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- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Palliative indications for pelvic irradiation; existence of a colostomy; known intolerance to proteolytic enzyme preparations or to contents of the study medication; participation in other clinical studies within the last 30 days)