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- Kadhim et al. (2021): Effect of Ginger Tea on Chemotherapy-Induced Nausea and Vomiting among Patients Attending the Oncology Teaching Hospital, Baghdad 2020 + (?)
- Montazeri et al. (2013): Iranian Red Crescent Medical JournalEffect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients. + (?)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (?)
- Sharp et al. (2009): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (?)
- Williams et al. (1996): Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity + (?)
- Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy + (A previous diagnosis of cancer, a concomitant cancer, distant metastases or recurrent cancer, prior radiation therapy or chemotherapy, pregnancy, an autoimmune disease, or drugs received that contained zinc)
- Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial + (Accompanying carcinoma in situ (CIS))
- Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (Active infection; other causes of haematoc … Active infection; other causes of haematochezia including bowel cancer; IBD; haemorrhoids; anal incontinence; anorectal fistula; anorectal stenosis; previous rectal surgery; pregnant or breastfeeding women; women of childbearing age without appropriate contraception; allergy to components of the ointments tested; use of antibiotics or steroidsnts tested; use of antibiotics or steroids)
- Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Active malignancy within 5 years (except n … Active malignancy within 5 years (except nonmelanoma skin cancer), significant active medical illness that would preclude protocol treatment, a history of hypercalcemia or vitamin D toxicity, or hospitalization for treatment of angina, myocardial infarction, or congestive heart failure in the previous 12 months;</br>kidney stones (calcium salt) within 5 years, hypersensitivity to calcitriol or drugs formulated with polysorbate-80, grade 2 or higher peripheral neuropathy, neutrophil count less than 1,500/mm<sup>3</sup> , platelet count lower than 100,000/ mm<sup>3</sup> , serum creatinine more than upper limit of normal (ULN), serum calcium more than ULN, conjugated bilirubin more than ULN, alkaline phosphatase more than 4 x ULN (patients with known bone involvement and a normal conjugated bilirubin, ALT, and AST were not excluded), ALT or AST more than 2.0 x ULN when alkaline phosphatase is less than 2.5 x ULN, ALT or AST more than 1.5 x ULN when alkaline phosphatase is more than 2.5 x ULN,</br>prior investigational therapy or use of calcitriol within 30 days, prior chemotherapy for prostate cancer except for adjuvant therapy more than 12 months before enrollment, prior chemotherapy with docetaxel, treatment with radiotherapy within 4 weeks or treatment with other radiopharmaceuticals within 8 weeks weeks or treatment with other radiopharmaceuticals within 8 weeks)
- Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (Adequate vitamin D levels; hypercalcemia, osteoporosis, stage IV kidney disease or myocardial infarction within the past year)
- Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Allergy to ginger; pregnancy or lactation; … Allergy to ginger; pregnancy or lactation; current radiotherapy; preexisting nausea or vomiting from any cause; the presence of other diseases as a possible cause of nausea or vomiting (hepatitis, gastrointestinal obstruction, or diseases); use of coumadin or heparin for therapeutic anticoagulation; blood disorders or a platelet count <100 000/µL disorders or a platelet count <100 000/µL)
- Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients + (Allergy to lycopene; hearing loss; significant neuropathy; metastatic renal involvement)
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Already taking a vitamin D supplement or active vitamin D; had a history of urinary tract stones; and other difficulties as judged by the surgeon in charge)
- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (Aromatase inhibitor therapy in the last 6 … Aromatase inhibitor therapy in the last 6 weeks, history of kidney stones, hypercalcemia at baseline, history of symptomatic hypercalcemia or hyperparathyroidism, baseline 25-OH Vitamin D level >50 ng/mL, currently taking phenytoin or phenobarbital, currently taking cholestyramine or orlistat, malabsorption syndrome, or chronic granulomata forming disorders, such as sarcoidosis or tuberculosisisorders, such as sarcoidosis or tuberculosis)
- Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Baseline use of morphine at > 500 mg mo … Baseline use of morphine at > 500 mg morphine equivalents/day (inclusive of maintenance and breakthrough opioids); current use of more than one type of breakthrough opioid analgesic; planned clinical interventions that would affect pain; any history of schizophrenia or substance abuse including recreational use of cannabis productncluding recreational use of cannabis product)
- Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (Baseline use of morphine at >500 mg mor … Baseline use of morphine at >500 mg morphine equivalents/day (inclusive of maintenance and breakthrough opioids); current use of more than one type of breakthrough opioid analgesic; planned clinical interventions that would affect pain; any history of schizophrenia or substance abusey history of schizophrenia or substance abuse)
- Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Baseline use of morphine at >500mg morp … Baseline use of morphine at >500mg morphine equivalents/day (inclusive of maintenance and breakthrough opioids); current use of more than one type of breakthrough opioid analgesic; planned clinical interventions that would affect pain; any </br>history of schizophrenia or substance abuse including recreational use of cannabis productncluding recreational use of cannabis product)
- Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (Being pregnant, diabetes, asthma, Sjogren' … Being pregnant, diabetes, asthma, Sjogren's syndrome, lack of ability to feed by mouth, using anti-depressant medications, a history of allergy to ginger or corn starch and people who have had recurrence of cancer and residence outside the city of Ahvaz and the lack of consent of the participation in the study.consent of the participation in the study.)
- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Bilateral breast cancer or metastatic disease; history of gastrointestinal bleeding; uncontrolled or significant comorbid illness; current use of hormone replacement therapy, tamoxifen, or raloxifene)
- Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Cancers affecting the oral cavity; radioth … Cancers affecting the oral cavity; radiotherapy to the floor of the mouth; major psychiatric or cardiovascular disorders; epilepsy; renal or hepatic impairment; pregnant, lactating, or not using adequate contraception; therapies expected to confound the study outcome (epidural analgesia within 48 hours of screening; palliative radio-, chemo-, or hormonal therapy within two weeks of screening; CBs within seven days of randomization); use of levodopa, sildenafil, or fentanyl; hypersensitivity to CBsafil, or fentanyl; hypersensitivity to CBs)
- Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (Chemotherapy treatment with neurotoxic drugs (cisplatin, carboplatin, oxaliplatin, vincristine, vinblastine, paclitaxel, or docetaxel) in the 6 months prior to the start of oxaliplatin-chemotherapy, pregnancy, or breastfeeding)
- Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens + (Clinical evidence of current or impending bowel obstruction, current radiotherapy, that is classified as high or intermediate risk of causing nausea and vomiting; pregnancy or lactation, concurrent use of ginger products)
- Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (Clinical stage T3 or T4, Gleason score ≥ 8 … Clinical stage T3 or T4, Gleason score ≥ 8, serum PSA ≥ 20 ng/mL, other prior surgery for prostate cancer, concurrent participation in another clinical trial which would require approval upon entry to this trial, gastrointestinal disorders such as inflammatory bowel disease, reflux and peptic ulcers and any adverse reaction to curcuminlcers and any adverse reaction to curcumin)
- Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (Clinical stage T3 or T4, Gleason score ≥ 8 … Clinical stage T3 or T4, Gleason score ≥ 8, serum PSA ≥ 20 ng/mL, other prior surgery for prostate cancer, concurrent participation in another clinical trial which would require approval upon entry to this trial, gastrointestinal disorders such as inflammatory bowel disease, reflux and peptic ulcers and any adverse reaction to curcuminlcers and any adverse reaction to curcumin)
- Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (Contraindications of surgery; long-term ad … Contraindications of surgery; long-term administration of medication, recent administration of glucocorticoids, antibiotics, or anodyne; recurrent pericoronitis of the impacted tooth; moderate caries of the wisdom tooth and adjacent teeth; periapical periodontitis, pulpitis, or periodontitis periodontitis, pulpitis, or periodontitis)
- Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (Corticosteroids, digestive problems, anticoagulation, radiotherapy)
- Montazeri et al. (2013): Effect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients + (Corticosteroids, digestive problems, anticoagulation, radiotherapy)
- Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (Current or planned therapy with chemothera … Current or planned therapy with chemotherapy, androgens, estrogens, progestational agents, corticosteroids, or other agents used for treating hot flashes, intake of two multivitamin tablets per day or over 60 IU of vitamin E daily, pregnant or lactating women could not participate, nor could those with a history of bleeding tendencies, immune deficiencies, or thrombophlebitis, immune deficiencies, or thrombophlebitis)
- Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (Current use of at least 600 IU/day of supp … Current use of at least 600 IU/day of supplemental vitamin D or high-dose calcium therapy within the prior 6 month and any prior cancer or other significant diseases that could hamper the participant’s safety or preclude the benefit of vitamin D supplementatione the benefit of vitamin D supplementation)
- Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (Demolitive surgery of the tongue, palate, … Demolitive surgery of the tongue, palate, or oropharynx; the presence of oral lesions, such as stomatitis, ulcers, necrosis, or candidiasis; complete or full upper dentures; elimination of the olfactory component of taste after laryngectomy; concomitant administration of chemotherapy and or any other kind of drug affecting taste; lesions of cranial nerves V, VII, IX, or X; damage to the nervous system after surgery or cerebral lesions; metabolic alterations or disorders; endocrine or neurologic diseases known to influence taste and/or smell sensitivity; local disease in the nose or ears; and lack of cooperation on the part of patientsack of cooperation on the part of patients)
- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Double tumour; other concomitant immunomodulatory therapy)
- Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (Drank tea regularly within 1 month of enro … Drank tea regularly within 1 month of enrollment (more than 6 servings of hot tea or 12 servings of iced tea or equivalent combination per week); receiving other investigational agents; history of allergic reactions attributed to compounds of similar chemical to polyphenon E; uncontrolled intercurrent illnesshenon E; uncontrolled intercurrent illness)
- Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Eastern Cooperative Oncology Group (ECOG) … Eastern Cooperative Oncology Group (ECOG) performance status of >2; a contraindication to medicinal cannabis such as unstable cardiovascular disease, substance use disorder, or significant mental health disorder; experiencing disease-related nausea and vomiting; receiving concomitant oral chemotherapy; had received/were planned to receive radiotherapy to the brain or gastrointestinal tract during the study periodastrointestinal tract during the study period)
- Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (Enteral or parenteral nutrition; had taken; taken anabolic agents, gestagens, cannabinoids, or corticosteroids within the past month; significant cause of secondary anorexia or psychiatric disorder (substance abuse or schizophrenia))
- Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (Evidence of rapid terminal decline, recent … Evidence of rapid terminal decline, recent traumatic injury, or hospitalization within the 2 weeks, skin diseases: acute psoriasis, eczema, severe bruises, skin infection or ulceration, open wound, recent burn or fracture, inflammatory conditions: acute rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, Reiter’s syndrome, cardiovascular conditions: history of deep vein thrombosis, phlebitis, angina, a pacemaker, recent discontinuation(less than 2 weeks) of physiotherapy that included massagetherapy, fever (recent temperature >102◦within past 24hours), or currently prescribed anticoagulant medication (e.g., Coumadin, Heparin, or derivative substances).Coumadin, Heparin, or derivative substances).)
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (Fungating malignant wound with fistula, sinus or exposure of bone; patients receiving systemic metronidazole; patients treated with topical metronidazole for more than 30 days and neutropenic patients with total white cell count of less than 1.5×109/L.)
- Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Had known metastatic disease to the bone, … Had known metastatic disease to the bone, kidney stones, primary hyperparathyroidism, Paget’s disease of the bone, severe arthritis, rheumatoid arthritis, severe neuropathy or 25OHD C 30 ng/ml;</br>treatment on the trial was stopped if the patient developed hypercalciuria (C250 mg/g creatinine) or hypercalcemia (C10.3 mg/dl)creatinine) or hypercalcemia (C10.3 mg/dl))
- Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (Had received immunotherapy or radiation treatment in the previous 3 weeks or concurrent malignancies)
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Having another trial participation session … Having another trial participation session, including previous participation in the pilot trial, pregnant or lactating women, hypercalcemia, hyperphosphatemia, tuberculosis, sarcoidosis, history of nephrolithiasis, history of hyperparathyroidism, medications interfering with vitamin D metabolism, renal insufficiency, patients having psychological diseases, abnormal mental function, and unconscious patients mental function, and unconscious patients)
- Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients + (Hemorrhage, epilepsy or fever, paraplegia or thrombosis, gall-kidney stone, leg varicosis or foot disease (open wound or fracture on foot), diagnosis of psychiatric disorder or dementia, having accepted to participate in the study)
- Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (History of any type of malignancy within the past 5 years and other serious medical or psychiatric illness that would preclude giving informed consent)