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- Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (Patients with a previous history of radiat … Patients with a previous history of radiation therapy, anemia, or clinical depression.</br>Patients who were unable to grant informed consent or those who had medical contraindindications for the use of guarana (because of its psychostimulant effect) such as uncontrolled hypertension)effect) such as uncontrolled hypertension))