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List of results

Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Oral, 800mg/day liquid + placebo)
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (Oral, day 0 chemotherapy: 500 µg 3x daily Duration: until 1 month after the end of chemotherapy)
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Orally rinsed with Polaprezinc solution (P … Orally rinsed with Polaprezinc solution (Polaprezinc granules (0.5g) were dissolved in 20 ml of 5% sodium alginate solution, a natural thickener used as food additive, by agitating intermittently for 1 hr) for 3 min 4 times in a day, the solution was swallowed after oral rinse;Duration: from the start to the end of the radiotherapym the start to the end of the radiotherapy)
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Orally rinsed with azulene solution (prepared by pouring 7 drops of 4% liquid solution into 100 ml water) for 3 min 4 times in a day; Duration: from the start to the end of the radiotherapy)
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (Orally, 2 capsules 3 times a day (each capsule contained 500mg roasted rice flour) Start: week -1 radiotherapy Duration: until the end of radiotherapy, approx. 9 weeks in total)
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (Orally, 2 capsules 3 times a day (each capsule contained 500mg roasted rice flour) Start: week -1 radiotherapy Duration: until the end of radiotherapy, approx. 9 weeks in total)
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Patients served as their own control first and then received reflexology; passive control/no intervention (1x 30 min), at least 48 h break, reflex therapy (1x 30 min))
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Patients were instructed to take 15ml of t … Patients were instructed to take 15ml of the solution 3x daily, beginning on the first day of radiation and continuing throughout the three-four weeks of the radiation course and continuing until the end of the 8th week follow-up.+ all patients: received the usual recommendations of daily rinsing with water, saline solution, if necessary rinsing with viscous lidocaine, or use of analgesics and antibiotics+ all patients: radiation therapybiotics + all patients: radiation therapy)
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Patients were instructed to take 15ml of t … Patients were instructed to take 15ml of the solution 3x daily, beginning on the first day of radiation and continuing throughout the three-four weeks of the radiation course and continuing until the end of the 8th week follow-up.+ all patients: received the usual recommendations of daily rinsing with water, saline solution, if necessary rinsing with viscous lidocaine, or use of analgesics and antibiotics+ all patients: radiation therapybiotics + all patients: radiation therapy)
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (Peripheral PN (PPN) 100ml (20% lipid emulsion) + carnitine, IV, -1st postoperative day OP to day 4, average administration: 72.6mg/kg daily (SD = 37.3) Duration: 4 days)
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (Peripheral PN (PPN) 100ml (20% lipid emulsion))
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (Placebo (oil drops), for 12 weeks)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Placebo after surgery until the end of the trial)
Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy + (Placebo capsules orally 2 times a day)
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (Placebo capsules with meals, per cycle for 5 days, starting on the day of chemotherapy over 3 cycles + Antiemetics (for 3 chemotherapy cycles, duration: day of chemo to 5 days post chemo))
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (Placebo capsules, a capsule after breakfast and dinner)
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Placebo mouthwash with the same colour, ta … Placebo mouthwash with the same colour, taste and density in identical 200mL bottles, with honey.Rinsing with 7ml of mouthwash 4 times per day (before each main meal and radiotherapy session) during weekdays, and 3 times per day (before each main meal) during weekends+all patients: concomitant chemoradiotherapy (daily treatment, 5 times per week, for 6-6.5 weeks)+ dental and nutritional evaluation before treatmentnd nutritional evaluation before treatment)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Placebo orally (high concentration formulation of calcitriol), weekly for 3 consecutive weeks of a 4-week cycle)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Placebo orally every 2nd day, start at the time of radiation therapy, mean (range) follow-up: 10.5 years (0.3-27.2) + "6% of participants in the placebo group reported taking supplemental beta-carotene or vitamin A")
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Placebo pill, orally, 2x daily, duration: 1 week prior to radiotherapy until 1 month after radiotherapy (average intervention period: 3 months))
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Placebo tablets * once a day before radiotherapy in the first week * twice a day in the second week * third week until end of radiotherapy: adjusted by radiation oncologist up to maximal 4 tablets)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (Placebo tablets 3 times daily after meals, Duration: from the onset of subjective perception of taste alterations (hypogeusia or dysgeusia) and continuing through radiotherapy until 1 month after radiotherapy termination)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Placebo twice daily, from the starting day of HDC to 14 days after transplantation)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Placebo via oral spray (self-applied by patient) Week 1: dose finding; week 2-5: stable dose Maximal number of sprays: variable (1-4, 6-10, 11-16))
Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (Placebo vitamin D weekly, over 24 weeks + all participants: daily multivitamin containing the RDA for vitamin D: 600 IU/day + 210 mg/day calcium and calcium supplements (800 mg/day))

Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (Placebo; Follow-up duration (mean (SD); median): 36.3 (20.7); 38.4 years)

Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (Povidone-iodine solution (diluted 1:100; 1ml Betadine, 100ml water), Mouthwash, 10ml twice daily Duration: 6 weeks)
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Propionyl-L-Carnitin (PLC) 2g daily + Acetyl-L-Carnitin (ALC) 2g daily + 100mg Sildenafil if required Duration: 4 month)
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety. + (Reading aloud by a partner/family member/friend (reading of own choice) Duration: 1x 30 minutes; And usual care)
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Received reflexology first and then served as their own control. (1x 30 min), at least 48 h break, passive control/no intervention (1x 30 min))
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Reflex therapy by study partners who were trained 2x in a 30min. protocol for reflex therapy by reflexologists (duration: 30 min., study weeks 1-4: minimum requirement 1x/week, real average 1.1/week; SW 5-11: no requirements, average 0.6/week))
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety. + (Reflexotherapy of the Ingram method by a partner/family member who has received 15-30 minutes of instruction from a certified reflex therapist Duration: 1x 30 minutes; And usual care)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (Same form and frequency as in Vit. B arm (oral, 3 lactose capsules daily))
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Sativex® (Nabiximol, THC 27 mg/mL, CBD 25 mg/mL) via oral spray (self-applied by patient) * week 1: dose finding; week 2-5: stable dose, max. 10 sprays * first week mean number of sprays: 3.7, stabilized over 4 weeks (6.3 sprays per day))
Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Sativex® (nabiximol, THC 27 mg/mL, CBD 25 … Sativex® (nabiximol, THC 27 mg/mL, CBD 25 mg/mL) via oral spray (self-applied by patient);week 1: dose finding; week 2-5: stable dose, max. 10 sprays* Part A: first week average number of sprays: 3.6; second week: 6.4* Part B: average daily number: 6.5k: 6.4 * Part B: average daily number: 6.5)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Selenium tablet (Webber Naturals, Coquitlam, BC, Canada, 200 mcg) twice daily, from the starting day of HDC to 14 days after transplantation)
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (Selenomethionine 3600 µg/m²(in 800 µg tablets) 2x daily 7 days before chemotherapy, during chemotherapy 1x daily, and daily for 3 weeks after chemotherapy)
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Sildenafil 100mg if required + Placebo Duration: 4 month)
Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients + (Sodium selenite was administered on days 3–7 of the chemotherapy)
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (Standard diet (55% carbohydrates, 15% protein, and 30% fat))
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Stimulation of the reflex points 20 min. of the right foot and 10 min. of the left foot, 2x/week, 5 weeks in total), + chemoradiantherapy)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Supplied by Genzyme as 2.5 μg soft gel cap … Supplied by Genzyme as 2.5 μg soft gel capsules,10 μg (i.e., four capsules of 2.5 μg) of doxercalciferol orally each day of the chemotherapy cycles before breakfast and at the same time,Duration: for 1-12 cycles of chemotherapy (each cycle: 28 days), median duration: 6 cyclescycle: 28 days), median duration: 6 cycles)
Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (Swedish Massage protocol was prespeciﬁed a … Swedish Massage protocol was prespeciﬁed and involved a combination of 10 minutes of light stroking and light pressure using the whole hand toplantar and dorsal surfaces and all tissue from the toes to the knee of each leg (20 minutes total). The Reﬂexology Intervention was based on the original Ingram method and useda combination of ﬁnger pivot and thumb walking techniquesto the base of the foot and the toes that correspond withreﬂex points. The sole, instep, and lateral aspects of the footwere stimulated 5 times, each foot for a total of 10 minutesper foot (20 minutes total). of 10 minutesper foot (20 minutes total).)
Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (Swedish Massage protocol was prespeciﬁed a … Swedish Massage protocol was prespeciﬁed and involved a combination of 10 minutes of light stroking and light pressure using the whole hand toplantar and dorsal surfaces and all tissue from the toes to the knee of each leg (20 minutes total). The Reﬂexology Intervention was based on the original Ingram method and useda combination of ﬁnger pivot and thumb walking techniquesto the base of the foot and the toes that correspond withreﬂex points. The sole, instep, and lateral aspects of the footwere stimulated 5 times, each foot for a total of 10 minutesper foot (20 minutes total). of 10 minutesper foot (20 minutes total).)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (THC extract via oral spray (2.7 mg), dosage variable; Week 1: dose finding Week 2: stable dose, maximum of 8 sprays every 3 hours and 48 sprays in 24 hours: dose was determined by patients themselves)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (THC:CBD via oral spray (self-applied by patient, one dose 2.7mg THC and 2.5mg CBD) Week 1: dose finding Week 2: stable dose, maximum of 8 sprays every 3 hours and 48 sprays in 24 hours: dose was determined by patients themselves)
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (The aloe vera solution consisted of 94.5% … The aloe vera solution consisted of 94.5% aloe juice, 5.0% pear juice concentrate, 0.4% lemon-lime flavor, and 0.1% citric acid.Patients were instructed to take a 20ml swish and swallow 4x daily, beginning on the first day and continuingthroughout the RT course.+ all patients were instructed to alleviate oral discomfort by rinsing daily with a baking soda mouth rinse, and swishing and swallowing Benadryl and nystatin combination mouthwashes and viscous lidocaine, as needed+ all patients: radiation dose 50-70 Gy at 1.8-2 Gy per dayadiation dose 50-70 Gy at 1.8-2 Gy per day)
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (The aloe vera solution consisted of 94.5% … The aloe vera solution consisted of 94.5% water, 5.0% pear juice concentrate, 0.4% lemon-lime flavor, and 0.1% citric acid.Patients were instructed to take a 20ml swish and swallow 4x daily, beginning on the first day and continuingthroughout the RT course.+ all patients were instructed to alleviate oral discomfort by rinsing daily with a baking soda mouth rinse, and swishing and swallowing Benadryl and nystatin combination mouthwashes and viscous lidocaine, as needed+ all patients: radiation dose 50-70 Gy at 1.8-2 Gy per dayadiation dose 50-70 Gy at 1.8-2 Gy per day)
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (The foot reflexology was initiated during the evening on postoperative day 2 while patients are on PCA and between 1 and 3 hours after a dose of pain medication, day 3 after surgery and day 4 after surgery, duration: 20 min each))
Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (The ointment was applied twice daily for six weeks by patients at home + all tumors were excised after eight weeks)
Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (The ointment was applied twice daily for six weeks by patients at home + all tumors were excised after eight weeks)