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List of results

Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Baseline use of morphine at >500mg morp … Baseline use of morphine at >500mg morphine equivalents/day (inclusive of maintenance and breakthrough opioids); current use of more than one type of breakthrough opioid analgesic; planned clinical interventions that would affect pain; any history of schizophrenia or substance abuse including recreational use of cannabis productncluding recreational use of cannabis product)
Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (Being pregnant, diabetes, asthma, Sjogren' … Being pregnant, diabetes, asthma, Sjogren's syndrome, lack of ability to feed by mouth, using anti-depressant medications, a history of allergy to ginger or corn starch and people who have had recurrence of cancer and residence outside the city of Ahvaz and the lack of consent of the participation in the study.consent of the participation in the study.)
Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Bilateral breast cancer or metastatic disease; history of gastrointestinal bleeding; uncontrolled or significant comorbid illness; current use of hormone replacement therapy, tamoxifen, or raloxifene)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Cancers affecting the oral cavity; radioth … Cancers affecting the oral cavity; radiotherapy to the floor of the mouth; major psychiatric or cardiovascular disorders; epilepsy; renal or hepatic impairment; pregnant, lactating, or not using adequate contraception; therapies expected to confound the study outcome (epidural analgesia within 48 hours of screening; palliative radio-, chemo-, or hormonal therapy within two weeks of screening; CBs within seven days of randomization); use of levodopa, sildenafil, or fentanyl; hypersensitivity to CBsafil, or fentanyl; hypersensitivity to CBs)
Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (Chemotherapy treatment with neurotoxic drugs (cisplatin, carboplatin, oxaliplatin, vincristine, vinblastine, paclitaxel, or docetaxel) in the 6 months prior to the start of oxaliplatin-chemotherapy, pregnancy, or breastfeeding)
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens + (Clinical evidence of current or impending bowel obstruction, current radiotherapy, that is classified as high or intermediate risk of causing nausea and vomiting; pregnancy or lactation, concurrent use of ginger products)
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (Clinical stage T3 or T4, Gleason score ≥ 8 … Clinical stage T3 or T4, Gleason score ≥ 8, serum PSA ≥ 20 ng/mL, other prior surgery for prostate cancer, concurrent participation in another clinical trial which would require approval upon entry to this trial, gastrointestinal disorders such as inflammatory bowel disease, reflux and peptic ulcers and any adverse reaction to curcuminlcers and any adverse reaction to curcumin)
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (Clinical stage T3 or T4, Gleason score ≥ 8 … Clinical stage T3 or T4, Gleason score ≥ 8, serum PSA ≥ 20 ng/mL, other prior surgery for prostate cancer, concurrent participation in another clinical trial which would require approval upon entry to this trial, gastrointestinal disorders such as inflammatory bowel disease, reflux and peptic ulcers and any adverse reaction to curcuminlcers and any adverse reaction to curcumin)
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (Contraindications of surgery; long-term ad … Contraindications of surgery; long-term administration of medication, recent administration of glucocorticoids, antibiotics, or anodyne; recurrent pericoronitis of the impacted tooth; moderate caries of the wisdom tooth and adjacent teeth; periapical periodontitis, pulpitis, or periodontitis periodontitis, pulpitis, or periodontitis)
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (Corticosteroids, digestive problems, anticoagulation, radiotherapy)
Montazeri et al. (2013): Eﬀect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients + (Corticosteroids, digestive problems, anticoagulation, radiotherapy)
Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (Current or planned therapy with chemothera … Current or planned therapy with chemotherapy, androgens, estrogens, progestational agents, corticosteroids, or other agents used for treating hot flashes, intake of two multivitamin tablets per day or over 60 IU of vitamin E daily, pregnant or lactating women could not participate, nor could those with a history of bleeding tendencies, immune deficiencies, or thrombophlebitis, immune deficiencies, or thrombophlebitis)
Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (Current use of at least 600 IU/day of supp … Current use of at least 600 IU/day of supplemental vitamin D or high-dose calcium therapy within the prior 6 month and any prior cancer or other significant diseases that could hamper the participant’s safety or preclude the benefit of vitamin D supplementatione the benefit of vitamin D supplementation)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (Demolitive surgery of the tongue, palate, … Demolitive surgery of the tongue, palate, or oropharynx; the presence of oral lesions, such as stomatitis, ulcers, necrosis, or candidiasis; complete or full upper dentures; elimination of the olfactory component of taste after laryngectomy; concomitant administration of chemotherapy and or any other kind of drug affecting taste; lesions of cranial nerves V, VII, IX, or X; damage to the nervous system after surgery or cerebral lesions; metabolic alterations or disorders; endocrine or neurologic diseases known to influence taste and/or smell sensitivity; local disease in the nose or ears; and lack of cooperation on the part of patientsack of cooperation on the part of patients)

Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Double tumour; other concomitant immunomodulatory therapy)

Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (Drank tea regularly within 1 month of enro … Drank tea regularly within 1 month of enrollment (more than 6 servings of hot tea or 12 servings of iced tea or equivalent combination per week); receiving other investigational agents; history of allergic reactions attributed to compounds of similar chemical to polyphenon E; uncontrolled intercurrent illnesshenon E; uncontrolled intercurrent illness)
Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Eastern Cooperative Oncology Group (ECOG) … Eastern Cooperative Oncology Group (ECOG) performance status of >2; a contraindication to medicinal cannabis such as unstable cardiovascular disease, substance use disorder, or significant mental health disorder; experiencing disease-related nausea and vomiting; receiving concomitant oral chemotherapy; had received/were planned to receive radiotherapy to the brain or gastrointestinal tract during the study periodastrointestinal tract during the study period)
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (Enteral or parenteral nutrition; had taken; taken anabolic agents, gestagens, cannabinoids, or corticosteroids within the past month; significant cause of secondary anorexia or psychiatric disorder (substance abuse or schizophrenia))
Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (Evidence of rapid terminal decline, recent … Evidence of rapid terminal decline, recent traumatic injury, or hospitalization within the 2 weeks, skin diseases: acute psoriasis, eczema, severe bruises, skin infection or ulceration, open wound, recent burn or fracture, inﬂammatory conditions: acute rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, Reiter’s syndrome, cardiovascular conditions: history of deep vein thrombosis, phlebitis, angina, a pacemaker, recent discontinuation(less than 2 weeks) of physiotherapy that included massagetherapy, fever (recent temperature >102◦within past 24hours), or currently prescribed anticoagulant medication (e.g., Coumadin, Heparin, or derivative substances).Coumadin, Heparin, or derivative substances).)
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (Fungating malignant wound with fistula, sinus or exposure of bone; patients receiving systemic metronidazole; patients treated with topical metronidazole for more than 30 days and neutropenic patients with total white cell count of less than 1.5×109/L.)
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Had known metastatic disease to the bone, … Had known metastatic disease to the bone, kidney stones, primary hyperparathyroidism, Paget’s disease of the bone, severe arthritis, rheumatoid arthritis, severe neuropathy or 25OHD C 30 ng/ml;treatment on the trial was stopped if the patient developed hypercalciuria (C250 mg/g creatinine) or hypercalcemia (C10.3 mg/dl)creatinine) or hypercalcemia (C10.3 mg/dl))
Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (Had received immunotherapy or radiation treatment in the previous 3 weeks or concurrent malignancies)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Having another trial participation session … Having another trial participation session, including previous participation in the pilot trial, pregnant or lactating women, hypercalcemia, hyperphosphatemia, tuberculosis, sarcoidosis, history of nephrolithiasis, history of hyperparathyroidism, medications interfering with vitamin D metabolism, renal insufficiency, patients having psychological diseases, abnormal mental function, and unconscious patients mental function, and unconscious patients)
Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients + (Hemorrhage, epilepsy or fever, paraplegia or thrombosis, gall-kidney stone, leg varicosis or foot disease (open wound or fracture on foot), diagnosis of psychiatric disorder or dementia, having accepted to participate in the study)
Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (History of any type of malignancy within the past 5 years and other serious medical or psychiatric illness that would preclude giving informed consent)
Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer + (History of autoimmune disease, chronic inflammatory disease, active infectious diseases, liver or kidney disease, use of immunosuppressive drugs, or supplements containing zinc or copper, and chemotherapy or radiotherapy within 12 months before the study)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (History of cancer (excluding basal cell carcinoma), participating in another clinical trial and clinically significant cognitive impairment or dementia.)
