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- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Nonadherent (did not complete 6 months of study drug) (n = 2),but completed their 6-month study evaluations; DLT (dose-limiting toxicity) (n = 3), but completed their 6-month study evaluations = completed follow-up n=11)