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- Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (Current use of at least 600 IU/day of supp … Current use of at least 600 IU/day of supplemental vitamin D or high-dose calcium therapy within the prior 6 month and any prior cancer or other significant diseases that could hamper the participant’s safety or preclude the benefit of vitamin D supplementatione the benefit of vitamin D supplementation)
- Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (Demolitive surgery of the tongue, palate, … Demolitive surgery of the tongue, palate, or oropharynx; the presence of oral lesions, such as stomatitis, ulcers, necrosis, or candidiasis; complete or full upper dentures; elimination of the olfactory component of taste after laryngectomy; concomitant administration of chemotherapy and or any other kind of drug affecting taste; lesions of cranial nerves V, VII, IX, or X; damage to the nervous system after surgery or cerebral lesions; metabolic alterations or disorders; endocrine or neurologic diseases known to influence taste and/or smell sensitivity; local disease in the nose or ears; and lack of cooperation on the part of patientsack of cooperation on the part of patients)
- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Double tumour; other concomitant immunomodulatory therapy)
- Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (Drank tea regularly within 1 month of enro … Drank tea regularly within 1 month of enrollment (more than 6 servings of hot tea or 12 servings of iced tea or equivalent combination per week); receiving other investigational agents; history of allergic reactions attributed to compounds of similar chemical to polyphenon E; uncontrolled intercurrent illnesshenon E; uncontrolled intercurrent illness)
- Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Eastern Cooperative Oncology Group (ECOG) … Eastern Cooperative Oncology Group (ECOG) performance status of >2; a contraindication to medicinal cannabis such as unstable cardiovascular disease, substance use disorder, or significant mental health disorder; experiencing disease-related nausea and vomiting; receiving concomitant oral chemotherapy; had received/were planned to receive radiotherapy to the brain or gastrointestinal tract during the study periodastrointestinal tract during the study period)
- Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (Enteral or parenteral nutrition; had taken; taken anabolic agents, gestagens, cannabinoids, or corticosteroids within the past month; significant cause of secondary anorexia or psychiatric disorder (substance abuse or schizophrenia))
- Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (Evidence of rapid terminal decline, recent … Evidence of rapid terminal decline, recent traumatic injury, or hospitalization within the 2 weeks, skin diseases: acute psoriasis, eczema, severe bruises, skin infection or ulceration, open wound, recent burn or fracture, inflammatory conditions: acute rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, Reiter’s syndrome, cardiovascular conditions: history of deep vein thrombosis, phlebitis, angina, a pacemaker, recent discontinuation(less than 2 weeks) of physiotherapy that included massagetherapy, fever (recent temperature >102◦within past 24hours), or currently prescribed anticoagulant medication (e.g., Coumadin, Heparin, or derivative substances).Coumadin, Heparin, or derivative substances).)
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (Fungating malignant wound with fistula, sinus or exposure of bone; patients receiving systemic metronidazole; patients treated with topical metronidazole for more than 30 days and neutropenic patients with total white cell count of less than 1.5×109/L.)
- Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Had known metastatic disease to the bone, … Had known metastatic disease to the bone, kidney stones, primary hyperparathyroidism, Paget’s disease of the bone, severe arthritis, rheumatoid arthritis, severe neuropathy or 25OHD C 30 ng/ml;</br>treatment on the trial was stopped if the patient developed hypercalciuria (C250 mg/g creatinine) or hypercalcemia (C10.3 mg/dl)creatinine) or hypercalcemia (C10.3 mg/dl))
- Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (Had received immunotherapy or radiation treatment in the previous 3 weeks or concurrent malignancies)
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Having another trial participation session … Having another trial participation session, including previous participation in the pilot trial, pregnant or lactating women, hypercalcemia, hyperphosphatemia, tuberculosis, sarcoidosis, history of nephrolithiasis, history of hyperparathyroidism, medications interfering with vitamin D metabolism, renal insufficiency, patients having psychological diseases, abnormal mental function, and unconscious patients mental function, and unconscious patients)
- Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients + (Hemorrhage, epilepsy or fever, paraplegia or thrombosis, gall-kidney stone, leg varicosis or foot disease (open wound or fracture on foot), diagnosis of psychiatric disorder or dementia, having accepted to participate in the study)
- Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (History of any type of malignancy within the past 5 years and other serious medical or psychiatric illness that would preclude giving informed consent)
- Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer + (History of autoimmune disease, chronic inflammatory disease, active infectious diseases, liver or kidney disease, use of immunosuppressive drugs, or supplements containing zinc or copper, and chemotherapy or radiotherapy within 12 months before the study)
- Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (History of cancer (excluding basal cell carcinoma), participating in another clinical trial and clinically significant cognitive impairment or dementia.)
- Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (History of chronic pain, disseminated cancer, narcotic or ethanol addiction, peripheral neuropathy, foot amputation, diagnosed deep vein thrombosis, open wound on foot, dementia, or psychiatric diagnoses.)
- Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (History of diabetes, history of peripheral … History of diabetes, history of peripheral neuropathy resulting from other causes, or seizure disorder; receiving any of the following medications used to treat CIPN were excluded: vitamin E, glutamine, gabapentin, nortriptyline, amitriptyline or duloxetine hydrochloride (HCL), and other nutritional supplements used to treat CIPNnutritional supplements used to treat CIPN)
- Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine + (History of diabetes, history of peripheral … History of diabetes, history of peripheral neuropathy resulting from other causes, or seizure disorder; receiving any of the following medications used to treat CIPN were excluded: vitamin E, glutamine, gabapentin, nortriptyline, amitriptyline or duloxetine hydrochloride (HCL), and other nutritional supplements used to treat CIPNnutritional supplements used to treat CIPN)
- Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (History of hepatitis, alcohol abuse and other significant medical or psychiatric condition; took 5-alpha reductase inhibitors, antiandrogens, or luteinizing hormone-releasing hormone agonists)
- Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (History of middle or inner ear disease; prior therapy with cisplatin; abnormal audiometric and audiometric impedance tests and abnormal distortion product otoacoustic emissions (DOPOAEs) within the range of frequencies tested)
- Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (History of peripheral neuropathy (i.e., he … History of peripheral neuropathy (i.e., hereditary, paraneoplastic, or associated with nutritional agents) and a history of systemic diseases (i.e., diabetes mellitus, SLE, HIV, alcohol abuse); excluded if they were not chemotherapy-naïve or if clinical or electrophysiological evidence of peripheral neuropathy was disclosed at baselineheral neuropathy was disclosed at baseline)
- Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (History of peripheral neuropathy (i.e., he … History of peripheral neuropathy (i.e., hereditary, paraneoplastic, or associated with nutritional agents) and a history of systemic diseases (i.e., diabetes mellitus, SLE, HIV, alcohol abuse); excluded if they were not chemotherapy-naïve or if clinical or electrophysiological evidence of peripheral neuropathy was disclosed at baselineheral neuropathy was disclosed at baseline)
- Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (History of peripheral neuropathy and systemic diseases such as diabetes mellitus, systemic lupus erythematosus, HIV, and alcohol problems, as well as those with a history of chemotherapy treatment)
- Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (History of previous malignancy or chemotherapy, history of other systemic diseases, metastatic condition or receiving other antiemetic drugs)
- Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (History of radiation therapy or chemothera … History of radiation therapy or chemotherapy in previous year, chemotherapy protocol in addition to radiotherapy, any allergy to condiments, especially "Turmeric root", any complications due to the use of topical gel during the study, suffering from any kind of oral disease such as active oral infection, ulcer, having any systemic disease or taking any medication systemic disease or taking any medication)
- Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (History of renal stones, hypercalcemia, or hyper- parathyroidism)
- Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Hypothyroidism; depression or other severe … Hypothyroidism; depression or other severe psychiatric illness; anemia; previous antineoplastic treatment; contraindications to guarana (insomnia, angina or other cardiovascular disease, uncontrolled hypertension, neurological disease); antidepressant, anxiolytic or sleep-inducing medications, anxiolytic or sleep-inducing medications)
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (If they were: - Receiving multiple-day ch … If they were: </br>- Receiving multiple-day chemotherapy; </br>- Receiving concurrent radiotherapy that was classified as high or intermediate risk of causing emesis (i.e., total body irradiation, hemi-body, upper abdomen, abdominalpelvic mantle, cranium, or craniospinal irradiation);</br>- taking therapeutic doses of coumadin (individuals on low-dose coumadin to maintain peripheral or central venous catheters were allowed), aspirin (individuals taking low- dose 81 mg aspirin were allowed), or heparin; </br>- Had a history of a bleeding disorder(s) and those experiencing clinically significant thrombocytopenia;</br>- Had an allergy to ginger or had taken ginger in the last week;</br>- Nursing mothers, pregnant women, or planning a pregnancy during the study period.nning a pregnancy during the study period.)
- Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Immunosuppressed patients; patients with genetic skin cancer disorders and tumors in the face and/or hairy scalp)
- Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (Infected tooth, ulcers, or mucositis of the oral cavity)
- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (Intake of carnitine, history of seizures, brain metastasis, nausea more than grade 1, and severely compromised renal, liver, or respiratory function)
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Karnofsky index < 50%; known intoleranc … Karnofsky index < 50%; known intolerance to enzyme preparations or additives; women declining to perform a pregnancy test (HCG method) before start of the study; pregnancy or lactation; participation in another clinical study within the previous 30 days; concurrent participation in another clinical studyrrent participation in another clinical study)
- Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (Karnofsky index <50, Dexamethasone >24 mg/day before radiotherapy)
- Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (Known hypersensitivity reaction to vitamin D or calcium com-pounds, known comorbidities affecting the vitamin D/calcium balance or bone health, concomitant vitamin D supplementation)
- Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (Known mechanical obstruction of the alimen … Known mechanical obstruction of the alimentary tract; malabsorption, or intractable vomiting; previous surgery that had included ablation or removal of the olfactory component of taste; known intolerance to zinc sulfate; or untreated oral thrush; women who were pregnant, nursing, or of childbearing potential and unwilling to use contraceptiontential and unwilling to use contraception)
- Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (Known pregnancy or lactation; history of i … Known pregnancy or lactation; history of intolerability to emzyme preparations or to the passive ingredients ; arterial closures and/or flow-off disorders at the ill arm and/or contra lateral arm; connate lmphatic oedema; treatment with venoactive drugs such as Rutosides, Bioflavonoides, Aescin, ets.; treatment with NSAIDs; contraindication for lymphatic drainage; participation in any clinical study in the last 30 days; simultaneous participation in any other clinical trial participation in any other clinical trial)
- Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (Liver dysfunction, respiratory dysfunction, cardiac dysfunction, renal failure, ongoing infection, history of recent immunosuppressive or immunologic disease (including preoperative chemo-therapy and/or radiation therapy), or diabetes mellitus)
- Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (Liver failure, a second malignancy, treatment with omega-3-fatty acids and the presence of a mental disorder precluding informed consent)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Metastatic disease; history of radiotherap … Metastatic disease; history of radiotherapy in the head and neck region; Karnofsky score <60; cognitive impairment; hepatic insufficiency; pregnant or breastfeeding woman; history of hypersensitivity or adverse reactions to marijuana or other cannabinoids; history of schizophrenia or any other form of psychosis schizophrenia or any other form of psychosis)
- Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization + (NA)
- Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial + (NA)
- Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer + (NI)
- Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (NI)
- Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (NI)
- Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (NI)
- Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients + (NI)
- Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients + (NI)
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (NI)
- Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (NI)
- Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (NI)
- Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (NI)