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (History of chronic pain, disseminated cancer, narcotic or ethanol addiction, peripheral neuropathy, foot amputation, diagnosed deep vein thrombosis, open wound on foot, dementia, or psychiatric diagnoses.)
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (History of diabetes, history of peripheral … History of diabetes, history of peripheral neuropathy resulting from other causes, or seizure disorder; receiving any of the following medications used to treat CIPN were excluded: vitamin E, glutamine, gabapentin, nortriptyline, amitriptyline or duloxetine hydrochloride (HCL), and other nutritional supplements used to treat CIPNnutritional supplements used to treat CIPN)
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine + (History of diabetes, history of peripheral … History of diabetes, history of peripheral neuropathy resulting from other causes, or seizure disorder; receiving any of the following medications used to treat CIPN were excluded: vitamin E, glutamine, gabapentin, nortriptyline, amitriptyline or duloxetine hydrochloride (HCL), and other nutritional supplements used to treat CIPNnutritional supplements used to treat CIPN)
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (History of hepatitis, alcohol abuse and other significant medical or psychiatric condition; took 5-alpha reductase inhibitors, antiandrogens, or luteinizing hormone-releasing hormone agonists)
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (History of middle or inner ear disease; prior therapy with cisplatin; abnormal audiometric and audiometric impedance tests and abnormal distortion product otoacoustic emissions (DOPOAEs) within the range of frequencies tested)
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (History of peripheral neuropathy (i.e., he … History of peripheral neuropathy (i.e., hereditary, paraneoplastic, or associated with nutritional agents) and a history of systemic diseases (i.e., diabetes mellitus, SLE, HIV, alcohol abuse); excluded if they were not chemotherapy-naïve or if clinical or electrophysiological evidence of peripheral neuropathy was disclosed at baselineheral neuropathy was disclosed at baseline)
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (History of peripheral neuropathy (i.e., he … History of peripheral neuropathy (i.e., hereditary, paraneoplastic, or associated with nutritional agents) and a history of systemic diseases (i.e., diabetes mellitus, SLE, HIV, alcohol abuse); excluded if they were not chemotherapy-naïve or if clinical or electrophysiological evidence of peripheral neuropathy was disclosed at baselineheral neuropathy was disclosed at baseline)
Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (History of peripheral neuropathy and systemic diseases such as diabetes mellitus, systemic lupus erythematosus, HIV, and alcohol problems, as well as those with a history of chemotherapy treatment)
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (History of previous malignancy or chemotherapy, history of other systemic diseases, metastatic condition or receiving other antiemetic drugs)
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (History of radiation therapy or chemothera … History of radiation therapy or chemotherapy in previous year, chemotherapy protocol in addition to radiotherapy, any allergy to condiments, especially "Turmeric root", any complications due to the use of topical gel during the study, suffering from any kind of oral disease such as active oral infection, ulcer, having any systemic disease or taking any medication systemic disease or taking any medication)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (History of renal stones, hypercalcemia, or hyper- parathyroidism)
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Hypothyroidism; depression or other severe … Hypothyroidism; depression or other severe psychiatric illness; anemia; previous antineoplastic treatment; contraindications to guarana (insomnia, angina or other cardiovascular disease, uncontrolled hypertension, neurological disease); antidepressant, anxiolytic or sleep-inducing medications, anxiolytic or sleep-inducing medications)
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (If they were: - Receiving multiple-day ch … If they were: - Receiving multiple-day chemotherapy; - Receiving concurrent radiotherapy that was classified as high or intermediate risk of causing emesis (i.e., total body irradiation, hemi-body, upper abdomen, abdominalpelvic mantle, cranium, or craniospinal irradiation);- taking therapeutic doses of coumadin (individuals on low-dose coumadin to maintain peripheral or central venous catheters were allowed), aspirin (individuals taking low- dose 81 mg aspirin were allowed), or heparin; - Had a history of a bleeding disorder(s) and those experiencing clinically significant thrombocytopenia;- Had an allergy to ginger or had taken ginger in the last week;- Nursing mothers, pregnant women, or planning a pregnancy during the study period.nning a pregnancy during the study period.)