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- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Ineligible (n = 10); No therapy (n = 12) … Ineligible (n = 10);</br>No therapy (n = 12)</br></br>Discontinued treatment:</br>Completed (n = 238);</br>Progression (n = 117);</br>Toxicity (n = 20);</br>Death (n = 18);</br>Withdrawal (n = 157);</br>Nonprotocol treatment (n = 1);</br>Complicating disease (n = 30);</br>Maximum dose (n = 2);</br>Other (n = 212)30); Maximum dose (n = 2); Other (n = 212))