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List of results
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Inability to swallow (n=1); follow-up <2 weeks because of adverse events (n=2); lack of compliance/withdrawal of consent (n=1))
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Ineligible (n = 10); No therapy (n = 12) … Ineligible (n = 10);</br>No therapy (n = 12)</br></br>Discontinued treatment:</br>Completed (n = 238);</br>Progression (n = 117);</br>Toxicity (n = 20);</br>Death (n = 18);</br>Withdrawal (n = 157);</br>Nonprotocol treatment (n = 1);</br>Complicating disease (n = 30);</br>Maximum dose (n = 2);</br>Other (n = 212)30); Maximum dose (n = 2); Other (n = 212))
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Ineligible (n = 6); No therapy (n = 2) Discontinued treatment: Completed (n = 134); Progression (n = 52); Toxicity (n = 8); Death (n = 12); Withdrawal (n = 67); Nonprotocol treatment (n = 3); Complicating disease (n = 17); Other (n = 105))
- Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Ineligible (n=12); never followed up cystoscopically (n=6))
- Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Ineligible (n=15); never followed up cystoscopically (n=6))
- Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Insufficient RNA quality or quantity (n=2))
- Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Insufficient RNA quality or quantity (n=6))
- Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Insufficient RNA quality or quantity (n=7))
- Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Interrupted cisplatin early n=19 Suspended Vitamin E after 1 month n=2 Received less than 300mg/m2 dose of cisplatin or completed only one visit n=20)
- Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Interrupted cisplatin early n=21 Received less than 300mg/m2 dose of cisplatin or completed only one visit n=23)
- Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Lack of compliance (n=2))
- Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Lack of compliance (n=4))
- Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial + (Later found to be ineligible (imposition of stricter registration and evaluation procedures))
- Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial + (Later found to be ineligible (imposition of stricter registration and evaluation procedures))
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Lost to follow-up)
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Lost to follow-up)
- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Lost to follow-up (n = 1); DLT (dose-limiting toxicity) (n = 1) = Completed follow-up n=1)
- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Lost to follow-up (n = 2))
- Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients + (Lost to follow-up (n=4) Discontinued inter … Lost to follow-up (n=4)</br>Discontinued intervention (n=36)</br>- Capsule side-effects (n=6)</br>- Difficulty swallowing capsules (n=3)</br>- Other medical problems (n=9)</br>- Participation too troublesome (n=13)</br>- Wanted to take vitamin E (n=2)</br>- Physician requested to stop (n=3) (n=2) - Physician requested to stop (n=3))
- Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients + (Lost to follow-up (n=4) Discontinued inter … Lost to follow-up (n=4)</br>Discontinued intervention (n=36)</br>- Capsule side-effects (n=6)</br>- Difficulty swallowing capsules (n=3)</br>- Other medical problems (n=9)</br>- Participation too troublesome (n=13)</br>- Wanted to take vitamin E (n=2)</br>- Physician requested to stop (n=3) (n=2) - Physician requested to stop (n=3))
- Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients + (Lost to follow-up (n=4) Discontinued inter … Lost to follow-up (n=4)</br>Discontinued intervention (n=36)</br>- Capsule side-effects (n=6)</br>- Difficulty swallowing capsules (n=3)</br>- Other medical problems (n=9)</br>- Participation too troublesome (n=13)</br>- Wanted to take vitamin E (n=2)</br>- Physician requested to stop (n=3) (n=2) - Physician requested to stop (n=3))
- Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients + (Lost to follow-up (n=7) Discontinued intervention (n=34) - Capsule side-effects (n=6) - Other medical problems (n=8) - Participation too troublesome (n=13) - Wanted to take vitamin E (n=5) - Physician requested to stop (n=2))
- Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients + (Lost to follow-up (n=7) Discontinued intervention (n=34) - Capsule side-effects (n=6) - Other medical problems (n=8) - Participation too troublesome (n=13) - Wanted to take vitamin E (n=5) - Physician requested to stop (n=2))
- Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients + (Lost to follow-up (n=7) Discontinued intervention (n=34) - Capsule side-effects (n=6) - Other medical problems (n=8) - Participation too troublesome (n=13) - Wanted to take vitamin E (n=5) - Physician requested to stop (n=2))
- Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Lost to follow-up 1 month post-radiotherapy (n=2, refusal/poor compliance) Lost to follow-up 6 month post-radiotherapy (n=4, 2x refusal/poor compliance), 2x disease recurrence))
- Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Lost to follow-up 6 month post-radiotherapy (n=1, refusal))
- Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Lost to follow-up or lack of compliance)
- Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Lost to follow-up or lack of compliance)
- Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Marked decline in % EF n=7 Cancer related death n=1)
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Missed follow-up)
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Missed follow-up)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (N=1 patient died, n=1 patient was non-adherent)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (N=1, radiation dermatitis; N=1, reduced neutrophil values)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (N=1, severe diarrhea; N=1, radiation dermatitis)
- Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (N=3 because of death; N=2 because of the change of drug regime; N=2 because of vomiting and capsule elimination and kack of capsules swallowing N=5 were under radiotherapy between the cycles of chemotherapy)
- Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (N=3 because of death; N=2 because of the change of drug regime; N=2 because of vomiting and capsule elimination and kack of capsules swallowing N=5 were under radiotherapy between the cycles of chemotherapy)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (NA)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (NA)
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (NA)
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (NA)
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (NA)
- Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (NA)
- Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (NA)
- Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (NA)
- Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (NA)
- Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (NA)
- Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (NA)
- Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (NA)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (NA)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (NA)
- Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (NA)