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List of results

Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (800 IU daily (2x 400 IU))
Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (800 μg selenium per day (yeast selenium); Follow-up duration (mean (SD); median): 33.3 (23.3); 33.8 years)
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (84 capsules for 1 week (3x4 capsules/day starting with the first day of radiotherapy))
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (8mg daily from day 1 of radiotherapy for 6 weeks)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (8x ± 1 sessions for 15min - patients dipp … 8x ± 1 sessions for 15min- patients dipped their arms up to a hand’s width above the elbow and their feet up to a hand’s width above the ankle into a specialwater basin with water at a temperature of about 35∘- cross-galvanisation of each individual extremity by low-frequency (50Hz) faradic current (direct current impulses) up to the individual’s sensitivethreshold (i.e., the point where the tingling feeling is considered to be just acceptable)eling is considered to be just acceptable))
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (8x ± 1 sessions for 15min Point combinati … 8x ± 1 sessions for 15minPoint combinations for ...- patients with CIPN symptoms in the lower extremities: LV3 (Taichong), SP9 (Xiongxiang), GB41 (Zulingqi),GB34 (Yanglingquan) - patients with CIPN symptoms in the upper extremities: LI4 (Hegu), LI11 (Quchi), SI3 (Houxi), and HT3 (Shaohai) - patients with CIPN symptoms in the upper and lower extremities: treated with complete point combinationAcupuncture needles were deeply inserted bilaterally until the deqi phenomenon was triggered; each session included 15 minutes of electrostimulation (50Hz) consisting of a combination of rectangular currents and high amplitude wavestangular currents and high amplitude waves)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (A loading dose of 8000 IU/d of vitamin D3 (two 4000 IU capsules) for cycle 1 followed by 4000 IU/d for subsequent cycles)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (A loading dose of 8000 IU/d of vitamin D3 (two 4000 IU capsules) for cycle 1 followed by 4000 IU/d for subsequent cycles)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (All participants: 4-week run-in period with 600 IU D3 to allow serum levels to begin to normalize High-dose of 4,000 IU D3 capsules daily + all participants: 1,000 mg calcium carbonate)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (All participants: 4-week run-in period with 600 IU D3 to allow serum levels to begin to normalize Usual care dose of 600 IU D3 capsules daily + all participants: 1,000 mg calcium carbonate)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (All participants: pain medication, including intravenous injection of apotel 1 g, morphine sulfate 3 mg, and oral acet-aminophen 500 mg, depending on each patient’s need in the intensive care unit and ward)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (All patients: During the dark period of the day, Melatonin was administered orally at a dose of 20 mg/day, every day until disease progression.)
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Aloe aborescens (300g fresh aloe leaves in … Aloe aborescens (300g fresh aloe leaves in 500g honey and 40ml 40% alcohol) was given orally at a dose of 10 ml thrice daily every day without interruption, either during or after chemotherapy, until the progression of disease, starting 6 days prior to the onset of chemotherapy. + all patients: chemotherapyemotherapy. + all patients: chemotherapy)
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Aloe vera mouthwash (containing pure Aloe … Aloe vera mouthwash (containing pure Aloe vera gel; 0.0009% Brilliant Blue dye; 0.0006% tartrazine yellow dye)5mL mouthwash 3x/day from the start to the end of radiotherapy (six weeks). Patients were asked not to eat or drink for 30 minutes after mouth rinsing.+ all patients: radiation therapyinsing. + all patients: radiation therapy)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Aloe vera was administered as a tincture ( … Aloe vera was administered as a tincture (Aloe vera leaves: 10%; 40% alcohol: 90%) at a dose of 1 ml twice/day (morning and evening), every day until disease progression.All patients: During the dark period of the day, Melatonin was administered orally at a dose of 20 mg/day, every day until disease progression./day, every day until disease progression.)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (An identical-appearing placebo prescribed at the same frequency, Duration: start within 7 days of the initiation of radiotherapy and continue for another 4 weeks after radiotherapy completion)
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (Antiemetics + bottle Glass pendant (in the form of a small flask), to be hung approx. 20 cm from the nose, the bottle was held directly under the nose and inhaled deeply at least 3 times a day for 2 minutes each time Start: Day 1 of chemotherapy)
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Antiemetics + bottle with 2 drops of ginge … Antiemetics + bottle with 2 drops of ginger oilGlass pendant (in the form of a small flask), to be hung approx. 20 cm from the nose, the bottle was held directly under the nose and inhaled deeply at least 3 times a day for 2 minutes each timeStart: Day 1 of chemotherapyes each time Start: Day 1 of chemotherapy)
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (Antiemetics + bottle with 2 drops of ginge … Antiemetics + bottle with 2 drops of ginger oilGlass pendant (in the form of a small flask), to be hung approx. 20 cm from the nose, the bottle was held directly under the nose and inhaled deeply at least 3 times a day for 2 minutes each timeStart: Day 1 of chemotherapyes each time Start: Day 1 of chemotherapy)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Applied directly after radiotherapy and in the evening or on treatment-free days in the morning and evening)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Applied directly after radiotherapy and in the evening or on treatment-free days in the morning and evening)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Apply approx. 2.5 ml of cream 3 times a day to irradiated skin during radiotherapy and for one month afterwards.)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Apply approx. 2.5 ml of placebo cream 3 times a day to irradiated skin during radiotherapy and for one month afterwards.)
Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Apply the 100% aloe vera gel to the irradi … Apply the 100% aloe vera gel to the irradiated skin up 6 to 8 times a day after radiotherapy from the start of radiotherapy until the end of therpy+ all patients: advised to gently clean the irradiated skin with mild, unscented soap and dry it with a soft, clean towel, protect the skin from injury, avoid prolonged exposure to sunlight and wear loose-fitting clothing. sunlight and wear loose-fitting clothing.)
Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (Approximately 5% of energy from carbohydra … Approximately 5% of energy from carbohydrate (≤20 g/day), 25% from protein (≤100 g/day) and 70% from fat (≥125 g/day)+ all participants received individual dietary advice from certified dieticians, weekly e-mails, and one-time personal meeting after baseline surveyime personal meeting after baseline survey)

Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Attention by study partners (duration: NI, 1x week, 4 weeks in total))

Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (BCM95, Biocurcumin (each capsule contained … BCM95, Biocurcumin (each capsule contained 440mg curcuminoids (347mg curcumin, 84mg desmethoxycurcumin, and 9mg bisdesmethoxycurcumin) and essential oil of turmeric 38mg)Orally, 2 capsules 3 times a dayStart: week -1 radiotherapyDuration: until the end of radiotherapy, approx. 9 weeks in total of radiotherapy, approx. 9 weeks in total)
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (BCM95, Biocurcumin (each capsule contained … BCM95, Biocurcumin (each capsule contained 440mg curcuminoids (347mg curcumin, 84mg desmethoxycurcumin, and 9mg bisdesmethoxycurcumin) and essential oil of turmeric 38mg)Orally, 2 capsules 3 times a dayStart: week -1 radiotherapyDuration: until the end of radiotherapy, approx. 9 weeks in total of radiotherapy, approx. 9 weeks in total)
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Baseline 25OHD levels between 20 and 29 ng … Baseline 25OHD levels between 20 and 29 ng/ml got a placebo, orally once a week for a total of eight consecutive weeks, and then once a month for the rest of the study;Baseline 25OHD levels between 10 and 19 ng/ml received a matching placebo orally for 16 consecutive weeks and then once a month for the rest of the studyhen once a month for the rest of the study)
Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (Baseline vitamin D deficiency level: <1 … Baseline vitamin D deficiency level: <10 ng/ml 100 000 IU vitamin D3 on day 1, 15, 28, 43, 58 and at 3 months,Baseline vitamin D deficiency level: 10-20 ng/ml 100 000 IU vitamin D3 on day 1, 15, 28, 43 and at 3 months, Baseline vitamin D deficiency level: 20-30 ng/ml 100 000 IU vitamin D3 on day 1, 15 and at 3 months00 IU vitamin D3 on day 1, 15 and at 3 months)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Beta-carotene 50mg orally every 2nd day, start at the time of radiation therapy, mean (range) follow-up: 10.5 years (0.3-27.2))
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (Between 5 and 15 tablets of WOBE-MUGOS daily for 5 weeks: first two weeks average daily dose 10.6 (4.0), day 14 to day 35 averge daily dose 10.3(4.0) + all participants: radiation)
Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Calcipotriol to the lateral side of the breast, Duration: while radiotherapy treatment)
Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Calcipotriol to the medial side of the breast, Duration: while radiotherapy treatment)
Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Capsules 3g one day before the chemotherapy cycle and 1 g/day for the following 21 days)
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Capsules filled with starch and designed s … Capsules filled with starch and designed same medicine firm, form and color to zinc sulphate, three times daily at 8 hours interval,Duration of intervention: started 10 days before beginning of treatment and continued to 8 weeks after the end of treatmentnued to 8 weeks after the end of treatment)
Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (Capsules three times a day, after meals, Duration of intervention: started with beginning of radiotherapy and continued one month after completion of irradiation)
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (Capsules, 120 mg 2x/day Duration: throughout cisplatin therapy according to the respective protocol for the tumor (cumulative doses ranged from 50 to 300mg/m2).)
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (Capsules, 120 mg 2x/day Duration: throughout cisplatin therapy according to the respective protocol for the tumor (cumulative doses ranged from 50 to 300mg/m2).)
Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders + (Capsules, containing lactose monohydrate powder and looked identical to the zinc capsules)
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Chemoradiantherapy, no information about duration in days)
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (Cholecalciferol 2000 IU daily, for 2 years or until death, whichever came first)
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (Coat entire mouth with gel 3 times a day Start: day 0 radiotherapy Duration: entire radiotherapy (21 days))
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (Cold-hot compress for two days after surgery + all patients: surgery: third molar extraction was performed under local anesthesia)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Combination of Megestrol Acetate (oral, 800mg/day liquid) and Dronabinol (oral, 2.5mg 2 times a day))
Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (Control arm patients did not receive any additional treatment + all patients received 50-60 Gy of external beam radiation in 20-30 fractions for 35(+/-1) days, followed by intra-cavitary rachytherapy at a dose of 20–30 Gy using a BARC applicator.)
Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (Curcumin solution; 1 capsule with 400g curcumin powder dissolved in approximately 80ml water (prepared by the nurse), 10ml as a mouthwash (4 times for 2 minutes each) Start: Day 1 radiotherapy, 6 times daily Duration: 7 weeks)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (DN-101 (45 μg) orally (high concentration formulation of calcitriol), weekly for 3 consecutive weeks of a 4-week cycle)
Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Daily)
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Daily)
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (Daily Duration: 12 weeks)