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List of results
- Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (Due to side effects: n=3, consent withdrawn: n= 4, severe nausea / vomiting: n=1)
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Dysphagia before radiotherapy (n=1); change to palliative treatment (n=1); follow-up <2 weeks because of adverse events (n=1); lack of compliance/withdrawal of consent (n=1))
- Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Excluded due to changing chemotherapy (n=1))
- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Finished the study prematurely at their own request)
- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Finished the study prematurely at their own request)
- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (First phase: Revocation: 31x, Side effect … First phase: </br>Revocation: 31x, Side effects: 11x, Treatment refused: 10x, Deceased: 4x, Disease progression: 3x, Other: 3x</br></br>Second phase: </br>Treatment ended early: 28x, Side effects: 11x, Treatment refused: 9x, Deceased: 2x, Disease progression: 2x, Other: 4xed: 2x, Disease progression: 2x, Other: 4x)
- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (First phase: Revocation: 36x, Side effect … First phase: </br>Revocation: 36x, Side effects: 17x, Treatment refused: 13x, Deceased: 1x, Disease progression: 1x, Other: 4x</br></br>Second phase: </br>Treatment ended early: 29x, Side effects: 11x, Treatment refused: 5x, Deceased: 5x, Disease progression: 3x, Other: 4xed: 5x, Disease progression: 3x, Other: 4x)
- Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (Forms not filled out correctly)
- Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (Forms not filled out correctly)
- Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (Frequent blood sampling; surgery; diabetes)
- Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (Gastrointestonal side effects)
- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (Hepatitis (n=1); brain metastasis (n=1))
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Inability to swallow (n=1); follow-up <2 weeks because of adverse events (n=2); lack of compliance/withdrawal of consent (n=1))
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Ineligible (n = 10); No therapy (n = 12) … Ineligible (n = 10);</br>No therapy (n = 12)</br></br>Discontinued treatment:</br>Completed (n = 238);</br>Progression (n = 117);</br>Toxicity (n = 20);</br>Death (n = 18);</br>Withdrawal (n = 157);</br>Nonprotocol treatment (n = 1);</br>Complicating disease (n = 30);</br>Maximum dose (n = 2);</br>Other (n = 212)30); Maximum dose (n = 2); Other (n = 212))
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Ineligible (n = 6); No therapy (n = 2) Discontinued treatment: Completed (n = 134); Progression (n = 52); Toxicity (n = 8); Death (n = 12); Withdrawal (n = 67); Nonprotocol treatment (n = 3); Complicating disease (n = 17); Other (n = 105))
- Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Ineligible (n=12); never followed up cystoscopically (n=6))
- Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Ineligible (n=15); never followed up cystoscopically (n=6))
- Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Insufficient RNA quality or quantity (n=2))
- Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Insufficient RNA quality or quantity (n=6))
- Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Insufficient RNA quality or quantity (n=7))
- Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Interrupted cisplatin early n=19 Suspended Vitamin E after 1 month n=2 Received less than 300mg/m2 dose of cisplatin or completed only one visit n=20)
- Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Interrupted cisplatin early n=21 Received less than 300mg/m2 dose of cisplatin or completed only one visit n=23)
- Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Lack of compliance (n=2))
- Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Lack of compliance (n=4))
- Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial + (Later found to be ineligible (imposition of stricter registration and evaluation procedures))
- Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial + (Later found to be ineligible (imposition of stricter registration and evaluation procedures))
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Lost to follow-up)
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Lost to follow-up)
- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Lost to follow-up (n = 1); DLT (dose-limiting toxicity) (n = 1) = Completed follow-up n=1)
- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Lost to follow-up (n = 2))
- Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients + (Lost to follow-up (n=4) Discontinued inter … Lost to follow-up (n=4)</br>Discontinued intervention (n=36)</br>- Capsule side-effects (n=6)</br>- Difficulty swallowing capsules (n=3)</br>- Other medical problems (n=9)</br>- Participation too troublesome (n=13)</br>- Wanted to take vitamin E (n=2)</br>- Physician requested to stop (n=3) (n=2) - Physician requested to stop (n=3))
- Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients + (Lost to follow-up (n=4) Discontinued inter … Lost to follow-up (n=4)</br>Discontinued intervention (n=36)</br>- Capsule side-effects (n=6)</br>- Difficulty swallowing capsules (n=3)</br>- Other medical problems (n=9)</br>- Participation too troublesome (n=13)</br>- Wanted to take vitamin E (n=2)</br>- Physician requested to stop (n=3) (n=2) - Physician requested to stop (n=3))
- Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients + (Lost to follow-up (n=4) Discontinued inter … Lost to follow-up (n=4)</br>Discontinued intervention (n=36)</br>- Capsule side-effects (n=6)</br>- Difficulty swallowing capsules (n=3)</br>- Other medical problems (n=9)</br>- Participation too troublesome (n=13)</br>- Wanted to take vitamin E (n=2)</br>- Physician requested to stop (n=3) (n=2) - Physician requested to stop (n=3))
- Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients + (Lost to follow-up (n=7) Discontinued intervention (n=34) - Capsule side-effects (n=6) - Other medical problems (n=8) - Participation too troublesome (n=13) - Wanted to take vitamin E (n=5) - Physician requested to stop (n=2))
- Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients + (Lost to follow-up (n=7) Discontinued intervention (n=34) - Capsule side-effects (n=6) - Other medical problems (n=8) - Participation too troublesome (n=13) - Wanted to take vitamin E (n=5) - Physician requested to stop (n=2))
- Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients + (Lost to follow-up (n=7) Discontinued intervention (n=34) - Capsule side-effects (n=6) - Other medical problems (n=8) - Participation too troublesome (n=13) - Wanted to take vitamin E (n=5) - Physician requested to stop (n=2))
- Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Lost to follow-up 1 month post-radiotherapy (n=2, refusal/poor compliance) Lost to follow-up 6 month post-radiotherapy (n=4, 2x refusal/poor compliance), 2x disease recurrence))
- Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Lost to follow-up 6 month post-radiotherapy (n=1, refusal))
- Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Lost to follow-up or lack of compliance)
- Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Lost to follow-up or lack of compliance)
- Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Marked decline in % EF n=7 Cancer related death n=1)
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Missed follow-up)
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Missed follow-up)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (N=1 patient died, n=1 patient was non-adherent)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (N=1, radiation dermatitis; N=1, reduced neutrophil values)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (N=1, severe diarrhea; N=1, radiation dermatitis)
- Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (N=3 because of death; N=2 because of the change of drug regime; N=2 because of vomiting and capsule elimination and kack of capsules swallowing N=5 were under radiotherapy between the cycles of chemotherapy)
- Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (N=3 because of death; N=2 because of the change of drug regime; N=2 because of vomiting and capsule elimination and kack of capsules swallowing N=5 were under radiotherapy between the cycles of chemotherapy)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (NA)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (NA)
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (NA)
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (NA)