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- Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Hypothyroidism; depression or other severe … Hypothyroidism; depression or other severe psychiatric illness; anemia; previous antineoplastic treatment; contraindications to guarana (insomnia, angina or other cardiovascular disease, uncontrolled hypertension, neurological disease); antidepressant, anxiolytic or sleep-inducing medications, anxiolytic or sleep-inducing medications)