from protein (≤100 g/day) and 70% from fat (≥125 g/day)+ all participants received individual dietary advice from certified dieticians, weekly e-mails, and one-time personal meeting after baseline surveyime personal meeting after baseline survey)
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Attention by study partners (duration: NI, 1x week, 4 weeks in total))