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List of results

Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Oral zinc (25 mg Pro-Z), three capsules per day)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Oral zinc (25 mg Pro-Z), three capsules per day)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Oral zinc (25 mg Pro-Z), three capsules per day)
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Oral zinc (25 mg Pro-Z), three capsules per day)
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Oral, 100mg Duration: week -1 radioiodine treatment until week +4 (total 5 weeks))
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Oral, 2.2g EPA daily + 2g/daily Resource Support Duration: 4 month)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Oral, 2.5mg 2 times a day + liquid placebo)
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Oral, 200mg Duration: week -1 radioiodine treatment until week +4 (total 5 weeks))
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Oral, 20mg 3 times daily)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Oral, 2x 100mg daily Duration: 4 month)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Oral, 2x 2g daily Duration: 4 month)
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (Oral, 2x daily Start: day -7 surgery Duration: until day 28 after surgery)
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Oral, 3 x 1000 mg daily (in two 500 mg tablets) Duration: 8 weeks)
Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients + (Oral, 30 mg/kg body weight for 2 weeks before surgery)
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Oral, 300mg Duration: week -1 radioiodine treatment until week +4 (total 5 weeks))
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Oral, 300mg, 2x daily Duration: during chemotherapy until 3 months afterwards)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Oral, 320mg daily MA or 500mg daily MPA Oral, 2.2g EPA daily + 2g/daily Resource Support Oral, 2x 2g daily L-Carnitine Oral, 2x 100mg daily Thalidomid Duration: 4 month)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Oral, 320mg daily MA or 500mg daily MPA Duration: 4 month)
Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (Oral, 400 IU daily Duration: length of study)
Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (Oral, 400 IU daily Duration: length of study)
Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial + (Oral, 400IU, 1x daily)
Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Oral, 400mg daily Start: after randomization prior to chemotherapy Duration: until 3 months post-CTX)
Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Oral, 400mg daily Start: after randomization prior to chemotherapy Duration: until 3 months post-CTX)
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (Oral, 400mg, 2x daily Start: day -7 surgery Duration: until day 28 after surgery)
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (Oral, 800 IU per day Start: Week -1 radioiodine therapy to 4 weeks after Duration: 5 weeks)

Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Oral, 800mg/day liquid + placebo)

Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (Oral, day 0 chemotherapy: 500 µg 3x daily Duration: until 1 month after the end of chemotherapy)
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Orally rinsed with Polaprezinc solution (P … Orally rinsed with Polaprezinc solution (Polaprezinc granules (0.5g) were dissolved in 20 ml of 5% sodium alginate solution, a natural thickener used as food additive, by agitating intermittently for 1 hr) for 3 min 4 times in a day, the solution was swallowed after oral rinse;Duration: from the start to the end of the radiotherapym the start to the end of the radiotherapy)
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Orally rinsed with azulene solution (prepared by pouring 7 drops of 4% liquid solution into 100 ml water) for 3 min 4 times in a day; Duration: from the start to the end of the radiotherapy)
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (Orally, 2 capsules 3 times a day (each capsule contained 500mg roasted rice flour) Start: week -1 radiotherapy Duration: until the end of radiotherapy, approx. 9 weeks in total)
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (Orally, 2 capsules 3 times a day (each capsule contained 500mg roasted rice flour) Start: week -1 radiotherapy Duration: until the end of radiotherapy, approx. 9 weeks in total)
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Patients served as their own control first and then received reflexology; passive control/no intervention (1x 30 min), at least 48 h break, reflex therapy (1x 30 min))
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Patients were instructed to take 15ml of t … Patients were instructed to take 15ml of the solution 3x daily, beginning on the first day of radiation and continuing throughout the three-four weeks of the radiation course and continuing until the end of the 8th week follow-up.+ all patients: received the usual recommendations of daily rinsing with water, saline solution, if necessary rinsing with viscous lidocaine, or use of analgesics and antibiotics+ all patients: radiation therapybiotics + all patients: radiation therapy)
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Patients were instructed to take 15ml of t … Patients were instructed to take 15ml of the solution 3x daily, beginning on the first day of radiation and continuing throughout the three-four weeks of the radiation course and continuing until the end of the 8th week follow-up.+ all patients: received the usual recommendations of daily rinsing with water, saline solution, if necessary rinsing with viscous lidocaine, or use of analgesics and antibiotics+ all patients: radiation therapybiotics + all patients: radiation therapy)
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (Peripheral PN (PPN) 100ml (20% lipid emulsion) + carnitine, IV, -1st postoperative day OP to day 4, average administration: 72.6mg/kg daily (SD = 37.3) Duration: 4 days)
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (Peripheral PN (PPN) 100ml (20% lipid emulsion))
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (Placebo (oil drops), for 12 weeks)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Placebo after surgery until the end of the trial)
Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy + (Placebo capsules orally 2 times a day)
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (Placebo capsules with meals, per cycle for 5 days, starting on the day of chemotherapy over 3 cycles + Antiemetics (for 3 chemotherapy cycles, duration: day of chemo to 5 days post chemo))
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (Placebo capsules, a capsule after breakfast and dinner)
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Placebo mouthwash with the same colour, ta … Placebo mouthwash with the same colour, taste and density in identical 200mL bottles, with honey.Rinsing with 7ml of mouthwash 4 times per day (before each main meal and radiotherapy session) during weekdays, and 3 times per day (before each main meal) during weekends+all patients: concomitant chemoradiotherapy (daily treatment, 5 times per week, for 6-6.5 weeks)+ dental and nutritional evaluation before treatmentnd nutritional evaluation before treatment)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Placebo orally (high concentration formulation of calcitriol), weekly for 3 consecutive weeks of a 4-week cycle)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Placebo orally every 2nd day, start at the time of radiation therapy, mean (range) follow-up: 10.5 years (0.3-27.2) + "6% of participants in the placebo group reported taking supplemental beta-carotene or vitamin A")
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Placebo pill, orally, 2x daily, duration: 1 week prior to radiotherapy until 1 month after radiotherapy (average intervention period: 3 months))
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Placebo tablets * once a day before radiotherapy in the first week * twice a day in the second week * third week until end of radiotherapy: adjusted by radiation oncologist up to maximal 4 tablets)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (Placebo tablets 3 times daily after meals, Duration: from the onset of subjective perception of taste alterations (hypogeusia or dysgeusia) and continuing through radiotherapy until 1 month after radiotherapy termination)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Placebo twice daily, from the starting day of HDC to 14 days after transplantation)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Placebo via oral spray (self-applied by patient) Week 1: dose finding; week 2-5: stable dose Maximal number of sprays: variable (1-4, 6-10, 11-16))
Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (Placebo vitamin D weekly, over 24 weeks + all participants: daily multivitamin containing the RDA for vitamin D: 600 IU/day + 210 mg/day calcium and calcium supplements (800 mg/day))
Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (Placebo; Follow-up duration (mean (SD); median): 36.3 (20.7); 38.4 years)